Reversal of age-dependent nuclear morphology by inhibition of prenylation does not affect lifespan in Caenorhabditis elegans

References

• Stuurman N, Heins S, Aebi U. Nuclear lamins: their structure, assembly and interactions. J Struct Biol 1998; 122:42 - 66
   PubMed Web of Science ®Google Scholar
• Herrmann H, Bär H, Kreplak L, Strelkov SV, Aebi U. Intermediate filaments: from cell architecture to nanomechanics. Nat Rev Cell Mol Biol 2007; 8:562 - 573
   PubMed Web of Science ®Google Scholar
• Goldman RD, Gruenbaum Y, Moir RD, Shumaker DK, Spann TP. Nuclear lamins: building blocks of nuclear architecture. Genes Dev 2002; 16:533 - 547
   PubMed Web of Science ®Google Scholar
• Gruenbaum Y, Margalit A, Goldman RD, Shumaker DK, Wilson KL. The nuclear lamina comes of age. Nat Rev Mol Cell Biol 2005; 6:21 - 31
   PubMed Web of Science ®Google Scholar
• Boban M, Braun J, Foisner R. Lamins: ‘structure goes cycling’. Biochem Soc Trans 2010; 38:301 - 306
   PubMed Web of Science ®Google Scholar
• Worman HJ, Ostlund C, Wang Y. Diseases of the nuclear envelope. Cold Spring Harb Perspect Biol 2010; 2:000760
   PubMed Web of Science ®Google Scholar
• Ramírez CL, Cadiäanos J, Varela I, Freije JM, López-Otín C. Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions. Cell Mol Life Sci 2007; 64:155 - 170
   PubMed Web of Science ®Google Scholar
• Dechat T, Pfleghaar K, Sengupta K, Shimi T, Shumaker DK, Solimando L, et al. Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin. Genes Dev 2008; 22:832 - 853
   PubMed Web of Science ®Google Scholar
• Goldman RD, Shumaker DK, Erdos MR, Eriksson M, Goldman AE, Gordon LB, et al. Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford Progeria Syndrome 2004; 101:8963 - 8968
   Google Scholar
• Scaffidi P, Misteli T. Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Nat Med 2005; 11:440 - 445
   PubMed Web of Science ®Google Scholar
• Fong LG, Frost D, Meta M, Qiao X, Yang SH, Coffinier C, Young SG. A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria. Science 2006; 311:1621 - 1623
   PubMed Web of Science ®Google Scholar
• Meta M, Yang SH, Bergo MO, Fong LG, Young SG. Protein farnesyltransferase inhibitors and progeria. Trends Mol Med 2006; 12:480 - 487
   PubMed Web of Science ®Google Scholar
• Yang SH, Meta M, Qiao X, Frost D, Bauch J, Coffinier C, et al. A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation. J Clin Invest 2006; 116:2115 - 2121
   PubMed Web of Science ®Google Scholar
• Varela I, Pereira S, Ugalde AP, Navarro CL, Suárez MF, Cau P, et al. Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging. Nat Med 2008; 14:767 - 772
   PubMed Web of Science ®Google Scholar
• Cao K, Capell BC, Erdos MR, Djabali K, Collins FS. A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells. Proc Natl Acad Sci USA 2007; 104:3939 - 3954
   Web of Science ®Google Scholar
• McClintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS, et al. The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin. PLoS One 2007; 2:1269
   PubMed Web of Science ®Google Scholar
• Brenner S. The genetics of Caenorhabditis elegans. Genetics 1974; 77:71 - 94
   PubMed Web of Science ®Google Scholar
• Haithcock E, Dayani Y, Neufeld E, Zahand AJ, Feinstein N, Mattout A, et al. Age-related changes of nuclear architecture in Caenorhabditis elegans. Proc Natl Acad Sci USA 2005; 102:16690 - 16695
   PubMed Web of Science ®Google Scholar
• Haithcock E, Dayani Y, Neufeld E, Zahand AJ, Feinstein N, Mattout N, et al. Age-related changes of nuclear architecture in Caenorhabditis elegans. Proc Natl Acad Sci USA 2005; 102:16690 - 16695
   PubMed Web of Science ®Google Scholar
• Bar DZ, Neufeld E, Feinstein N, Gruenbaum Y. Gliotoxin reverses age-dependent nuclear morphology phenotypes, ameliorates motility, but fails to affect lifespan of adult Caenorhabditis elegans. Cell Motil Cytoskeleton 2009; 66:791 - 797
   PubMed Web of Science ®Google Scholar
