Strong HCV NS3/4a, NS4b, NS5a, NS5b-specific cellular immune responses induced in Rhesus macaques by a novel HCV genotype 1a/1b consensus DNA vaccine

References

• Mohd Hanafiah K, Groeger J, Flaxman AD, Wiersma ST. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology 2013; 57:1333 - 42; http://dx.doi.org/10.1002/hep.26141; PMID: 23172780
   PubMed Web of Science ®Google Scholar
• Lawitz E, Mangia A, Wyles D, Rodriguez-Torres M, Hassanein T, Gordon SC, Schultz M, Davis MN, Kayali Z, Reddy KR, et al. Sofosbuvir for previously untreated chronic hepatitis C infection. N Engl J Med 2013; 368:1878 - 87; http://dx.doi.org/10.1056/NEJMoa1214853; PMID: 23607594
   PubMed Web of Science ®Google Scholar
• Hepatitis and Liver Cancer: A National Strategy for Prevention and Control of Hepatitis B and C, The National Academies Press, 2010.
   Google Scholar
• Stepanova M, Kanwal F, El-Serag HB, Younossi ZM. Insurance status and treatment candidacy of hepatitis C patients: analysis of population-based data from the United States. Hepatology 2011; 53:737 - 45; http://dx.doi.org/10.1002/hep.24131; PMID: 21319199
   PubMed Web of Science ®Google Scholar
• Razavi H, Elkhoury AC, Elbasha E, Estes C, Pasini K, Poynard T, Kumar R. Chronic hepatitis C virus (HCV) disease burden and cost in the United States. Hepatology 2013; 57:2164 - 70; http://dx.doi.org/10.1002/hep.26218; PMID: 23280550
   PubMed Web of Science ®Google Scholar
• Massad E, Coutinho FA, Chaib E, Burattini MN. Cost-effectiveness analysis of a hypothetical hepatitis C vaccine compared to antiviral therapy. Epidemiol Infect 2009; 137:241 - 9; http://dx.doi.org/10.1017/S0950268808000873; PMID: 18631422
   PubMed Web of Science ®Google Scholar
• Plotkin SA, Orenstein WA, Offit PA. Vaccines, 6th edn Elsevier Saunders: Philadelphia? Pa., 2013.
   Google Scholar
• Walker CM. Adaptive immunity to the hepatitis C virus. Adv Virus Res 2010; 78:43 - 86; http://dx.doi.org/10.1016/B978-0-12-385032-4.00002-1; PMID: 21040831
   PubMed Web of Science ®Google Scholar
• Bagarazzi ML, Yan J, Morrow MP, Shen X, Parker RL, Lee JC, et al. Immunotherapy against HPV16/18 generates potent TH1 and cytotoxic cellular immune responses. Sci Transl Med. 2012 Oct 10;4(155):155ra138
   Google Scholar
• Kalams SA, Parker SD, Elizaga M, Metch B, Edupuganti S, Hural J, De Rosa S, Carter DK, Rybczyk K, Frank I, et al, NIAID HIV Vaccine Trials Network. Safety and comparative immunogenicity of an HIV-1 DNA vaccine in combination with plasmid interleukin 12 and impact of intramuscular electroporation for delivery. J Infect Dis 2013; 208:818 - 29; http://dx.doi.org/10.1093/infdis/jit236; PMID: 23840043
   PubMed Web of Science ®Google Scholar
• Ferraro B, Talbott KT, Balakrishnan A, Cisper N, Morrow MP, Hutnick NA, Myles DJ, Shedlock DJ, Obeng-Adjei N, Yan J, et al. Inducing humoral and cellular responses to multiple sporozoite and liver-stage malaria antigens using exogenous plasmid DNA. Infect Immun 2013; 81:3709 - 20; http://dx.doi.org/10.1128/IAI.00180-13; PMID: 23897618
   PubMed Web of Science ®Google Scholar
• Lang Kuhs KA, Ginsberg AA, Yan J, Wiseman RW, Khan AS, Sardesai NY, O’Connor DH, Weiner DB. Hepatitis C virus NS3/NS4A DNA vaccine induces multiepitope T cell responses in rhesus macaques mimicking human immune responses [corrected]. [corrected] Mol Ther 2012; 20:669 - 78; http://dx.doi.org/10.1038/mt.2011.188; PMID: 21952169
