The yellow fever 17D virus as a platform for new live attenuated vaccines

References

• Strode GK. Yellow fever. New York: McGraw-Hill Book Company, 1951.
   Google Scholar
• Galler R, Post PR, Santos CN, Ferreira II. Genetic variability among yellow fever virus 17D substrains. Vaccine 1998; 16:1024 - 8; http://dx.doi.org/10.1016/S0264-410X(97)00278-8; PMID: 9682354
   PubMed Web of Science ®Google Scholar
• Marchevsky RS, Freire MS, Coutinho ES, Galler R. Neurovirulence of yellow fever 17DD vaccine virus to rhesus monkeys. Virology 2003; 316:55 - 63; http://dx.doi.org/10.1016/S0042-6822(03)00583-X; PMID: 14599790
   PubMed Web of Science ®Google Scholar
• Camacho LA, de Aguiar SG, Freire MdaS, Leal MdaL, do Nascimento JP, Iguchi T, Lozana JA, Farias RH, Collaborative Group for the Study of Yellow Fever Vaccines. Reactogenicity of yellow fever vaccines in a randomized, placebo-controlled trial. Rev Saude Publica 2005; 39:413 - 20; http://dx.doi.org/10.1590/S0034-89102005000300012; PMID: 15997317
   PubMed Web of Science ®Google Scholar
• Monath TP, Barrett AD. Pathogenesis and pathophysiology of yellow fever. Adv Virus Res 2003; 60:343 - 95; http://dx.doi.org/10.1016/S0065-3527(03)60009-6; PMID: 14689698
   PubMed Web of Science ®Google Scholar
• Lefeuvre A, Marianneau P, Deubel V. Current Assessment of Yellow Fever and Yellow Fever Vaccine. Curr Infect Dis Rep 2004; 6:96 - 104; http://dx.doi.org/10.1007/s11908-996-0005-9; PMID: 15023271
   PubMedGoogle Scholar
• Poland JD, Calisher CH, Monath TP, Downs WG, Murphy K. Persistence of neutralizing antibody 30-35 years after immunization with 17D yellow fever vaccine. Bull World Health Organ 1981; 59:895 - 900; PMID: 6978196
   PubMed Web of Science ®Google Scholar
• Miller JD, van der Most RG, Akondy RS, Glidewell JT, Albott S, Masopust D, Murali-Krishna K, Mahar PL, Edupuganti S, Lalor S, et al. Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines. Immunity 2008; 28:710 - 22; http://dx.doi.org/10.1016/j.immuni.2008.02.020; PMID: 18468462
   PubMed Web of Science ®Google Scholar
• Franco D, Li W, Qing F, Stoyanov CT, Moran T, Rice CM, Ho DD. Evaluation of yellow fever virus 17D strain as a new vector for HIV-1 vaccine development. Vaccine 2010; 28:5676 - 85; http://dx.doi.org/10.1016/j.vaccine.2010.06.052; PMID: 20600494
   PubMed Web of Science ®Google Scholar
• Querec T, Bennouna S, Alkan S, Laouar Y, Gorden K, Flavell R, Akira S, Ahmed R, Pulendran B. Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity. J Exp Med 2006; 203:413 - 24; http://dx.doi.org/10.1084/jem.20051720; PMID: 16461338
   PubMed Web of Science ®Google Scholar
• Pulendran B, Oh JZ, Nakaya HI, Ravindran R, Kazmin DA. Immunity to viruses: learning from successful human vaccines. Immunol Rev 2013; 255:243 - 55; http://dx.doi.org/10.1111/imr.12099; PMID: 23947360
   PubMed Web of Science ®Google Scholar
• Childs KS, Randall RE, Goodbourn S. LGP2 plays a critical role in sensitizing mda-5 to activation by double-stranded RNA. PLoS One 2013; 8:e64202; http://dx.doi.org/10.1371/journal.pone.0064202; PMID: 23671710
   PubMedGoogle Scholar
• Cao W, Manicassamy S, Tang H, Kasturi SP, Pirani A, Murthy N, Pulendran B. Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway. Nat Immunol 2008; 9:1157 - 64; http://dx.doi.org/10.1038/ni.1645; PMID: 18758466
   PubMed Web of Science ®Google Scholar
