Molecular pharming

References

• Sparrow PA, Irwin JA, Dale PJ, Twyman RM, Ma JK. Pharma-Planta: road testing the developing regulatory guidelines for plant-made pharmaceuticals. Transgenic Res 2007; 16:147 - 161
   PubMed Web of Science ®Google Scholar
• Spok A, Twyman RM, Fischer R, Ma JK, Sparrow PA. Evolution of a regulatory framework for pharmaceuticals derived from genetically modified plants. Trends Biotechnol 2008; 26:506 - 517
   PubMed Web of Science ®Google Scholar
• Cooper PJ, Chico ME, Losonsky G, Sandoval C, Espinel I, Sridhara R, et al. Albendazole treatment of children with ascariasis enhances the vibriocidal antibody response to the live attenuated oral cholera vaccine CVD 103-HgR. J Infect Dis 2000; 182:1199 - 1206
   PubMed Web of Science ®Google Scholar
• Cleaveland S, Fevre EM, Kaare M, Coleman PG. Estimating human rabies mortality in the United Republic of Tanzania from dog bite injuries. Bull World Health Organ 2002; 80:304 - 310
   PubMed Web of Science ®Google Scholar
• Warrell DA. The clinical picture of rabies in man. Trans R Soc Trop Med Hyg 1976; 70:188 - 195
   PubMed Web of Science ®Google Scholar
• Muller T, Dietzschold B, Ertl H, Fooks AR, Freuling C, Fehlner-Gardiner C, et al. Development of a mouse monoclonal antibody cocktail for post-exposure rabies prophylaxis in humans. PLoS Negl Trop Dis 2009; 3:e542
   PubMed Web of Science ®Google Scholar
• Bakker AB, Python C, Kissling CJ, Pandya P, Marissen WE, Brink MF, et al. First administration to humans of a monoclonal antibody cocktail against rabies virus: safety, tolerability, and neutralizing activity. Vaccine 2008; 26:5922 - 5927
   PubMed Web of Science ®Google Scholar
• Abdel-Motal U, Wang S, Lu S, Wigglesworth K, Galili U. Increased immunogenicity of human immunodeficiency virus gp120 engineered to express Galalpha1-3Galbeta1-4GlcNAc-R epitopes. J Virol 2006; 80:6943 - 6951
   PubMed Web of Science ®Google Scholar
• Polyanskaya N, Bergmeier LA, Sharpe SA, Cook N, Leech S, Hall G, et al. Mucosal exposure to subinfectious doses of SIV primes gut-associated antibody-secreting cells and T cells: lack of enhancement by nonneutralizing antibody. Virology 2001; 279:527 - 538
   PubMed Web of Science ®Google Scholar
• Regnault A, Lankar D, Lacabanne V, Rodriguez A, Thery C, Rescigno M, et al. Fc gamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization. J Exp Med 1999; 189:371 - 380
   PubMed Web of Science ®Google Scholar
• Schuurhuis DH, Ioan-Facsinay A, Nagelkerken B, van Schip JJ, Sedlik C, Melief CJM, et al. Antigen-antibody immune complexes empower dendritic cells to efficiently prime specific CD8(+) CTL responses in vivo. J Immunol 2002; 168:2240 - 2246
   PubMed Web of Science ®Google Scholar
• Villinger F, Mayne AE, Bostik P, Mori K, Jensen PE, Ahmed R, et al. Evidence for antibody-mediated enhancement of simian immunodeficiency virus (SIV) Gag antigen processing and cross presentation in SIV-infected rhesus macaques. J Virol 2003; 77:10 - 24
   PubMed Web of Science ®Google Scholar
• Hemsley PA. Protein S-acylation in plants (Review). Mol Membr Biol 2009; 26:114 - 125
   PubMed Web of Science ®Google Scholar
