Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge

References

• Zhang H, Hale BG, Xu K, Sun B. Viral and host factors required for avian H5N1 influenza A virus replication in mammalian cells. Viruses 2013; 5:1431 - 46; http://dx.doi.org/10.3390/v5061431; PMID: 23752648
   PubMed Web of Science ®Google Scholar
• Ngai KL, Chan MC, Chan PK. Replication and transcription activities of ribonucleoprotein complexes reconstituted from avian H5N1, H1N1pdm09 and H3N2 influenza A viruses. PLoS One 2013; 8:e65038; http://dx.doi.org/10.1371/journal.pone.0065038; PMID: 23750226
   PubMedGoogle Scholar
• Guan Y, Smith GJ. The emergence and diversification of panzootic H5N1 influenza viruses. Virus Res 2013; http://dx.doi.org/10.1016/j.virusres.2013.05.012; PMID: 23735533
   PubMed Web of Science ®Google Scholar
• de Jong JCCE, Claas EC, Osterhaus AD, Webster RG, Lim WL. A pandemic warning?. Nature 1997; 389:554; http://dx.doi.org/10.1038/39218; PMID: 9335492
   PubMed Web of Science ®Google Scholar
• Peiris JSMYW, Yu WC, Leung CW, Cheung CY, Ng WF, Nicholls JM, Ng TK, Chan KH, Lai ST, Lim WL, et al. Re-emergence of fatal human influenza A subtype H5N1 disease. Lancet 2004; 363:617 - 9; http://dx.doi.org/10.1016/S0140-6736(04)15595-5; PMID: 14987888
   PubMed Web of Science ®Google Scholar
• Bodewes R, Kreijtz JH, Hillaire ML, Geelhoed-Mieras MM, Fouchier RA, Osterhaus AD, Rimmelzwaan GF. Vaccination with whole inactivated virus vaccine affects the induction of heterosubtypic immunity against influenza virus A/H5N1 and immunodominance of virus-specific CD8+ T-cell responses in mice. J Gen Virol 2010; 91:1743 - 53; http://dx.doi.org/10.1099/vir.0.020784-0; PMID: 20335492
   PubMed Web of Science ®Google Scholar
• McMurry JA, Johansson BE, De Groot AS. A call to cellular & humoral arms: enlisting cognate T cell help to develop broad-spectrum vaccines against influenza A. Hum Vaccin 2008; 4:148 - 57; http://dx.doi.org/10.4161/hv.4.2.5169; PMID: 18382131
   PubMed Web of Science ®Google Scholar
• MacLeod MK, Clambey ET, Kappler JW, Marrack P. CD4 memory T cells: what are they and what can they do?. Semin Immunol 2009; 21:53 - 61; http://dx.doi.org/10.1016/j.smim.2009.02.006; PMID: 19269850
   PubMed Web of Science ®Google Scholar
• Teijaro JR, Verhoeven D, Page CA, Turner D, Farber DL. Memory CD4 T cells direct protective responses to influenza virus in the lungs through helper-independent mechanisms. J Virol 2010; 84:9217 - 26; http://dx.doi.org/10.1128/JVI.01069-10; PMID: 20592069
   PubMed Web of Science ®Google Scholar
• Jin H, Li Y, Ma Z, Zhang F, Xie Q, Gu D, Wang B. Effect of chemical adjuvants on DNA vaccination. Vaccine 2004; 22:2925 - 35; http://dx.doi.org/10.1016/j.vaccine.2003.12.026; PMID: 15246629
   PubMed Web of Science ®Google Scholar
• Zou Q, Hu Y, Xue J, Fan X, Jin Y, Shi X, Meng D, Wang X, Feng C, Xie X, et al. Use of praziquantel as an adjuvant enhances protection and Tc-17 responses to killed H5N1 virus vaccine in mice. PLoS One 2012; 7:e34865; http://dx.doi.org/10.1371/journal.pone.0034865; PMID: 22529945
   PubMedGoogle Scholar
• Huang MH, Lin SC, Hsiao CH, Chao HJ, Yang HR, Liao CC, Chuang PW, Wu HP, Huang CY, Leng CH, et al. Emulsified nanoparticles containing inactivated influenza virus and CpG oligodeoxynucleotides critically influences the host immune responses in mice. PLoS One 2010; 5:e12279; http://dx.doi.org/10.1371/journal.pone.0012279; PMID: 20808862
   PubMed Web of Science ®Google Scholar
• El Sahly H. MF59™ as a vaccine adjuvant: a review of safety and immunogenicity. Expert Rev Vaccines 2010; 9:1135 - 41; http://dx.doi.org/10.1586/erv.10.111; PMID: 20923265