• Gaucher D, Therrien R, Kettaf N, Angermann BR, Boucher G, Filali-Mouhim A, Moser JM, Mehta RS, Drake DR 3rd, Castro E, et al. Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses. J Exp Med 2008; 205:3119 - 31; http://dx.doi.org/10.1084/jem.20082292; PMID: 19047440
   PubMed Web of Science ®Google Scholar
• Neves PC, Rudersdorf RA, Galler R, Bonaldo MC, de Santana MG, Mudd PA, Martins MA, Rakasz EG, Wilson NA, Watkins DI. CD8+ gamma-delta TCR+ and CD4+ T cells produce IFN-γ at 5-7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses. Vaccine 2010; 28:8183 - 8; http://dx.doi.org/10.1016/j.vaccine.2010.09.090; PMID: 20939995
   PubMed Web of Science ®Google Scholar
• Silva ML, Martins MA, Espírito-Santo LR, Campi-Azevedo AC, Silveira-Lemos D, Ribeiro JG, Homma A, Kroon EG, Teixeira-Carvalho A, Elói-Santos SM, et al. Characterization of main cytokine sources from the innate and adaptive immune responses following primary 17DD yellow fever vaccination in adults. Vaccine 2011; 29:583 - 92; http://dx.doi.org/10.1016/j.vaccine.2010.08.046; PMID: 20732465
   PubMed Web of Science ®Google Scholar
• Neves PCC, Santos JR, Tubarão LN, Bonaldo MC, Galler R. Early IFN-gamma production after YF 17D vaccine virus immunization in mice and its association with adaptive immune responses. PLoS One 2013; 8:e81953; http://dx.doi.org/10.1371/journal.pone.0081953; PMID: 24324734
   PubMed Web of Science ®Google Scholar
• Pulendran B. Learning immunology from the yellow fever vaccine: innate immunity to systems vaccinology. Nat Rev Immunol 2009; 9:741 - 7; PMID: 19763148
   PubMed Web of Science ®Google Scholar
• Richter JD, Sonenberg N. Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature 2005; 433:477 - 80; http://dx.doi.org/10.1038/nature03205; PMID: 15690031
   PubMed Web of Science ®Google Scholar
• Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 2007; 8:519 - 29; http://dx.doi.org/10.1038/nrm2199; PMID: 17565364
   PubMed Web of Science ®Google Scholar
• Reinhardt B, Jaspert R, Niedrig M, Kostner C, L’age-Stehr J. Development of viremia and humoral and cellular parameters of immune activation after vaccination with yellow fever virus strain 17D: a model of human flavivirus infection. J Med Virol 1998; 56:159 - 67; http://dx.doi.org/10.1002/(SICI)1096-9071(199810)56:2<159::AID-JMV10>3.0.CO;2-B; PMID: 9746073
   PubMed Web of Science ®Google Scholar
• Mudd PA, Piaskowski SM, Neves PC, Rudersdorf R, Kolar HL, Eernisse CM, Weisgrau KL, de Santana MG, Wilson NA, Bonaldo MC, et al. The live-attenuated yellow fever vaccine 17D induces broad and potent T cell responses against several viral proteins in Indian rhesus macaques--implications for recombinant vaccine design. Immunogenetics 2010; 62:593 - 600; http://dx.doi.org/10.1007/s00251-010-0461-0; PMID: 20607226
   PubMed Web of Science ®Google Scholar
• Co MD, Kilpatrick ED, Rothman AL. Dynamics of the CD8 T-cell response following yellow fever virus 17D immunization. Immunology 2009; 128:Suppl e718 - 27; http://dx.doi.org/10.1111/j.1365-2567.2009.03070.x; PMID: 19740333
   PubMedGoogle Scholar
• van der Most RG, Harrington LE, Giuggio V, Mahar PL, Ahmed R. Yellow fever virus 17D envelope and NS3 proteins are major targets of the antiviral T cell response in mice. Virology 2002; 296:117 - 24; http://dx.doi.org/10.1006/viro.2002.1432; PMID: 12036323
   PubMed Web of Science ®Google Scholar
