A plant-produced protective antigen vaccine confers protection in rabbits against a lethal aerosolized challenge with Bacillus anthracis Ames spores

References

• Koch R.. The aetiology of anthrax based on the ontogeny of the anthrax bacillus. Med Classics 1937; 2:787 - 821
   Google Scholar
• Brachman P, Kauffman A. Anthrax. 1998. In Evans AS and Brachman PS (Eds.). Bacterial infections of humans. New York: Plenum Medical Book Company.
   Google Scholar
• Davies JCA. A major epidemic of anthrax in Zimbabwe. Cent Afr J Med 1982; 28:291 - 8; PMID: 7168859
   PubMedGoogle Scholar
• Van Ness GB. Ecology of anthrax. Science 1971; 172:1303 - 7; http://dx.doi.org/10.1126/science.172.3990.1303; PMID: 4996306
   PubMed Web of Science ®Google Scholar
• Inglesby TV, Henderson DA, Bartlett JG, Ascher MS, Eitzen E, Friedlander AM, et al, Working Group on Civilian Biodefense. Anthrax as a biological weapon: medical and public health management. [Consensus statement from the Working Group on Civilian Biodefense] JAMA 1999; 281:1735 - 45; http://dx.doi.org/10.1001/jama.281.18.1735; PMID: 10328075
   PubMed Web of Science ®Google Scholar
• Department of Homeland Security. 2006. Bioterrorism risk assessment. Biological Threat Characterization Center of the National Biodefense Analysis and Countermeasures Center. Fort Detrick, MD.
   Google Scholar
• Jernigan JA, Stephens DS, Ashford DA, Omenaca C, Topiel MS, Galbraith M, et al, Anthrax Bioterrorism Investigation Team. Bioterrorism-related inhalational anthrax: the first 10 cases reported in the United States. Emerg Infect Dis 2001; 7:933 - 44; http://dx.doi.org/10.3201/eid0706.010604; PMID: 11747719
   PubMed Web of Science ®Google Scholar
• Brachman PS, Plotkin SA, Bumford FH, Atchison MM. An epidemic of inhalation anthrax: the first in the twentieth century. II. Epidemiology. Am J Hyg 1960; 72:6 - 23; PMID: 13803672
   PubMed Web of Science ®Google Scholar
• Young JA, Collier RJ. Anthrax toxin: receptor binding, internalization, pore formation, and translocation. Annu Rev Biochem 2007; 76:243 - 65; http://dx.doi.org/10.1146/annurev.biochem.75.103004.142728; PMID: 17335404
   PubMed Web of Science ®Google Scholar
• Little SF, Ivins BE, Fellows PF, Friedlander AM. Passive protection by polyclonal antibodies against Bacillus anthracis infection in guinea pigs. Infect Immun 1997; 65:5171 - 5; PMID: 9393812
   PubMed Web of Science ®Google Scholar
• Fowler K, McBride BW, Turnbull PC, Baillie LW. Immune correlates of protection against anthrax. J Appl Microbiol 1999; 87:305; http://dx.doi.org/10.1046/j.1365-2672.1999.00898.x; PMID: 10475976
   PubMed Web of Science ®Google Scholar
• Pitt ML, Little SF, Ivins BE, Fellows P, Barth J, Hewetson J, et al. In vitro correlate of immunity in a rabbit model of inhalational anthrax. Vaccine 2001; 19:4768 - 73; http://dx.doi.org/10.1016/S0264-410X(01)00234-1; PMID: 11535328
   PubMed Web of Science ®Google Scholar
• Little SF, Ivins BE, Fellows PF, Pitt ML, Norris SL, Andrews GP. Defining a serological correlate of protection in rabbits for a recombinant anthrax vaccine. Vaccine 2004; 22:422 - 30; http://dx.doi.org/10.1016/j.vaccine.2003.07.004; PMID: 14670324
   PubMed Web of Science ®Google Scholar
• Weiss S, Kobiler D, Levy H, Marcus H, Pass A, Rothschild N, et al. Immunological correlates for protection against intranasal challenge of Bacillus anthracis spores conferred by a protective antigen-based vaccine in rabbits. Infect Immun 2006; 74:394 - 8; http://dx.doi.org/10.1128/IAI.74.1.394-398.2006; PMID: 16368995
   PubMed Web of Science ®Google Scholar
• BioThrax® (Anthrax Vaccine Adsorbed). Prescribing Information. Emergent BioSolutions. May 2012.