   PubMed Web of Science ®Google Scholar
• Prieto-Lara E, Llanos-Méndez A. Safety and immunogenicity of prepandemic H5N1 influenza vaccines: a systematic review of the literature. Vaccine 2010; 28:4328 - 34; http://dx.doi.org/10.1016/j.vaccine.2010.03.068; PMID: 20403350
   PubMed Web of Science ®Google Scholar
• Lanzon-Miller S, Pounder RE, Chronos NA, Raymond F, Hamilton MR, Dalgleish D. Twenty four hour intragastric acidity and plasma gastrin concentration in healthy volunteers taking nizatidine 150 mg, nizatidine 300 mg, ranitidine 300 mg, or placebo at 21:00 h. Gut 1988; 29:1364 - 9; http://dx.doi.org/10.1136/gut.29.10.1364; PMID: 2904394
   PubMed Web of Science ®Google Scholar
• Klotz U, Dammann HG, Gottlieb WR, Walter TA, Keohane P. Nizatidine (300 mg nocte) does not interfere with diazepam pharmacokinetics in man. Br J Clin Pharmacol 1987; 23:105 - 6; http://dx.doi.org/10.1111/j.1365-2125.1987.tb03019.x; PMID: 3101726
   PubMed Web of Science ®Google Scholar
• Okamoto O, Fujiwara S. Drug eruption caused by ranitidine hydrochloride (Zantac) which showed a strong reaction in a drug-induced lymphocyte stimulation test. J Dermatol 2007; 34:74 - 9; http://dx.doi.org/10.1111/j.1346-8138.2007.00221.x; PMID: 17204107
   PubMed Web of Science ®Google Scholar
• Testa B, Mesolella C, Mosti MR, Mesolella M, Testa D, Motta G. Changes in serum interferon-gamma, interleukin-4, and interleukin-12 cytokine levels in anti-histamine type 2-treated allergic rhinitis patients. Laryngoscope 2001; 111:236 - 9; http://dx.doi.org/10.1097/00005537-200102000-00009; PMID: 11210867
   PubMed Web of Science ®Google Scholar
• Sakhalkar SP, Patterson EB, Khan MM. Involvement of histamine H1 and H2 receptors in the regulation of STAT-1 phosphorylation: inverse agonism exhibited by the receptor antagonists. Int Immunopharmacol 2005; 5:1299 - 309; http://dx.doi.org/10.1016/j.intimp.2005.03.019; PMID: 15914334
   PubMed Web of Science ®Google Scholar
• Zhang W, Wang J, Su B, Li R, Ding Z, Kang Y, Wang B. Cimetidine augments Th1/Th2 dual polarized immune responses to recombinant HBV antigens. Vaccine 2011; 29:4862 - 8; http://dx.doi.org/10.1016/j.vaccine.2011.03.091; PMID: 21481324
   PubMed Web of Science ®Google Scholar
• Wang J, Su B, Ding Z, Du X, Wang B. Cimetidine enhances immune response of HBV DNA vaccination via impairment of the regulatory function of regulatory T cells. Biochem Biophys Res Commun 2008; 372:491 - 6; http://dx.doi.org/10.1016/j.bbrc.2008.04.191; PMID: 18502198
   PubMed Web of Science ®Google Scholar
• Reiss CSSJ, Schulman JL. Cellular immune responses of mice to influenza virus vaccines. J Immunol 1980; 125:2182 - 8; PMID: 7191866
   PubMed Web of Science ®Google Scholar
• MacLeod MK, Clambey ET, Kappler JW, Marrack P. CD4 memory T cells: what are they and what can they do?. Semin Immunol 2009; 21:53 - 61; http://dx.doi.org/10.1016/j.smim.2009.02.006; PMID: 19269850
   PubMed Web of Science ®Google Scholar
• Teijaro JR, Verhoeven D, Page CA, Turner D, Farber DL. Memory CD4 T cells direct protective responses to influenza virus in the lungs through helper-independent mechanisms. J Virol 2010; 84:9217 - 26; http://dx.doi.org/10.1128/JVI.01069-10; PMID: 20592069
   PubMed Web of Science ®Google Scholar
• Wan YY, Flavell RA. How diverse--CD4 effector T cells and their functions. J Mol Cell Biol 2009; 1:20 - 36; http://dx.doi.org/10.1093/jmcb/mjp001; PMID: 19482777
   PubMed Web of Science ®Google Scholar
• Schweitzer AN, Sharpe AH. Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production. J Immunol 1998; 161:2762 - 71; PMID: 9743334
   PubMed Web of Science ®Google Scholar
