Vaccination against trypanosomiasis

REFERENCES

• Raper J, Fung R, Ghiso J, Nussenzweig V, Tomlinson S. Characterization of a novel trypanosome lytic factor from human serum. Infect Immun 1999; 67:1910 - 6; PMID: 10085035
   PubMed Web of Science ®Google Scholar
• Barth P. A new method for the isolation of the trypanocidal factor from normal human serum. Acta Trop 1989; 46:71 - 3; http://dx.doi.org/10.1016/0001-706X(89)90019-3; PMID: 2566265
   PubMed Web of Science ®Google Scholar
• Shaw A. The economics of African trypanosomiasis. in The trypanosomiasis edited by I Maudlin, P Holmes & M Miles Wallingford: CABI Publishing 2004.
   Google Scholar
• Desquesnes M, Dia ML. Mechanical transmission of Trypanosoma congolense in cattle by the African tabanid Atylotus agrestis. Exp Parasitol 2003; 105:226 - 31; http://dx.doi.org/10.1016/j.exppara.2003.12.014; PMID: 14990316
   PubMed Web of Science ®Google Scholar
• Desquesnes M, Dia ML. Mechanical transmission of Trypanosoma vivax in cattle by the African tabanid Atylotus fuscipes. Vet Parasitol 2004; 119:9 - 19; http://dx.doi.org/10.1016/j.vetpar.2003.10.015; PMID: 15036572
   PubMed Web of Science ®Google Scholar
• Otte MJ, Abuabara JY. Transmission of South American Trypanosoma vivax by the neotropical horsefly Tabanus nebulosus. Acta Trop 1991; 49:73 - 6; http://dx.doi.org/10.1016/0001-706X(91)90033-G; PMID: 1678579
   PubMed Web of Science ®Google Scholar
• Brun R, Hecker H, Lun ZR. Trypanosoma evansi and T. equiperdum: distribution, biology, treatment and phylogenetic relationship (a review). Vet Parasitol 1998; 79:95 - 107; http://dx.doi.org/10.1016/S0304-4017(98)00146-0; PMID: 9806490
   PubMed Web of Science ®Google Scholar
• WHO. Human African trypanosomiasis: number of new cases drops to historically low level in 50 years. Available at: http://whoint/neglected_diseases/integrated_media/integrated_media_hat_june_2010/en/indexhtml 2010.
   Google Scholar
• Xong HV, Vanhamme L, Chamekh M, Chimfwembe CE, Van Den Abbeele J, Pays A, et al. A VSG expression site-associated gene confers resistance to human serum in Trypanosoma rhodesiense. Cell 1998; 95:839 - 46; http://dx.doi.org/10.1016/S0092-8674(00)81706-7; PMID: 9865701
   PubMed Web of Science ®Google Scholar
• De Greef C, Hamers R. The serum resistance-associated (SRA) gene of Trypanosoma brucei rhodesiense encodes a variant surface glycoprotein-like protein. Mol Biochem Parasitol 1994; 68:277 - 84; http://dx.doi.org/10.1016/0166-6851(94)90172-4; PMID: 7739673
   PubMed Web of Science ®Google Scholar
• Kieft R, Capewell P, Turner CM, Veitch NJ, MacLeod A, Hajduk S. Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor. Proc Natl Acad Sci USA 2010; 107:16137 - 41; http://dx.doi.org/10.1073/pnas.1007074107; PMID: 20805508
   PubMed Web of Science ®Google Scholar
• Simarro PP, Cecchi G, Paone M, Franco JR, Diarra A, Ruiz JA, et al. The Atlas of human African trypanosomiasis: a contribution to global mapping of neglected tropical diseases. Int J Health Geogr 2010; 9:57; http://dx.doi.org/10.1186/1476-072X-9-57; PMID: 21040555
   PubMed Web of Science ®Google Scholar
