650
Views
13
CrossRef citations to date
0
Altmetric
Research Paper

Mucosal and systemic antibody responses to potential Pseudomonas aeruginosa vaccine protein antigens in young children with cystic fibrosis following colonization and infection

, , , , , & show all
Pages 506-514 | Received 10 Oct 2012, Accepted 23 Oct 2012, Published online: 18 Dec 2012

References

  • McCullin M, Fick RBJ. Pathogenesis of Pseudomonal lung disease in cystic fibrosis. Boca Raton, Fla: CRC Press, 1993.
  • Parsons YN, Panagea S, Smart CH, Walshaw MJ, Hart CA, Winstanley C. Use of subtractive hybridization to identify a diagnostic probe for a cystic fibrosis epidemic strain of Pseudomonas aeruginosa. J Clin Microbiol 2002; 40:4607 - 11; http://dx.doi.org/10.1128/JCM.40.12.4607-4611.2002; PMID: 12454160
  • Levitan IB. The basic defect in cystic fibrosis. Science 1989; 244:1423; http://dx.doi.org/10.1126/science.2544028; PMID: 2544028
  • Speert DP. Prevention of severe lower respiratory infections in patients with cystic fibrosis. Semin Respir Infect 1989; 4:266 - 71; PMID: 2516638
  • Piedra P, Ogra PL. Immunologic aspects of surface infections in the lung. J Pediatr 1986; 108:817 - 23; http://dx.doi.org/10.1016/S0022-3476(86)80751-X; PMID: 3084749
  • Welsh MJ, Smith AE. Cystic fibrosis. Sci Am 1995; 273:52 - 9; http://dx.doi.org/10.1038/scientificamerican1295-52; PMID: 8525348
  • Buret A, Cripps AW. The immunoevasive activities of Pseudomonas aeruginosa. Relevance for cystic fibrosis. Am Rev Respir Dis 1993; 148:793 - 805; http://dx.doi.org/10.1164/ajrccm/148.3.793; PMID: 8368651
  • Wood RE, Boat TF, Doershuk CF. Cystic fibrosis. Am Rev Respir Dis 1976; 113:833 - 78; PMID: 779549
  • Cripps AW, Dunkley ML, Taylor DC, Cousins S, Clancy RL. Immunity to Pseudomonas aeruginosa induced by OprF following intestinal immunization. Adv Exp Med Biol 1995; 371B:761 - 3; PMID: 7502893
  • Thomas LD, Kyd JM, Bastin DA, Dunkley ML, Cripps AW. Immunisation with non-integral OMPs promotes pulmonary clearance of Pseudomonas aeruginosa. FEMS Immunol Med Microbiol 2003; 37:155 - 60; http://dx.doi.org/10.1016/S0928-8244(03)00073-7; PMID: 12832119
  • Thomas LD, Cripps AW, Kyd JM. Immune response mechanisms against Pseudomonas aeruginosa associated with mucosal immunization with protein antigens in a rat model of acute lung infection. Vaccine 2009; 27:3324 - 30; http://dx.doi.org/10.1016/j.vaccine.2009.01.085; PMID: 19200832
  • Thomas LD, Dunkley ML, Moore R, Reynolds S, Bastin DA, Kyd JM, et al. Catalase immunization from Pseudomonas aeruginosa enhances bacterial clearance in the rat lung. Vaccine 2000; 19:348 - 57; http://dx.doi.org/10.1016/S0264-410X(00)00146-8; PMID: 10930690
  • Cripps AW, Dunkley ML, Clancy RL. Mucosal and systemic immunizations with killed Pseudomonas aeruginosa protect against acute respiratory infection in rats. Infect Immun 1994; 62:1427 - 36; PMID: 8132349
  • Cripps AW, Peek K, Dunkley M, Vento K, Marjason JK, McIntyre ME, et al. Safety and immunogenicity of an oral inactivated whole-cell pseudomonas aeruginosa vaccine administered to healthy human subjects. Infect Immun 2006; 74:968 - 74; http://dx.doi.org/10.1128/IAI.74.2.968-974.2006; PMID: 16428742
  • Döring G, Pier GB. Vaccines and immunotherapy against Pseudomonas aeruginosa. Vaccine 2008; 26:1011 - 24; http://dx.doi.org/10.1016/j.vaccine.2007.12.007; PMID: 18242792
