Making vaccines “on demand”

References

• Graham B, Talent J. World at Risk. 2008 Dec 3. Retrieved from http://www.preventwmd.gov/static/docs/report/worldatrisk_full.pdf
   Google Scholar
• Graham B, Talent J. Prevention of WMD Proliferation and Terrorism Report Card. 2010. Retrieved from http://www.preventwmd.gov/static/docs/report-card.pdf
   Google Scholar
• Government Accounting Agency. Report GAO-11-318SP: Homeland security/Law enforcement: Strategic oversight mechanisms could help integrate fragmented interagency efforts to defend against biological threats. 2011 Mar 1. Retrieved from http://www.gao.gov/modules/ereport/handler.php?m=1&p=1&path=/ereport/GAO-11-318SP/data_center/Homeland_security–Law_enforcement/Strategic_oversight_mechanisms_could_help_integrate_fragmented_interagency_efforts_to_defend_against_biological_threats
   Google Scholar
• Franco C, Sell TK. Federal agency biodefense funding, FY2012-FY2013. Biosecur Bioterror 2012; 10:162 - 81; http://dx.doi.org/10.1089/bsp.2012.0025; PMID: 22691277
   PubMed Web of Science ®Google Scholar
• Department of Health and Human Services. HHS creates new centers to develop, manufacture medical countermeasures. 2012. Retrieved from http://www.hhs.gov/news/press/2012pres/06/20120618a.html
   Google Scholar
• GISAID. EpiFlu Database. 2008-2013. Retrieved from http://platform.gisaid.org/epi3/frontend#36c986
   Google Scholar
• De Groot AS, Ardito M, Moise L, Gustafson EA, Spero D, Tejada G, et al. Immunogenic consensus sequence T helper epitopes for a pan-Burkholderia biodefense vaccine. Immunome Res 2011; 7:7; PMID: 22130150
   PubMedGoogle Scholar
• Simmons CP, Hussell T, Sparer T, Walzl G, Openshaw P, Dougan G. Mucosal delivery of a respiratory syncytial virus CTL peptide with enterotoxin-based adjuvants elicits protective, immunopathogenic, and immunoregulatory antiviral CD8+ T cell responses. J Immunol 2001; 166:1106 - 13; PMID: 11145691
   PubMed Web of Science ®Google Scholar
• Franke ED, Sette A, Sacci J Jr., Southwood S, Corradin G, Hoffman SL. A subdominant CD8(+) cytotoxic T lymphocyte (CTL) epitope from the Plasmodium yoelii circumsporozoite protein induces CTLs that eliminate infected hepatocytes from culture. Infect Immun 2000; 68:3403 - 11; http://dx.doi.org/10.1128/IAI.68.6.3403-3411.2000; PMID: 10816491
   PubMed Web of Science ®Google Scholar
• Schadeck EB, Partidos CD, Fooks AR, Obeid OE, Wilkinson GW, Stephenson JR, et al. CTL epitopes identified with a defective recombinant adenovirus expressing measles virus nucleoprotein and evaluation of their protective capacity in mice. Virus Res 1999; 65:75 - 86; http://dx.doi.org/10.1016/S0168-1702(99)00103-3; PMID: 10564754
   PubMed Web of Science ®Google Scholar
• Rosenthal KS, Mao H, Horne WI, Wright C, Zimmerman D. Immunization with a LEAPS heteroconjugate containing a CTL epitope and a peptide from beta-2-microglobulin elicits a protective and DTH response to herpes simplex virus type 1. Vaccine 1999; 17:535 - 42; http://dx.doi.org/10.1016/S0264-410X(98)00231-X; PMID: 10075159