• Kohler S, Bethke N, Böthe M, Sommerick S, Frentsch M, Romagnani C, Niedrig M, Thiel A. The early cellular signatures of protective immunity induced by live viral vaccination. Eur J Immunol 2012; 42:2363 - 73; http://dx.doi.org/10.1002/eji.201142306; PMID: 22733156
   PubMed Web of Science ®Google Scholar
• Blom K, Braun M, Ivarsson MA, Gonzalez VD, Falconer K, Moll M, Ljunggren HG, Michaëlsson J, Sandberg JK. Temporal dynamics of the primary human T cell response to yellow fever virus 17D as it matures from an effector- to a memory-type response. J Immunol 2013; 190:2150 - 8; http://dx.doi.org/10.4049/jimmunol.1202234; PMID: 23338234
   PubMed Web of Science ®Google Scholar
• Camacho LA, Freire MdaS, Leal MdaL, Aguiar SG, Nascimento JP, Iguchi T, Lozana JdeA, Farias RH, Collaborative Group for the Study of Yellow Fever Vaccines. Immunogenicity of WHO-17D and Brazilian 17DD yellow fever vaccines: a randomized trial. Rev Saude Publica 2004; 38:671 - 8; http://dx.doi.org/10.1590/S0034-89102004000500009; PMID: 15499438
   PubMed Web of Science ®Google Scholar
• Julander JG, Trent DW, Monath TP. Immune correlates of protection against yellow fever determined by passive immunization and challenge in the hamster model. Vaccine 2011; 29:6008 - 16; http://dx.doi.org/10.1016/j.vaccine.2011.06.034; PMID: 21718741
   PubMed Web of Science ®Google Scholar
• Brandriss MW, Schlesinger JJ, Walsh EE. Immunogenicity of a purified fragment of 17D yellow fever envelope protein. J Infect Dis 1990; 161:1134 - 9; http://dx.doi.org/10.1093/infdis/161.6.1134; PMID: 1693159
   PubMed Web of Science ®Google Scholar
• Lobigs M, Dalgarno L, Schlesinger JJ, Weir RC. Location of a neutralization determinant in the E protein of yellow fever virus (17D vaccine strain). Virology 1987; 161:474 - 8; http://dx.doi.org/10.1016/0042-6822(87)90141-3; PMID: 2446422
   PubMed Web of Science ®Google Scholar
• Akondy RS, Monson ND, Miller JD, Edupuganti S, Teuwen D, Wu H, Quyyumi F, Garg S, Altman JD, Del Rio C, et al. The yellow fever virus vaccine induces a broad and polyfunctional human memory CD8+ T cell response. J Immunol 2009; 183:7919 - 30; http://dx.doi.org/10.4049/jimmunol.0803903; PMID: 19933869
   PubMed Web of Science ®Google Scholar
• Rice CM, Grakoui A, Galler R, Chambers TJ. Transcription of infectious yellow fever RNA from full-length cDNA templates produced by in vitro ligation. New Biol 1989; 1:285 - 96; PMID: 2487295
   PubMedGoogle Scholar
• Bray M, Lai CJ. Construction of intertypic chimeric dengue viruses by substitution of structural protein genes. Proc Natl Acad Sci U S A 1991; 88:10342 - 6; http://dx.doi.org/10.1073/pnas.88.22.10342; PMID: 1682924
   PubMed Web of Science ®Google Scholar
• Chambers TJ, Nestorowicz A, Mason PW, Rice CM. Yellow fever/Japanese encephalitis chimeric viruses: construction and biological properties. J Virol 1999; 73:3095 - 101; PMID: 10074160
   PubMed Web of Science ®Google Scholar
• Arroyo J, Miller C, Catalan J, Myers GA, Ratterree MS, Trent DW, Monath TP. ChimeriVax-West Nile virus live-attenuated vaccine: preclinical evaluation of safety, immunogenicity, and efficacy. J Virol 2004; 78:12497 - 507; http://dx.doi.org/10.1128/JVI.78.22.12497-12507.2004; PMID: 15507637
   PubMed Web of Science ®Google Scholar
