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Commentary

Beyond new chemical entities

Advancing drug development based on functional versatility of antibodies

&
Pages 1639-1644 | Received 30 Jan 2014, Accepted 12 Feb 2014, Published online: 14 Mar 2014

References

  • Cariuk P, Gardener MJ, Vaughan TJ. Evolution of biologics screening technologies. Pharmaceuticals (Basel) 2013; 6:681 - 8; http://dx.doi.org/10.3390/ph6050681; PMID: 24276173
  • De Rosa L, Russomanno A, Romanelli A, D’Andrea LD. Semi-synthesis of labeled proteins for spectroscopic applications. Molecules 2013; 18:440 - 65; http://dx.doi.org/10.3390/molecules18010440; PMID: 23282535
  • Adelman B. Opening up drug development to everyone. Hematology Am Soc Hematol Educ Program 2013; 2013:311 - 5; http://dx.doi.org/10.1182/asheducation-2013.1.311; PMID: 24319197
  • Caoili SE. Antidotes, antibody-mediated immunity and the future of pharmaceutical product development. Hum Vaccin Immunother 2013; 9:294 - 9; http://dx.doi.org/10.4161/hv.22858; PMID: 23291934
  • Subbarayappa BV. The roots of ancient medicine: an historical outline. J Biosci 2001; 26:135 - 43; http://dx.doi.org/10.1007/BF02703637; PMID: 11426049
  • Schmidt B, Ribnicky DM, Poulev A, Logendra S, Cefalu WT, Raskin I. A natural history of botanical therapeutics. Metabolism 2008; 57:Suppl 1 S3 - 9; http://dx.doi.org/10.1016/j.metabol.2008.03.001; PMID: 18555851
  • Bosch F, Rosich L. The contributions of Paul Ehrlich to pharmacology: a tribute on the occasion of the centenary of his Nobel Prize. Pharmacology 2008; 82:171 - 9; http://dx.doi.org/10.1159/000149583; PMID: 18679046
  • Nabel GJ. Designing tomorrow’s vaccines. N Engl J Med 2013; 368:551 - 60; http://dx.doi.org/10.1056/NEJMra1204186; PMID: 23388006
  • Yoneyama H, Katsumata R. Antibiotic resistance in bacteria and its future for novel antibiotic development. Biosci Biotechnol Biochem 2006; 70:1060 - 75; http://dx.doi.org/10.1271/bbb.70.1060; PMID: 16717405
  • Chen L, Lu J, Zhang J, Feng KR, Zheng MY, Cai YD. Predicting chemical toxicity effects based on chemical-chemical interactions. PLoS One 2013; 8:e56517; http://dx.doi.org/10.1371/journal.pone.0056517; PMID: 23457578
  • Greek R, Pippus A, Hansen LA. The Nuremberg Code subverts human health and safety by requiring animal modeling. BMC Med Ethics 2012; 13:16; http://dx.doi.org/10.1186/1472-6939-13-16; PMID: 22769234
  • Gillon R. “Primum non nocere” and the principle of non-maleficence. Br Med J (Clin Res Ed) 1985; 291:130 - 1; http://dx.doi.org/10.1136/bmj.291.6488.130; PMID: 3926081
  • Waddell WJ. History of dose response. J Toxicol Sci 2010; 35:1 - 8; http://dx.doi.org/10.2131/jts.35.1; PMID: 20118619
  • Eddleston M, Persson H. Acute plant poisoning and antitoxin antibodies. J Toxicol Clin Toxicol 2003; 41:309 - 15; http://dx.doi.org/10.1081/CLT-120021116; PMID: 12807314
  • Pan Y, Gao D, Zhan CG. Modeling the catalysis of anti-cocaine catalytic antibody: competing reaction pathways and free energy barriers. J Am Chem Soc 2008; 130:5140 - 9; http://dx.doi.org/10.1021/ja077972s; PMID: 18341277
  • Chmura AJ, Orton MS, Meares CF. Antibodies with infinite affinity. Proc Natl Acad Sci U S A 2001; 98:8480 - 4; http://dx.doi.org/10.1073/pnas.151260298; PMID: 11447282
  • Stone MJ, Bogen SA. Evidence-based focused review of management of hyperviscosity syndrome. Blood 2012; 119:2205 - 8; http://dx.doi.org/10.1182/blood-2011-04-347690; PMID: 22147890
  • Foote J, Eisen HN. Breaking the affinity ceiling for antibodies and T cell receptors. Proc Natl Acad Sci U S A 2000; 97:10679 - 81; http://dx.doi.org/10.1073/pnas.97.20.10679; PMID: 11005851
  • Gigant B, Charbonnier JB, Eshhar Z, Green BS, Knossow M. X-ray structures of a hydrolytic antibody and of complexes elucidate catalytic pathway from substrate binding and transition state stabilization through water attack and product release. Proc Natl Acad Sci U S A 1997; 94:7857 - 61; http://dx.doi.org/10.1073/pnas.94.15.7857; PMID: 9223277
  • Kolesnikov AV, Kozyr AV, Alexandrova ES, Koralewski F, Demin AV, Titov MI, Avalle B, Tramontano A, Paul S, Thomas D, et al. Enzyme mimicry by the antiidiotypic antibody approach. Proc Natl Acad Sci U S A 2000; 97:13526 - 31; http://dx.doi.org/10.1073/pnas.200360497; PMID: 11095704
  • Paul S, Planque S, Zhou YX, Taguchi H, Bhatia G, Karle S, Hanson C, Nishiyama Y. Specific HIV gp120-cleaving antibodies induced by covalently reactive analog of gp120. J Biol Chem 2003; 278:20429 - 35; http://dx.doi.org/10.1074/jbc.M300870200; PMID: 12665517
