Comparison of BCG prime-DNA booster and rBCG regimens for protection against tuberculosis

References

• World Health Organization. Global tuberculosis report 2012. Available from: http://apps.who.int/iris/bitstream/10665/75938/1/9789241564502_eng.pdf
   Google Scholar
• Colditz GA, Brewer TF, Berkey CS, Wilson ME, Burdick E, Fineberg HV, Mosteller F. Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature. JAMA 1994; 271:698 - 702; http://dx.doi.org/10.1001/jama.1994.03510330076038; PMID: 8309034
   PubMed Web of Science ®Google Scholar
• Fine PE. Variation in protection by BCG: implications of and for heterologous immunity. Lancet 1995; 346:1339 - 45; http://dx.doi.org/10.1016/S0140-6736(95)92348-9; PMID: 7475776
   PubMed Web of Science ®Google Scholar
• Kaufmann SH, Hussey G, Lambert PH. New vaccines for tuberculosis. Lancet 2010; 375:2110 - 9; http://dx.doi.org/10.1016/S0140-6736(10)60393-5; PMID: 20488515
   PubMed Web of Science ®Google Scholar
• Ottenhoff TH, Kaufmann SH. Vaccines against tuberculosis: where are we and where do we need to go?. PLoS Pathog 2012; 8:e1002607; http://dx.doi.org/10.1371/journal.ppat.1002607; PMID: 22589713
   PubMed Web of Science ®Google Scholar
• Chen Z, Fan X. Research progress in BCG prime-boost vaccination strategy against tuberculosis. Chinese Journal of Antituberculosis 2012; 3:188 - 91
   Google Scholar
• Brennan MJ, Clagett B, Fitzgerald H, Chen V, Williams A, Izzo AA, Barker LF. Preclinical evidence for implementing a prime-boost vaccine strategy for tuberculosis. Vaccine 2012; 30:2811 - 23; http://dx.doi.org/10.1016/j.vaccine.2012.02.036; PMID: 22387630
   PubMed Web of Science ®Google Scholar
• WHO. . http://apps.who.int/vaccines/globalsummary/immunization/timeseries/tswucoveragebcg.htm. 2013.
   Google Scholar
• Rouanet C, Debrie AS, Lecher S, Locht C. Subcutaneous boosting with heparin binding haemagglutinin increases BCG-induced protection against tuberculosis. Microbes Infect 2009; 11:995 - 1001; http://dx.doi.org/10.1016/j.micinf.2009.07.005; PMID: 19635582
   PubMed Web of Science ®Google Scholar
• Brandt L, Skeiky YA, Alderson MR, Lobet Y, Dalemans W, Turner OC, Basaraba RJ, Izzo AA, Lasco TM, Chapman PL, et al. The protective effect of the Mycobacterium bovis BCG vaccine is increased by coadministration with the Mycobacterium tuberculosis 72-kilodalton fusion polyprotein Mtb72F in M. tuberculosis-infected guinea pigs. Infect Immun 2004; 72:6622 - 32; http://dx.doi.org/10.1128/IAI.72.11.6622-6632.2004; PMID: 15501795
   PubMed Web of Science ®Google Scholar
• Dietrich J, Andersen C, Rappuoli R, Doherty TM, Jensen CG, Andersen P. Mucosal administration of Ag85B-ESAT-6 protects against infection with Mycobacterium tuberculosis and boosts prior bacillus Calmette-Guerin immunity. J Immunol 2006; 177:6353 - 60; PMID: 17056566
   PubMed Web of Science ®Google Scholar
• Mollenkopf HJ, Grode L, Mattow J, Stein M, Mann P, Knapp B, Ulmer J, Kaufmann SH. Application of mycobacterial proteomics to vaccine design: improved protection by Mycobacterium bovis BCG prime-Rv3407 DNA boost vaccination against tuberculosis. Infect Immun 2004; 72:6471 - 9; http://dx.doi.org/10.1128/IAI.72.11.6471-6479.2004; PMID: 15501778
   PubMed Web of Science ®Google Scholar
• Fan X, Gao Q, Fu R. DNA vaccine encoding ESAT-6 enhances the protective efficacy of BCG against Mycobacterium tuberculosis infection in mice. Scand J Immunol 2007; 66:523 - 8; http://dx.doi.org/10.1111/j.1365-3083.2007.02006.x; PMID: 17916110
