Permeating the nuclear pore complex

References

• Paine PL, Moore LC, Horowitz SB. Nuclear envelope permeability. Nature 1975; 254:14 - 17
   Web of Science ®Google Scholar
• Keminer O, Peters R. Permeability of single nuclear pores. Biophys J 1999; 77:217 - 228
   PubMed Web of Science ®Google Scholar
• Chook YM, Blobel G. Karyopherins and nuclear import. Curr Opin Struct Biol 2001; 11:703 - 715
   PubMed Web of Science ®Google Scholar
• Conti E, Muller CW, Stewart M. Karyopherin flexibility in nucleocytoplasmic transport. Curr Opin Struct Biol 2006; 16:237 - 244
   PubMed Web of Science ®Google Scholar
• Cook A, Bono F, Jinek M, Conti E. Structural biology of nucleocytoplasmic transport. Annu Rev Biochem 2007; 76:647 - 671
   PubMed Web of Science ®Google Scholar
• Bayliss R, Littlewood T, Stewart M. Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking. Cell 2000; 102:99 - 108
   PubMed Web of Science ®Google Scholar
• Bayliss R, Littlewood T, Strawn LA, Wente SR, Stewart M. GLFG and FxFG nucleoporins bind to overlapping sites on importin-beta. J Biol Chem 2002; 277:50597 - 50606
   PubMed Web of Science ®Google Scholar
• Morrison J, Yang JC, Stewart M, Neuhaus D. Solution NMR study of the interaction between NTF2 and nucleoporin FxFG repeats. J Mol Biol 2003; 333:587 - 603
   PubMed Web of Science ®Google Scholar
• Isgro TA, Schulten K. Binding dynamics of isolated nucleoporin repeat regions to importin-beta. Structure 2005; 13:1869 - 1879
   PubMed Web of Science ®Google Scholar
• Liu SM, Stewart M. Structural basis for the highaffinity binding of nucleoporin Nup1p to the Saccharomyces cerevisiae importin-beta homologue, Kap95p. J Mol Biol 2005; 349:515 - 525
   PubMed Web of Science ®Google Scholar
• Isgro TA, Schulten K. Cse1p-binding dynamics reveal a binding pattern for FG-repeat nucleoporins on transport receptors. Structure 2007; 15:977 - 991
   PubMed Web of Science ®Google Scholar
• Isgro TA, Schulten K. Association of nuclear pore FG-repeat domains to NTF2 import and export complexes. J Mol Biol 2007; 366:330 - 345
   PubMed Web of Science ®Google Scholar
• Quan Y, Ji ZL, Wang X, Tartakoff AM, Tao T. Evolutionary and transcriptional analysis of karyopherin beta superfamily proteins. Mol Cell Proteomics 2008; 7:1254 - 1269
   PubMed Web of Science ®Google Scholar
• Mattaj IW, Englmeier L. Nucleocytoplasmic transport: the soluble phase. Annu Rev Biochem 1998; 67:265 - 306
   PubMed Web of Science ®Google Scholar
• Gorlich D, Kutay U. Transport between the cell nucleus and the cytoplasm. Annu Rev Cell Dev Biol 1999; 15:607 - 660
   PubMed Web of Science ®Google Scholar
• Weis K. Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle. Cell 2003; 112:441 - 451
   PubMed Web of Science ®Google Scholar
• Pemberton LF, Paschal BM. Mechanisms of receptor-mediated nuclear import and nuclear export. Traffic 2005; 6:187 - 198
   PubMed Web of Science ®Google Scholar
• Steggerda SM, Paschal BM. Regulation of nuclear import and export by the GTPase Ran. Int Rev Cytol 2002; 217:41 - 91
   PubMed Web of Science ®Google Scholar
• Kuersten S, Ohno M, Mattaj IW. Nucleocytoplasmic transport: Ran, beta and beyond. Rends Cell Biol 2001; 11:497 - 503
   PubMed Web of Science ®Google Scholar
• Terry LJ, Wente SR. Flexible gates: dynamic topologies and functions for FG nucleoporins in nucleocytoplasmic transport. Eukaryotic cell 2009; 8:1814 - 1827
   PubMed Web of Science ®Google Scholar
• Alber F, Dokudovskaya S, Veenhoff LM, Zhang W, Kipper J, Devos D, et al. The molecular architecture of the nuclear pore complex. Nature 2007; 450:695 - 701
   PubMed Web of Science ®Google Scholar
• Ribbeck K, Gorlich D. Kinetic analysis of translocation through nuclear pore complexes. EMBO J 2001; 20:1320 - 1330
   PubMed Web of Science ®Google Scholar
• Ribbeck K, Gorlich D. The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion. EMBO J 2002; 21:2664 - 2671
   PubMed Web of Science ®Google Scholar
