661
Views
4
CrossRef citations to date
0
Altmetric
Short Report

Anti-leukemia T cells in AML

TNF-α+ CD8+ T cells may escape detection and possibly reflect a stage of functional impairment

, , , , , & show all
Pages 1200-1204 | Received 28 Oct 2012, Accepted 09 Mar 2013, Published online: 08 Apr 2013

References

  • Barrett AJ, Le Blanc K. Immunotherapy prospects for acute myeloid leukaemia. Clin Exp Immunol 2010; 161:223 - 32; PMID: 20529084
  • Anguille S, Van Tendeloo VF, Berneman ZN. Leukemia-associated antigens and their relevance to the immunotherapy of acute myeloid leukemia. Leukemia 2012; 26:2186 - 96; http://dx.doi.org/10.1038/leu.2012.145; PMID: 22652755
  • Siebert JC, Walker EB. Monitoring cytokine profiles during immunotherapy. Immunotherapy 2010; 2:799 - 816; http://dx.doi.org/10.2217/imt.10.76; PMID: 21091113
  • Westermann J, Lessen A, Schlimper C, Baskaynak G, le Coutre P, Dörken B, et al. Simultaneous cytokine analysis by cytometric bead array for the detection of leukaemia-reactive T cells in patients with chronic myeloid leukaemia. Br J Haematol 2006; 132:32 - 5; http://dx.doi.org/10.1111/j.1365-2141.2005.05844.x; PMID: 16371017
  • Gannagé M, Abel M, Michallet AS, Delluc S, Lambert M, Giraudier S, et al. Ex vivo characterization of multiepitopic tumor-specific CD8 T cells in patients with chronic myeloid leukemia: implications for vaccine development and adoptive cellular immunotherapy. J Immunol 2005; 174:8210 - 8; PMID: 15944330
  • Westermann J, Flörcken A, Willimsky G, van Lessen A, Kopp J, Takvorian A, et al. Allogeneic gene-modified tumor cells (RCC-26/IL-7/CD80) as a vaccine in patients with metastatic renal cell cancer: a clinical phase-I study. Gene Ther 2011; 18:354 - 63; http://dx.doi.org/10.1038/gt.2010.143; PMID: 21068778
  • Whiteside TL, Zhao Y, Tsukishiro T, Elder EM, Gooding W, Baar J. Enzyme-linked immunospot, cytokine flow cytometry, and tetramers in the detection of T-cell responses to a dendritic cell-based multipeptide vaccine in patients with melanoma. Clin Cancer Res 2003; 9:641 - 9; PMID: 12576430
  • Tassignon J, Burny W, Dahmani S, Zhou L, Stordeur P, Byl B, et al. Monitoring of cellular responses after vaccination against tetanus toxoid: comparison of the measurement of IFN-gamma production by ELISA, ELISPOT, flow cytometry and real-time PCR. J Immunol Methods 2005; 305:188 - 98; http://dx.doi.org/10.1016/j.jim.2005.07.014; PMID: 16157348
  • Wherry EJ. T cell exhaustion. Nat Immunol 2011; 12:492 - 9; http://dx.doi.org/10.1038/ni.2035; PMID: 21739672
  • Yi JS, Cox MA, Zajac AJ. T-cell exhaustion: characteristics, causes and conversion. Immunology 2010; 129:474 - 81; http://dx.doi.org/10.1111/j.1365-2567.2010.03255.x; PMID: 20201977
  • Wherry EJ, Ahmed R. Memory CD8 T-cell differentiation during viral infection. J Virol 2004; 78:5535 - 45; http://dx.doi.org/10.1128/JVI.78.11.5535-5545.2004; PMID: 15140950
  • Mueller SN, Ahmed R. High antigen levels are the cause of T cell exhaustion during chronic viral infection. Proc Natl Acad Sci U S A 2009; 106:8623 - 8; http://dx.doi.org/10.1073/pnas.0809818106; PMID: 19433785
  • Baitsch L, Baumgaertner P, Devêvre E, Raghav SK, Legat A, Barba L, et al. Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patients. J Clin Invest 2011; 121:2350 - 60; http://dx.doi.org/10.1172/JCI46102; PMID: 21555851
  • Zippelius A, Batard P, Rubio-Godoy V, Bioley G, Liénard D, Lejeune F, et al. Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional tolerance. Cancer Res 2004; 64:2865 - 73; http://dx.doi.org/10.1158/0008-5472.CAN-03-3066; PMID: 15087405
  • Ahmadzadeh M, Johnson LA, Heemskerk B, Wunderlich JR, Dudley ME, White DE, et al. Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood 2009; 114:1537 - 44; http://dx.doi.org/10.1182/blood-2008-12-195792; PMID: 19423728
  • Zhou Q, Munger ME, Veenstra RG, Weigel BJ, Hirashima M, Munn DH, et al. Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. Blood 2011; 117:4501 - 10; http://dx.doi.org/10.1182/blood-2010-10-310425; PMID: 21385853
  • Narita M, Takahashi M, Liu A, Nikkuni K, Furukawa T, Toba K, et al. Leukemia blast-induced T-cell anergy demonstrated by leukemia-derived dendritic cells in acute myelogenous leukemia. Exp Hematol 2001; 29:709 - 19; http://dx.doi.org/10.1016/S0301-472X(01)00636-1; PMID: 11378266

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.