References
- Office for National Statistics online, 2012. Available from URL: http://www.ons.gov.uk/ons/rel/mortality-ageing/mortality-in-england-and-wales/average-life-span/rpt-average-life-span.html (Accessed 23.03.13).
- House of Lords Report: Ageing: Scientific Aspects. July 2005. Available from URL: http://www.publications.parliament.uk/pa/ld200506/ldselect/ldsctech/20/20i.pdf.
- Fleming DM, Elliot AJ. The impact of influenza on the health and health care utilisation of elderly people. Vaccine 2005; 23:Suppl 1 S1 - 9; http://dx.doi.org/10.1016/j.vaccine.2005.04.018; PMID: 15908058
- Coe CL, Lubach GR, Kinnard J. Immune senescence in old and very old rhesus monkeys: reduced antibody response to influenza vaccination. Age (Dordr) 2012; 34:1169 - 77; http://dx.doi.org/10.1007/s11357-011-9356-8; PMID: 22231440
- Murasko DM, Bernstein ED, Gardner EM, Gross P, Munk G, Dran S, et al. Role of humoral and cell-mediated immunity in protection from influenza disease after immunization of healthy elderly. Exp Gerontol 2002; 37:427 - 39; http://dx.doi.org/10.1016/S0531-5565(01)00210-8; PMID: 11772530
- Ademokun A, Wu YC, Martin V, Mitra R, Sack U, Baxendale H, et al. Vaccination-induced changes in human B-cell repertoire and pneumococcal IgM and IgA antibody at different ages. Aging Cell 2011; 10:922 - 30; http://dx.doi.org/10.1111/j.1474-9726.2011.00732.x; PMID: 21726404
- Hainz U, Jenewein B, Asch E, Pfeiffer KP, Berger P, Grubeck-Loebenstein B. Insufficient protection for healthy elderly adults by tetanus and TBE vaccines. Vaccine 2005; 23:3232 - 5; http://dx.doi.org/10.1016/j.vaccine.2005.01.085; PMID: 15837226
- Fletcher JM, Vukmanovic-Stejic M, Dunne PJ, Birch KE, Cook JE, Jackson SE, et al. Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion. J Immunol 2005; 175:8218 - 25; PMID: 16339561
- Lindstrom TM, Robinson WH. Rheumatoid arthritis: a role for immunosenescence?. J Am Geriatr Soc 2010; 58:1565 - 75; http://dx.doi.org/10.1111/j.1532-5415.2010.02965.x; PMID: 20942872
- Derhovanessian E, Theeten H, Hähnel K, Van Damme P, Cools N, Pawelec G. Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination. Vaccine 2013; 31:685 - 90; http://dx.doi.org/10.1016/j.vaccine.2012.11.041; PMID: 23196209
- Moro-Garcia MA, Alonso-Arias R, Lopez-Larrea C. Molecular Mechanisms Involved in the Aging of the T-cell Immune Response. Curr Genomics 2012; 13:589 - 602; http://dx.doi.org/10.2174/138920212803759749
- Phillips AC, Gallagher S, Carroll D, Drayson M. Preliminary evidence that morning vaccination is associated with an enhanced antibody response in men. Psychophysiology 2008; 45:663 - 6; http://dx.doi.org/10.1111/j.1469-8986.2008.00662.x; PMID: 18346041
- Gallagher S, Phillips AC, Drayson MT, Carroll D. Caregiving for children with developmental disabilities is associated with a poor antibody response to influenza vaccination. Psychosom Med 2009; 71:341 - 4; http://dx.doi.org/10.1097/PSY.0b013e31819d1910; PMID: 19297308
- Kiecolt-Glaser JK, Glaser R, Gravenstein S, Malarkey WB, Sheridan J. Chronic stress alters the immune response to influenza virus vaccine in older adults. Proc Natl Acad Sci U S A 1996; 93:3043 - 7; http://dx.doi.org/10.1073/pnas.93.7.3043; PMID: 8610165
- Phillips AC, Carroll D, Burns VE, Ring C, Macleod J, Drayson M. Bereavement and marriage are associated with antibody response to influenza vaccination in the elderly. Brain Behav Immun 2006; 20:279 - 89; http://dx.doi.org/10.1016/j.bbi.2005.08.003; PMID: 16198083
- Qian F, Wang X, Zhang L, Chen S, Piecychna M, Allore H, et al. Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly. Aging Cell 2012; 11:104 - 10; http://dx.doi.org/10.1111/j.1474-9726.2011.00759.x; PMID: 22023165
- Kohut ML, Lee W, Martin A, Arnston B, Russell DW, Ekkekakis P, et al. The exercise-induced enhancement of influenza immunity is mediated in part by improvements in psychosocial factors in older adults. Brain Behav Immun 2005; 19:357 - 66; http://dx.doi.org/10.1016/j.bbi.2004.12.002; PMID: 15944076