• Frey S, Richter RP, Gorlich D. FG-rich repeats of nuclear pore proteins form a three-dimensional meshwork with hydrogel-like properties. Science 2006; 314:815 - 817
   PubMed Web of Science ®Google Scholar
• Frey S, Gorlich D. A saturated FG-repeat hydrogel can reproduce the permeability properties of nuclear pore complexes. Cell 2007; 130:512 - 523
   PubMed Web of Science ®Google Scholar
• Frey S, Gorlich D. FG/FxFG as well as GLFG repeats form a selective permeability barrier with self-healing properties. EMBO J 2009; 28:2554 - 2567
   PubMed Web of Science ®Google Scholar
• Rout MP, Aitchison JD, Magnasco MO, Chait BT. Virtual gating and nuclear transport: the hole picture. Trends Cell Biol 2003; 13:622 - 628
   PubMed Web of Science ®Google Scholar
• Jovanovic-Talisman T, Tetenbaum-Novatt J, McKenney AS, Zilman A, Peters R, Rout MP, et al. Artificial nanopores that mimic the transport selectivity of the nuclear pore complex. Nature 2009; 457:1023 - 1027
   PubMed Web of Science ®Google Scholar
• Lim RY, Huang NP, Koser J, Deng J, Lau KH, Schwarz-Herion K, et al. Flexible phenylalanineglycine nucleoporins as entropic barriers to nucleocytoplasmic transport. Proc Natl Acad Sci USA 2006; 103:9512 - 9517
   PubMed Web of Science ®Google Scholar
• Lim RY, Fahrenkrog B, Koser J, Schwarz-Herion K, Deng J, Aebi U. Nanomechanical basis of selective gating by the nuclear pore complex. Science 2007; 318:640 - 643
   PubMed Web of Science ®Google Scholar
• Peters R. Translocation through the nuclear pore complex: selectivity and speed by reduction-of-dimensionality. Traffic 2005; 6:421 - 427
   PubMed Web of Science ®Google Scholar
• Ma J, Yang W. Three-dimensional distribution of transient interactions in the nuclear pore complex obtained from single-molecule snapshots. Proc Natl Acad Sci USA 107:7305 - 7310
   PubMed Web of Science ®Google Scholar
• Yamada J, Phillips JL, Patel S, Goldfien G, Calestagne-Morelli A, Huang H, et al. A bimodal distribution of two distinct categories of intrinsically-disordered structures with separate functions in FG nucleoporins. Mol Cell Proteomics
   Web of Science ®Google Scholar
• Hinshaw JE, Carragher BO, Milligan RA. Architecture and design of the nuclear pore complex. Cell 1992; 69:1133 - 1141
   PubMed Web of Science ®Google Scholar
• Akey CW, Radermacher M. Architecture of the Xenopus nuclear pore complex revealed by three-dimensional cryo-electron microscopy. J Cell Biol 1993; 122:1 - 19
   PubMed Web of Science ®Google Scholar
• Stoffler D, Feja B, Fahrenkrog B, Walz J, Typke D, Aebi U. Cryo-electron tomography provides novel insights into nuclear pore architecture: implications for nucleocytoplasmic transport. J Mol Biol 2003; 328:119 - 130
   PubMed Web of Science ®Google Scholar
• Beck M, Forster F, Ecke M, Plitzko JM, Melchior F, Gerisch G, et al. Nuclear pore complex structure and dynamics revealed by cryoelectron tomography. Science 2004; 306:1387 - 1390
   PubMed Web of Science ®Google Scholar
• Goldberg MW, Allen TD. The nuclear pore complex: three-dimensional surface structure revealed by field emission, in-lens scanning electron microscopy, with underlying structure uncovered by proteolysis. J Cell Sci 1993; 106:261 - 274
   PubMed Web of Science ®Google Scholar
• Nevo R, Markiewicz P, Kapon R, Elbaum M, Reich Z. High-resolution imaging of the nuclear pore complex by AC scanning force microscopy. Single molecules 2000; 1:109 - 114
   Google Scholar
• Rout MP, Aitchison JD, Suprapto A, Hjertaas K, Zhao Y, Chait BT. The yeast nuclear pore complex: composition, architecture and transport mechanism. J Cell Biol 2000; 148:635 - 651
   PubMed Web of Science ®Google Scholar
• Talcott B, Moore MS. Getting across the nuclear pore complex. Trends Cell Biol 1999; 9:312 - 318
   PubMed Web of Science ®Google Scholar
• Ben-Efraim I, Gerace L. Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import. J Cell Biol 2001; 152:411 - 417
   PubMed Web of Science ®Google Scholar
• Allen NP, Huang L, Burlingame A, Rexach M. Proteomic analysis of nucleoporin interacting proteins. J Biol Chem 2001; 276:29268 - 29274