  • Bumann D, Behre C, Behre K, Herz S, Gewecke B, Gessner JE, et al. Systemic, nasal and oral live vaccines against Pseudomonas aeruginosa: a clinical trial of immunogenicity in lower airways of human volunteers. Vaccine 2010; 28:707 - 13; http://dx.doi.org/10.1016/j.vaccine.2009.10.080; PMID: 19887136
  • Sharma A, Krause A, Worgall S. Recent developments for Pseudomonas vaccines. Hum Vaccin 2011; 7:999 - 1011; http://dx.doi.org/10.4161/hv.7.10.16369; PMID: 21941090
  • Sorichter S, Baumann U, Baumgart A, Walterspacher S, von Specht BU. Immune responses in the airways by nasal vaccination with systemic boosting against Pseudomonas aeruginosa in chronic lung disease. Vaccine 2009; 27:2755 - 9; http://dx.doi.org/10.1016/j.vaccine.2009.03.010; PMID: 19366571
  • Döring G. Prevention of Pseudomonas aeruginosa infection in cystic fibrosis patients. Int J Med Microbiol 2010; 300:573 - 7; http://dx.doi.org/10.1016/j.ijmm.2010.08.010; PMID: 20940108
  • Döring G. Vaccine development for patients with cystic fibrosis. Expert Rev Vaccines 2012; 11:259 - 61; http://dx.doi.org/10.1586/erv.12.1; PMID: 22380816
  • Beckmann C, Brittnacher M, Ernst R, Mayer-Hamblett N, Miller SI, Burns JL. Use of phage display to identify potential Pseudomonas aeruginosa gene products relevant to early cystic fibrosis airway infections. Infect Immun 2005; 73:444 - 52; http://dx.doi.org/10.1128/IAI.73.1.444-452.2005; PMID: 15618183
  • Rao AR, Splaingard MS, Gershan WM, Havens PL, Thill A, Barbieri JT. Detection of Pseudomonas aeruginosa type III antibodies in children with tracheostomies. Pediatr Pulmonol 2005; 39:402 - 7; http://dx.doi.org/10.1002/ppul.20194; PMID: 15666370
  • Jaffar-Bandjee MC, Carrère J, Bally M, Guy-Crotte O, Galabert C. Immunoenzymometric assays for alkaline protease and exotoxin A from Pseudomonas aeruginosa: development and use in detecting exoproteins in clinical isolates from patients with cystic fibrosis. Eur J Clin Chem Clin Biochem 1994; 32:893 - 9; PMID: 7696436
  • Pedersen SS, Møller H, Espersen F, Sørensen CH, Jensen T, Høiby N. Mucosal immunity to Pseudomonas aeruginosa alginate in cystic fibrosis. APMIS 1992; 100:326 - 34; http://dx.doi.org/10.1111/j.1699-0463.1992.tb00879.x; PMID: 1581041
  • Pressler T, Pedersen SS, Espersen F, Høiby N, Koch C. IgG subclass antibodies to Pseudomonas aeruginosa in sera from patients with chronic Ps. aeruginosa infection investigated by ELISA. Clin Exp Immunol 1990; 81:428 - 34; http://dx.doi.org/10.1111/j.1365-2249.1990.tb05351.x; PMID: 2118845
  • Fomsgaard A, Dinesen B, Shand GH, Pressler T, Høiby N. Antilipopolysaccharide antibodies and differential diagnosis of chronic Pseudomonas aeruginosa lung infection in cystic fibrosis. J Clin Microbiol 1989; 27:1222 - 9; PMID: 2502558
  • Baltimore RS, Fick RB Jr., Fino L. Antibody to multiple mucoid strains of Pseudomonas aeruginosa in patients with cystic fibrosis, measured by an enzyme-linked immunosorbent assay. Pediatr Res 1986; 20:1085 - 90; http://dx.doi.org/10.1203/00006450-198611000-00005; PMID: 3099248
  • Shand GH, Pedersen SS, Brown MR, Høiby N. Serum antibodies to Pseudomonas aeruginosa outer-membrane proteins and iron-regulated membrane proteins at different stages of chronic cystic fibrosis lung infection. J Med Microbiol 1991; 34:203 - 12; http://dx.doi.org/10.1099/00222615-34-4-203; PMID: 1902261
