β-cell metabolic alterations under chronic nutrient overload in rat and human islets

References

• Unger RH, Zhou YT. Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover. Diabetes 2001; 50:Suppl 1 S118 - 21; http://dx.doi.org/10.2337/diabetes.50.2007.S118; PMID: 11272168
   PubMed Web of Science ®Google Scholar
• Unger RH. Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology 2003; 144:5159 - 65; http://dx.doi.org/10.1210/en.2003-0870; PMID: 12960011
   PubMed Web of Science ®Google Scholar
• Raz I, Eldor R, Cernea S, Shafrir E. Diabetes: insulin resistance and derangements in lipid metabolism. Cure through intervention in fat transport and storage. Diabetes Metab Res Rev 2005; 21:3 - 14; http://dx.doi.org/10.1002/dmrr.493; PMID: 15386813
   PubMed Web of Science ®Google Scholar
• Milburn JL Jr., Hirose H, Lee YH, Nagasawa Y, Ogawa A, Ohneda M, et al. Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids. J Biol Chem 1995; 270:1295 - 9; PMID: 7836394
   PubMed Web of Science ®Google Scholar
• Sone H, Kagawa Y. Pancreatic beta cell senescence contributes to the pathogenesis of type 2 diabetes in high-fat diet-induced diabetic mice. Diabetologia 2005; 48:58 - 67; http://dx.doi.org/10.1007/s00125-004-1605-2; PMID: 15624098
   PubMed Web of Science ®Google Scholar
• Londos C, Brasaemle DL, Schultz CJ, Segrest JP, Kimmel AR. Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells. Semin Cell Dev Biol 1999; 10:51 - 8; http://dx.doi.org/10.1006/scdb.1998.0275; PMID: 10355028
   PubMed Web of Science ®Google Scholar
• Hickenbottom SJ, Kimmel AR, Londos C, Hurley JH. Structure of a lipid droplet protein; the PAT family member TIP47. Structure 2004; 12:1199 - 207; http://dx.doi.org/10.1016/j.str.2004.04.021; PMID: 15242596
   PubMed Web of Science ®Google Scholar
• Londos C, Sztalryd C, Tansey JT, Kimmel AR. Role of PAT proteins in lipid metabolism. Biochimie 2005; 87:45 - 9; http://dx.doi.org/10.1016/j.biochi.2004.12.010; PMID: 15733736
   PubMed Web of Science ®Google Scholar
• Borg J, Klint C, Wierup N, Ström K, Larsson S, Sundler F, et al. Perilipin is present in islets of Langerhans and protects against lipotoxicity when overexpressed in the beta-cell line INS-1. Endocrinology 2009; 150:3049 - 57; http://dx.doi.org/10.1210/en.2008-0913; PMID: 19299455
   PubMed Web of Science ®Google Scholar
• Faleck DM, Ali K, Roat R, Graham MJ, Crooke RM, Battisti R, et al. Adipose differentiation-related protein regulates lipids and insulin in pancreatic islets. Am J Physiol Endocrinol Metab 2010; 299:E249 - 57; PMID: 20484013
   PubMedGoogle Scholar
• Coleman DL. Diabetes-obesity syndromes in mice. Diabetes 1982; 31:Suppl 1 Pt 2 1 - 6; PMID: 7160533
   PubMed Web of Science ®Google Scholar
• Hull RL, Kodama K, Utzschneider KM, Carr DB, Prigeon RL, Kahn SE. Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation. Diabetologia 2005; 48:1350 - 8; http://dx.doi.org/10.1007/s00125-005-1772-9; PMID: 15937671
   PubMed Web of Science ®Google Scholar
• Bonner-Weir S, Deery D, Leahy JL, Weir GC. Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion. Diabetes 1989; 38:49 - 53; http://dx.doi.org/10.2337/diabetes.38.1.49; PMID: 2642434
   PubMed Web of Science ®Google Scholar
• Steil GM, Trivedi N, Jonas JC, Hasenkamp WM, Sharma A, Bonner-Weir S, et al. Adaptation of beta-cell mass to substrate oversupply: enhanced function with normal gene expression. Am J Physiol Endocrinol Metab 2001; 280:E788 - 96; PMID: 11287362