• Guirakhoo F, Arroyo J, Pugachev KV, Miller C, Zhang ZX, Weltzin R, Georgakopoulos K, Catalan J, Ocran S, Soike K, et al. Construction, safety, and immunogenicity in nonhuman primates of a chimeric yellow fever-dengue virus tetravalent vaccine. J Virol 2001; 75:7290 - 304; http://dx.doi.org/10.1128/JVI.75.16.7290-7304.2001; PMID: 11462001
   PubMed Web of Science ®Google Scholar
• Caufour PS, Motta MC, Yamamura AM, Vazquez S, Ferreira II, Jabor AV, Bonaldo MC, Freire MS, Galler R. Construction, characterization and immunogenicity of recombinant yellow fever 17D-dengue type 2 viruses. Virus Res 2001; 79:1 - 14; http://dx.doi.org/10.1016/S0168-1702(01)00273-8; PMID: 11551641
   PubMed Web of Science ®Google Scholar
• Pugachev KV, Guirakhoo F, Ocran SW, Mitchell F, Parsons M, Penal C, Girakhoo S, Pougatcheva SO, Arroyo J, Trent DW, et al. High fidelity of yellow fever virus RNA polymerase. J Virol 2004; 78:1032 - 8; http://dx.doi.org/10.1128/JVI.78.2.1032-1038.2004; PMID: 14694136
   PubMed Web of Science ®Google Scholar
• Guy B, Guirakhoo F, Barban V, Higgs S, Monath TP, Lang J. Preclinical and clinical development of YFV 17D-based chimeric vaccines against dengue, West Nile and Japanese encephalitis viruses. Vaccine 2010; 28:632 - 49; http://dx.doi.org/10.1016/j.vaccine.2009.09.098; PMID: 19808029
   PubMed Web of Science ®Google Scholar
• Capeding RZ, Luna IA, Bomasang E, Lupisan S, Lang J, Forrat R, Wartel A, Crevat D. Live-attenuated, tetravalent dengue vaccine in children, adolescents and adults in a dengue endemic country: randomized controlled phase I trial in the Philippines. Vaccine 2011; 29:3863 - 72; http://dx.doi.org/10.1016/j.vaccine.2011.03.057; PMID: 21477675
   PubMed Web of Science ®Google Scholar
• Dayan GH, Garbes P, Noriega F, Izoton de Sadovsky AD, Rodrigues PM, Giuberti C, Dietze R. Immunogenicity and safety of a recombinant tetravalent dengue vaccine in children and adolescents ages 9-16 years in Brazil. Am J Trop Med Hyg 2013; 89:1058 - 65; http://dx.doi.org/10.4269/ajtmh.13-0304; PMID: 24189367
   PubMed Web of Science ®Google Scholar
• Dayan GH, Thakur M, Boaz M, Johnson C. Safety and immunogenicity of three tetravalent dengue vaccine formulations in healthy adults in the USA. Vaccine 2013; 31:5047 - 54; http://dx.doi.org/10.1016/j.vaccine.2013.08.088; PMID: 24021313
   PubMed Web of Science ®Google Scholar
• Guirakhoo F, Kitchener S, Morrison D, Forrat R, McCarthy K, Nichols R, Yoksan S, Duan X, Ermak TH, Kanesa-Thasan N, et al. Live attenuated chimeric yellow fever dengue type 2 (ChimeriVax-DEN2) vaccine: Phase I clinical trial for safety and immunogenicity: effect of yellow fever pre-immunity in induction of cross neutralizing antibody responses to all 4 dengue serotypes. Hum Vaccin 2006; 2:60 - 7; http://dx.doi.org/10.4161/hv.2.2.2555; PMID: 17012873
   PubMed Web of Science ®Google Scholar
• Qiao M, Shaw D, Forrat R, Wartel-Tram A, Lang J. Priming effect of dengue and yellow fever vaccination on the immunogenicity, infectivity, and safety of a tetravalent dengue vaccine in humans. Am J Trop Med Hyg 2011; 85:724 - 31; http://dx.doi.org/10.4269/ajtmh.2011.10-0436; PMID: 21976579
   PubMed Web of Science ®Google Scholar
• Sabchareon A, Wallace D, Sirivichayakul C, Limkittikul K, Chanthavanich P, Suvannadabba S, Jiwariyavej V, Dulyachai W, Pengsaa K, Wartel TA, et al. Protective efficacy of the recombinant, live-attenuated, CYD tetravalent dengue vaccine in Thai schoolchildren: a randomised, controlled phase 2b trial. Lancet 2012; 380:1559 - 67; http://dx.doi.org/10.1016/S0140-6736(12)61428-7; PMID: 22975340
