1,706
Views
25
CrossRef citations to date
0
Altmetric
Report

Improved stability of multivalent antibodies containing the human collagen XV trimerization domain

, , , , , , , , & show all
Pages 226-232 | Received 17 Nov 2011, Accepted 21 Dec 2011, Published online: 01 Mar 2012

References

  • Holliger P, Hudson PJ. Engineered antibody fragments and the rise of single domains. Nat Biotechnol 2005; 23:1126 - 1136; PMID: 16151406; http://dx.doi.org/10.1038/nbt1142
  • Sanz L, Cuesta AM, Compte M, Alvarez-Vallina L. Antibody engineering: facing new challenges in cancer therapy. Acta Pharmacol Sin 2005; 26:641 - 648; PMID: 15916728; http://dx.doi.org/10.1111/j.1745-7254.2005.00135.x
  • Cuesta AM, Sainz-Pastor N, Bonet J, Oliva B, Alvarez-Vallina L. Multivalent antibodies: when design surpasses evolution. Trends Biotechnol 2010; 28:355 - 362; PMID: 20447706; http://dx.doi.org/10.1016/j.tibtech.2010.03.007
  • Holliger P, Prospero T, Winter G. “Diabodies”: small bivalent and bispecific antibody fragments. Proc Natl Acad Sci USA 1993; 90:6444 - 6448; PMID: 8341653; http://dx.doi.org/10.1073/pnas.90.14.6444
  • Hudson PJ, Kortt AA. High avidity scFv multimers; diabodies and triabodies. J Immunol Methods 1999; 231:177 - 189; PMID: 10648937; http://dx.doi.org/10.1016/S0022-1759(99)00157-X
  • Hu S, Shively L, Raubitschek A, Sherman M, Williams LE, Wong JY, et al. Minibody: A novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-CH3) which exhibits rapid, high-level targeting of xenografts. Cancer Res 1996; 56:3055 - 3061; PMID: 8674062
  • Sánchez-Arévalo Lobo VJ, Cuesta AM, Sanz L, Compte M, García P, Prieto J, et al. Enhanced antiangiogenic therapy with antibody-collagen XVIII NC1 domain fusion proteins engineered to exploit matrix remodeling events. Int J Cancer 2006; 119:455 - 462; PMID: 16477626; http://dx.doi.org/10.1002/ijc.21851
  • Cuesta AM, Sánchez-Martín D, Sanz L, Bonet J, Compte M, Kremer L, et al. In vivo tumor targeting and imaging with engineered trivalent antibody fragments containing collagen-derived sequences. PLoS One 2009; 4:5381; PMID: 19401768; http://dx.doi.org/10.1371/journal.pone.0005381
  • Sánchez-Martín D, Cuesta AM, Fogal V, Ruoslahti E, Alvarez-Vallina L. The multicompartmental p32/gClqR as a new target for antibody-based tumor targeting strategies. J Biol Chem 2011; 286:5197 - 5203; PMID: 21156793; http://dx.doi.org/10.1074/jbc.M110.161927
  • Pihlajaniemi T, Rehn M. Two new collagen subgroups: membrane-associated collagens and types XV and XVII. Prog Nucleic Acid Res Mol Biol 1995; 50:225 - 262; PMID: 7754035; http://dx.doi.org/10.1016/S0079-6603(08)60816-8
  • Myers JC, Kivirikko S, Gordon MK, Dion AS, Pihlajaniemi T. Identification of a previously unknown human collagen chain, alpha1(XV), characterized by extensive interruptions in the triple-helical region. Proc Natl Acad Sci USA 1992; 89:10144 - 10148; PMID: 1279671; http://dx.doi.org/10.1073/pnas.89.21.10144
  • Rehn M, Hintikka E, Pihlajaniemi T. Primary structure of the alpha 1 chain of mouse type XVIII collagen, partial structure of the corresponding gene, and comparison of the alpha1(XVIII) chain with its homologue, the alpha1(XV) collagen chain. J Biol Chem 1994; 269:13929 - 13935; PMID: 8188673
  • Rehn M, Pihlajaniemi T. Alpha1(XVIII), a collagen chain with frequent interruptions in the collagenous sequence, a distinct tissue distribution and homology with type XV collagen. Proc Natl Acad Sci USA 1994; 91:4234 - 4238; PMID: 8183894; http://dx.doi.org/10.1073/pnas.91.10.4234
  • Sasaki T, Fukai N, Mann K, Göhring W, Olsen BR, Timpl R. Structure, function and tissue forms of the C-terminal globular domain of collagen XVIII containing the angiogenesis inhibitor endostatin. EMBO J 1998; 17:4249 - 4256; PMID: 9687493; http://dx.doi.org/10.1093/emboj/17.15.4249
  • Sasaki T, Larsson H, Tisi D, Claesson-Welsh L, Hohenester E, Timpl R. Endostatins derived from collagens XV and XVIII differ in structural and binding properties, tissue distribution and anti-angiogenic activity. J Mol Biol 2000; 301:1179 - 1190; PMID: 10966814; http://dx.doi.org/10.1006/jmbi.2000.3996
  • Boudko SP, Sasaki T, Engel J, Lerch TF, Nix J, Chapman MS, et al. Crystal structure of human collagen XVIII trimerization domain: A novel collagen trimerization Fold. J Mol Biol 2009; 392:787 - 802; PMID: 19631658; http://dx.doi.org/10.1016/j.jmb.2009.07.057