   PubMed Web of Science ®Google Scholar
• Fontés G, Zarrouki B, Hagman DK, Latour MG, Semache M, Roskens V, et al. Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass. Diabetologia 2010; 53:2369 - 79; http://dx.doi.org/10.1007/s00125-010-1850-5; PMID: 20628728
   PubMed Web of Science ®Google Scholar
• Delghingaro-Augusto V, Nolan CJ, Gupta D, Jetton TL, Latour MG, Peshavaria M, et al. Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass. Diabetologia 2009; 52:1122 - 32; http://dx.doi.org/10.1007/s00125-009-1317-8; PMID: 19294363
   PubMed Web of Science ®Google Scholar
• Kargar C, Ktorza A. Anatomical versus functional beta-cell mass in experimental diabetes. Diabetes Obes Metab 2008; 10:Suppl 4 43 - 53; http://dx.doi.org/10.1111/j.1463-1326.2008.00940.x; PMID: 18834432
   PubMedGoogle Scholar
• McDaniel ML, Marshall CA, Pappan KL, Kwon G. Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells. Diabetes 2002; 51:2877 - 85; http://dx.doi.org/10.2337/diabetes.51.10.2877; PMID: 12351422
   PubMed Web of Science ®Google Scholar
• Harris TE, Lawrence JC, Jr. TOR signaling. Sci STKE 2003; 2003:re15.
   Google Scholar
• Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004; 18:1926 - 45; http://dx.doi.org/10.1101/gad.1212704; PMID: 15314020
   PubMed Web of Science ®Google Scholar
• Fingar DC, Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004; 23:3151 - 71; http://dx.doi.org/10.1038/sj.onc.1207542; PMID: 15094765
   PubMed Web of Science ®Google Scholar
• Pende M, Kozma SC, Jaquet M, Oorschot V, Burcelin R, Le Marchand-Brustel Y, et al. Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice. Nature 2000; 408:994 - 7; http://dx.doi.org/10.1038/35050135; PMID: 11140689
   PubMed Web of Science ®Google Scholar
• Lee CH, Inoki K, Guan KL. mTOR pathway as a target in tissue hypertrophy. Annu Rev Pharmacol Toxicol 2007; 47:443 - 67; http://dx.doi.org/10.1146/annurev.pharmtox.47.120505.105359; PMID: 16968213
   PubMed Web of Science ®Google Scholar
• Wang X, Beugnet A, Murakami M, Yamanaka S, Proud CG. Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins. Mol Cell Biol 2005; 25:2558 - 72; http://dx.doi.org/10.1128/MCB.25.7.2558-2572.2005; PMID: 15767663
   PubMed Web of Science ®Google Scholar
• Um SH, D’Alessio D, Thomas G. Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metab 2006; 3:393 - 402; http://dx.doi.org/10.1016/j.cmet.2006.05.003; PMID: 16753575
   PubMed Web of Science ®Google Scholar
• Patti ME, Kahn BB. Nutrient sensor links obesity with diabetes risk. Nat Med 2004; 10:1049 - 50; http://dx.doi.org/10.1038/nm1004-1049; PMID: 15459705
   PubMed Web of Science ®Google Scholar
• Liu H, Remedi MS, Pappan KL, Kwon G, Rohatgi N, Marshall CA, et al. Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets. Diabetes 2009; 58:663 - 72; http://dx.doi.org/10.2337/db07-1208; PMID: 19073772
   PubMed Web of Science ®Google Scholar
• Balcazar N, Sathyamurthy A, Elghazi L, Gould A, Weiss A, Shiojima I, et al. mTORC1 activation regulates beta-cell mass and proliferation by modulation of cyclin D2 synthesis and stability. J Biol Chem 2009; 284:7832 - 42; http://dx.doi.org/10.1074/jbc.M807458200; PMID: 19144649
   PubMed Web of Science ®Google Scholar
• Fu A, Ng AC, Depatie C, Wijesekara N, He Y, Wang GS, et al. Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice. Cell Metab 2009; 10:285 - 95; http://dx.doi.org/10.1016/j.cmet.2009.08.008; PMID: 19808021