  • Likavcanova E, Lagacé J. Quantitative analysis of immunoglobulin G subclass responses to Pseudomonas aeruginosa antigens in cystic fibrosis. J Med Microbiol 1992; 36:437 - 44; http://dx.doi.org/10.1099/00222615-36-6-437; PMID: 1613784
  • Kubesch P, von Specht BU, Tümmler B. Immune response in cystic fibrosis to outer membrane proteins of Pseudomonas aeruginosa. Zentralbl Bakteriol Mikrobiol Hyg A 1988; 269:395 - 410; http://dx.doi.org/10.1016/S0176-6724(88)80183-4; PMID: 3146171
  • Kappler M, Kraxner A, Reinhardt D, Ganster B, Griese M, Lang T. Diagnostic and prognostic value of serum antibodies against Pseudomonas aeruginosa in cystic fibrosis. Thorax 2006; 61:684 - 8; http://dx.doi.org/10.1136/thx.2005.049536; PMID: 16449259
  • Fito-Boncompte L, Chapalain A, Bouffartigues E, Chaker H, Lesouhaitier O, Gicquel G, et al. Full virulence of Pseudomonas aeruginosa requires OprF. Infect Immun 2011; 79:1176 - 86; http://dx.doi.org/10.1128/IAI.00850-10; PMID: 21189321
  • Edrington TC, Kintz E, Goldberg JB, Tamm LK. Structural basis for the interaction of lipopolysaccharide with outer membrane protein H (OprH) from Pseudomonas aeruginosa. J Biol Chem 2011; 286:39211 - 23; http://dx.doi.org/10.1074/jbc.M111.280933; PMID: 21865172
  • McPhee JB, Tamber S, Bains M, Maier E, Gellatly S, Lo A, et al. The major outer membrane protein OprG of Pseudomonas aeruginosa contributes to cytotoxicity and forms an anaerobically regulated, cation-selective channel. FEMS Microbiol Lett 2009; 296:241 - 7; http://dx.doi.org/10.1111/j.1574-6968.2009.01651.x; PMID: 19486157
  • Wainwright CE, France MW, O’Rourke P, Anuj S, Kidd TJ, Nissen MD, et al. Cough-generated aerosols of Pseudomonas aeruginosa and other Gram-negative bacteria from patients with cystic fibrosis. Thorax 2009; 64:926 - 31; http://dx.doi.org/10.1136/thx.2008.112466; PMID: 19574243
  • Griffiths AL, Jamsen K, Carlin JB, Grimwood K, Carzino R, Robinson PJ, et al. Effects of segregation on an epidemic Pseudomonas aeruginosa strain in a cystic fibrosis clinic. Am J Respir Crit Care Med 2005; 171:1020 - 5; http://dx.doi.org/10.1164/rccm.200409-1194OC; PMID: 15709051
  • Kidd TJ, Ritchie SR, Ramsay KA, Grimwood K, Bell SC, Rainey PB. Pseudomonas aeruginosa exhibits frequent recombination, but only a limited association between genotype and ecological setting. PLoS One 2012; 7:e44199; http://dx.doi.org/10.1371/journal.pone.0044199; PMID: 22970178
  • Kubesch P, Lingner M, Grothues D, Wehsling M, Tümmler B. Strategies of Pseudomonas aeruginosa to colonize and to persist in the cystic fibrosis lung. Scand J Gastroenterol Suppl 1988; 143:77 - 80; http://dx.doi.org/10.3109/00365528809090222; PMID: 3133755
  • von Specht B, Knapp B, Hungerer K, Lücking C, Schmitt A, Domdey H. Outer membrane proteins of Pseudomonas aeruginosa as vaccine candidates. J Biotechnol 1996; 44:145 - 53; http://dx.doi.org/10.1016/0168-1656(95)00161-1; PMID: 8717398
  • Pressler T, Kronborg G, Shand GH, Mansa B, Høiby N. Determination of IgG subclass antibodies to Pseudomonas aeruginosa outer membrane proteins in cystic fibrosis lung infection using immunoblotting and enzyme-linked immunosorbent assay. Med Microbiol Immunol 1992; 181:339 - 49; http://dx.doi.org/10.1007/BF00191546; PMID: 1287420