   PubMed Web of Science ®Google Scholar
• Wang C, Chen Z, Fu R, Zhang Y, Chen L, Huang L, Li J, Shi C, Fan X. A DNA vaccine expressing CFP21 and MPT64 fusion protein enhances BCG-induced protective immunity against Mycobacterium tuberculosis infection in mice. Med Microbiol Immunol 2011; 200:165 - 75; http://dx.doi.org/10.1007/s00430-011-0188-z; PMID: 21340709
   PubMed Web of Science ®Google Scholar
• Lu J, Wang C, Zhou Z, Zhang Y, Cao T, Shi C, Chen Z, Chen L, Cai C, Fan X. Immunogenicity and protective efficacy against murine tuberculosis of a prime-boost regimen with BCG and a DNA vaccine expressing ESAT-6 and Ag85A fusion protein. Clin Dev Immunol 2011; 2011:617892; http://dx.doi.org/10.1155/2011/617892; PMID: 21461375
   PubMed Web of Science ®Google Scholar
• Derrick SC, Yang AL, Morris SL. A polyvalent DNA vaccine expressing an ESAT6-Ag85B fusion protein protects mice against a primary infection with Mycobacterium tuberculosis and boosts BCG-induced protective immunity. Vaccine 2004; 23:780 - 8; http://dx.doi.org/10.1016/j.vaccine.2004.07.036; PMID: 15542202
   PubMed Web of Science ®Google Scholar
• Vordermeier HM, Villarreal-Ramos B, Cockle PJ, McAulay M, Rhodes SG, Thacker T, Gilbert SC, McShane H, Hill AV, Xing Z, et al. Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis. Infect Immun 2009; 77:3364 - 73; http://dx.doi.org/10.1128/IAI.00287-09; PMID: 19487476
   PubMed Web of Science ®Google Scholar
• Xing Z, McFarland CT, Sallenave JM, Izzo A, Wang J, McMurray DN. Intranasal mucosal boosting with an adenovirus-vectored vaccine markedly enhances the protection of BCG-primed guinea pigs against pulmonary tuberculosis. PLoS One 2009; 4:e5856; http://dx.doi.org/10.1371/journal.pone.0005856; PMID: 19516906
   PubMed Web of Science ®Google Scholar
• Goonetilleke NP, McShane H, Hannan CM, Anderson RJ, Brookes RH, Hill AV. Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille Calmette-Guérin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus Ankara. J Immunol 2003; 171:1602 - 9; PMID: 12874255
   PubMed Web of Science ®Google Scholar
• Hawkridge T, Scriba TJ, Gelderbloem S, Smit E, Tameris M, Moyo S, Lang T, Veldsman A, Hatherill M, Merwe Lv, et al. Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa. J Infect Dis 2008; 198:544 - 52; http://dx.doi.org/10.1086/590185; PMID: 18582195
   PubMed Web of Science ®Google Scholar
• Scriba TJ, Tameris M, Mansoor N, Smit E, van der Merwe L, Mauff K, Hughes EJ, Moyo S, Brittain N, Lawrie A, et al. Dose-finding study of the novel tuberculosis vaccine, MVA85A, in healthy BCG-vaccinated infants. J Infect Dis 2011; 203:1832 - 43; http://dx.doi.org/10.1093/infdis/jir195; PMID: 21606542
   PubMed Web of Science ®Google Scholar
• Pathan AA, Sander CR, Fletcher HA, Poulton I, Alder NC, Beveridge NE, Whelan KT, Hill AV, McShane H. Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: different boosting intervals and implications for efficacy trials. PLoS One 2007; 2:e1052; http://dx.doi.org/10.1371/journal.pone.0001052; PMID: 17957238
   PubMedGoogle Scholar
• Horwitz MA, Harth G, Dillon BJ, Maslesa-Galic’ S. Recombinant bacillus calmette-guerin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model. Proc Natl Acad Sci U S A 2000; 97:13853 - 8; http://dx.doi.org/10.1073/pnas.250480397; PMID: 11095745
   PubMed Web of Science ®Google Scholar