   PubMed Web of Science ®Google Scholar
• Kutzler MA, Weiner DB. DNA vaccines: ready for prime time?. Nat Rev Genet 2008; 9:776 - 88; http://dx.doi.org/10.1038/nrg2432; PMID: 18781156
   PubMed Web of Science ®Google Scholar
• Neumann-Haefelin C, Thimme R. Adaptive immune responses in hepatitis C virus infection. Curr Top Microbiol Immunol 2013; 369:243 - 62; http://dx.doi.org/10.1007/978-3-642-27340-7_10; PMID: 23463204
   PubMed Web of Science ®Google Scholar
• Kim Y, Vaughan K, Greenbaum J, Peters B, Law M, Sette A. A meta-analysis of the existing knowledge of immunoreactivity against hepatitis C virus (HCV). PLoS One 2012; 7:e38028; http://dx.doi.org/10.1371/journal.pone.0038028; PMID: 22675428
   PubMedGoogle Scholar
• Grebely J, Conway B, Raffa JD, Lai C, Krajden M, Tyndall MW. Hepatitis C virus reinfection in injection drug users. Hepatology 2006; 44:1139 - 45; http://dx.doi.org/10.1002/hep.21376; PMID: 17058216
   PubMed Web of Science ®Google Scholar
• Page K, Hahn JA, Evans J, Shiboski S, Lum P, Delwart E, Tobler L, Andrews W, Avanesyan L, Cooper S, et al. Acute hepatitis C virus infection in young adult injection drug users: a prospective study of incident infection, resolution, and reinfection. J Infect Dis 2009; 200:1216 - 26; http://dx.doi.org/10.1086/605947; PMID: 19764883
   PubMed Web of Science ®Google Scholar
• Osburn WO, Fisher BE, Dowd KA, Urban G, Liu L, Ray SC, Thomas DL, Cox AL. Spontaneous control of primary hepatitis C virus infection and immunity against persistent reinfection. Gastroenterology 2010; 138:315 - 24; http://dx.doi.org/10.1053/j.gastro.2009.09.017; PMID: 19782080
   PubMed Web of Science ®Google Scholar
• Lang Kuhs KA, Toporovski R, Ginsberg AA, Olsen AL, Shedlock DJ, Morrow MP, Yan J, Wells RG, Weiner DB. Peripheral immunization induces functional intrahepatic hepatitis C specific immunity following selective retention of vaccine-specific CD8 T cells by the liver. Hum Vaccin 2011; 7:1326 - 35; http://dx.doi.org/10.4161/hv.7.12.18279; PMID: 22108033
   PubMed Web of Science ®Google Scholar
• Lang Kuhs KA, Toporovski R, Yan J, Ginsberg AA, Shedlock DJ, Weiner DB. Induction of intrahepatic HCV NS4B, NS5A and NS5B-specific cellular immune responses following peripheral immunization. PLoS One 2012; 7:e52165; http://dx.doi.org/10.1371/journal.pone.0052165; PMID: 23284919
   PubMedGoogle Scholar
• Lang KA, Yan J, Draghia-Akli R, Khan A, Weiner DB. Strong HCV NS3- and NS4A-specific cellular immune responses induced in mice and Rhesus macaques by a novel HCV genotype 1a/1b consensus DNA vaccine. Vaccine 2008; 26:6225 - 31; http://dx.doi.org/10.1016/j.vaccine.2008.07.052; PMID: 18692108
   PubMed Web of Science ®Google Scholar
• Shin EC, Capone S, Cortese R, Colloca S, Nicosia A, Folgori A, Rehermann B. The kinetics of hepatitis C virus-specific CD8 T-cell responses in the blood mirror those in the liver in acute hepatitis C virus infection. J Virol 2008; 82:9782 - 8; http://dx.doi.org/10.1128/JVI.00475-08; PMID: 18667501
   PubMed Web of Science ®Google Scholar
• Shoukry NH, Grakoui A, Houghton M, Chien DY, Ghrayeb J, Reimann KA, Walker CM. Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection. J Exp Med 2003; 197:1645 - 55; http://dx.doi.org/10.1084/jem.20030239; PMID: 12810686
   PubMed Web of Science ®Google Scholar
• Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 1989; 244:359 - 62; http://dx.doi.org/10.1126/science.2523562; PMID: 2523562
   PubMed Web of Science ®Google Scholar
• Terilli RR, Cox AL. Immunity and hepatitis C: a review. Curr HIV/AIDS Rep 2013; 10:51 - 8; http://dx.doi.org/10.1007/s11904-012-0146-4; PMID: 23180007
   PubMed Web of Science ®Google Scholar
• Park SH, Veerapu NS, Shin EC, Biancotto A, McCoy JP, Capone S, Folgori A, Rehermann B. Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection. Nat Med 2013; 19:1638 - 42; http://dx.doi.org/10.1038/nm.3408; PMID: 24270546
   PubMed Web of Science ®Google Scholar
• Park SH, Shin EC, Capone S, Caggiari L, De Re V, Nicosia A, et al. Successful vaccination induces multifunctional memory T-cell precursors associated with early control of hepatitis C virus. Gastroenterology. 2012 Oct;143(4):1048-60.e4
   Google Scholar
• Barnes E, Folgori A, Capone S, Swadling L, Aston S, Kurioka A, et al. Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man. Sci Transl Med. 2012 Jan 4;4(115):115ra1
   Google Scholar
• Schirmbeck R, Reimann J, Kochanek S, Kreppel F. The immunogenicity of adenovirus vectors limits the multispecificity of CD8 T-cell responses to vector-encoded transgenic antigens. Mol Ther 2008; 16:1609 - 16; http://dx.doi.org/10.1038/mt.2008.141; PMID: 18612271
   PubMed Web of Science ®Google Scholar
• Fu TM, Friedman A, Ulmer JB, Liu MA, Donnelly JJ. Protective cellular immunity: cytotoxic T-lymphocyte responses against dominant and recessive epitopes of influenza virus nucleoprotein induced by DNA immunization. J Virol 1997; 71:2715 - 21; PMID: 9060624
   PubMed Web of Science ®Google Scholar
• Flingai S, Czerwonko M, Goodman J, Kudchodkar SB, Muthumani K, Weiner DB. Synthetic DNA Vaccines: Improved Vaccine Potency by Electroporation and Co-Delivered Genetic Adjuvants. Front Immunol 2013; 4:354; http://dx.doi.org/10.3389/fimmu.2013.00354; PMID: 24204366
   PubMed Web of Science ®Google Scholar
• Yan J, Corbitt N, Pankhong P, Shin T, Khan A, Sardesai NY, Weiner DB. Immunogenicity of a novel engineered HIV-1 clade C synthetic consensus-based envelope DNA vaccine. Vaccine 2011; 29:7173 - 81; http://dx.doi.org/10.1016/j.vaccine.2011.05.076; PMID: 21651948
   PubMed Web of Science ®Google Scholar
• Halwani R, Boyer JD, Yassine-Diab B, Haddad EK, Robinson TM, Kumar S, Parkinson R, Wu L, Sidhu MK, Phillipson-Weiner R, et al. Therapeutic vaccination with simian immunodeficiency virus (SIV)-DNA + IL-12 or IL-15 induces distinct CD8 memory subsets in SIV-infected macaques. J Immunol 2008; 180:7969 - 79; http://dx.doi.org/10.4049/jimmunol.180.12.7969; PMID: 18523260
   PubMed Web of Science ®Google Scholar
• Sardesai NY, Weiner DB. Electroporation delivery of DNA vaccines: prospects for success. Curr Opin Immunol 2011; 23:421 - 9; http://dx.doi.org/10.1016/j.coi.2011.03.008; PMID: 21530212
   PubMed Web of Science ®Google Scholar
• Thimme R, Bukh J, Spangenberg HC, Wieland S, Pemberton J, Steiger C, Govindarajan S, Purcell RH, Chisari FV. Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease. Proc Natl Acad Sci U S A 2002; 99:15661 - 8; http://dx.doi.org/10.1073/pnas.202608299; PMID: 12441397
   PubMed Web of Science ®Google Scholar
• Heim MH. Innate immunity and HCV. J Hepatol 2013; 58:564 - 74; http://dx.doi.org/10.1016/j.jhep.2012.10.005; PMID: 23063572
   PubMed Web of Science ®Google Scholar