STATs get their move on

References

• Hetzer MW. The nuclear envelope. Cold Spring Harb Perspect Biol 2010; 2:a000539; http://dx.doi.org/10.1101/cshperspect.a000539; PMID: 20300205
   PubMed Web of Science ®Google Scholar
• Wilson KL, Berk JM. The nuclear envelope at a glance. J Cell Sci 2010; 123:1973 - 8; http://dx.doi.org/10.1242/jcs.019042; PMID: 20519579
   PubMed Web of Science ®Google Scholar
• Rout MP, Aitchison JD. The nuclear pore complex as a transport machine. J Biol Chem 2001; 276:16593 - 6; http://dx.doi.org/10.1074/jbc.R100015200; PMID: 11283009
   PubMed Web of Science ®Google Scholar
• Levy DE, Darnell JE Jr.. Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol 2002; 3:651 - 62; http://dx.doi.org/10.1038/nrm909; PMID: 12209125
   PubMed Web of Science ®Google Scholar
• Schindler C, Levy DE, Decker T. JAK-STAT signaling: from interferons to cytokines. J Biol Chem 2007; 282:20059 - 63; http://dx.doi.org/10.1074/jbc.R700016200; PMID: 17502367
   PubMed Web of Science ®Google Scholar
• Reich NC, Liu L. Tracking STAT nuclear traffic. Nat Rev Immunol 2006; 6:602 - 12; http://dx.doi.org/10.1038/nri1885; PMID: 16868551
   PubMed Web of Science ®Google Scholar
• Stark GR, Darnell JE Jr.. The JAK-STAT pathway at twenty. Immunity 2012; 36:503 - 14; http://dx.doi.org/10.1016/j.immuni.2012.03.013; PMID: 22520844
   PubMed Web of Science ®Google Scholar
• Cheon H, Yang J, Stark GR. The functions of signal transducers and activators of transcriptions 1 and 3 as cytokine-inducible proteins. J Interferon Cytokine Res 2011; 31:33 - 40; http://dx.doi.org/10.1089/jir.2010.0100; PMID: 21166594
   PubMed Web of Science ®Google Scholar
• Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C, Darnell JE Jr.. Stat3 as an oncogene. Cell 1999; 98:295 - 303; http://dx.doi.org/10.1016/S0092-8674(00)81959-5; PMID: 10458605
   PubMed Web of Science ®Google Scholar
• Akira S. Functional roles of STAT family proteins: lessons from knockout mice. Stem Cells 1999; 17:138 - 46; http://dx.doi.org/10.1002/stem.170138; PMID: 10342556
   PubMed Web of Science ®Google Scholar
• O’Shea JJ, Holland SM, Staudt LM. JAKs and STATs in immunity, immunodeficiency, and cancer. N Engl J Med 2013; 368:161 - 70; http://dx.doi.org/10.1056/NEJMra1202117; PMID: 23301733
   PubMed Web of Science ®Google Scholar
• Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 2009; 9:798 - 809; http://dx.doi.org/10.1038/nrc2734; PMID: 19851315
   PubMed Web of Science ®Google Scholar
• Casanova JL, Holland SM, Notarangelo LD. Inborn errors of human JAKs and STATs. Immunity 2012; 36:515 - 28; http://dx.doi.org/10.1016/j.immuni.2012.03.016; PMID: 22520845
   PubMed Web of Science ®Google Scholar
• Walters AD, Bommakanti A, Cohen-Fix O. Shaping the nucleus: factors and forces. J Cell Biochem 2012; 113:2813 - 21; http://dx.doi.org/10.1002/jcb.24178; PMID: 22566057
   PubMed Web of Science ®Google Scholar
• Aitchison JD, Rout MP. The yeast nuclear pore complex and transport through it. Genetics 2012; 190:855 - 83; http://dx.doi.org/10.1534/genetics.111.127803; PMID: 22419078
   PubMed Web of Science ®Google Scholar
• Raices M, D’Angelo MA. Nuclear pore complex composition: a new regulator of tissue-specific and developmental functions. Nat Rev Mol Cell Biol 2012; 13:687 - 99; http://dx.doi.org/10.1038/nrm3461; PMID: 23090414
   PubMed Web of Science ®Google Scholar
• Wente SR, Rout MP. The nuclear pore complex and nuclear transport. Cold Spring Harb Perspect Biol 2010; 2:a000562; http://dx.doi.org/10.1101/cshperspect.a000562; PMID: 20630994