   PubMed Web of Science ®Google Scholar
• Tsuji M, Bergmann CC, Takita-Sonoda Y, Murata K, Rodrigues EG, Nussenzweig RS, et al. Recombinant Sindbis viruses expressing a cytotoxic T-lymphocyte epitope of a malaria parasite or of influenza virus elicit protection against the corresponding pathogen in mice. J Virol 1998; 72:6907 - 10; PMID: 9658144
   PubMed Web of Science ®Google Scholar
• Hislop AD, Good MF, Mateo L, Gardner J, Gatei MH, Daniel RC, et al. Vaccine-induced cytotoxic T lymphocytes protect against retroviral challenge. Nat Med 1998; 4:1193 - 6; http://dx.doi.org/10.1038/2690; PMID: 9771756
   PubMed Web of Science ®Google Scholar
• Davis BS, Chang GJ, Cropp B, Roehrig JT, Martin DA, Mitchell CJ, et al. West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assays. J Virol 2001; 75:4040 - 7; http://dx.doi.org/10.1128/JVI.75.9.4040-4047.2001; PMID: 11287553
   PubMed Web of Science ®Google Scholar
• De Groot AS, Ardito M, McClaine EM, Moise L, Martin WD. Immunoinformatic comparison of T-cell epitopes contained in novel swine-origin influenza A (H1N1) virus with epitopes in 2008-2009 conventional influenza vaccine. Vaccine 2009; 27:5740 - 7; http://dx.doi.org/10.1016/j.vaccine.2009.07.040; PMID: 19660593
   PubMed Web of Science ®Google Scholar
• Greenbaum JA, Kotturi MF, Kim Y, Oseroff C, Vaughan K, Salimi N, et al. Pre-existing immunity against swine-origin H1N1 influenza viruses in the general human population. Proc Natl Acad Sci U S A 2009; 106:20365 - 70; http://dx.doi.org/10.1073/pnas.0911580106; PMID: 19918065
   PubMed Web of Science ®Google Scholar
• Schanen BC, De Groot AS, Moise L, Ardito M, McClaine E, Martin W, et al. Coupling sensitive in vitro and in silico techniques to assess cross-reactive CD4(+) T cells against the swine-origin H1N1 influenza virus. Vaccine 2011; 29:3299 - 309; http://dx.doi.org/10.1016/j.vaccine.2011.02.019; PMID: 21349362
   PubMed Web of Science ®Google Scholar
• De Groot AS, Ardito M, Terry F, Levitz L, Ross TM, Moise L, et al. Low immunogenicity predicted for emerging avian-origin H7N9: Implication for influenza vaccine design. Hum Vaccin Immunother 2013; 9:950 - 6; http://dx.doi.org/10.4161/hv.24939; PMID: 23807079
   PubMed Web of Science ®Google Scholar
• Gilbert SC. T-cell-inducing vaccines - what’s the future. Immunology 2012; 135:19 - 26; http://dx.doi.org/10.1111/j.1365-2567.2011.03517.x; PMID: 22044118
   PubMed Web of Science ®Google Scholar
• Hastie KM, Kimberlin CR, Zandonatti MA, MacRae IJ, Saphire EO. Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3′ to 5′ exonuclease activity essential for immune suppression. Proc Natl Acad Sci U S A 2011; 108:2396 - 401; http://dx.doi.org/10.1073/pnas.1016404108; PMID: 21262835
   PubMed Web of Science ®Google Scholar
• Cohen T, Moise L, Martin W, DeGroot AS. Immunoinformatics: The next step in vaccine design. In: Sintchenko V, ed. Infectious Disease Informatics. New York: Springer, 2010:223-244.