• Salomon B, Bluestone JA. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu Rev Immunol 2001; 19:225 - 52; http://dx.doi.org/10.1146/annurev.immunol.19.1.225; PMID: 11244036
   PubMed Web of Science ®Google Scholar
• Clark EA. CD40: a cytokine receptor in search of a ligand. Tissue Antigens 1990; 36:33 - 6; http://dx.doi.org/10.1111/j.1399-0039.1990.tb01795.x; PMID: 1701063
   PubMed Web of Science ®Google Scholar
• Fujii S-i, Liu K, Smith C, Bonito AJ, Steinman RM. The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation. J Exp Med 2004; 199:1607 - 18; http://dx.doi.org/10.1084/jem.20040317; PMID: 15197224
   PubMed Web of Science ®Google Scholar
• Shugart JA, Bambina S, Alice AF, Montler R, Bahjat KS. A self-help program for memory CD8+ T cells: positive feedback via CD40-CD40L signaling as a critical determinant of secondary expansion. PLoS One 2013; 8:e64878; http://dx.doi.org/10.1371/journal.pone.0064878; PMID: 23717671
   PubMedGoogle Scholar
• Duarte JH, Zelenay S, Bergman M-L, Martins AC, Demengeot J. Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions. Eur J Immunol 2009; 39:948 - 55; http://dx.doi.org/10.1002/eji.200839196; PMID: 19291701
   PubMed Web of Science ®Google Scholar
• Villadangos JA, Schnorrer P. Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo. Nat Rev Immunol 2007; 7:543 - 55; http://dx.doi.org/10.1038/nri2103; PMID: 17589544
   PubMed Web of Science ®Google Scholar
• Wang L, Lin J, Zhou Z, Huo R, Shen B, Sun Y, Li N. Up-regulation of Th17 cells may underlie inhibition of Treg development caused by immunization with activated syngeneic T cells. PLoS One 2011; 6:e27289; http://dx.doi.org/10.1371/journal.pone.0027289; PMID: 22087281
   PubMedGoogle Scholar
• Moore KW, de Waal Malefyt R, Coffman RL, O’Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001; 19:683 - 765; http://dx.doi.org/10.1146/annurev.immunol.19.1.683; PMID: 11244051
   PubMed Web of Science ®Google Scholar
• Walline CC, Sehra S, Fisher AJ, Guindon LM, Kratzke IM, Montgomery JB, Lipking KP, Glosson NL, Benson HL, Sandusky GE, et al. Allergic airway disease in mice alters T and B cell responses during an acute respiratory poxvirus infection. PLoS One 2013; 8:e62222; http://dx.doi.org/10.1371/journal.pone.0062222; PMID: 23620814
   PubMedGoogle Scholar
• Rigopoulou EI, Abbott WG, Haigh P, Naoumov NV. Blocking of interleukin-10 receptor--a novel approach to stimulate T-helper cell type 1 responses to hepatitis C virus. Clin Immunol 2005; 117:57 - 64; http://dx.doi.org/10.1016/j.clim.2005.06.003; PMID: 16006191
   PubMed Web of Science ®Google Scholar
• Secor JW, Speeg KV Jr., Meredith CG, Johnson RF, Snowdy P, Schenker S. Lack of effect of nizatidine on hepatic drug metabolism in man. Br J Clin Pharmacol 1985; 20:710 - 3; http://dx.doi.org/10.1111/j.1365-2125.1985.tb05136.x; PMID: 2868746
   PubMed Web of Science ®Google Scholar
• Nwokolo CU, Smith JT, Sawyerr AM, Pounder RE. Rebound intragastric hyperacidity after abrupt withdrawal of histamine H2 receptor blockade. Gut 1991; 32:1455 - 60; http://dx.doi.org/10.1136/gut.32.12.1455; PMID: 1685465
   PubMed Web of Science ®Google Scholar
• Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65:55 - 63; http://dx.doi.org/10.1016/0022-1759(83)90303-4; PMID: 6606682
   PubMed Web of Science ®Google Scholar
• Jin YZG, Zhang G, Hu Y, Ding M, Li Y, Cao S, Xue J, Sun LQ, Wang M. Inhibition of highly pathogenic avian H5N1 influenza virus propagation by RNA oligonucleotides targeting the PB2 gene in combination with celecoxib. J Gene Med 2011; 13:243 - 9; http://dx.doi.org/10.1002/jgm.1558; PMID: 21449039
   PubMed Web of Science ®Google Scholar