   PubMed Web of Science ®Google Scholar
• Villar LA, Rivera-Medina DM, Arredondo-García JL, Boaz M, Starr-Spires L, Thakur M, Zambrano B, Miranda MC, Rivas E, Dayan GH. Safety and immunogenicity of a recombinant tetravalent dengue vaccine in 9-16 year olds: a randomized, controlled, phase II trial in Latin America. Pediatr Infect Dis J 2013; 32:1102 - 9; http://dx.doi.org/10.1097/INF.0b013e31829b8022; PMID: 24067553
   PubMed Web of Science ®Google Scholar
• Mantel N, Girerd Y, Geny C, Bernard I, Pontvianne J, Lang J, Barban V. Genetic stability of a dengue vaccine based on chimeric yellow fever/dengue viruses. Vaccine 2011; 29:6629 - 35; http://dx.doi.org/10.1016/j.vaccine.2011.06.101; PMID: 21745519
   PubMed Web of Science ®Google Scholar
• Monath TP, McCarthy K, Bedford P, Johnson CT, Nichols R, Yoksan S, Marchesani R, Knauber M, Wells KH, Arroyo J, et al. Clinical proof of principle for ChimeriVax: recombinant live, attenuated vaccines against flavivirus infections. Vaccine 2002; 20:1004 - 18; http://dx.doi.org/10.1016/S0264-410X(01)00457-1; PMID: 11803060
   PubMed Web of Science ®Google Scholar
• Chokephaibulkit K, Sirivichayakul C, Thisyakorn U, Sabchareon A, Pancharoen C, Bouckenooghe A, Gailhardou S, Boaz M, Feroldi E. Safety and immunogenicity of a single administration of live-attenuated Japanese encephalitis vaccine in previously primed 2- to 5-year-olds and naive 12- to 24-month-olds: multicenter randomized controlled trial. Pediatr Infect Dis J 2010; 29:1111 - 7; http://dx.doi.org/10.1097/INF.0b013e3181f68e9c; PMID: 20856164
   PubMed Web of Science ®Google Scholar
• Monath TP, Guirakhoo F, Nichols R, Yoksan S, Schrader R, Murphy C, Blum P, Woodward S, McCarthy K, Mathis D, et al. Chimeric live, attenuated vaccine against Japanese encephalitis (ChimeriVax-JE): phase 2 clinical trials for safety and immunogenicity, effect of vaccine dose and schedule, and memory response to challenge with inactivated Japanese encephalitis antigen. J Infect Dis 2003; 188:1213 - 30; http://dx.doi.org/10.1086/378356; PMID: 14551893
   PubMed Web of Science ®Google Scholar
• Nasveld PE, Ebringer A, Elmes N, Bennett S, Yoksan S, Aaskov J, McCarthy K, Kanesa-thasan N, Meric C, Reid M. Long term immunity to live attenuated Japanese encephalitis chimeric virus vaccine: randomized, double-blind, 5-year phase II study in healthy adults. Hum Vaccin 2010; 6:1038 - 46; http://dx.doi.org/10.4161/hv.6.12.13057; PMID: 21150279
   PubMed Web of Science ®Google Scholar
• Biedenbender R, Bevilacqua J, Gregg AM, Watson M, Dayan G. Phase II, randomized, double-blind, placebo-controlled, multicenter study to investigate the immunogenicity and safety of a West Nile virus vaccine in healthy adults. J Infect Dis 2011; 203:75 - 84; http://dx.doi.org/10.1093/infdis/jiq003; PMID: 21148499
   PubMed Web of Science ®Google Scholar
• De Filette M, Ulbert S, Diamond M, Sanders NN. Recent progress in West Nile virus diagnosis and vaccination. Vet Res 2012; 43:16; http://dx.doi.org/10.1186/1297-9716-43-16; PMID: 22380523
   PubMed Web of Science ®Google Scholar
• McAllister A, Arbetman AE, Mandl S, Peña-Rossi C, Andino R. Recombinant yellow fever viruses are effective therapeutic vaccines for treatment of murine experimental solid tumors and pulmonary metastases. J Virol 2000; 74:9197 - 205; http://dx.doi.org/10.1128/JVI.74.19.9197-9205.2000; PMID: 10982366