   Google Scholar
• De Groot AS, Martin W. From immunome to vaccine: epitope mapping and vaccine design tools. Novartis Found Symp 2003; 254:57 - 72, discussion 72-6, 98-101, 250-2; http://dx.doi.org/10.1002/0470090766.ch5; PMID: 14712932
   PubMedGoogle Scholar
• De Groot AS. How the SARS vaccine effort can learn from HIV-speeding towards the future, learning from the past. Vaccine 2003; 21:4095 - 104; http://dx.doi.org/10.1016/S0264-410X(03)00489-4; PMID: 14505885
   PubMed Web of Science ®Google Scholar
• De Groot AS, Ardito M, McClaine EM, Moise L, Martin WD. Immunoinformatic comparison of T-cell epitopes contained in novel swine-origin influenza A (H1N1) virus with epitopes in 2008-2009 conventional influenza vaccine. Vaccine 2009; 27:5740 - 7; http://dx.doi.org/10.1016/j.vaccine.2009.07.040; PMID: 19660593
   PubMed Web of Science ®Google Scholar
• Moise L, Buller RM, Schriewer J, Lee J, Frey SE, Weiner DB, et al. VennVax, a DNA-prime, peptide-boost multi-T-cell epitope poxvirus vaccine, induces protective immunity against vaccinia infection by T cell response alone. Vaccine 2011; 29:501 - 11; http://dx.doi.org/10.1016/j.vaccine.2010.10.064; PMID: 21055490
   PubMed Web of Science ®Google Scholar
• De Groot AS, Saint-Aubin CS, Bosma A, Sbai H, Rayner J, Martin W. Rapid determination of HLA B*07 ligands from the West Nile virus NY99 genome. Emerg Infect Dis 2001; 7:706 - 13; PMID: 11585536
   PubMed Web of Science ®Google Scholar
• De Groot AS, Martin W, Moise L, Guirakhoo F, Monath T. Analysis of ChimeriVax Japanese Encephalitis Virus envelope for T-cell epitopes and comparison to circulating strain sequences. Vaccine 2007; 25:8077 - 84; http://dx.doi.org/10.1016/j.vaccine.2007.09.026; PMID: 17942198
   PubMed Web of Science ®Google Scholar
• Moss SF, Moise L, Lee DS, Kim W, Zhang S, Lee J, et al. HelicoVax: epitope-based therapeutic Helicobacter pylori vaccination in a mouse model. Vaccine 2011; 29:2085 - 91; http://dx.doi.org/10.1016/j.vaccine.2010.12.130; PMID: 21236233
   PubMed Web of Science ®Google Scholar
• De Groot AS, Ardito MA, Terry F, Levitz L, Ross TM, Moise L, et al. Low immunogenicity predicted for emerging avian-origin H7N9: Implication for influenza vaccine design. Hum Vaccin Immunother 2013; 9; http://dx.doi.org/10.4161/hv.24939; PMID: 23807079
   PubMed Web of Science ®Google Scholar
• Moutaftsi M, Peters B, Pasquetto V, Tscharke DC, Sidney J, Bui HH, et al. A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus. Nat Biotechnol 2006; 24:817 - 9; http://dx.doi.org/10.1038/nbt1215; PMID: 16767078
   PubMed Web of Science ®Google Scholar
• Moise L, De Groot AS. Putting immunoinformatics to the test. Nat Biotechnol 2006; 24:791 - 2; http://dx.doi.org/10.1038/nbt0706-791; PMID: 16841062
   PubMed Web of Science ®Google Scholar
• Wille-Reece U, Wu CY, Flynn BJ, Kedl RM, Seder RA. Immunization with HIV-1 Gag protein conjugated to a TLR7/8 agonist results in the generation of HIV-1 Gag-specific Th1 and CD8+ T cell responses. J Immunol 2005; 174:7676 - 83; PMID: 15944268
   PubMed Web of Science ®Google Scholar
• Sette A, Sidney J. Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism. Immunogenetics 1999; 50:201 - 12; http://dx.doi.org/10.1007/s002510050594; PMID: 10602880