• Courtin F, Jamonneau V, Duvallet G, Garcia A, Coulibaly B, Doumenge JP, et al. Sleeping sickness in West Africa (1906-2006): changes in spatial repartition and lessons from the past. Trop Med Int Health 2008; 13:334 - 44; http://dx.doi.org/10.1111/j.1365-3156.2008.02007.x; PMID: 18397396
   PubMed Web of Science ®Google Scholar
• Waiswa C, Kabasa JD. Experiences with an in-training community service model in the control of zoonotic sleeping sickness in Uganda. J Vet Med Educ 2010; 37:276 - 81; http://dx.doi.org/10.3138/jvme.37.3.276; PMID: 20847337
   PubMed Web of Science ®Google Scholar
• Murray M, Morrison WI, Whitelaw DD. Host susceptibility to African trypanosomiasis: trypanotolerance. Adv Parasitol 1982; 21:1 - 68; http://dx.doi.org/10.1016/S0065-308X(08)60274-2; PMID: 6762064
   PubMed Web of Science ®Google Scholar
• Naessens J, Leak SG, Kennedy DJ, Kemp SJ, Teale AJ. Responses of bovine chimaeras combining trypanosomosis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense. Vet Parasitol 2003; 111:125 - 42; http://dx.doi.org/10.1016/S0304-4017(02)00360-6; PMID: 12531289
   PubMed Web of Science ®Google Scholar
• Jamonneau V, Ravel S, Garcia A, Koffi M, Truc P, Laveissiere C, et al. Characterization of Trypanosoma brucei s.l. infecting asymptomatic sleeping-sickness patients in Cote d'Ivoire: a new genetic group?. Ann Trop Med Parasitol 2004; 98:329 - 37; http://dx.doi.org/10.1179/000349804225003406; PMID: 15228714
   PubMed Web of Science ®Google Scholar
• Jamonneau V, Ravel S, Garcia A, Koffi M, Truc P, Laveissiere C, et al. Characterization of Trypanosoma brucei s.l. infecting asymptomatic sleeping-sickness patients in Cote d'Ivoire: a new genetic group?. Ann Trop Med Parasitol 2004; 98:329 - 37; http://dx.doi.org/10.1179/000349804225003406; PMID: 15228714
   PubMed Web of Science ®Google Scholar
• Wery M, Burke J. Human “healthy carriers” of Trypanosoma (brucei type) discovered by immunofluorescence test in the Republique Democratique du Congo. Trans R Soc Trop Med Hyg 1972; 66:332 - 3; http://dx.doi.org/10.1016/0035-9203(72)90209-X; PMID: 4558826
   PubMed Web of Science ®Google Scholar
• Buyst H. The epidemiology of sleeping sickness in the historical Luangwa valley. Ann Soc Belg Med Trop 1977; 57:349 - 59; PMID: 345980
   PubMedGoogle Scholar
• MacLean L, Chisi JE, Odiit M, Gibson WC, Ferris V, Picozzi K, et al. Severity of human african trypanosomiasis in East Africa is associated with geographic location, parasite genotype, and host inflammatory cytokine response profile. Infect Immun 2004; 72:7040 - 4; http://dx.doi.org/10.1128/IAI.72.12.7040-7044.2004; PMID: 15557627
   PubMed Web of Science ®Google Scholar
• Morrison LJ, Tait A, McLellan S, Sweeney L, Turner CM, MacLeod A. A major genetic locus in Trypanosoma brucei is a determinant of host pathology. PLoS Negl Trop Dis 2009; 3:e557; http://dx.doi.org/10.1371/journal.pntd.0000557; PMID: 19956590
   PubMed Web of Science ®Google Scholar
• Clayton CE. Trypanosoma brucei: influence of host strain and parasite antigenic type on infections in mice. Exp Parasitol 1978; 44:202 - 8; http://dx.doi.org/10.1016/0014-4894(78)90099-1; PMID: 658218
   PubMed Web of Science ®Google Scholar