   PubMed Web of Science ®Google Scholar
• Chook YM, Blobel G. Karyopherins and nuclear import. Curr Opin Struct Biol 2001; 11:703 - 15; http://dx.doi.org/10.1016/S0959-440X(01)00264-0; PMID: 11751052
   PubMed Web of Science ®Google Scholar
• Hülsmann BB, Labokha AA, Görlich D. The permeability of reconstituted nuclear pores provides direct evidence for the selective phase model. Cell 2012; 150:738 - 51; http://dx.doi.org/10.1016/j.cell.2012.07.019; PMID: 22901806
   PubMed Web of Science ®Google Scholar
• Peters R. Translocation through the nuclear pore complex: selectivity and speed by reduction-of-dimensionality. Traffic 2005; 6:421 - 7; http://dx.doi.org/10.1111/j.1600-0854.2005.00287.x; PMID: 15813752
   PubMed Web of Science ®Google Scholar
• Rout MP, Aitchison JD, Magnasco MO, Chait BT. Virtual gating and nuclear transport: the hole picture. Trends Cell Biol 2003; 13:622 - 8; http://dx.doi.org/10.1016/j.tcb.2003.10.007; PMID: 14624840
   PubMed Web of Science ®Google Scholar
• Cook A, Bono F, Jinek M, Conti E. Structural biology of nucleocytoplasmic transport. Annu Rev Biochem 2007; 76:647 - 71; http://dx.doi.org/10.1146/annurev.biochem.76.052705.161529; PMID: 17506639
   PubMed Web of Science ®Google Scholar
• Macara IG. Transport into and out of the nucleus. Microbiol Mol Biol Rev 2001; 65:570 - 94; http://dx.doi.org/10.1128/MMBR.65.4.570-594.2001; PMID: 11729264
   PubMed Web of Science ®Google Scholar
• Pemberton LF, Paschal BM. Mechanisms of receptor-mediated nuclear import and nuclear export. Traffic 2005; 6:187 - 98; http://dx.doi.org/10.1111/j.1600-0854.2005.00270.x; PMID: 15702987
   PubMed Web of Science ®Google Scholar
• Mattaj IW, Englmeier L. Nucleocytoplasmic transport: the soluble phase. Annu Rev Biochem 1998; 67:265 - 306; http://dx.doi.org/10.1146/annurev.biochem.67.1.265; PMID: 9759490
   PubMed Web of Science ®Google Scholar
• Görlich D, Kutay U. Transport between the cell nucleus and the cytoplasm. Annu Rev Cell Dev Biol 1999; 15:607 - 60; http://dx.doi.org/10.1146/annurev.cellbio.15.1.607; PMID: 10611974
   PubMed Web of Science ®Google Scholar
• Stewart M. Molecular mechanism of the nuclear protein import cycle. Nat Rev Mol Cell Biol 2007; 8:195 - 208; http://dx.doi.org/10.1038/nrm2114; PMID: 17287812
   PubMed Web of Science ®Google Scholar
• Goldfarb DS, Corbett AH, Mason DA, Harreman MT, Adam SA. Importin alpha: a multipurpose nuclear-transport receptor. Trends Cell Biol 2004; 14:505 - 14; http://dx.doi.org/10.1016/j.tcb.2004.07.016; PMID: 15350979
   PubMed Web of Science ®Google Scholar
• Köhler M, Speck C, Christiansen M, Bischoff FR, Prehn S, Haller H, Görlich D, Hartmann E. Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import. Mol Cell Biol 1999; 19:7782 - 91; PMID: 10523667
   PubMed Web of Science ®Google Scholar
• Fornerod M, Ohno M, Yoshida M, Mattaj IW. CRM1 is an export receptor for leucine-rich nuclear export signals. [see comments] Cell 1997; 90:1051 - 60; http://dx.doi.org/10.1016/S0092-8674(00)80371-2; PMID: 9323133
   PubMed Web of Science ®Google Scholar
• Kudo N, Wolff B, Sekimoto T, Schreiner EP, Yoneda Y, Yanagida M, Horinouchi S, Yoshida M. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp Cell Res 1998; 242:540 - 7; http://dx.doi.org/10.1006/excr.1998.4136; PMID: 9683540
   PubMed Web of Science ®Google Scholar
• Tsien RY. The green fluorescent protein. Annu Rev Biochem 1998; 67:509 - 44; http://dx.doi.org/10.1146/annurev.biochem.67.1.509; PMID: 9759496
   PubMed Web of Science ®Google Scholar