   PubMed Web of Science ®Google Scholar
• Pyhtila B, Rexach M. A gradient of affinity for the karyopherin Kap95p along the yeast nuclear pore complex. J Biol Chem 2003; 278:42699 - 42709
   PubMed Web of Science ®Google Scholar
• Patel SS, Rexach MF. Discovering novel interactions at the nuclear pore complex using bead halo: a rapid method for detecting molecular interactions of high and low affinity at equilibrium. Mol Cell Proteomics 2008; 7:121 - 131
   Google Scholar
• Tokunaga M, Imamoto N, Sakata-Sogawa K. Highly inclined thin illumination enables clear single-molecule imaging in cells. Nat Methods 2008; 5:159 - 161
   PubMed Web of Science ®Google Scholar
• Naim B, Zbaida D, Dagan S, Kapon R, Reich Z. Cargo surface hydrophobicity is sufficient to overcome the nuclear pore complex selectivity barrier. EMBO J 2009; 28:2697 - 2705
   PubMed Web of Science ®Google Scholar
• Patel SS, Belmont BJ, Sante JM, Rexach MF. Natively unfolded nucleoporins gate protein diffusion across the nuclear pore complex. Cell 2007; 129:83 - 96
   PubMed Web of Science ®Google Scholar
• Zilman A, Di Talia S, Chait BT, Rout MP, Magnasco MO. Efficiency, selectivity and robustness of nucleocytoplasmic transport. PLoS Comput Biol 2007; 3:125
   Web of Science ®Google Scholar
• Eisele NB, Frey S, Piehler J, Gorlich D, Richter RP. Ultrathin nucleoporin phenylalanine-glycine repeat films and their interaction with nuclear transport receptors. EMBO rep
   Web of Science ®Google Scholar
• Naim B, Brumfeld V, Kapon R, Kiss V, Nevo R, Reich Z. Passive and facilitated transport in nuclear pore complexes is largely uncoupled. J Biol Chem 2007; 282:3881 - 3888
   PubMed Web of Science ®Google Scholar
• Danker T, Schillers H, Storck J, Shahin V, Kramer B, Wilhelmi M, et al. Nuclear hourglass technique: an approach that detects electrically open nuclear pores in Xenopus laevis oocyte. Proc Natl Acad Sci USA 1999; 96:13530 - 13535
   PubMed Web of Science ®Google Scholar
• Shahin V, Danker T, Enss K, Ossig R, Oberleithner H. Evidence for Ca2+- and ATP-sensitive peripheral channels in nuclear pore complexes. Faseb J 2001; 15:1895 - 1901
   PubMed Web of Science ®Google Scholar
• Mazzanti M, Bustamante JO, Oberleithner H. Electrical dimension of the nuclear envelope. Physiol Rev 2001; 81:1 - 19
   PubMed Web of Science ®Google Scholar
• Enss K, Danker T, Schlune A, Buchholz I, Oberleithner H. Passive transport of macromolecules through Xenopus laevis nuclear envelope. J Membr Biol 2003; 196:147 - 155
   PubMed Web of Science ®Google Scholar
• Kramer A, Ludwig Y, Shahin V, Oberleithner H. A pathway separate from the central channel through the nuclear pore complex for inorganic ions and small macromolecules. J Biol Chem 2007; 282:31437 - 31443
   PubMed Web of Science ®Google Scholar
• Kramer A, Liashkovich I, Ludwig Y, Shahin V. Atomic force microscopy visualises a hydrophobic meshwork in the central channel of the nuclear pore. Pflugers Arch 2008; 456:155 - 162
   PubMed Web of Science ®Google Scholar
• Feldherr CM, Akin D. The location of the transport gate in the nuclear pore complex. J Cell Sci 1997; 110:3065 - 3070
   PubMed Web of Science ®Google Scholar
• Rexach M, Blobel G. Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors and nucleoporins. Cell 1995; 83:683 - 692
   PubMed Web of Science ®Google Scholar
• Gorlich D, Pante N, Kutay U, Aebi U, Bischoff FR. Identification of different roles for RanGDP and RanGTP in nuclear protein import. EMBO J 1996; 15:5584 - 5594
   PubMed Web of Science ®Google Scholar
• Shah S, Forbes DJ. Separate nuclear import pathways converge on the nucleoporin Nup153 and can be dissected with dominant-negative inhibitors. Curr Biol 1998; 8:1376 - 1386
   PubMed Web of Science ®Google Scholar
• Shah S, Tugendreich S, Forbes D. Major binding sites for the nuclear import receptor are the internal nucleoporin Nup153 and the adjacent nuclear filament protein Tpr. J Cell Biol 1998; 141:31 - 49
   PubMed Web of Science ®Google Scholar