   PubMed Web of Science ®Google Scholar
• Rachdi L, Balcazar N, Osorio-Duque F, Elghazi L, Weiss A, Gould A, et al. Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner. Proc Natl Acad Sci U S A 2008; 105:9250 - 5; http://dx.doi.org/10.1073/pnas.0803047105; PMID: 18587048
   PubMed Web of Science ®Google Scholar
• Yoon KH, Ko SH, Cho JH, Lee JM, Ahn YB, Song KH, et al. Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea. J Clin Endocrinol Metab 2003; 88:2300 - 8; http://dx.doi.org/10.1210/jc.2002-020735; PMID: 12727989
   PubMed Web of Science ®Google Scholar
• Gromada J, Franklin I, Wollheim CB. Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocr Rev 2007; 28:84 - 116; http://dx.doi.org/10.1210/er.2006-0007; PMID: 17261637
   PubMed Web of Science ®Google Scholar
• Cnop M, Hannaert JC, Hoorens A, Eizirik DL, Pipeleers DG. Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation. Diabetes 2001; 50:1771 - 7; http://dx.doi.org/10.2337/diabetes.50.8.1771; PMID: 11473037
   PubMed Web of Science ®Google Scholar
• Maedler K, Spinas GA, Dyntar D, Moritz W, Kaiser N, Donath MY. Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function. Diabetes 2001; 50:69 - 76; http://dx.doi.org/10.2337/diabetes.50.1.69; PMID: 11147797
   PubMed Web of Science ®Google Scholar
• Listenberger LL, Han X, Lewis SE, Cases S, Farese RV Jr., Ory DS, et al. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci U S A 2003; 100:3077 - 82; http://dx.doi.org/10.1073/pnas.0630588100; PMID: 12629214
   PubMed Web of Science ®Google Scholar
• Cunha DA, Hekerman P, Ladrière L, Bazarra-Castro A, Ortis F, Wakeham MC, et al. Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. J Cell Sci 2008; 121:2308 - 18; http://dx.doi.org/10.1242/jcs.026062; PMID: 18559892
   PubMed Web of Science ®Google Scholar
• Kwon G, Marshall CA, Liu H, Pappan KL, Remedi MS, McDaniel ML. Glucose-stimulated DNA synthesis through mammalian target of rapamycin (mTOR) is regulated by KATP channels: effects on cell cycle progression in rodent islets. J Biol Chem 2006; 281:3261 - 7; http://dx.doi.org/10.1074/jbc.M508821200; PMID: 16344552
   PubMed Web of Science ®Google Scholar
• Koyanagi M, Asahara S, Matsuda T, Hashimoto N, Shigeyama Y, Shibutani Y, et al. Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1. PLoS One 2011; 6:e23238; http://dx.doi.org/10.1371/journal.pone.0023238; PMID: 21886784
   PubMed Web of Science ®Google Scholar
• Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003; 52:102 - 10; http://dx.doi.org/10.2337/diabetes.52.1.102; PMID: 12502499
   PubMed Web of Science ®Google Scholar
• Klöppel G, Löhr M, Habich K, Oberholzer M, Heitz PU. Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv Synth Pathol Res 1985; 4:110 - 25; PMID: 3901180
   PubMedGoogle Scholar
• Tomita T, Doull V, Pollock HG, Krizsan D. Pancreatic islets of obese hyperglycemic mice (ob/ob). Pancreas 1992; 7:367 - 75; http://dx.doi.org/10.1097/00006676-199205000-00015; PMID: 1594559
   PubMed Web of Science ®Google Scholar
• Kwon G, Pappan KL, Marshall CA, Schaffer JE, McDaniel ML. cAMP Dose-dependently prevents palmitate-induced apoptosis by both protein kinase A- and cAMP-guanine nucleotide exchange factor-dependent pathways in beta-cells. J Biol Chem 2004; 279:8938 - 45; http://dx.doi.org/10.1074/jbc.M310330200; PMID: 14688288
   PubMed Web of Science ®Google Scholar