787
Views
10
CrossRef citations to date
0
Altmetric
Commentary

Narcolepsy and A(H1N1)pdm09 vaccination

Shaping the research on the observed signal

, , , &
Pages 572-576 | Received 22 Nov 2013, Accepted 03 Dec 2013, Published online: 16 Dec 2013

References

  • Nohynek H, Jokinen J, Partinen M, Vaarala O, Kirjavainen T, Sundman J, Himanen SL, Hublin C, Julkunen I, Olsén P, et al. AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland. PLoS One 2012; 7:e33536; http://dx.doi.org/10.1371/journal.pone.0033536; PMID: 22470453
  • European Centre for Disease Prevention and Control. Narcolepsy in association with pandemic influenza vaccination-a multi-country European epidemiological investigation. Stockholm, ECDC, September. 2012.
  • Miller E, Andrews N, Stellitano L, Stowe J, Winstone AM, Shneerson J, Verity C. Risk of narcolepsy in children and young people receiving AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine: retrospective analysis. BMJ 2013; 346:f794; http://dx.doi.org/10.1136/bmj.f794; PMID: 23444425
  • Heier MS, Gautvik KM, Wannag E, Bronder KH, Midtlyng E, Kamaleri Y, Storsaeter J. Incidence of narcolepsy in Norwegian children and adolescents after vaccination against H1N1 influenza A. Sleep Med 2013; 14:867 - 71; http://dx.doi.org/10.1016/j.sleep.2013.03.020; PMID: 23773727
  • Szakács A, Darin N, Hallböök T. Increased childhood incidence of narcolepsy in western Sweden after H1N1 influenza vaccination. Neurology 2013; 80:1315 - 21; http://dx.doi.org/10.1212/WNL.0b013e31828ab26f; PMID: 23486871
  • Roman F, Clément F, Dewé W, Walravens K, Maes C, Willekens J, De Boever F, Hanon E, Leroux-Roels G. Effect on cellular and humoral immune responses of the AS03 adjuvant system in an A/H1N1/2009 influenza virus vaccine administered to adults during two randomized controlled trials. Clin Vaccine Immunol 2011; 18:835 - 43; http://dx.doi.org/10.1128/CVI.00480-10; PMID: 21450978
  • Morel S, Didierlaurent A, Bourguignon P, Delhaye S, Baras B, Jacob V, Planty C, Elouahabi A, Harvengt P, Carlsen H, et al. Adjuvant System AS03 containing α-tocopherol modulates innate immune response and leads to improved adaptive immunity. Vaccine 2011; 29:2461 - 73; http://dx.doi.org/10.1016/j.vaccine.2011.01.011; PMID: 21256188
  • Han F, Lin L, Warby SC, Faraco J, Li J, Dong SX, An P, Zhao L, Wang LH, Li QY, et al. Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China. Ann Neurol 2011; 70:410 - 7; http://dx.doi.org/10.1002/ana.22587; PMID: 21866560
  • Mahlios J, De la Herrán-Arita AK, Mignot E. The autoimmune basis of narcolepsy. Curr Opin Neurobiol 2013; 23:767 - 73; http://dx.doi.org/10.1016/j.conb.2013.04.013; PMID: 23725858
  • Kornum BR, Faraco J, Mignot E. Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain. Curr Opin Neurobiol 2011; 21:897 - 903; http://dx.doi.org/10.1016/j.conb.2011.09.003; PMID: 21963829
  • Hor H, Kutalik Z, Dauvilliers Y, Valsesia A, Lammers GJ, Donjacour CE, Iranzo A, Santamaria J, Peraita Adrados R, Vicario JL, et al. Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. Nat Genet 2010; 42:786 - 9; http://dx.doi.org/10.1038/ng.647; PMID: 20711174
  • Hallmayer J, Faraco J, Lin L, Hesselson S, Winkelmann J, Kawashima M, Mayer G, Plazzi G, Nevsimalova S, Bourgin P, et al. Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet 2009; 41:708 - 11; http://dx.doi.org/10.1038/ng.372; PMID: 19412176
  • Lim AS, Scammell TE. The trouble with Tribbles: do antibodies against TRIB2 cause narcolepsy?. Sleep 2010; 33:857 - 8; PMID: 20614841
  • Han F, Faraco J, Dong XS, Ollila HM, Lin L, Li J, An P, Wang S, Jiang KW, Gao ZC, et al. Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic. PLoS Genet 2013; 9:e1003880; http://dx.doi.org/10.1371/journal.pgen.1003880; PMID: 24204295