  • Brown SM, Howell ML, Vasil ML, Anderson AJ, Hassett DJ. Cloning and characterization of the katB gene of Pseudomonas aeruginosa encoding a hydrogen peroxide-inducible catalase: purification of KatB, cellular localization, and demonstration that it is essential for optimal resistance to hydrogen peroxide. J Bacteriol 1995; 177:6536 - 44; PMID: 7592431
  • Brett MM, Ghoneim AT, Littlewood JM, Losowsky MS. Development of enzyme linked immunosorbent assay (ELISA) to detect antibodies to Pseudomonas aeruginosa cell surface antigens in sera of patients with cystic fibrosis. J Clin Pathol 1986; 39:1124 - 9; http://dx.doi.org/10.1136/jcp.39.10.1124; PMID: 3097080
  • Pedersen SS. Lung infection with alginate-producing, mucoid Pseudomonas aeruginosa in cystic fibrosis. APMIS Suppl 1992; 28:1 - 79; PMID: 1449848
  • Skurnik D, Kropec A, Roux D, Theilacker C, Huebner J, Pier GB. Natural antibodies in normal human serum inhibit Staphylococcus aureus capsular polysaccharide vaccine efficacy. Clin Infect Dis 2012; 55:1188 - 97; http://dx.doi.org/10.1093/cid/cis624; PMID: 22806596
  • Hayes E, Pohl K, McElvaney NG, Reeves EP. The cystic fibrosis neutrophil: a specialized yet potentially defective cell. Arch Immunol Ther Exp (Warsz) 2011; 59:97 - 112; http://dx.doi.org/10.1007/s00005-011-0113-6; PMID: 21311988
  • Ratner D, Mueller C. Immune responses in cystic fibrosis: are they intrinsically defective?. Am J Respir Cell Mol Biol 2012; 46:715 - 22; http://dx.doi.org/10.1165/rcmb.2011-0399RT; PMID: 22403802
  • Sedlak-Weinstein E, Cripps AW, Kyd JM, Foxwell AR. Pseudomonas aeruginosa: the potential to immunise against infection. Expert Opin Biol Ther 2005; 5:967 - 82; http://dx.doi.org/10.1517/14712598.5.7.967; PMID: 16018741
  • Nixon GM, Armstrong DS, Carzino R, Carlin JB, Olinsky A, Robertson CF, et al. Clinical outcome after early Pseudomonas aeruginosa infection in cystic fibrosis. J Pediatr 2001; 138:699 - 704; http://dx.doi.org/10.1067/mpd.2001.112897; PMID: 11343046
  • Armstrong DS, Grimwood K, Carzino R, Carlin JB, Olinsky A, Phelan PD. Lower respiratory infection and inflammation in infants with newly diagnosed cystic fibrosis. BMJ 1995; 310:1571 - 2; http://dx.doi.org/10.1136/bmj.310.6994.1571; PMID: 7787647
  • Armstrong DS, Grimwood K, Carlin JB, Carzino R, Olinsky A, Phelan PD. Bronchoalveolar lavage or oropharyngeal cultures to identify lower respiratory pathogens in infants with cystic fibrosis. Pediatr Pulmonol 1996; 21:267 - 75; http://dx.doi.org/10.1002/(SICI)1099-0496(199605)21:5<267::AID-PPUL1>3.0.CO;2-K; PMID: 8726151
  • Kidd TJ, Ramsay KA, Hu H, Bye PTB, Elkins MR, Grimwood K, et al, ACPinCF Investigators. Low rates of Pseudomonas aeruginosa misidentification in isolates from cystic fibrosis patients. J Clin Microbiol 2009; 47:1503 - 9; http://dx.doi.org/10.1128/JCM.00014-09; PMID: 19261796
  • Murphy TF, Bartos LC. Surface-exposed and antigenically conserved determinants of outer membrane proteins of Branhamella catarrhalis. Infect Immun 1989; 57:2938 - 41; PMID: 2476393
  • Suzuki H, Terada T. Removal of dodecyl sulfate from protein solution. Anal Biochem 1988; 172:259 - 63; http://dx.doi.org/10.1016/0003-2697(88)90440-X; PMID: 3189769

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.