• Balmer O, Stearns SC, Schotzau A, Brun R. Intraspecific competition between co-infecting parasite strains enhances host survival in African trypanosomes. Ecology 2009; 90:3367 - 78; http://dx.doi.org/10.1890/08-2291.1; PMID: 20120806
   PubMed Web of Science ®Google Scholar
• Truc P, Jamonneau V, N'Guessan P, N'Dri L, Diallo PB, Cuny G. Trypanosoma brucei ssp. and T congolense: mixed human infection in Cote d'Ivoire. Trans R Soc Trop Med Hyg 1998; 92:537 - 8; http://dx.doi.org/10.1016/S0035-9203(98)90904-X; PMID: 9861372
   PubMed Web of Science ®Google Scholar
• Kemp SJ, Iraqi F, Darvasi A, Soller M, Teale AJ. Localization of genes controlling resistance to trypanosomiasis in mice. Nat Genet 1997; 16:194 - 6; http://dx.doi.org/10.1038/ng0697-194; PMID: 9171834
   PubMed Web of Science ®Google Scholar
• Magez S, Radwanska M, Drennan M, Fick L, Baral TN, Allie N, et al. Tumor necrosis factor (TNF) receptor-1 (TNFp55) signal transduction and macrophage-derived soluble TNF are crucial for nitric oxide-mediated Trypanosoma congolense parasite killing. J Infect Dis 2007; 196:954 - 62; http://dx.doi.org/10.1086/520815; PMID: 17703428
   PubMed Web of Science ®Google Scholar
• Magez S, Lucas R, Darji A, Songa EB, Hamers R, De Baetselier P. Murine tumour necrosis factor plays a protective role during the initial phase of the experimental infection with Trypanosoma brucei brucei. Parasite Immunol 1993; 15:635 - 41; http://dx.doi.org/10.1111/j.1365-3024.1993.tb00577.x; PMID: 7877840
   PubMed Web of Science ®Google Scholar
• Magez S, Geuskens M, Beschin A, del Favero H, Verschueren H, Lucas R, et al. Specific uptake of tumor necrosis factor-alpha is involved in growth control of Trypanosoma brucei. J Cell Biol 1997; 137:715 - 27; http://dx.doi.org/10.1083/jcb.137.3.715; PMID: 9151676
   PubMed Web of Science ®Google Scholar
• Tabel H, Kaushik RS, Uzonna JE. Susceptibility and resistance to Trypanosoma congolense infections. Microbes Infect 2000; 2:1619 - 29; http://dx.doi.org/10.1016/S1286-4579(00)01318-6; PMID: 11113381
   PubMed Web of Science ®Google Scholar
• Mege JL, Meghari S, Honstettre A, Capo C, Raoult D. The two faces of interleukin 10 in human infectious diseases. Lancet Infect Dis 2006; 6:557 - 69; http://dx.doi.org/10.1016/S1473-3099(06)70577-1; PMID: 16931407
   PubMed Web of Science ®Google Scholar
• Bosschaerts T, Guilliams M, Noel W, Herin M, Burk RF, Hill KE, et al. Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P. J Immunol 2008; 180:6168 - 75; PMID: 18424738
   PubMed Web of Science ®Google Scholar
• Maclean L, Odiit M, Macleod A, Morrison L, Sweeney L, Cooper A, et al. Spatially and genetically distinct African Trypanosome virulence variants defined by host interferon-gamma response. J Infect Dis 2007; 196:1620 - 8; http://dx.doi.org/10.1086/522011; PMID: 18008245
   PubMed Web of Science ®Google Scholar
• Sternberg JM, Maclean L. A spectrum of disease in human African trypanosomiasis: the host and parasite genetics of virulence. Parasitology 2010; 137:2007 - 15; http://dx.doi.org/10.1017/S0031182010000946; PMID: 20663245
   PubMed Web of Science ®Google Scholar
• MacLean LM, Odiit M, Chisi JE, Kennedy PG, Sternberg JM. Focus-specific clinical profiles in human African Trypanosomiasis caused by Trypanosoma brucei rhodesiense. PLoS Negl Trop Dis 2010; 4:e906; http://dx.doi.org/10.1371/journal.pntd.0000906; PMID: 21151878