   PubMed Web of Science ®Google Scholar
• Barba-Spaeth G, Longman RS, Albert ML, Rice CM. Live attenuated yellow fever 17D infects human DCs and allows for presentation of endogenous and recombinant T cell epitopes. J Exp Med 2005; 202:1179 - 84; http://dx.doi.org/10.1084/jem.20051352; PMID: 16260489
   PubMed Web of Science ®Google Scholar
• Nogueira RT, Nogueira AR, Pereira MC, Rodrigues MM, Neves PC, Galler R, Bonaldo MC. Recombinant yellow fever viruses elicit CD8+ T cell responses and protective immunity against Trypanosoma cruzi. PLoS One 2013; 8:e59347; http://dx.doi.org/10.1371/journal.pone.0059347; PMID: 23527169
   PubMed Web of Science ®Google Scholar
• Tao D, Barba-Spaeth G, Rai U, Nussenzweig V, Rice CM, Nussenzweig RS. Yellow fever 17D as a vaccine vector for microbial CTL epitopes: protection in a rodent malaria model. J Exp Med 2005; 201:201 - 9; http://dx.doi.org/10.1084/jem.20041526; PMID: 15657290
   PubMed Web of Science ®Google Scholar
• Nogueira RT, Nogueira AR, Pereira MC, Rodrigues MM, Galler R, Bonaldo MC. Biological and immunological characterization of recombinant Yellow Fever 17D viruses expressing a Trypanosoma cruzi Amastigote Surface Protein-2 CD8+ T cell epitope at two distinct regions of the genome. Virol J 2011; 8:127; http://dx.doi.org/10.1186/1743-422X-8-127; PMID: 21418577
   PubMed Web of Science ®Google Scholar
• de Melo AB, Nascimento EJ, Braga-Neto U, Dhalia R, Silva AM, Oelke M, Schneck JP, Sidney J, Sette A, Montenegro SM, et al. T-cell memory responses elicited by yellow fever vaccine are targeted to overlapping epitopes containing multiple HLA-I and -II binding motifs. PLoS Negl Trop Dis 2013; 7:e1938; http://dx.doi.org/10.1371/journal.pntd.0001938; PMID: 23383350
   PubMed Web of Science ®Google Scholar
• Bonaldo MC, Garratt RC, Caufour PS, Freire MS, Rodrigues MM, Nussenzweig RS, Galler R. Surface expression of an immunodominant malaria protein B cell epitope by yellow fever virus. J Mol Biol 2002; 315:873 - 85; http://dx.doi.org/10.1006/jmbi.2001.5258; PMID: 11812154
   PubMed Web of Science ®Google Scholar
• Bonaldo MC, Garratt RC, Freire MS, Galler R. Expression of foreign protein epitopes at the surface of recombinant yellow fever 17D viruses based on three-dimensional modeling of its envelope protein. Cell Biochem Biophys 2006; 44:313 - 24; http://dx.doi.org/10.1385/CBB:44:3:313; PMID: 16679518
   PubMed Web of Science ®Google Scholar
• Bonaldo MC, Garratt RC, Marchevsky RS, Coutinho ES, Jabor AV, Almeida LF, Yamamura AM, Duarte AS, Oliveira PJ, Lizeu JO, et al. Attenuation of recombinant yellow fever 17D viruses expressing foreign protein epitopes at the surface. J Virol 2005; 79:8602 - 13; http://dx.doi.org/10.1128/JVI.79.13.8602-8613.2005; PMID: 15956601
   PubMed Web of Science ®Google Scholar
• Rumyantsev AA, Zhang ZX, Gao QS, Moretti N, Brown N, Kleanthous H, Delagrave S, Guirakhoo F, Collett MS, Pugachev KV. Direct random insertion of an influenza virus immunologic determinant into the NS1 glycoprotein of a vaccine flavivirus. Virology 2010; 396:329 - 38; http://dx.doi.org/10.1016/j.virol.2009.10.033; PMID: 19913267
   PubMed Web of Science ®Google Scholar
• Auclair SM, Bhanu MK, Kendall DA. Signal peptidase I: cleaving the way to mature proteins. Protein Sci 2012; 21:13 - 25; http://dx.doi.org/10.1002/pro.757; PMID: 22031009
   PubMed Web of Science ®Google Scholar