• Chudakov DM, Matz MV, Lukyanov S, Lukyanov KA. Fluorescent proteins and their applications in imaging living cells and tissues. Physiol Rev 2010; 90:1103 - 63; http://dx.doi.org/10.1152/physrev.00038.2009; PMID: 20664080
   PubMed Web of Science ®Google Scholar
• Wang Y, Shyy JY, Chien S. Fluorescence proteins, live-cell imaging, and mechanobiology: seeing is believing. Annu Rev Biomed Eng 2008; 10:1 - 38; http://dx.doi.org/10.1146/annurev.bioeng.010308.161731; PMID: 18647110
   PubMed Web of Science ®Google Scholar
• Shaner NC, Steinbach PA, Tsien RY. A guide to choosing fluorescent proteins. Nat Methods 2005; 2:905 - 9; http://dx.doi.org/10.1038/nmeth819; PMID: 16299475
   PubMed Web of Science ®Google Scholar
• Bach EA, Aguet M, Schreiber RD. The IFN gamma receptor: a paradigm for cytokine receptor signaling. Annu Rev Immunol 1997; 15:563 - 91; http://dx.doi.org/10.1146/annurev.immunol.15.1.563; PMID: 9143700
   PubMed Web of Science ®Google Scholar
• Chen X, Vinkemeier U, Zhao Y, Jeruzalmi D, Darnell JE Jr., Kuriyan J. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell 1998; 93:827 - 39; http://dx.doi.org/10.1016/S0092-8674(00)81443-9; PMID: 9630226
   PubMed Web of Science ®Google Scholar
• Mao X, Ren Z, Parker GN, Sondermann H, Pastorello MA, Wang W, McMurray JS, Demeler B, Darnell JE Jr., Chen X. Structural bases of unphosphorylated STAT1 association and receptor binding. Mol Cell 2005; 17:761 - 71; http://dx.doi.org/10.1016/j.molcel.2005.02.021; PMID: 15780933
   PubMed Web of Science ®Google Scholar
• Zhong M, Henriksen MA, Takeuchi K, Schaefer O, Liu B, ten Hoeve J, Ren Z, Mao X, Chen X, Shuai K, et al. Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation-inactivation cycle. Proc Natl Acad Sci U S A 2005; 102:3966 - 71; http://dx.doi.org/10.1073/pnas.0501063102; PMID: 15753310
   PubMed Web of Science ®Google Scholar
• Köster M, Hauser H. Dynamic redistribution of STAT1 protein in IFN signaling visualized by GFP fusion proteins. Eur J Biochem 1999; 260:137 - 44; http://dx.doi.org/10.1046/j.1432-1327.1999.00149.x; PMID: 10091593
   PubMedGoogle Scholar
• David M, Grimley PM, Finbloom DS, Larner AC. A nuclear tyrosine phosphatase downregulates interferon-induced gene expression. Mol Cell Biol 1993; 13:7515 - 21; PMID: 8246969
   PubMed Web of Science ®Google Scholar
• Haspel RL, Salditt-Georgieff M, Darnell JE Jr.. The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase. EMBO J 1996; 15:6262 - 8; PMID: 8947049
   PubMed Web of Science ®Google Scholar
• McBride KM, McDonald C, Reich NC. Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor. EMBO J 2000; 19:6196 - 206; http://dx.doi.org/10.1093/emboj/19.22.6196; PMID: 11080165
   PubMed Web of Science ®Google Scholar
• ten Hoeve J, de Jesus Ibarra-Sanchez M, Fu Y, Zhu W, Tremblay M, David M, Shuai K. Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol Cell Biol 2002; 22:5662 - 8; http://dx.doi.org/10.1128/MCB.22.16.5662-5668.2002; PMID: 12138178
   PubMed Web of Science ®Google Scholar
• Shuai K, Liu B. Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat Rev Immunol 2005; 5:593 - 605; http://dx.doi.org/10.1038/nri1667; PMID: 16056253
   PubMed Web of Science ®Google Scholar
• Meyer T, Marg A, Lemke P, Wiesner B, Vinkemeier U. DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1. Genes Dev 2003; 17:1992 - 2005; http://dx.doi.org/10.1101/gad.268003; PMID: 12923054
   PubMed Web of Science ®Google Scholar
• Smith CL. Basic confocal microscopy. Current protocols in molecular biology / edited by Frederick M Ausubel [et al 2008; Chapter 14:Unit 14 1.