  • Melén K, Partinen M, Tynell J, Sillanpää M, Himanen S-L, Saarenpää-Heikkilä O, Hublin C, Olsen P, Ilonen J, Nohynek H, et al. No serological evidence of influenza A H1N1pdm09 virus infection as a contributing factor in childhood narcolepsy after Pandemrix vaccination campaign in Finland. PLoS One 2013; 8:e68402; http://dx.doi.org/10.1371/journal.pone.0068402; PMID: 23950869
  • Aran A, Lin L, Nevsimalova S, Plazzi G, Hong SC, Weiner K, Zeitzer J, Mignot E. Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset. Sleep 2009; 32:979 - 83; PMID: 19725248
  • Kebir H, Kreymborg K, Ifergan I, Dodelet-Devillers A, Cayrol R, Bernard M, Giuliani F, Arbour N, Becher B, Prat A. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med 2007; 13:1173 - 5; http://dx.doi.org/10.1038/nm1651; PMID: 17828272
  • Dauvilliers Y, Montplaisir J, Cochen V, Desautels A, Einen M, Lin L, Kawashima M, Bayard S, Monaca C, Tiberge M, et al. Post-H1N1 narcolepsy-cataplexy. Sleep 2010; 33:1428 - 30; PMID: 21102981
  • Lang HL, Jacobsen H, Ikemizu S, Andersson C, Harlos K, Madsen L, Hjorth P, Sondergaard L, Svejgaard A, Wucherpfennig K, et al. A functional and structural basis for TCR cross-reactivity in multiple sclerosis. Nat Immunol 2002; 3:940 - 3; http://dx.doi.org/10.1038/ni835; PMID: 12244309
  • Su LF, Kidd BA, Han A, Kotzin JJ, Davis MM. Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adults. Immunity 2013; 38:373 - 83; http://dx.doi.org/10.1016/j.immuni.2012.10.021; PMID: 23395677
  • Bardage C, Persson I, Örtqvist A, Bergman U, Ludvigsson JF, Granath F. Neurological and autoimmune disorders after vaccination against pandemic influenza A (H1N1) with a monovalent adjuvanted vaccine: population based cohort study in Stockholm, Sweden. BMJ 2011; 343:d5956; http://dx.doi.org/10.1136/bmj.d5956; PMID: 21994316
  • Gabay C, Bel M, Combescure C, Ribi C, Meier S, Posfay-Barbe K, Grillet S, Seebach JD, Kaiser L, Wunderli W, et al, H1N1 Study Group. Impact of synthetic and biologic disease-modifying antirheumatic drugs on antibody responses to the AS03-adjuvanted pandemic influenza vaccine: a prospective, open-label, parallel-cohort, single-center study. Arthritis Rheum 2011; 63:1486 - 96; http://dx.doi.org/10.1002/art.30325; PMID: 21384334
  • Chen L, Brown RE, McKenna JT, McCarley RW. Animal models of narcolepsy. CNS Neurol Disord Drug Targets 2009; 8:296 - 308; http://dx.doi.org/10.2174/187152709788921717; PMID: 19689311
  • Metzker ML. Sequencing technologies - the next generation. Nat Rev Genet 2010; 11:31 - 46; http://dx.doi.org/10.1038/nrg2626; PMID: 19997069
  • Borbulevych OY, Piepenbrink KH, Baker BM. Conformational melding permits a conserved binding geometry in TCR recognition of foreign and self molecular mimics. J Immunol 2011; 186:2950 - 8; http://dx.doi.org/10.4049/jimmunol.1003150; PMID: 21282516
  • Cvetkovic-Lopes V, Bayer L, Dorsaz S, Maret S, Pradervand S, Dauvilliers Y, Lecendreux M, Lammers GJ, Donjacour CE, Du Pasquier RA, et al. Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients. J Clin Invest 2010; 120:713 - 9; http://dx.doi.org/10.1172/JCI41366; PMID: 20160349
  • Becher B, Segal BMT. T(H)17 cytokines in autoimmune neuro-inflammation. Curr Opin Immunol 2011; 23:707 - 12; http://dx.doi.org/10.1016/j.coi.2011.08.005; PMID: 21907555
  • Eichelberger MC. The cotton rat as a model to study influenza pathogenesis and immunity. Viral Immunol 2007; 20:243 - 9; http://dx.doi.org/10.1089/vim.2007.0017; PMID: 17603841

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.