• Bonaldo MC, Mello SM, Trindade GF, Rangel AA, Duarte AS, Oliveira PJ, Freire MS, Kubelka CF, Galler R. Construction and characterization of recombinant flaviviruses bearing insertions between E and NS1 genes. Virol J 2007; 4:115; http://dx.doi.org/10.1186/1743-422X-4-115; PMID: 17971212
   PubMed Web of Science ®Google Scholar
• Trindade GF, Santana MG, Santos JR, Galler R, Bonaldo MC. Retention of a recombinant GFP protein expressed by the yellow fever 17D virus in the E/NS1 intergenic region in the endoplasmic reticulum. Mem Inst Oswaldo Cruz 2012; 107:262 - 72; http://dx.doi.org/10.1590/S0074-02762012000200017; PMID: 22415267
   PubMed Web of Science ®Google Scholar
• Bredenbeek PJ, Molenkamp R, Spaan WJ, Deubel V, Marianneau P, Salvato MS, Moshkoff D, Zapata J, Tikhonov I, Patterson J, et al. A recombinant Yellow Fever 17D vaccine expressing Lassa virus glycoproteins. Virology 2006; 345:299 - 304; http://dx.doi.org/10.1016/j.virol.2005.12.001; PMID: 16412488
   PubMed Web of Science ®Google Scholar
• Jiang X, Dalebout TJ, Bredenbeek PJ, Carrion R Jr., Brasky K, Patterson J, Goicochea M, Bryant J, Salvato MS, Lukashevich IS. Yellow fever 17D-vectored vaccines expressing Lassa virus GP1 and GP2 glycoproteins provide protection against fatal disease in guinea pigs. Vaccine 2011; 29:1248 - 57; http://dx.doi.org/10.1016/j.vaccine.2010.11.079; PMID: 21145373
   PubMed Web of Science ®Google Scholar
• Weill L, James L, Ulryck N, Chamond N, Herbreteau CH, Ohlmann T, Sargueil B. A new type of IRES within gag coding region recruits three initiation complexes on HIV-2 genomic RNA. Nucleic Acids Res 2010; 38:1367 - 81; http://dx.doi.org/10.1093/nar/gkp1109; PMID: 19969542
   PubMed Web of Science ®Google Scholar
• Santana MGV, Neves PCC, Santos JR, Lima NS. SANTOS AAC, SANTOS JR, Watkins DI, Galler R, Bonaldo MC. Improved genetic stability of recombinant yellow fever 17D virus expressing a lentiviral Gag gene fragment. Virology In press
   PubMedGoogle Scholar
• Bonaldo MC, Martins MA, Rudersdorf R, Mudd PA, Sacha JB, Piaskowski SM, Costa Neves PC, Veloso de Santana MG, Vojnov L, Capuano S 3rd, et al. Recombinant yellow fever vaccine virus 17D expressing simian immunodeficiency virus SIVmac239 gag induces SIV-specific CD8+ T-cell responses in rhesus macaques. J Virol 2010; 84:3699 - 706; http://dx.doi.org/10.1128/JVI.02255-09; PMID: 20089645
   PubMed Web of Science ®Google Scholar
• Martins MA, Bonaldo MC, Rudersdorf RA, Piaskowski SM, Rakasz EG, Weisgrau KL, Furlott JR, Eernisse CM, Veloso de Santana MG, Hidalgo B, et al. Immunogenicity of seven new recombinant yellow fever viruses 17D expressing fragments of SIVmac239 Gag, Nef, and Vif in Indian rhesus macaques. PLoS One 2013; 8:e54434; http://dx.doi.org/10.1371/journal.pone.0054434; PMID: 23336000
   PubMed Web of Science ®Google Scholar
• Mudd PA, Martins MA, Ericsen AJ, Tully DC, Power KA, Bean AT, Piaskowski SM, Duan L, Seese A, Gladden AD, et al. Vaccine-induced CD8+ T cells control AIDS virus replication. Nature 2012; 491:129 - 33; http://dx.doi.org/10.1038/nature11443; PMID: 23023123
   PubMed Web of Science ®Google Scholar
• Deas TS, Binduga-Gajewska I, Tilgner M, Ren P, Stein DA, Moulton HM, Iversen PL, Kauffman EB, Kramer LD, Shi PY. Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication. J Virol 2005; 79:4599 - 609; http://dx.doi.org/10.1128/JVI.79.8.4599-4609.2005; PMID: 15795246