   Google Scholar
• Lillemeier BF, Köster M, Kerr IM. STAT1 from the cell membrane to the DNA. EMBO J 2001; 20:2508 - 17; http://dx.doi.org/10.1093/emboj/20.10.2508; PMID: 11350940
   PubMed Web of Science ®Google Scholar
• Schindler C, Shuai K, Prezioso VR, Darnell JE Jr.. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science 1992; 257:809 - 13; http://dx.doi.org/10.1126/science.1496401; PMID: 1496401
   PubMed Web of Science ®Google Scholar
• Sekimoto T, Imamoto N, Nakajima K, Hirano T, Yoneda Y. Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1. EMBO J 1997; 16:7067 - 77; http://dx.doi.org/10.1093/emboj/16.23.7067; PMID: 9384585
   PubMed Web of Science ®Google Scholar
• LaCasse EC, Lefebvre YA. Nuclear localization signals overlap DNA- or RNA-binding domains in nucleic acid-binding proteins. Nucleic Acids Res 1995; 23:1647 - 56; http://dx.doi.org/10.1093/nar/23.10.1647; PMID: 7540284
   PubMed Web of Science ®Google Scholar
• Cokol M, Nair R, Rost B. Finding nuclear localization signals. EMBO Rep 2000; 1:411 - 5; http://dx.doi.org/10.1093/embo-reports/kvd092; PMID: 11258480
   PubMed Web of Science ®Google Scholar
• McBride KM, Banninger G, McDonald C, Reich NC. Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha. EMBO J 2002; 21:1754 - 63; http://dx.doi.org/10.1093/emboj/21.7.1754; PMID: 11927559
   PubMed Web of Science ®Google Scholar
• McKendry R, John J, Flavell D, Müller M, Kerr IM, Stark GR. High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons. Proc Natl Acad Sci U S A 1991; 88:11455 - 9; http://dx.doi.org/10.1073/pnas.88.24.11455; PMID: 1837150
   PubMed Web of Science ®Google Scholar
• Fagerlund R, Mélen K, Kinnunen L, Julkunen I. Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5. J Biol Chem 2002; 277:30072 - 8; http://dx.doi.org/10.1074/jbc.M202943200; PMID: 12048190
   PubMed Web of Science ®Google Scholar
• Meyer T, Begitt A, Lödige I, van Rossum M, Vinkemeier U. Constitutive and IFN-gamma-induced nuclear import of STAT1 proceed through independent pathways. EMBO J 2002; 21:344 - 54; http://dx.doi.org/10.1093/emboj/21.3.344; PMID: 11823427
   PubMed Web of Science ®Google Scholar
• Johnson HM, Subramaniam PS, Olsnes S, Jans DA. Trafficking and signaling pathways of nuclear localizing protein ligands and their receptors. Bioessays 2004; 26:993 - 1004; http://dx.doi.org/10.1002/bies.20086; PMID: 15351969
   PubMed Web of Science ®Google Scholar
• Johnson HM, Noon-Song EN, Dabelic R, Ahmed CM. IFN signaling: how a non-canonical model led to the development of IFN mimetics. Front Immunol 2013; 4:202; http://dx.doi.org/10.3389/fimmu.2013.00202; PMID: 23898330
   PubMedGoogle Scholar
• Chatterjee-Kishore M, Wright KL, Ting JP, Stark GR. How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene. EMBO J 2000; 19:4111 - 22; http://dx.doi.org/10.1093/emboj/19.15.4111; PMID: 10921891
   PubMed Web of Science ®Google Scholar
• Marg A, Shan Y, Meyer T, Meissner T, Brandenburg M, Vinkemeier U. Nucleocytoplasmic shuttling by nucleoporins Nup153 and Nup214 and CRM1-dependent nuclear export control the subcellular distribution of latent Stat1. J Cell Biol 2004; 165:823 - 33; http://dx.doi.org/10.1083/jcb.200403057; PMID: 15210729
   PubMed Web of Science ®Google Scholar
• Banninger G, Reich NC. STAT2 nuclear trafficking. J Biol Chem 2004; 279:39199 - 206; http://dx.doi.org/10.1074/jbc.M400815200; PMID: 15175343
   PubMed Web of Science ®Google Scholar