• Margalit A, Neufeld E, Feinstein N, Wilson KL, Podbilewicz B, Gruenbaum Y. Barrier to autointegration factor blocks premature cell fusion and maintains adult muscle integrity in C. elegans. J Cell Biol 2007; 178:661 - 673
   Google Scholar
• Wiesel N, Mattout A, Melcer S, Melamed-Book N, Herrmann H, Medalia O, et al. Laminopathic mutations interfere with the assembly, localization and dynamics of nuclear lamins. Proc Natl Acad Sci USA 2008; 105:180 - 185
   PubMed Web of Science ®Google Scholar
• Ramot D, Johnson BE, Berry TLJ, Carnell L, Goodman MB. The Parallel Worm Tracker: a platform for measuring average speed and drug-induced paralysis in nematodes. PLoS One 2008; 3:2208
   PubMed Web of Science ®Google Scholar
• Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 2003; 33:40 - 48
   PubMed Web of Science ®Google Scholar
• Hara M, Han M. Ras farnesyltransferase inhibitors suppress the phenotype resulting from an activated ras mutation in Caenorhabditis elegans. Proc Natl Acad Sci USA 1995; 92:3333 - 3337
   PubMed Web of Science ®Google Scholar
• Merideth MA, Gordon LB, Clauss S, Sachdev V, Smith AC, Perry MB, et al. Phenotype and course of Hutchinson-Gilford progeria syndrome. N Engl J Med 2008; 358:592 - 604
   PubMed Web of Science ®Google Scholar
• Herndon LA, Schmeissner PJ, Dudaronek JM, Brown PA, Listner KM, Sakano Y, et al. Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 2002; 419:808 - 814
   PubMed Web of Science ®Google Scholar
• Young SG, Fong LG, Michaelis S, Prelamin A. Zmpste24, misshapen cell nuclei and progeria—New evidence suggesting that protein farnesylation could be important for disease pathogenesis. J Lipid Res 2005; 46:2531 - 2558
   PubMed Web of Science ®Google Scholar
• Navarro CL, Cau P, Lévy N. Molecular bases of progeroid syndromes. Hum Mol Genet 2006; 2:151 - 161
   Web of Science ®Google Scholar
• Broers JL, Ramaekers FC, Bonne G, Yaou RB, Hutchison CJ. Nuclear lamins: laminopathies and their role in premature ageing. Physiol Rev 2006; 86:967 - 1008
   PubMed Web of Science ®Google Scholar
• Mallampalli MP, Huyer G, Bendale P, Gelb MH, Michaelis S. Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci USA 2005; 102:14416 - 14421
   PubMed Web of Science ®Google Scholar
• Yang SH, Bergo MO, Toth JI, Qiao X, Hu Y, Sandoval S, et al. Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation. Proc Natl Acad Sci USA 2005; 102:10291 - 10296
   PubMed Web of Science ®Google Scholar
• Ralle T, Grund C, Franke WW, Stick R. Intranuclear membrane structure formations by CaaX-containing nuclear proteins. J Cell Sci 2004; 117:6095 - 6104
   PubMed Web of Science ®Google Scholar
• Goldberg MW, Huttenlauch I, Hutchison CJ, Stick R. Filaments made from A- and B-type lamins differ in structure and organization. J Cell Sci 2008; 121:215 - 225
   PubMed Web of Science ®Google Scholar
• Prufert K, Vogel A, Krohne G. The lamin CxxM motif promotes nuclear membrane growth. J Cell Sci 2004; 117:6105 - 6116
   PubMed Web of Science ®Google Scholar
• Brandt A, Papagiannouli F, Wagner N, Wilschbrauninger M, Braun M, Furlong EE, et al. Developmental control of nuclear size and shape by Kugelkern and Kurzkern. Curr Biol 2006; 16:543 - 552
   PubMed Web of Science ®Google Scholar
• Collins JJ, Huang C, Hughe S, Kornfeld K. WormBook. The measurement and analysis of age-related changes in Caenorhabditis elegans. The C. elegans Research Community, WormBook 2008; DOI/101895/wormbook11371, http://wwwwormbookorg
   Google Scholar
• Kroll M, Arenzana-Seisdedos F, Bachelerie F, Thomas D, Friguet B, Conconi M. The secondary fungal metabolite gliotoxin targets proteolytic activities of the proteasome. Chem Biol 1999; 6:689 - 698
   PubMed Web of Science ®Google Scholar
• Young SG, Meta M, Yang SH, Fong LG. Prelamin a farnesylation and progeroid syndromes. J Biol Chem 2006; 281:39741 - 39745
   PubMed Web of Science ®Google Scholar