• Wang C, Fu R, Chen Z, Tan K, Chen L, Teng X, Lu J, Shi C, Fan X. Immunogenicity and protective efficacy of a novel recombinant BCG strain overexpressing antigens Ag85A and Ag85B. Clin Dev Immunol 2012; 2012:563838; http://dx.doi.org/10.1155/2012/563838; PMID: 22570667
   PubMed Web of Science ®Google Scholar
• Pym AS, Brodin P, Majlessi L, Brosch R, Demangel C, Williams A, Griffiths KE, Marchal G, Leclerc C, Cole ST. Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis. Nat Med 2003; 9:533 - 9; http://dx.doi.org/10.1038/nm859; PMID: 12692540
   PubMed Web of Science ®Google Scholar
• Tang C, Yamada H, Shibata K, Maeda N, Yoshida S, Wajjwalku W, Ohara N, Yamada T, Kinoshita T, Yoshikai Y. Efficacy of recombinant bacille Calmette-Guérin vaccine secreting interleukin-15/antigen 85B fusion protein in providing protection against Mycobacterium tuberculosis. J Infect Dis 2008; 197:1263 - 74; http://dx.doi.org/10.1086/586902; PMID: 18422438
   PubMed Web of Science ®Google Scholar
• Xu Y, Zhu B, Wang Q, Chen J, Qie Y, Wang J, Wang H, Wang B, Wang H. Recombinant BCG coexpressing Ag85B, ESAT-6 and mouse-IFN-gamma confers effective protection against Mycobacterium tuberculosis in C57BL/6 mice. FEMS Immunol Med Microbiol 2007; 51:480 - 7; http://dx.doi.org/10.1111/j.1574-695X.2007.00322.x; PMID: 17919299
   PubMed Web of Science ®Google Scholar
• Desel C, Dorhoi A, Bandermann S, Grode L, Eisele B, Kaufmann SH. Recombinant BCG ΔureC hly+ induces superior protection over parental BCG by stimulating a balanced combination of type 1 and type 17 cytokine responses. J Infect Dis 2011; 204:1573 - 84; http://dx.doi.org/10.1093/infdis/jir592; PMID: 21933877
   PubMed Web of Science ®Google Scholar
• Wang LM, Shi CH, Fan XL, Xue Y, Bai YL, Xu ZK. Expression and immunogenicity of recombinant Mycobacterium bovis Bacillus Calmette-Guérin strains secreting the antigen ESAT-6 from Mycobacterium tuberculosis in mice. Chin Med J (Engl) 2007; 120:1220 - 5; PMID: 17697571
   PubMed Web of Science ®Google Scholar
• Bao L, Chen W, Zhang H, Wang X. Virulence, immunogenicity, and protective efficacy of two recombinant Mycobacterium bovis bacillus Calmette-Guérin strains expressing the antigen ESAT-6 from Mycobacterium tuberculosis. Infect Immun 2003; 71:1656 - 61; http://dx.doi.org/10.1128/IAI.71.4.1656-1661.2003; PMID: 12654778
   PubMed Web of Science ®Google Scholar
• Brandt L, Elhay M, Rosenkrands I, Lindblad EB, Andersen P. ESAT-6 subunit vaccination against Mycobacterium tuberculosis. Infect Immun 2000; 68:791 - 5; http://dx.doi.org/10.1128/IAI.68.2.791-795.2000; PMID: 10639447
   PubMed Web of Science ®Google Scholar
• Behr MA, Wilson MA, Gill WP, Salamon H, Schoolnik GK, Rane S, Small PM. Comparative genomics of BCG vaccines by whole-genome DNA microarray. Science 1999; 284:1520 - 3; http://dx.doi.org/10.1126/science.284.5419.1520; PMID: 10348738
   PubMed Web of Science ®Google Scholar
• Belisle JT, Vissa VD, Sievert T, Takayama K, Brennan PJ, Besra GS. Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis. Science 1997; 276:1420 - 2; http://dx.doi.org/10.1126/science.276.5317.1420; PMID: 9162010
   PubMed Web of Science ®Google Scholar
• Castañon-Arreola M, López-Vidal Y, Espitia-Pinzón C, Hernández-Pando R. A new vaccine against tuberculosis shows greater protection in a mouse model with progressive pulmonary tuberculosis. Tuberculosis (Edinb) 2005; 85:115 - 26; http://dx.doi.org/10.1016/j.tube.2004.10.004; PMID: 15687035
   PubMed Web of Science ®Google Scholar
