725
Views
5
CrossRef citations to date
0
Altmetric
Commentary

TLR7 inhibition

A novel strategy for pancreatic cancer treatment?

&
Article: e23011 | Published online: 01 Jan 2013

References

  • Burnet FM. The concept of immunological surveillance. Prog Exp Tumor Res 1970; 13:1 - 27; PMID: 4921480
  • Pardoll D. Does the immune system see tumors as foreign or self?. Annu Rev Immunol 2003; 21:807 - 39; http://dx.doi.org/10.1146/annurev.immunol.21.120601.141135; PMID: 12615893
  • Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005; 5:749 - 59; http://dx.doi.org/10.1038/nri1703; PMID: 16175180
  • Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ, et al. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 2004; 118:285 - 96; http://dx.doi.org/10.1016/j.cell.2004.07.013; PMID: 15294155
  • Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 2004; 431:461 - 6; http://dx.doi.org/10.1038/nature02924; PMID: 15329734
  • Kumagai Y, Akira S. Identification and functions of pattern-recognition receptors. J Allergy Clin Immunol 2010; 125:985 - 92; http://dx.doi.org/10.1016/j.jaci.2010.01.058; PMID: 20392481
  • Wolska A, Lech-Marańda E, Robak T. Toll-like receptors and their role in carcinogenesis and anti-tumor treatment. Cell Mol Biol Lett 2009; 14:248 - 72; http://dx.doi.org/10.2478/s11658-008-0048-z; PMID: 19096763
  • Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med 2007; 13:552 - 9; http://dx.doi.org/10.1038/nm1589; PMID: 17479101
  • Prins RM, Craft N, Bruhn KW, Khan-Farooqi H, Koya RC, Stripecke R, et al. The TLR-7 agonist, imiquimod, enhances dendritic cell survival and promotes tumor antigen-specific T cell priming: relation to central nervous system antitumor immunity. J Immunol 2006; 176:157 - 64; PMID: 16365406
  • Zheng R, Cohen PA, Paustian CA, Johnson TD, Lee WT, Shu S, et al. Paired Toll-like receptor agonists enhance vaccine therapy through induction of interleukin-12. Cancer Res 2008; 68:4045 - 9; http://dx.doi.org/10.1158/0008-5472.CAN-07-6669; PMID: 18519662
  • Eberle F, Sirin M, Binder M, Dalpke AH. Bacterial RNA is recognized by different sets of immunoreceptors. Eur J Immunol 2009; 39:2537 - 47; http://dx.doi.org/10.1002/eji.200838978; PMID: 19662634
  • Connolly MK, Bedrosian AS, Malhotra A, Henning JR, Ibrahim J, Vera V, et al. In hepatic fibrosis, liver sinusoidal endothelial cells acquire enhanced immunogenicity. J Immunol 2010; 185:2200 - 8; http://dx.doi.org/10.4049/jimmunol.1000332; PMID: 20639479
  • Corcoran RB, Contino G, Deshpande V, Tzatsos A, Conrad C, Benes CH, et al. STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis. Cancer Res 2011; 71:5020 - 9; http://dx.doi.org/10.1158/0008-5472.CAN-11-0908; PMID: 21586612
  • Fukuda A, Wang SC, Morris JP 4th, Folias AE, Liou A, Kim GE, et al. Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression. Cancer Cell 2011; 19:441 - 55; http://dx.doi.org/10.1016/j.ccr.2011.03.002; PMID: 21481787
  • Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Klöppel G, et al. Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell 2011; 19:456 - 69; http://dx.doi.org/10.1016/j.ccr.2011.03.009; PMID: 21481788
  • Weronika Kulesza D, Carre T, Chouaib S, Kaminska B. Silencing of the transcription factor STAT3 sensitizes lung cancer cells to DNA damaging drugs, but not to TNFα- and NK cytotoxicity. Exp Cell Res 2013; 319:506 - 16; http://dx.doi.org/10.1016/j.yexcr.2012.11.005; PMID: 23149124
  • Fukata M, Chen A, Vamadevan AS, Cohen J, Breglio K, Krishnareddy S, et al. Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. Gastroenterology 2007; 133:1869 - 81; http://dx.doi.org/10.1053/j.gastro.2007.09.008; PMID: 18054559
  • Tye H, Kennedy CL, Najdovska M, McLeod L, McCormack W, Hughes N, et al. STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation. Cancer Cell 2012; 22:466 - 78; http://dx.doi.org/10.1016/j.ccr.2012.08.010; PMID: 23079657
  • Ganguly D, Chamilos G, Lande R, Gregorio J, Meller S, Facchinetti V, et al. Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. J Exp Med 2009; 206:1983 - 94; http://dx.doi.org/10.1084/jem.20090480; PMID: 19703986
  • Lau CM, Broughton C, Tabor AS, Akira S, Flavell RA, Mamula MJ, et al. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med 2005; 202:1171 - 7; http://dx.doi.org/10.1084/jem.20050630; PMID: 16260486
  • Vollmer J, Tluk S, Schmitz C, Hamm S, Jurk M, Forsbach A, et al. Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J Exp Med 2005; 202:1575 - 85; http://dx.doi.org/10.1084/jem.20051696; PMID: 16330816
  • Gehrig S, Eberle ME, Botschen F, Rimbach K, Eberle F, Eigenbrod T, et al. Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity. J Exp Med 2012; 209:225 - 33; http://dx.doi.org/10.1084/jem.20111044; PMID: 22312113
  • Jöckel S, Nees G, Sommer R, Zhao Y, Cherkasov D, Hori H, et al. The 2′-O-methylation status of a single guanosine controls transfer RNA-mediated Toll-like receptor 7 activation or inhibition. J Exp Med 2012; 209:235 - 41; http://dx.doi.org/10.1084/jem.20111075; PMID: 22312111
  • Karikó K, Buckstein M, Ni H, Weissman D. Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity 2005; 23:165 - 75; http://dx.doi.org/10.1016/j.immuni.2005.06.008; PMID: 16111635
  • Koski GK, Karikó K, Xu S, Weissman D, Cohen PA, Czerniecki BJ. Cutting edge: innate immune system discriminates between RNA containing bacterial versus eukaryotic structural features that prime for high-level IL-12 secretion by dendritic cells. J Immunol 2004; 172:3989 - 93; PMID: 15034009
  • Fabbri M, Paone A, Calore F, Galli R, Gaudio E, Santhanam R, et al. MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci U S A 2012; 109:E2110 - 6; http://dx.doi.org/10.1073/pnas.1209414109; PMID: 22753494
  • El-Serag HB, Engels EA, Landgren O, Chiao E, Henderson L, Amaratunge HC, et al. Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection: A population-based study of U.S. veterans. Hepatology 2009; 49:116 - 23; http://dx.doi.org/10.1002/hep.22606; PMID: 19085911
  • Hassan MM, Li D, El-Deeb AS, Wolff RA, Bondy ML, Davila M, et al. Association between hepatitis B virus and pancreatic cancer. J Clin Oncol 2008; 26:4557 - 62; http://dx.doi.org/10.1200/JCO.2008.17.3526; PMID: 18824707
  • Tomasiewicz K, Modrzewska R, Lyczak A, Krawczuk G. TT virus infection and pancreatic cancer: relationship or accidental coexistence. World J Gastroenterol 2005; 11:2847 - 9; PMID: 15884138