   PubMed Web of Science ®Google Scholar
• Kuepfer I, Hhary EP, Allan M, Edielu A, Burri C, Blum JA. Clinical Presentation of T.b. rhodesiense Sleeping Sickness in Second Stage Patients from Tanzania and Uganda. PLoS Negl Trop Dis 2011; 5:e968; http://dx.doi.org/10.1371/journal.pntd.0000968; PMID: 21407802
   PubMedGoogle Scholar
• Cornelissen AW, Bakkeren GA, Barry JD, Michels PA, Borst P. Characteristics of trypanosome variant antigen genes active in the tsetse fly. Nucleic Acids Res 1985; 13:4661 - 76; http://dx.doi.org/10.1093/nar/13.13.4661; PMID: 4022771
   PubMed Web of Science ®Google Scholar
• Field MC, Carrington M. The trypanosome flagellar pocket. Nat Rev Microbiol 2009; 7:775 - 86; http://dx.doi.org/10.1038/nrmicro2221; PMID: 19806154
   PubMed Web of Science ®Google Scholar
• Mkunza F, Olaho WM, Powell CN. Partial protection against natural trypanosomiasis after vaccination with a flagellar pocket antigen from Trypanosoma brucei rhodesiense. Vaccine 1995; 13:151 - 4; http://dx.doi.org/10.1016/0264-410X(95)93128-V; PMID: 7625108
   PubMed Web of Science ®Google Scholar
• Radwanska M, Magez S, Dumont N, Pays A, Nolan D, Pays E. Antibodies raised against the flagellar pocket fraction of Trypanosoma brucei preferentially recognize HSP60 in cDNA expression library. Parasite Immunol 2000; 22:639 - 50; http://dx.doi.org/10.1046/j.1365-3024.2000.00348.x; PMID: 11123756
   PubMed Web of Science ®Google Scholar
• Steverding D, Stierhof YD, Chaudhri M, Ligtenberg M, Schell D, Beck-Sickinger AG, et al. ESAG 6 and 7 products of Trypanosoma brucei form a transferrin binding protein complex. Eur J Cell Biol 1994; 64:78 - 87; PMID: 7957316
   PubMed Web of Science ®Google Scholar
• Jackson DG, Windle HJ, Voorheis HP. The identification, purification, and characterization of two invariant surface glycoproteins located beneath the surface coat barrier of bloodstream forms of Trypanosoma brucei. J Biol Chem 1993; 268:8085 - 95; PMID: 8463323
   PubMed Web of Science ®Google Scholar
• Ziegelbauer K, Overath P. Identification of invariant surface glycoproteins in the bloodstream stage of Trypanosoma brucei. J Biol Chem 1992; 267:10791 - 6; PMID: 1587855
   PubMed Web of Science ®Google Scholar
• Ziegelbauer K, Overath P. Organization of two invariant surface glycoproteins in the surface coat of Trypanosoma brucei. Infect Immun 1993; 61:4540 - 5; PMID: 8406850
   PubMed Web of Science ®Google Scholar
• Lança AS, de Sousa KP, Atouguia J, Prazeres DM, Monteiro GA, Silva MS. Trypanosoma brucei: immunisation with plasmid DNA encoding invariant surface glycoprotein gene is able to induce partial protection in experimental African trypanosomiasis. Exp Parasitol 2011; 127:18 - 24; http://dx.doi.org/10.1016/j.exppara.2010.06.017; PMID: 20599996
   PubMed Web of Science ®Google Scholar
• García-Salcedo JA, Perez-Morga D, Gijon P, Dilbeck V, Pays E, Nolan DP. A differential role for actin during the life cycle of Trypanosoma brucei. EMBO J 2004; 23:780 - 9; http://dx.doi.org/10.1038/sj.emboj.7600094; PMID: 14963487
   PubMed Web of Science ®Google Scholar