   PubMed Web of Science ®Google Scholar
• Zou G, Xu HY, Qing M, Wang QY, Shi PY. Development and characterization of a stable luciferase dengue virus for high-throughput screening. Antiviral Res 2011; 91:11 - 9; http://dx.doi.org/10.1016/j.antiviral.2011.05.001; PMID: 21575658
   PubMed Web of Science ®Google Scholar
• Corver J, Lenches E, Smith K, Robison RA, Sando T, Strauss EG, Strauss JH. Fine mapping of a cis-acting sequence element in yellow fever virus RNA that is required for RNA replication and cyclization. J Virol 2003; 77:2265 - 70; http://dx.doi.org/10.1128/JVI.77.3.2265-2270.2003; PMID: 12525663
   PubMed Web of Science ®Google Scholar
• Stoyanov CT, Boscardin SB, Deroubaix S, Barba-Spaeth G, Franco D, Nussenzweig RS, Nussenzweig M, Rice CM. Immunogenicity and protective efficacy of a recombinant yellow fever vaccine against the murine malarial parasite Plasmodium yoelii. Vaccine 2010; 28:4644 - 52; http://dx.doi.org/10.1016/j.vaccine.2010.04.071; PMID: 20451637
   PubMed Web of Science ®Google Scholar
• Mutebi JP, Rijnbrand RC, Wang H, Ryman KD, Wang E, Fulop LD, Titball R, Barrett AD. Genetic relationships and evolution of genotypes of yellow fever virus and other members of the yellow fever virus group within the Flavivirus genus based on the 3′ noncoding region. J Virol 2004; 78:9652 - 65; http://dx.doi.org/10.1128/JVI.78.18.9652-9665.2004; PMID: 15331698
   PubMed Web of Science ®Google Scholar
• Andino R, McAllister A. Recombinant Bicistronic Flaviviruses and Methods of Use Thereof USA: University of California, 2001:28.
   Google Scholar
• Kaptein SJ, De Burghgraeve T, Froeyen M, Pastorino B, Alen MM, Mondotte JA, Herdewijn P, Jacobs M, de Lamballerie X, Schols D, et al. A derivate of the antibiotic doxorubicin is a selective inhibitor of dengue and yellow fever virus replication in vitro. Antimicrob Agents Chemother 2010; 54:5269 - 80; http://dx.doi.org/10.1128/AAC.00686-10; PMID: 20837762
   PubMed Web of Science ®Google Scholar
• Pierson TC, Diamond MS, Ahmed AA, Valentine LE, Davis CW, Samuel MA, Hanna SL, Puffer BA, Doms RW. An infectious West Nile virus that expresses a GFP reporter gene. Virology 2005; 334:28 - 40; http://dx.doi.org/10.1016/j.virol.2005.01.021; PMID: 15749120
   PubMed Web of Science ®Google Scholar
• Yun SI, Kim SY, Rice CM, Lee YM. Development and application of a reverse genetics system for Japanese encephalitis virus. J Virol 2003; 77:6450 - 65; http://dx.doi.org/10.1128/JVI.77.11.6450-6465.2003; PMID: 12743302
   PubMed Web of Science ®Google Scholar
• Grant D, Tan GK, Qing M, Ng JK, Yip A, Zou G, Xie X, Yuan Z, Schreiber MJ, Schul W, et al. A single amino acid in nonstructural protein NS4B confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis. J Virol 2011; 85:7775 - 87; http://dx.doi.org/10.1128/JVI.00665-11; PMID: 21632767
   PubMed Web of Science ®Google Scholar
• Schoggins JW, Dorner M, Feulner M, Imanaka N, Murphy MY, Ploss A, Rice CM. Dengue reporter viruses reveal viral dynamics in interferon receptor-deficient mice and sensitivity to interferon effectors in vitro. Proc Natl Acad Sci U S A 2012; 109:14610 - 5; http://dx.doi.org/10.1073/pnas.1212379109; PMID: 22908290
   PubMed Web of Science ®Google Scholar
• Bonaldo MC, Galler R. Method for the Production of Recombinant Virus, DNA Constructs, Recombinant Virus and Vaccine Compositions BRAZIL: Fundação Oswaldo Cruz, 2005:93.
   Google Scholar