   Google Scholar
• Chichester JA, Yusibov V. Plants as alternative systems for production of vaccines. Hum Vaccin 2007; 3:146 - 8; http://dx.doi.org/10.4161/hv.3.4.4148; PMID: 17643065
   PubMed Web of Science ®Google Scholar
• Mett V, Farrance CE, Green BJ, Yusibov V. Plants as biofactories. Biologicals 2008; 36:354 - 8; http://dx.doi.org/10.1016/j.biologicals.2008.09.001; PMID: 18938088
   PubMed Web of Science ®Google Scholar
• Rybicki EP. Plant-made vaccines for humans and animals. Plant Biotechnol J 2010; 8:620 - 37; http://dx.doi.org/10.1111/j.1467-7652.2010.00507.x; PMID: 20233333
   PubMed Web of Science ®Google Scholar
• Musiychuk K, Stephenson N, Bi H, Farrance CE, Orozovic G, Brodelius M, et al. A launch vector for the production of vaccine antigens in plants. Influenza Other Respi Viruses 2007; 1:19 - 25; http://dx.doi.org/10.1111/j.1750-2659.2006.00005.x; PMID: 19453476
   PubMed Web of Science ®Google Scholar
• Chichester JA, Musiychuk K, de la Rosa P, Horsey A, Stevenson N, Ugulava N, et al. Immunogenicity of a subunit vaccine against Bacillus anthracis. Vaccine 2007; 25:3111 - 4; http://dx.doi.org/10.1016/j.vaccine.2007.01.068; PMID: 17280756
   PubMed Web of Science ®Google Scholar
• Mett V, Lyons J, Musiychuk K, Chichester JA, Brasil T, Couch R, et al. A plant-produced plague vaccine candidate confers protection to monkeys. Vaccine 2007; 25:3014 - 7; http://dx.doi.org/10.1016/j.vaccine.2007.01.017; PMID: 17287055
   PubMed Web of Science ®Google Scholar
• Shoji Y, Chichester JA, Bi H, Musiychuk K, de la Rosa P, Goldschmidt L, et al. Plant-expressed HA as a seasonal influenza vaccine candidate. Vaccine 2008; 26:2930 - 4; http://dx.doi.org/10.1016/j.vaccine.2008.03.045; PMID: 18440103
   PubMed Web of Science ®Google Scholar
• Shoji Y, Bi H, Musiychuk K, Rhee A, Horsey A, Roy G, et al. Plant-derived hemagglutinin protects ferrets against challenge infection with the A/Indonesia/05/05 strain of avian influenza. Vaccine 2009; 27:1087 - 92; http://dx.doi.org/10.1016/j.vaccine.2008.11.108; PMID: 19100806
   PubMed Web of Science ®Google Scholar
• Shoji Y, Chichester JA, Jones M, Manceva SD, Damon E, Mett V, et al. Plant-based rapid production of recombinant subunit hemagglutinin vaccines targeting H1N1 and H5N1 influenza. Hum Vaccin 2011; 7:Suppl 41 - 50; http://dx.doi.org/10.4161/hv.7.0.14561; PMID: 21266846
   PubMed Web of Science ®Google Scholar
• Ivins BE, Pitt ML, Fellows PF, Farchaus JW, Benner GE, Waag DM, et al. Comparative efficacy of experimental anthrax vaccine candidates against inhalation anthrax in rhesus macaques. Vaccine 1998; 16:1141 - 8; http://dx.doi.org/10.1016/S0264-410X(98)80112-6; PMID: 9682372
   PubMed Web of Science ®Google Scholar
• Fellows PF, Linscott MK, Ivins BE, Pitt ML, Rossi CA, Gibbs PH, et al. Efficacy of a human anthrax vaccine in guinea pigs, rabbits, and rhesus macaques against challenge by Bacillus anthracis isolates of diverse geographical origin. Vaccine 2001; 19:3241 - 7; http://dx.doi.org/10.1016/S0264-410X(01)00021-4; PMID: 11312020
   PubMed Web of Science ®Google Scholar
• Williamson ED, Hodgson I, Walker NJ, Topping AW, Duchars MG, Mott JM, et al. Immunogenicity of recombinant protective antigen and efficacy against aerosol challenge with anthrax. Infect Immun 2005; 73:5978 - 87; http://dx.doi.org/10.1128/IAI.73.9.5978-5987.2005; PMID: 16113318
   PubMed Web of Science ®Google Scholar