• Li SQ, Yang WB, Ma LJ, Xi SM, Chen QL, Song XW, et al. Immunization with recombinant actin from Trypanosoma evansi induces protective immunity against T. evansi, T. equiperdum and T. b. brucei infection. Parasitol Res 2009; 104:429 - 35; http://dx.doi.org/10.1007/s00436-008-1216-9; PMID: 18923843
   PubMed Web of Science ®Google Scholar
• Li SQ, Fung MC, Reid SA, Inoue N, Lun ZR. Immunization with recombinant beta-tubulin from Trypanosoma evansi induced protection against T. evansi, T. equiperdum and T. b. brucei infection in mice. Parasite Immunol 2007; 29:191 - 9; http://dx.doi.org/10.1111/j.1365-3024.2006.00933.x; PMID: 17371456
   PubMed Web of Science ®Google Scholar
• Lubega GW, Byarugaba DK, Prichard RK. Immunization with a tubulin-rich preparation from Trypanosoma brucei confers broad protection against African trypanosomosis. Exp Parasitol 2002; 102:9 - 22; http://dx.doi.org/10.1016/S0014-4894(02)00140-6; PMID: 12615162
   PubMed Web of Science ®Google Scholar
• Schneider A, Sherwin T, Sasse R, Russell DG, Gull K, Seebeck T. Subpellicular and flagellar microtubules of Trypanosoma brucei brucei contain the same alpha-tubulin isoforms. J Cell Biol 1987; 104:431 - 8; http://dx.doi.org/10.1083/jcb.104.3.431; PMID: 3818788
   PubMed Web of Science ®Google Scholar
• Schenkman S, Jiang MS, Hart GW, Nussenzweig V. A novel cell surface trans-sialidase of Trypanosoma cruzi generates a stage-specific epitope required for invasion of mammalian cells. Cell 1991; 65:1117 - 25; http://dx.doi.org/10.1016/0092-8674(91)90008-M; PMID: 1712251
   PubMed Web of Science ®Google Scholar
• Silva MS, Prazeres DM, Lanca A, Atouguia J, Monteiro GA. Trans-sialidase from Trypanosoma brucei as a potential target for DNA vaccine development against African trypanosomiasis. Parasitol Res 2009; 105:1223 - 9; http://dx.doi.org/10.1007/s00436-009-1542-6; PMID: 19582478
   PubMed Web of Science ®Google Scholar
• Ramey K, Eko FO, Thompson WE, Armah H, Igietseme JU, Stiles JK. Immunolocalization and challenge studies using a recombinant Vibrio cholerae ghost expressing Trypanosoma brucei Ca(2+) ATPase (TBCA2) antigen. Am J Trop Med Hyg 2009; 81:407 - 15; PMID: 19706905
   PubMed Web of Science ®Google Scholar
• Sileghem M, Flynn JN, Logan-Henfrey L, Ellis J. Tumour necrosis factor production by monocytes from cattle infected with Trypanosoma (Duttonella) vivax and Trypanosoma (Nannomonas) congolense: possible association with severity of anaemia associated with the disease. Parasite Immunol 1994; 16:51 - 4; http://dx.doi.org/10.1111/j.1365-3024.1994.tb00304.x; PMID: 7908735
   PubMed Web of Science ®Google Scholar
• Okomo-Assoumou MC, Daulouede S, Lemesre JL, N'Zila-Mouanda A, Vincendeau P. Correlation of high serum levels of tumor necrosis factor-alpha with disease severity in human African trypanosomiasis. Am J Trop Med Hyg 1995; 53:539 - 43; PMID: 7485714
   PubMed Web of Science ®Google Scholar
• Magez S, Radwanska M, Beschin A, Sekikawa K, De Baetselier P. Tumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei infections. Infect Immun 1999; 67:3128 - 32; PMID: 10338530
   PubMed Web of Science ®Google Scholar