• Traverso JA, Meinnel T, Giglione C. Expanded impact of protein N-myristoylation in plants. Plant Signal Behav 2008; 3:501 - 502
   PubMedGoogle Scholar
• Crowell DN, Hemmerlin A, Gerber E, Hartmann M, Heintz D, Rohmer M, Bach TJ. A role for plastids in plant protein isoprenylation. Plant Signal Behav 2009; 4:217 - 218
   PubMedGoogle Scholar
• Sherrier DJ, Prime TA, Dupree P. Glycosylphosphatidylinositol-anchored cell-surface proteins from Arabidopsis. Electrophoresis 1999; 20:2027 - 2035
   PubMed Web of Science ®Google Scholar
• Chargelegue D, Drake PM, Obregon P, Prada A, Fairweather N, Ma JK. Highly immunogenic and protective recombinant vaccine candidate expressed in transgenic plants. Infect Immun 2005; 73:5915 - 5922
   PubMed Web of Science ®Google Scholar
• Chen Q, He J, Phoolcharoen W, Mason HS. Geminiviral vectors based on bean yellow dwarf virus for production of vaccine antigens and monoclonal antibodies in plants. Hum Vaccin 7:331 - 338
   PubMed Web of Science ®Google Scholar
• Sainsbury F, Thuenemann EC, Lomonossoff GP. pEAQ: versatile expression vectors for easy and quick transient expression of heterologous proteins in plants. Plant Biotechnol J 2009; 7:682 - 693
   PubMed Web of Science ®Google Scholar
• Obregon P, Chargelegue D, Drake PM, Prada A, Nuttall J, Frigerio L, Ma JK. HIV-1 p24-immunoglobulin fusion molecule: a new strategy for plant-based protein production. Plant Biotechnol J 2006; 4:195 - 207
   PubMed Web of Science ®Google Scholar
• Watts C, Antoniou A, Manoury B, Hewitt EW, McKay LM, Grayson L, Fairweather NF, Emsley P, Isaacs N, Simitsek PD. Modulation by epitope-specific antibodies of class II MHC-restricted presentation of the tetanus toxin antigen. Immunol Rev 1998; 164:11 - 16
   PubMed Web of Science ®Google Scholar
• Natsume A, In M, Takamura H, Nakagawa T, Shimizu Y, Kitajima K, Wakitani M, Ohta S, Satoh M, Shitara K, Niwa R. Engineered antibodies of IgG1/IgG3 mixed isotype with enhanced cytotoxic activities. Cancer Res 2008; 68:3863 - 3872
   PubMed Web of Science ®Google Scholar
• Lazar GA, Dang W, Karki S, Vafa O, Peng JS, Hyun L, Chan C, Chung HS, Eivazi A, Yoder SC, Vielmetter J, Carmichael DF, Hayes RJ, Dahiyat BI. Engineered antibody Fc variants with enhanced effector function. Proc Natl Acad Sci USA 2006; 103:4005 - 4010
   PubMed Web of Science ®Google Scholar
• Drossard J. Downstream Processing of Plant-Derived Recombinant Therapeutic Proteins 2004; Weinheim, Germany Wiley-VCH Veriag GmbH & Co
   Google Scholar
• Ma JK, Lehner T, Stabila P, Fux CI, Hiatt A. Assembly of monoclonal antibodies with IgG1 and IgA heavy chain domains in transgenic tobacco plants. Eur J Immunol 1994; 24:131 - 138
   PubMed Web of Science ®Google Scholar
• Firek S, Draper J, Owen MRL, Gandecha A, Cockburn B, Whitelam GC. Secretion of a functional single-chain Fv protein in transgenic tobacco plants and cell suspension cultures. Plant Mol Biol 1993; 23:861 - 870
   PubMed Web of Science ®Google Scholar
• Magnuson NS, Linzmaier PM, Gao JW, Reeves R, An GH, Lee JM. Enhanced recovery of a secreted mammalian protein from suspension culture of genetically modified tobacco cells. Protein Expr Purif 1996; 7:220 - 228
   PubMed Web of Science ®Google Scholar