• Gorse GJ, Keitel W, Keyserling H, Taylor DN, Lock M, Alves K, et al. Immunogenicity and tolerance of ascending doses of a recombinant protective antigen (rPA102) anthrax vaccine: a randomized, double-blinded, controlled, multicenter trial. Vaccine 2006; 24:5950 - 9; http://dx.doi.org/10.1016/j.vaccine.2006.05.044; PMID: 16797805
   PubMed Web of Science ®Google Scholar
• Campbell JD, Clement KH, Wasserman SS, Donegan S, Chrisley L, Kotloff KL. Safety, reactogenicity and immunogenicity of a recombinant protective antigen anthrax vaccine given to healthy adults. Hum Vaccin 2007; 3:205 - 11; http://dx.doi.org/10.4161/hv.3.5.4459; PMID: 17881903
   PubMed Web of Science ®Google Scholar
• Bellanti JA, Lin FY, Chu C, Shiloach J, Leppla SH, Benavides GA, et al. Phase 1 study of a recombinant mutant protective antigen of Bacillus anthracis. Clin Vaccine Immunol 2012; 19:140 - 5; http://dx.doi.org/10.1128/CVI.05556-11; PMID: 22190398
   PubMed Web of Science ®Google Scholar
• PharmAthene. RECOMBINANT PROTECTIVE ANTIGEN (rPA) ANTHRAX VACCINES SPARVAX(TM) – NOVEL SECOND GENERATION VACCINE TECHNOLOGY. http://www.pharmathene.com/FactSheet_SparVax.pdf (accessed 10 October 2012).
   Google Scholar
• Yusibov V, Streatfield SJ, Kushnir N. Clinical development of plant-produced recombinant pharmaceuticals: vaccines, antibodies and beyond. Hum Vaccin 2011; 7:313 - 21; http://dx.doi.org/10.4161/hv.7.3.14207; PMID: 21346417
   PubMed Web of Science ®Google Scholar
• Koya V, Moayeri M, Leppla SH, Daniell H. Plant-based vaccine: mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal toxin challenge. Infect Immun 2005; 73:8266 - 74; http://dx.doi.org/10.1128/IAI.73.12.8266-8274.2005; PMID: 16299323
   PubMed Web of Science ®Google Scholar
• Zaucha GM, Pitt LM, Estep J, Ivins BE, Friedlander AM. The pathology of experimental anthrax in rabbits exposed by inhalation and subcutaneous inoculation. Arch Pathol Lab Med 1998; 122:982 - 92; PMID: 9822127
   PubMed Web of Science ®Google Scholar
• Porath J. Immobilized metal ion affinity chromatography. Protein Expr Purif 1992; 3:263 - 81; http://dx.doi.org/10.1016/1046-5928(92)90001-D; PMID: 1422221
   PubMed Web of Science ®Google Scholar
• Herman EM, Tague BW, Hoffman LM, Kjemtrupp SE, Chrispeels MJ. Retention of phytohemagglutinin with carboxyterminal tetrapeptide KDEL in the nuclear envelope and the endoplasmic reticulum. Planta 1990; 182:302 - 12; http://dx.doi.org/10.1007/BF00197126
   Google Scholar
• Green BJ, Fujiki M, Mett V, Kaczmarczyk J, Shamloul M, Musiychuk K, et al. Transient protein expression in three Pisum sativum (green pea) varieties. Biotechnol J 2009; 4:230 - 7; http://dx.doi.org/10.1002/biot.200800256; PMID: 19156736
   PubMedGoogle Scholar
• Ausar SF, Chan J, Hoque W, James O, Jayasundara K, Harper K. Application of extrinsic fluorescence spectroscopy for the high throughput formulation screening of aluminum-adjuvanted vaccines. J Pharm Sci 2011; 100:431 - 40; http://dx.doi.org/10.1002/jps.22282; PMID: 20740682
   PubMed Web of Science ®Google Scholar
• Hull AK, Criscuolo CJ, Mett V, Groen H, Steeman W, Westra H, et al. Human-derived, plant-produced monoclonal antibody for the treatment of anthrax. Vaccine 2005; 23:2082 - 6; http://dx.doi.org/10.1016/j.vaccine.2005.01.013; PMID: 15755575
   PubMed Web of Science ®Google Scholar
• Mett V, Chichester JA, Stewart ML, Musiychuk K, Bi H, Reifsnyder CJ, et al. A non-glycosylated, plant-produced human monoclonal antibody against anthrax protective antigen protects mice and non-human primates from B. anthracis spore challenge. Hum Vaccin 2011; 7:Suppl 183 - 90; http://dx.doi.org/10.4161/hv.7.0.14586; PMID: 21270531
   PubMed Web of Science ®Google Scholar