• Frahm T, Hauser H, Köster M. IFN-type-I-mediated signaling is regulated by modulation of STAT2 nuclear export. J Cell Sci 2006; 119:1092 - 104; http://dx.doi.org/10.1242/jcs.02822; PMID: 16507591
   PubMed Web of Science ®Google Scholar
• Horvath CM, Stark GR, Kerr IM, Darnell JE Jr.. Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex. Mol Cell Biol 1996; 16:6957 - 64; PMID: 8943351
   PubMed Web of Science ®Google Scholar
• Martinez-Moczygemba M, Gutch MJ, French DL, Reich NC. Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3. J Biol Chem 1997; 272:20070 - 6; http://dx.doi.org/10.1074/jbc.272.32.20070; PMID: 9242679
   PubMed Web of Science ®Google Scholar
• Tamura T, Yanai H, Savitsky D, Taniguchi T. The IRF family transcription factors in immunity and oncogenesis. Annu Rev Immunol 2008; 26:535 - 84; http://dx.doi.org/10.1146/annurev.immunol.26.021607.090400; PMID: 18303999
   PubMed Web of Science ®Google Scholar
• Lau JF, Parisien JP, Horvath CM. Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors. Proc Natl Acad Sci U S A 2000; 97:7278 - 83; http://dx.doi.org/10.1073/pnas.97.13.7278; PMID: 10860992
   PubMed Web of Science ®Google Scholar
• Pellegrini S, John J, Shearer M, Kerr IM, Stark GR. Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway. Mol Cell Biol 1989; 9:4605 - 12; PMID: 2513475
   PubMed Web of Science ®Google Scholar
• Melen K, Fagerlund R, Franke J, Kohler M, Kinnunen L, Julkunen I. Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein. J Biol Chem 2003; 278:28193 - 200; http://dx.doi.org/10.1074/jbc.M303571200; PMID: 12740372
   PubMed Web of Science ®Google Scholar
• Yamamoto K, Quelle FW, Thierfelder WE, Kreider BL, Gilbert DJ, Jenkins NA, Copeland NG, Silvennoinen O, Ihle JN. Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation. Mol Cell Biol 1994; 14:4342 - 9; PMID: 8007943
   PubMed Web of Science ®Google Scholar
• Zhong Z, Wen Z, Darnell JE Jr.. Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci U S A 1994; 91:4806 - 10; http://dx.doi.org/10.1073/pnas.91.11.4806; PMID: 7545930
   PubMed Web of Science ®Google Scholar
• Herrada G, Wolgemuth DJ. The mouse transcription factor Stat4 is expressed in haploid male germ cells and is present in the perinuclear theca of spermatozoa. J Cell Sci 1997; 110:1543 - 53; PMID: 9247188
   PubMed Web of Science ®Google Scholar
• Bacon CM, Petricoin EF 3rd, Ortaldo JR, Rees RC, Larner AC, Johnston JA, O’Shea JJ. Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc Natl Acad Sci U S A 1995; 92:7307 - 11; http://dx.doi.org/10.1073/pnas.92.16.7307; PMID: 7638186
   PubMed Web of Science ®Google Scholar
• Jacobson NG, Szabo SJ, Weber-Nordt RM, Zhong Z, Schreiber RD, Darnell JE Jr., Murphy KM. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J Exp Med 1995; 181:1755 - 62; http://dx.doi.org/10.1084/jem.181.5.1755; PMID: 7722452
   PubMed Web of Science ®Google Scholar
• Watford WT, Hissong BD, Bream JH, Kanno Y, Muul L, O’Shea JJ. Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol Rev 2004; 202:139 - 56; http://dx.doi.org/10.1111/j.0105-2896.2004.00211.x; PMID: 15546391
   PubMed Web of Science ®Google Scholar
• Dumler I, Kopmann A, Wagner K, Mayboroda OA, Jerke U, Dietz R, Haller H, Gulba DC. Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells. J Biol Chem 1999; 274:24059 - 65; http://dx.doi.org/10.1074/jbc.274.34.24059; PMID: 10446176
   PubMed Web of Science ®Google Scholar
• Berenson LS, Gavrieli M, Farrar JD, Murphy TL, Murphy KM. Distinct characteristics of murine STAT4 activation in response to IL-12 and IFN-alpha. J Immunol 2006; 177:5195 - 203; PMID: 17015705