   PubMed Web of Science ®Google Scholar
• Schirmbeck R, Fissolo N, Chaplin P, Reimann J. Enhanced priming of multispecific, murine CD8+ T cell responses by DNA vaccines expressing stress protein-binding polytope peptides. J Immunol 2003; 171:1240 - 6; PMID: 12874211
   PubMed Web of Science ®Google Scholar
• Saade F, Petrovsky N. Technologies for enhanced efficacy of DNA vaccines. Expert Rev Vaccines 2012; 11:189 - 209; http://dx.doi.org/10.1586/erv.11.188; PMID: 22309668
   PubMed Web of Science ®Google Scholar
• Prausnitz MR, Mikszta JA, Cormier M, Andrianov AK. Microneedle-based vaccines. Curr Top Microbiol Immunol 2009; 333:369 - 93; http://dx.doi.org/10.1007/978-3-540-92165-3_18; PMID: 19768415
   PubMedGoogle Scholar
• Ramirez LA, Arango T, Boyer J. Therapeutic and prophylactic DNA vaccines for HIV-1. Expert Opin Biol Ther 2013; 13:563 - 73; http://dx.doi.org/10.1517/14712598.2013.758709; PMID: 23477730
   PubMed Web of Science ®Google Scholar
• Dhir V, Fort M, Mahmood A, Higbee R, Warren W, Narayanan P, et al. A predictive biomimetic model of cytokine release induced by TGN1412 and other therapeutic monoclonal antibodies. J Immunotoxicol 2012; 9:34 - 42; http://dx.doi.org/10.3109/1547691X.2011.613419; PMID: 22074378
   PubMed Web of Science ®Google Scholar
• Perdue ML, Bright RA. United States of America Department of Health and Human Services support for advancing influenza vaccine manufacturing in the developing world. [Review] Vaccine 2011; 29:Suppl 1 A48 - 50; http://dx.doi.org/10.1016/j.vaccine.2011.02.080; PMID: 21684430
   PubMedGoogle Scholar
• Sonpavde G, Kantoff PW. Immunotherapy for castration-resistant prostate cancer. [Review] Urol Clin North Am 2012; 39:465 - 81; http://dx.doi.org/10.1016/j.ucl.2012.07.004; PMID: 23084524
   PubMed Web of Science ®Google Scholar
• Gardner TA, Elzey BD, Hahn NM. Sipuleucel-T (Provenge) autologous vaccine approved for treatment of men with asymptomatic or minimally symptomatic castrate-resistant metastatic prostate cancer. Hum Vaccin Immunother 2012; 8:534 - 9; http://dx.doi.org/10.4161/hv.19795; PMID: 22832254
   PubMed Web of Science ®Google Scholar
• Aarntzen EH, De Vries IJ, Lesterhuis WJ, Schuurhuis D, Jacobs JF, Bol K, et al. Targeting CD4(+) T-helper cells improves the induction of antitumor responses in dendritic cell-based vaccination. Cancer Res 2013; 73:19 - 29; http://dx.doi.org/10.1158/0008-5472.CAN-12-1127; PMID: 23087058
   PubMed Web of Science ®Google Scholar
• Grosso JF, Jure-Kunkel MN. CTLA-4 blockade in tumor models: an overview of preclinical and translational research. Cancer Immun 2013; 13:5; PMID: 23390376
   PubMedGoogle Scholar
• Gilbert SC. T-cell-inducing vaccines - what’s the future. Immunology 2012; 135:19 - 26; http://dx.doi.org/10.1111/j.1365-2567.2011.03517.x; PMID: 22044118
   PubMed Web of Science ®Google Scholar
• Powell TJ, Peng Y, Berthoud TK, Blais ME, Lillie PJ, Hill AV, et al. Examination of influenza specific T cell responses after influenza virus challenge in individuals vaccinated with MVA-NP+M1 vaccine. PLoS One 2013; 8:e62778; http://dx.doi.org/10.1371/journal.pone.0062778; PMID: 23658773
   PubMed Web of Science ®Google Scholar