• Rolin S, Hanocq-Quertier J, Paturiaux-Hanocq F, Nolan D, Salmon D, Webb H, et al. Simultaneous but independent activation of adenylate cyclase and glycosylphosphatidylinositol-phospholipase C under stress conditions in Trypanosoma brucei. J Biol Chem 1996; 271:10844 - 52; http://dx.doi.org/10.1074/jbc.271.18.10844; PMID: 8631899
   PubMed Web of Science ®Google Scholar
• Fox JA, Duszenko M, Ferguson MA, Low MG, Cross GA. Purification and characterization of a novel glycan-phosphatidylinositol-specific phospholipase C from Trypanosoma brucei. J Biol Chem 1986; 261:15767 - 71; PMID: 3782089
   PubMed Web of Science ®Google Scholar
• Magez S, Stijlemans B, Radwanska M, Pays E, Ferguson MA, De Baetselier P. The glycosyl-inositol-phosphate and dimyristoylglycerol moieties of the glycosylphosphatidylinositol anchor of the trypanosome variant-specific surface glycoprotein are distinct macrophage-activating factors. J Immunol 1998; 160:1949 - 56; PMID: 9469458
   PubMed Web of Science ®Google Scholar
• Philip R, Epstein LB. Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, gamma-interferon and interleukin-1. Nature 1986; 323:86 - 9; http://dx.doi.org/10.1038/323086a0; PMID: 3092113
   PubMed Web of Science ®Google Scholar
• Pentreath VW. Endotoxins and their significance for murine trypanosomiasis. Parasitol Today 1994; 10:226 - 9; http://dx.doi.org/10.1016/0169-4758(94)90122-8; PMID: 15275456
   PubMedGoogle Scholar
• Stijlemans B, Baral TN, Guilliams M, Brys L, Korf J, Drennan M, et al. A glycosylphosphatidylinositol-based treatment alleviates trypanosomiasis-associated immunopathology. J Immunol 2007; 179:4003 - 14; PMID: 17785839
   PubMed Web of Science ®Google Scholar
• Schofield L, Hewitt MC, Evans K, Siomos MA, Seeberger PH. Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria. Nature 2002; 418:785 - 9; http://dx.doi.org/10.1038/nature00937; PMID: 12181569
   PubMed Web of Science ®Google Scholar
• Boutlis CS, Gowda DC, Naik RS, Maguire GP, Mgone CS, Bockarie MJ, et al. Antibodies to Plasmodium falciparum glycosylphosphatidylinositols: inverse association with tolerance of parasitemia in Papua New Guinean children and adults. Infect Immun 2002; 70:5052 - 7; http://dx.doi.org/10.1128/IAI.70.9.5052-5057.2002; PMID: 12183552
   PubMed Web of Science ®Google Scholar
• Authié E, Duvallet G, Robertson C, Williams DJ. Antibody responses to a 33 kDa cysteine protease of Trypanosoma congolense: relationship to 'trypanotolerance' in cattle. Parasite Immunol 1993; 15:465 - 74; http://dx.doi.org/10.1111/j.1365-3024.1993.tb00632.x; PMID: 8233561
   PubMed Web of Science ®Google Scholar
• Authie E, Boulange A, Muteti D, Lalmanach G, Gauthier F, Musoke AJ. Immunisation of cattle with cysteine proteinases of Trypanosoma congolense: targetting the disease rather than the parasite. Int J Parasitol 2001; 31:1429 - 33; http://dx.doi.org/10.1016/S0020-7519(01)00266-1; PMID: 11595229
   PubMed Web of Science ®Google Scholar
• Boulangé A, Serveau C, Brillard M, Minet C, Gauthier F, Diallo A, et al. Functional expression of the catalytic domains of two cysteine proteinases from Trypanosoma congolense. Int J Parasitol 2001; 31:1435 - 40; http://dx.doi.org/10.1016/S0020-7519(01)00267-3; PMID: 11595230
   PubMed Web of Science ®Google Scholar