   PubMed Web of Science ®Google Scholar
• Toyoda H, Ido M, Hayashi T, Gabazza EC, Suzuki K, Bu J, Tanaka S, Nakano T, Kamiya H, Chipeta J, et al. Impairment of IL-12-dependent STAT4 nuclear translocation in a patient with recurrent Mycobacterium avium infection. J Immunol 2004; 172:3905 - 12; PMID: 15004198
   PubMed Web of Science ®Google Scholar
• Huang Yu-Mei WY-P. Li Xuan-An, Yuan Yuan, Luo Qi-Zhi, LIi Ming. Amino acids 395–416 in DNA binding domain of STAT4 is involved in IL-12-induced nuclear import of STAT4. Acta Phys Sin 2012; 64:372 - 8
   PubMedGoogle Scholar
• Liu L, McBride KM, Reich NC. STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3. Proc Natl Acad Sci U S A 2005; 102:8150 - 5; http://dx.doi.org/10.1073/pnas.0501643102; PMID: 15919823
   PubMed Web of Science ®Google Scholar
• Cimica V, Chen HC, Iyer JK, Reich NC. Dynamics of the STAT3 transcription factor: nuclear import dependent on Ran and importin-β1. PLoS One 2011; 6:e20188; http://dx.doi.org/10.1371/journal.pone.0020188; PMID: 21625522
   PubMedGoogle Scholar
• Herrmann A, Sommer U, Pranada AL, Giese B, Küster A, Haan S, Becker W, Heinrich PC, Müller-Newen G. STAT3 is enriched in nuclear bodies. J Cell Sci 2004; 117:339 - 49; http://dx.doi.org/10.1242/jcs.00833; PMID: 14657276
   PubMed Web of Science ®Google Scholar
• Ma J, Zhang T, Novotny-Diermayr V, Tan AL, Cao X. A novel sequence in the coiled-coil domain of Stat3 essential for its nuclear translocation. J Biol Chem 2003; 278:29252 - 60; http://dx.doi.org/10.1074/jbc.M304196200; PMID: 12746441
   PubMed Web of Science ®Google Scholar
• Becker S, Groner B, Müller CW. Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature 1998; 394:145 - 51; http://dx.doi.org/10.1038/28101; PMID: 9671298
   PubMed Web of Science ®Google Scholar
• Nkansah E, Shah R, Collie GW, Parkinson GN, Palmer J, Rahman KM, Bui TT, Drake AF, Husby J, Neidle S, et al. Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography. FEBS Lett 2013; 587:833 - 9; http://dx.doi.org/10.1016/j.febslet.2013.01.065; PMID: 23434585
   PubMed Web of Science ®Google Scholar
• Pranada AL, Metz S, Herrmann A, Heinrich PC, Müller-Newen G. Real time analysis of STAT3 nucleocytoplasmic shuttling. J Biol Chem 2004; 279:15114 - 23; http://dx.doi.org/10.1074/jbc.M312530200; PMID: 14701810
   PubMed Web of Science ®Google Scholar
• Ma J, Cao X. Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements. Cell Signal 2006; 18:1117 - 26; http://dx.doi.org/10.1016/j.cellsig.2005.06.016; PMID: 16298512
   PubMed Web of Science ®Google Scholar
• Kawashima T, Bao YC, Minoshima Y, Nomura Y, Hatori T, Hori T, Fukagawa T, Fukada T, Takahashi N, Nosaka T, et al. A Rac GTPase-activating protein, MgcRacGAP, is a nuclear localizing signal-containing nuclear chaperone in the activation of STAT transcription factors. Mol Cell Biol 2009; 29:1796 - 813; http://dx.doi.org/10.1128/MCB.01423-08; PMID: 19158271
   PubMed Web of Science ®Google Scholar
• Cimica V, Reich NC. Nuclear trafficking of STAT proteins visualized by live cell imaging. Methods Mol Biol 2013; 967:189 - 202; http://dx.doi.org/10.1007/978-1-62703-242-1_14; PMID: 23296731
   PubMedGoogle Scholar
• Herrmann A, Vogt M, Mönnigmann M, Clahsen T, Sommer U, Haan S, Poli V, Heinrich PC, Müller-Newen G. Nucleocytoplasmic shuttling of persistently activated STAT3. J Cell Sci 2007; 120:3249 - 61; http://dx.doi.org/10.1242/jcs.03482; PMID: 17726064