• Wongsamuth R, Doran PM. Production of monoclonal antibodies by tobacco hairy roots. Biotechnol Bioeng 1997; 54:401 - 415
   PubMed Web of Science ®Google Scholar
• Gleba D, Borisjuk NV, Borisjuk LG, Kneer R, Poulev A, Sarzhinskaya M, et al. Use of plant roots for phytore-mediation and molecular farming. Proc Natl Acad Sci USA 1999; 96:5973 - 5977
   PubMed Web of Science ®Google Scholar
• Borisjuk NV, Borisjuk LG, Logendra S, Petersen F, Gleba Y, Raskin I. Production of recombinant proteins in plant root exudates. Nature Biotechnol 1999; 17:466 - 469
   PubMed Web of Science ®Google Scholar
• Drake PM, Chargelegue DM, Vine ND, van Dolleweerd CJ, Obregon P, Ma JK. Rhizosecretion of a monoclonal antibody protein complex from transgenic tobacco roots. Plant Mol Biol 2003; 52:233 - 241
   PubMed Web of Science ®Google Scholar
• Sexton A, Drake PM, Mahmood N, Harman SJ, Shattock RJ, Ma JK. Transgenic plant production of Cyanovirin-N, an HIV microbicide. FASEB J 2006; 20:356 - 358
   PubMed Web of Science ®Google Scholar
• Drake PM, Barbi T, Sexton A, McGowan E, Stadlmann J, Navarre C, Paul MJ, Ma JK. Development of rhizosecretion as a production system for recombinant proteins from hydroponic cultivated tobacco. FASEB J 2009;
   Web of Science ®Google Scholar
• Komarnytsky S, Borisjuk N, Yakoby N, Garvey A, Raskin I. Cosecretion of protease inhibitor stabilizes antibodies produced by plant roots. Plant Physiology 2006; 141:1185 - 1193
   PubMed Web of Science ®Google Scholar
• Gaume A, Komarnytsky S, Borisjuk N, Raskin I. Rhizosecretion of recombinant proteins from plant hairy roots. Plant Cell Reports 2003; 21:1188 - 1193
   PubMed Web of Science ®Google Scholar
• Johri MM MD. Action of plant hormones. Current Science 2001; 80:6
   Google Scholar
• Chargelegue D, Drake PM, Obregon P, Prada A, Fairweather N, Ma JK. Highly immunogenic and protective recombinant vaccine candidate expressed in transgenic plants. Infect Immun 2005; 73:5915 - 5922
   PubMed Web of Science ®Google Scholar
• Thangaraj H, van Dolleweerd CJ, McGowan EG, Ma JK. Dynamics of global disclosure through patent and journal publications for biopharmaceutical products. Nat Biotechnol 2009; 27:614 - 618
   PubMed Web of Science ®Google Scholar
• Drake PM, Thangaraj H. Molecular farming, patents and access to medicines. Expert Rev Vaccines 9:811 - 819
   PubMed Web of Science ®Google Scholar
• Strasser R, Castilho A, Stadlmann J, Kunert R, Quendler H, Gattinger P, et al. Improved virus neutralization by plant-produced anti-HIV antibodies with a homogeneous beta1,4-galactosylated N-glycan profile. J Biol Chem 2009; 284:20479 - 20485
   PubMed Web of Science ®Google Scholar
• Kong QX, Richter L, Yang YF, Arntzen CJ, Mason HS, Thanavala Y. Oral immunization with hepatitis B surface antigen expressed in transgenic plants. Proceedings of the National Academy of Sciences of the United States of America 2001; 98:11539 - 11544
   PubMed Web of Science ®Google Scholar
• Webster DE, Cooney ML, Huang Z, Drew DR, Ramshaw IA, Dry IB, et al. Successful boosting of a DNA measles immunization with an oral plant-derived measles virus vaccine. J Virol 2002; 76:7910 - 7912
   PubMed Web of Science ®Google Scholar