• Pays E, Vanhamme L, Perez-Morga D. Antigenic variation in Trypanosoma brucei: facts, challenges and mysteries. Curr Opin Microbiol 2004; 7:369 - 74; http://dx.doi.org/10.1016/j.mib.2004.05.001; PMID: 15288623
   PubMed Web of Science ®Google Scholar
• Vanhamme L, Pays E, McCulloch R, Barry JD. An update on antigenic variation in African trypanosomes. Trends Parasitol 2001; 17:338 - 43; http://dx.doi.org/10.1016/S1471-4922(01)01922-5; PMID: 11423377
   PubMed Web of Science ®Google Scholar
• Berriman M, Ghedin E, Hertz-Fowler C, Blandin G, Renauld H, Bartholomeu DC, et al. The genome of the African trypanosome Trypanosoma brucei. Science 2005; 309:416 - 22; http://dx.doi.org/10.1126/science.1112642; PMID: 16020726
   PubMed Web of Science ®Google Scholar
• Goodwin LG. The pathology of African trypanosomiasis. Trans R Soc Trop Med Hyg 1970; 64:797 - 817; http://dx.doi.org/10.1016/0035-9203(70)90096-9; PMID: 5495630
   PubMed Web of Science ®Google Scholar
• Urquhart GM, Murray M, Murray PK, Jennings FW, Bate E. Immunosuppression in Trypanosoma brucei infections in rats and mice. Trans R Soc Trop Med Hyg 1973; 67:528 - 35; http://dx.doi.org/10.1016/0035-9203(73)90083-7; PMID: 4785461
   PubMed Web of Science ®Google Scholar
• Terry RJ, Freeman J, Hudson KM, Longstaffe JA. Immunoglobulin M production and immunosuppression in trypanosomiasis: a linking hypothesis. Trans R Soc Trop Med Hyg 1973; 67:263; http://dx.doi.org/10.1016/0035-9203(73)90167-3; PMID: 4544655
   PubMed Web of Science ®Google Scholar
• Jennings FW, Murray PK, Murray M, Urquhart GM. Protein catabolism in trypanosomiasis. Trans R Soc Trop Med Hyg 1973; 67:277; http://dx.doi.org/10.1016/0035-9203(73)90191-0; PMID: 4784083
   PubMed Web of Science ®Google Scholar
• Murray PK, Jennings FW, Murray M, Urquhart GM. The nature of immunosuppression in Trypanosoma brucei infections in mice. II. The role of the T and B lymphocytes. Immunology 1974; 27:825 - 40; PMID: 4548043
   PubMed Web of Science ®Google Scholar
• Morrison WI, Murray M, Bovell DL. Response of the murine lymphoid system to a chronic infection with Trypanosoma congolense. I. The spleen. Lab Invest 1981; 45:547 - 57; PMID: 7033658
   PubMed Web of Science ®Google Scholar
• Radwanska M, Guirnalda P, De Trez C, Ryffel B, Black S, Magez S. Trypanosomiasis-induced B cell apoptosis results in loss of protective anti-parasite antibody responses and abolishment of vaccine-induced memory responses. PLoS Pathog 2008; 4:e1000078; http://dx.doi.org/10.1371/journal.ppat.1000078; PMID: 18516300
   PubMed Web of Science ®Google Scholar
• Magez S, Schwegmann A, Atkinson R, Claes F, Drennan M, De Baetselier P, et al. The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice. PLoS Pathog 2008; 4:e1000122; http://dx.doi.org/10.1371/journal.ppat.1000122; PMID: 18688274
   PubMedGoogle Scholar
• Antoine-Moussiaux N, Magez S, Desmecht D. Contributions of experimental mouse models to the understanding of African trypanosomiasis. Trends Parasitol 2008; 24:411 - 8; http://dx.doi.org/10.1016/j.pt.2008.05.010; PMID: 18684669
   PubMed Web of Science ®Google Scholar
• Iraqi F, Sekikawa K, Rowlands J, Teale A. Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection. Parasite Immunol 2001; 23:445 - 51; http://dx.doi.org/10.1046/j.1365-3024.2001.00401.x; PMID: 11489168