• Lillie PJ, Berthoud TK, Powell TJ, Lambe T, Mullarkey C, Spencer AJ, et al. Preliminary assessment of the efficacy of a T-cell-based influenza vaccine, MVA-NP+M1, in humans. Clin Infect Dis 2012; 55:19 - 25; http://dx.doi.org/10.1093/cid/cis327; PMID: 22441650
   PubMed Web of Science ®Google Scholar
• Elliott SL, Suhrbier A, Miles JJ, Lawrence G, Pye SJ, Le TT, et al. Phase I trial of a CD8+ T-cell peptide epitope-based vaccine for infectious mononucleosis. J Virol 2008; 82:1448 - 57; http://dx.doi.org/10.1128/JVI.01409-07; PMID: 18032491
   PubMed Web of Science ®Google Scholar
• Rappuoli R, Covacci A. Reverse vaccinology and genomics. Science 2003; 302:602; http://dx.doi.org/10.1126/science.1092329; PMID: 14576423
   PubMed Web of Science ®Google Scholar
• Pederson T. The immunome. Mol Immunol 1999; 36:1127 - 8; http://dx.doi.org/10.1016/S0161-5890(99)00125-X; PMID: 10698314
   PubMed Web of Science ®Google Scholar
• De Groot AS, Martin W. From immunome to vaccine: epitope mapping and vaccine design tools. Novartis Found Symp 2003; 254:57 - 72, discussion 72-6, 98-101, 250-2; http://dx.doi.org/10.1002/0470090766.ch5; PMID: 14712932
   PubMedGoogle Scholar
• Doytchinova IA, Taylor P, Flower DR. Proteomics in Vaccinology and Immunobiology: An Informatics Perspective of the Immunone. J Biomed Biotechnol 2003; 2003:267 - 90; http://dx.doi.org/10.1155/S1110724303209232; PMID: 14688414
   PubMedGoogle Scholar
• De Groot AS, McMurry J, Marcon L, Franco J, Rivera D, Kutzler M, et al. Developing an epitope-driven tuberculosis (TB) vaccine. Vaccine 2005; 23:2121 - 31; http://dx.doi.org/10.1016/j.vaccine.2005.01.059; PMID: 15755582
   PubMed Web of Science ®Google Scholar
• De Groot AS, Marcon L, Bishop EA, Rivera D, Kutzler M, Weiner DB, et al. HIV vaccine development by computer assisted design: the GAIA vaccine. Vaccine 2005; 23:2136 - 48; http://dx.doi.org/10.1016/j.vaccine.2005.01.097; PMID: 15755584
   PubMed Web of Science ®Google Scholar
• Otero M, Calarota SA, Dai A, De Groot AS, Boyer JD, Weiner DB. Efficacy of novel plasmid DNA encoding vaccinia antigens in improving current smallpox vaccination strategy. Vaccine 2005; 24:4461 - 70; http://dx.doi.org/10.1016/j.vaccine.2005.08.010
   PubMed Web of Science ®Google Scholar
• De Groot AS, Ardito M, Moise L, Gustafson EA, Spero D, Tejada G, et al. Immunogenic consensus sequence T helper epitopes for a pan-Burkholderia biodefense vaccine. Immunome Res 2011; 7:7; http://immunome-research.net/ PMID: 22130150
   PubMedGoogle Scholar
• Schanen BC, De Groot AS, Moise L, Ardito M, McClaine E, Martin W, et al. Coupling sensitive in vitro and in silico techniques to assess cross-reactive CD4(+) T cells against the swine-origin H1N1 influenza virus. Vaccine 2011; 29:3299 - 309; http://dx.doi.org/10.1016/j.vaccine.2011.02.019; PMID: 21349362
   PubMed Web of Science ®Google Scholar
• Levitz L, Koita OA, Sangare K, Ardito MT, Boyle CM, Rozehnal J, et al. Conservation of HIV-1 T cell epitopes across time and clades: validation of immunogenic HLA-A2 epitopes selected for the GAIA HIV vaccine. Vaccine 2012; 30:7547 - 60; http://dx.doi.org/10.1016/j.vaccine.2012.10.042; PMID: 23102976
   PubMed Web of Science ®Google Scholar