   PubMed Web of Science ®Google Scholar
• Bhattacharya S, Schindler C. Regulation of Stat3 nuclear export. J Clin Invest 2003; 111:553 - 9; PMID: 12588893
   PubMed Web of Science ®Google Scholar
• Liu X, Robinson GW, Gouilleux F, Groner B, Hennighausen L. Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc Natl Acad Sci U S A 1995; 92:8831 - 5; http://dx.doi.org/10.1073/pnas.92.19.8831; PMID: 7568026
   PubMed Web of Science ®Google Scholar
• Mui AL, Wakao H, Harada N, O’Farrell AM, Miyajima A. Interleukin-3, granulocyte-macrophage colony-stimulating factor, and interleukin-5 transduce signals through two forms of STAT5. J Leukoc Biol 1995; 57:799 - 803; PMID: 7539031
   PubMed Web of Science ®Google Scholar
• Neculai D, Neculai AM, Verrier S, Straub K, Klumpp K, Pfitzner E, Becker S. Structure of the unphosphorylated STAT5A dimer. J Biol Chem 2005; 280:40782 - 7; http://dx.doi.org/10.1074/jbc.M507682200; PMID: 16192273
   PubMed Web of Science ®Google Scholar
• Gouilleux F, Wakao H, Mundt M, Groner B. Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. EMBO J 1994; 13:4361 - 9; PMID: 7925280
   PubMed Web of Science ®Google Scholar
• Zeng R, Aoki Y, Yoshida M, Arai K, Watanabe S. Stat5B shuttles between cytoplasm and nucleus in a cytokine-dependent and -independent manner. J Immunol 2002; 168:4567 - 75; PMID: 11971004
   PubMed Web of Science ®Google Scholar
• Iyer J, Reich NC. Constitutive nuclear import of latent and activated STAT5A by its coiled-coil domain. FASEB J 2008; 22:391 - 400; http://dx.doi.org/10.1096/fj.07-8965com; PMID: 17846080
   PubMed Web of Science ®Google Scholar
• Shin HY, Reich NC. Dynamic trafficking of STAT5 depends on an unconventional nuclear localization signal. J Cell Sci 2013; 126:3333 - 43; http://dx.doi.org/10.1242/jcs.123042; PMID: 23704351
   PubMed Web of Science ®Google Scholar
• Chen HC, Reich NC. Live cell imaging reveals continuous STAT6 nuclear trafficking. J Immunol 2010; 185:64 - 70; http://dx.doi.org/10.4049/jimmunol.0903323; PMID: 20498360
   PubMed Web of Science ®Google Scholar
• Gough DJ, Corlett A, Schlessinger K, Wegrzyn J, Larner AC, Levy DE. Mitochondrial STAT3 supports Ras-dependent oncogenic transformation. Science 2009; 324:1713 - 6; http://dx.doi.org/10.1126/science.1171721; PMID: 19556508
   PubMed Web of Science ®Google Scholar
• Wegrzyn J, Potla R, Chwae YJ, Sepuri NB, Zhang Q, Koeck T, Derecka M, Szczepanek K, Szelag M, Gornicka A, et al. Function of mitochondrial Stat3 in cellular respiration. Science 2009; 323:793 - 7; http://dx.doi.org/10.1126/science.1164551; PMID: 19131594
   PubMed Web of Science ®Google Scholar
• Verma NK, Dourlat J, Davies AM, Long A, Liu WQ, Garbay C, Kelleher D, Volkov Y. STAT3-stathmin interactions control microtubule dynamics in migrating T-cells. J Biol Chem 2009; 284:12349 - 62; http://dx.doi.org/10.1074/jbc.M807761200; PMID: 19251695
   PubMed Web of Science ®Google Scholar
• Reid SP, Valmas C, Martinez O, Sanchez FM, Basler CF. Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1. J Virol 2007; 81:13469 - 77; http://dx.doi.org/10.1128/JVI.01097-07; PMID: 17928350
   PubMed Web of Science ®Google Scholar
• Palosaari H, Parisien JP, Rodriguez JJ, Ulane CM, Horvath CM. STAT protein interference and suppression of cytokine signal transduction by measles virus V protein. J Virol 2003; 77:7635 - 44; http://dx.doi.org/10.1128/JVI.77.13.7635-7644.2003; PMID: 12805463
   PubMed Web of Science ®Google Scholar