   PubMed Web of Science ®Google Scholar
• Shi M, Wei G, Pan W, Tabel H. Experimental African trypanosomiasis: a subset of pathogenic, IFN-gamma-producing, MHC class II-restricted CD4+ T cells mediates early mortality in highly susceptible mice. J Immunol 2006; 176:1724 - 32; PMID: 16424202
   PubMed Web of Science ®Google Scholar
• Magez S, Radwanska M, Drennan M, Fick L, Baral TN, Brombacher F, et al. Interferon-gamma and nitric oxide in combination with antibodies are key protective host immune factors during trypanosoma congolense Tc13 Infections. J Infect Dis 2006; 193:1575 - 83; http://dx.doi.org/10.1086/503808; PMID: 16652287
   PubMed Web of Science ®Google Scholar
• Namangala B, Noel W, De Baetselier P, Brys L, Beschin A. Relative contribution of interferon-gamma and interleukin-10 to resistance to murine African trypanosomosis. J Infect Dis 2001; 183:1794 - 800; http://dx.doi.org/10.1086/320731; PMID: 11372033
   PubMed Web of Science ®Google Scholar
• Dubois ME, Demick KP, Mansfield JM. Trypanosomes expressing a mosaic variant surface glycoprotein coat escape early detection by the immune system. Infect Immun 2005; 73:2690 - 7; http://dx.doi.org/10.1128/IAI.73.5.2690-2697.2005; PMID: 15845470
   PubMed Web of Science ®Google Scholar
• Magez S, Stijlemans B, Baral T, De Baetselier P. VSG-GPI anchors of African trypanosomes: their role in macrophage activation and induction of infection-associated immunopathology. Microbes Infect 2002; 4:999 - 1006; http://dx.doi.org/10.1016/S1286-4579(02)01617-9; PMID: 12106794
   PubMed Web of Science ®Google Scholar
• McEvoy SM, Maeda N. Complex events in the evolution of the haptoglobin gene cluster in primates. J Biol Chem 1988; 263:15740 - 7; PMID: 3170608
   PubMed Web of Science ®Google Scholar
• Gichuki C, Brun R. Animal models of CNS (second stage) sleeping sickness. In: Handbook of Animal Models of Infection (eds O Zak & M Sande) Academic Press, New York, 1999:pp. 795– 800.
   Google Scholar
• Ouwe-Missi-Oukem-Boyer O, Mezui-Me-Ndong J, Boda C, Lamine I, Labrousse F, Bisser S, et al. The vervet monkey (Chlorocebus aethiops) as an experimental model for Trypanosoma brucei gambiense human African trypanosomiasis: a clinical, biological and pathological study. Trans R Soc Trop Med Hyg 2006; 100:427 - 36; http://dx.doi.org/10.1016/j.trstmh.2005.07.023; PMID: 16325877
   PubMed Web of Science ®Google Scholar
• Schmidt H, Sayer P. Trypanosoma brucei rhodesiense infection in vervet monkeys. II. Provocation of the encephalitic late phase by treatment of infected monkeys. Tropenmed Parasitol 1982; 33:255 - 9; PMID: 7164167
   PubMedGoogle Scholar
• Thuita JK, Kagira JM, Mwangangi D, Matovu E, Turner CM, Masiga D. Trypanosoma brucei rhodesiense transmitted by a single tsetse fly bite in vervet monkeys as a model of human African trypanosomiasis. PLoS Negl Trop Dis 2008; 2:e238; http://dx.doi.org/10.1371/journal.pntd.0000238; PMID: 18846231
   PubMedGoogle Scholar
• Jenkins G, Facer CA. Haematology of African trypanosomiasis. In: Tizard I, ed Immunology and Pathogenesis Boca Raton: CRC press 1985:pp 13–4.
   Google Scholar