• Shi C, Wang X, Zhang H, Xu Z, Li Y, Yuan L. Immune responses and protective efficacy induced by 85B antigen and early secreted antigenic target-6 kDa antigen fusion protein secreted by recombinant bacille Calmette-Guérin. Acta Biochim Biophys Sin (Shanghai) 2007; 39:290 - 6; http://dx.doi.org/10.1111/j.1745-7270.2007.00281.x; PMID: 17417685
   PubMed Web of Science ®Google Scholar
• Palendira U, Spratt JM, Britton WJ, Triccas JA. Expanding the antigenic repertoire of BCG improves protective efficacy against aerosol Mycobacterium tuberculosis infection. Vaccine 2005; 23:1680 - 5; http://dx.doi.org/10.1016/j.vaccine.2004.10.007; PMID: 15705472
   PubMed Web of Science ®Google Scholar
• Shi C, Chen L, Chen Z, Zhang Y, Zhou Z, Lu J, Fu R, Wang C, Fang Z, Fan X. Enhanced protection against tuberculosis by vaccination with recombinant BCG over-expressing HspX protein. Vaccine 2010; 28:5237 - 44; http://dx.doi.org/10.1016/j.vaccine.2010.05.063; PMID: 20538090
   PubMed Web of Science ®Google Scholar
• Wang Jl, Qie Yq, Zhu Bd, Zhang Hm, Xu Y, Wang Qz, Chen Jz, Liu W, Wang Hh. Evaluation of a recombinant BCG expressing antigen Ag85B and PPE protein Rv3425 from DNA segment RD11 of Mycobacterium tuberculosis in C57BL/6 mice. Med Microbiol Immunol 2009; 198:5 - 11; http://dx.doi.org/10.1007/s00430-008-0098-x; PMID: 18491134
   PubMed Web of Science ®Google Scholar
• Sun R, Skeiky YA, Izzo A, Dheenadhayalan V, Imam Z, Penn E, Stagliano K, Haddock S, Mueller S, Fulkerson J, et al. Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis. Vaccine 2009; 27:4412 - 23; http://dx.doi.org/10.1016/j.vaccine.2009.05.048; PMID: 19500523
   PubMed Web of Science ®Google Scholar
• Chieppa M, Bianchi G, Doni A, Del Prete A, Sironi M, Laskarin G, Monti P, Piemonti L, Biondi A, Mantovani A, et al. Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program. J Immunol 2003; 171:4552 - 60; PMID: 14568928
   PubMed Web of Science ®Google Scholar
• Geijtenbeek TB, Van Vliet SJ, Koppel EA, Sanchez-Hernandez M, Vandenbroucke-Grauls CM, Appelmelk B, Van Kooyk Y. Mycobacteria target DC-SIGN to suppress dendritic cell function. J Exp Med 2003; 197:7 - 17; http://dx.doi.org/10.1084/jem.20021229; PMID: 12515809
   PubMed Web of Science ®Google Scholar
• MacMicking JD, North RJ, LaCourse R, Mudgett JS, Shah SK, Nathan CF. Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc Natl Acad Sci U S A 1997; 94:5243 - 8; http://dx.doi.org/10.1073/pnas.94.10.5243; PMID: 9144222
   PubMed Web of Science ®Google Scholar
• Forbes EK, Sander C, Ronan EO, McShane H, Hill AV, Beverley PC, Tchilian EZ. Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice. J Immunol 2008; 181:4955 - 64; PMID: 18802099
   PubMed Web of Science ®Google Scholar
• Badell E, Nicolle F, Clark S, Majlessi L, Boudou F, Martino A, Castello-Branco L, Leclerc C, Lewis DJ, Marsh PD, et al. Protection against tuberculosis induced by oral prime with Mycobacterium bovis BCG and intranasal subunit boost based on the vaccine candidate Ag85B-ESAT-6 does not correlate with circulating IFN-gamma producing T-cells. Vaccine 2009; 27:28 - 37; http://dx.doi.org/10.1016/j.vaccine.2008.10.034; PMID: 18977269
   PubMed Web of Science ®Google Scholar
• Tameris MD, Hatherill M, Landry BS, Scriba TJ, Snowden MA, Lockhart S, Shea JE, McClain JB, Hussey GD, Hanekom WA, et al, MVA85A 020 Trial Study Team. Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial. Lancet 2013; 381:1021 - 8; http://dx.doi.org/10.1016/S0140-6736(13)60177-4; PMID: 23391465
   PubMed Web of Science ®Google Scholar