  • Hifumi E, Honjo E, Fujimoto N, Arakawa M, Nishizono A, Uda T. Highly efficient method of preparing human catalytic antibody light chains and their biological characteristics. FASEB J 2012; 26:1607 - 15; http://dx.doi.org/10.1096/fj.11-195339; PMID: 22205784
  • O’Hear CE, Foote J. Antibody buffering of a ligand in vivo. Proc Natl Acad Sci U S A 2005; 102:40 - 4; http://dx.doi.org/10.1073/pnas.0405797102; PMID: 15615858
  • Medeiros-Souza P, Santos-Neto LL, Kusano LT, Pereira MG. Diagnosis and control of polypharmacy in the elderly. Rev Saude Publica 2007; 41:1049 - 53; http://dx.doi.org/10.1590/S0034-89102006005000050; PMID: 17992356
  • Wootla B, Lacroix-Desmazes S, Warrington AE, Bieber AJ, Kaveri SV, Rodriguez M. Autoantibodies with enzymatic properties in human autoimmune diseases. J Autoimmun 2011; 37:144 - 50; http://dx.doi.org/10.1016/j.jaut.2011.05.007; PMID: 21624820
  • Schleidgen S, Klingler C, Bertram T, Rogowski WH, Marckmann G. What is personalized medicine: sharpening a vague term based on a systematic literature review. BMC Med Ethics 2013; 14:55; http://dx.doi.org/10.1186/1472-6939-14-55; PMID: 24359531
  • Shah RR, Shah DR. Personalized medicine: is it a pharmacogenetic mirage?. Br J Clin Pharmacol 2012; 74:698 - 721; http://dx.doi.org/10.1111/j.1365-2125.2012.04328.x; PMID: 22591598
  • Cascorbi I. Overlapping effects of genetic variation and epigenetics on drug response: challenges of pharmacoepigenomics. Pharmacogenomics 2013; 14:1807 - 9; http://dx.doi.org/10.2217/pgs.13.194; PMID: 24236479
  • Uetrecht J, Naisbitt DJ. Idiosyncratic adverse drug reactions: current concepts. Pharmacol Rev 2013; 65:779 - 808; http://dx.doi.org/10.1124/pr.113.007450; PMID: 23476052
  • Henderson PT, Pan CX. Human microdosing for the prediction of patient response. Bioanalysis 2010; 2:373 - 6; http://dx.doi.org/10.4155/bio.10.3; PMID: 21083245
  • Maynard KI. Hormesis pervasiveness and its potential implications for pharmaceutical research and development. Dose Response 2011; 9:377 - 86; http://dx.doi.org/10.2203/dose-response.11-026.Maynard; PMID: 22013400
  • Cascorbi I. Drug interactions--principles, examples and clinical consequences. Dtsch Arztebl Int 2012; 109:546 - 55, quiz 556; PMID: 23152742
  • Ho M, Segre M. Inhibition of cocaine binding to the human dopamine transporter by a single chain anti-idiotypic antibody: its cloning, expression, and functional properties. Biochim Biophys Acta 2003; 1638:257 - 66; http://dx.doi.org/10.1016/S0925-4439(03)00091-7; PMID: 12878327
  • Datta-Mannan A, Witcher DR, Tang Y, Watkins J, Wroblewski VJ. Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor. J Biol Chem 2007; 282:1709 - 17; http://dx.doi.org/10.1074/jbc.M607161200; PMID: 17135257
  • Schlapschy M, Binder U, Börger C, Theobald I, Wachinger K, Kisling S, Haller D, Skerra A. PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins. Protein Eng Des Sel 2013; 26:489 - 501; http://dx.doi.org/10.1093/protein/gzt023; PMID: 23754528
  • Cousens LP, Najafian N, Mingozzi F, Elyaman W, Mazer B, Moise L, Messitt TJ, Su Y, Sayegh M, High K, et al. In vitro and in vivo studies of IgG-derived Treg epitopes (Tregitopes): a promising new tool for tolerance induction and treatment of autoimmunity. J Clin Immunol 2013; 33:Suppl 1 S43 - 9; http://dx.doi.org/10.1007/s10875-012-9762-4; PMID: 22941509
  • Shao L, Hewitt MC. The kinetic isotope effect in the search for deuterated drugs. Drug News Perspect 2010; 23:398 - 404; PMID: 20697607
  • Hollis A, Ahmed Z. Preserving antibiotics, rationally. N Engl J Med 2013; 369:2474 - 6; http://dx.doi.org/10.1056/NEJMp1311479; PMID: 24369073
  • Robinson JA. Max Bergmann lecture protein epitope mimetics in the age of structural vaccinology. J Pept Sci 2013; 19:127 - 40; http://dx.doi.org/10.1002/psc.2482; PMID: 23349031
  • Swamidass SJ, Lu Z, Agarwal P, Butte AJ. Computational approaches to drug repurposing and pharmacology -session introduction. Pac Symp Biocomput 2014; 19:110 - 3
  • Imai K, Takaoka A. Comparing antibody and small-molecule therapies for cancer. Nat Rev Cancer 2006; 6:714 - 27; http://dx.doi.org/10.1038/nrc1913; PMID: 16929325
  • Humphreys G. The health-care challenges posed by population ageing. Bull World Health Organ 2012; 90:82 - 3; PMID: 22423156
  • McMichael AJ. Impediments to comprehensive research on climate change and health. Int J Environ Res Public Health 2013; 10:6096 - 105; http://dx.doi.org/10.3390/ijerph10116096; PMID: 24225646