  • Wirz JA, Boudko SP, Lerch TF, Chapman MS, Bächinger HP. Crystal structure of the human collagen XV trimerization domain: a potent trimerizing unit common to multiplexin collagens. Matrix Biol 2011; 30:9 - 15; PMID: 20932905; http://dx.doi.org/10.1016/j.matbio.2010.09.005
  • Sanz L, Kristensen P, Blanco B, Facteau S, Russell SJ, Winter G, et al. Single-chain antibody-based gene therapy: inhibition of tumor growth by in situ production of phage-derived human antibody fragments blocking functionally active sites of cell-associated matrices. Gene Ther 2002; 9:1049 - 1053; PMID: 12101437; http://dx.doi.org/10.1038/sj.gt.3301725
  • Willuda J, Honegger A, Waibel R, Schubiger PA, Stahel R, Zangemeister-Wittke U, et al. High thermal stability is essential for tumor targeting of antibody fragments: engineering of a humanized anti-epithelial glycoprotein-2 (epithelial cell adhesion molecule) single-chain Fv fragment. Cancer Res 1999; 59:5758 - 5767; PMID: 10582696
  • Kane SE, Gottesman MM. The role of cathepsin L in malignant transformation. Semin Cancer Biol 1990; 1:127 - 136; PMID: 2103489
  • Denhardt DT, Greenberg AH, Egan SE, Hamilton RT, Wright JA. Cysteine proteinase cathepsin L expression correlates closely with the metastatic potential of H-ras-transformed murine fibroblasts. Oncogene 1987; 2:55 - 59; PMID: 3438085
  • Yamashita J, Tashiro K, Yoneda S, Kawahara K, Shirakusa T. Local increase in polymorphonuclear leukocyte elastase is associated with tumor invasiveness in non-small cell lung cancer. Chest 1996; 109:1328 - 1334; PMID: 8625686; http://dx.doi.org/10.1378/chest.109.5.1328
  • Halfter W, Dong S, Schurer B, Cole GJ. Collagen XVIII is a basement membrane heparan sulfate proteoglycan. J Biol Chem 1998; 273:25404 - 25412; PMID: 9738008; http://dx.doi.org/10.1074/jbc.273.39.25404
  • Amenta PS, Scivoletti NA, Newman MD, Sciancalepore JP, Li D, Myers JC. Proteoglycan-collagen XV in human tissues is seen linking banded collagen fibers subjacent to the basement membrane. J Histochem Cytochem 2005; 53:165 - 176; PMID: 15684329; http://dx.doi.org/10.1369/jhc.4A6376.2005
  • Ackley BD, Crew JR, Elamaa H, Pihlajaniemi T, Kuo CJ, Kramer JM. The NC1/endostatin domain of Caenorhabditis elegans type XVIII collagen affects cell migration and axon guidance. J Cell Biol 2001; 152:1219 - 1232; PMID: 11257122; http://dx.doi.org/10.1083/jcb.152.6.1219
  • Brezski RJ, Vafa O, Petrone D, Tam SH, Powers G, Ryan MH, et al. Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge. Proc Natl Acad Sci USA 2009; 106:17864 - 17869; PMID: 19815504; http://dx.doi.org/10.1073/pnas.0904174106
  • Alvarez-Vallina L, Hawkins RE. Antigen-specific targeting of CD28-mediated T cell co-stimulation using chimeric single-chain antibody variable fragment-CD28 receptors. Eur J Immunol 1996; 26:2304 - 2309; PMID: 8898938; http://dx.doi.org/10.1002/eji.1830261006
  • Sanz L, Kristensen P, Russell SJ, Ramirez García JR, Alvarez-Vallina L. Generation and characterization of recombinant human antibodies specific for native laminin epitopes: potential application in cancer therapy. Cancer Immunol Immunother 2001; 50:557 - 565; PMID: 11776378; http://dx.doi.org/10.1007/s00262-001-0235-5
  • Sanz L, García-Bermejo L, Blanco FJ, Kristensen P, Feijóo M, Suárez E, et al. A novel cell binding site in the coiled-coil domain of laminin involved in capillary morphogenesis. EMBO J 2003; 22:1508 - 1517; PMID: 12660158; http://dx.doi.org/10.1093/emboj/cdg150
  • Schuck P. Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. Biophys J 2000; 78:1606 - 1619; PMID: 10692345; http://dx.doi.org/10.1016/S0006-3495(00)76713-0
  • Schuck P, Perugini MA, Gonzales NR, Howlett GJ, Schubert D. Size-distribution analysis of proteins by analytical ultracentrifugation: strategies and application to model systems. Biophys J 2002; 82:1096 - 1111; PMID: 11806949; http://dx.doi.org/10.1016/S0006-3495(02)75469-6
  • Laue T. Harding SE, Rowe AJ, Horton JC. Computer-aided interpretation of analytical sedimentation data for proteins. Ultracentrifugation in biochemistry and polymer science 1992; Cambridge Royal Society of Chemistry 90 - 125
  • Cole JL. Analysis of heterogeneous interactions. Methods Enzymol 2004; 384:212 - 232; PMID: 15081689; http://dx.doi.org/10.1016/S0076-6879(04)84013-8

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.