• De Groot AS, Levitz L, Ardito MT, Skowron G, Mayer KH, Buus S, et al. Further progress on defining highly conserved immunogenic epitopes for a global HIV vaccine: HLA-A3-restricted GAIA vaccine epitopes. Hum Vaccin Immunother 2012; 8:987 - 1000; http://tinyurl.com/GAIA-HLA-A3 http://dx.doi.org/10.4161/hv.20528; PMID: 22777092
   PubMed Web of Science ®Google Scholar
• Moise L, Buller RM, Schriewer J, Lee J, Frey SE, Weiner DB, et al. VennVax, a DNA-prime, peptide-boost multi-T-cell epitope poxvirus vaccine, induces protective immunity against vaccinia infection by T cell response alone. Vaccine 2011; 29:501 - 11; http://dx.doi.org/10.1016/j.vaccine.2010.10.064; PMID: 21055490
   PubMed Web of Science ®Google Scholar
• Moss SF, Moise L, Lee DS, Kim W, Zhang S, Lee J, et al. HelicoVax: Epitope-based therapeutic H. pylori vaccination in a mouse model of gastric cancer. Vaccine 2011; 29:2085 - 91; http://dx.doi.org/10.1016/j.vaccine.2010.12.130; PMID: 21236233
   PubMed Web of Science ®Google Scholar
• Moise L, Gutierrez AH, Bailey-Kellogg C, Terry F, Leng Q, Abdel Hady KM, et al. The two-faced T cell epitope: Examining the host-microbe interface with JanusMatrix. Hum Vaccin Immunother 2013; 9; http://dx.doi.org/10.4161/hv.24615; PMID: 23584251
   PubMed Web of Science ®Google Scholar
• Moise L, Gutierrez AH, Bailey-Kellogg C, Terry FA, Leng Q, Abdel Hady KM, et al. The two-faced T cell epitope: Examining the host-microbe interface with JanusMatrix. Hum Vaccin Immunother 2013; 9; In press http://dx.doi.org/10.4161/hv.24615; PMID: 23584251
   PubMed Web of Science ®Google Scholar
• Elfaki ME, Khalil EA, De Groot AS, Musa AM, Gutierrez A, Younis BM, et al. Immunogenicity and immune modulatory effects of in silico predicted L. donovani candidate peptide vaccines. Hum Vaccin Immunother 2012; 8:1769 - 74; http://dx.doi.org/10.4161/hv.21881; PMID: 22922767
   PubMed Web of Science ®Google Scholar
• Poland GA. Vaccines against Lyme disease: What happened and what lessons can we learn?. Clin Infect Dis 2011; 52:Suppl 3 s253 - 8; http://dx.doi.org/10.1093/cid/ciq116; PMID: 21217172
   PubMed Web of Science ®Google Scholar
• Robinson HL, Amara RR. T cell vaccines for microbial infections. Nat Med 2005; 11:Suppl S25 - 32; http://dx.doi.org/10.1038/nm1212; PMID: 15812486
   PubMed Web of Science ®Google Scholar
• Chen L, Li B, Yang WC, He JL, Li NY, Hu J, et al. A dominant CD4(+) T-cell response to Helicobacter pylori reduces risk for gastric disease in humans. Gastroenterology 2013; 144:591 - 600; http://dx.doi.org/10.1053/j.gastro.2012.12.002; PMID: 23232294
   PubMed Web of Science ®Google Scholar
• Kaabinejadian S, Piazza PA, McMurtrey CP, Vernon SR, Cate SJ, Bardet W, et al. Identification of Class I HLA T Cell Control Epitopes for West Nile Virus. PLoS One 2013; 8:e66298; http://dx.doi.org/10.1371/journal.pone.0066298; PMID: 23762485
   PubMedGoogle Scholar
• Silva EB, Dow SW. Development of Burkholderia mallei and pseudomallei vaccines. Front Cell Infect Microbiol 2013; 3:10; http://dx.doi.org/10.3389/fcimb.2013.00010; PMID: 23508691
   PubMed Web of Science ®Google Scholar
• Eneslätt K, Normark M, Björk R, Rietz C, Zingmark C, Wolfraim LA, et al. Signatures of T cells as correlates of immunity to Francisella tularensis. PLoS One 2012; 7:e32367; http://dx.doi.org/10.1371/journal.pone.0032367; PMID: 22412866
   PubMed Web of Science ®Google Scholar