Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2

References

• Hunter T. When is a lipid kinase not a lipid kinase? When it is a protein kinase. Cell 1995; 83:1 - 4; http://dx.doi.org/10.1016/0092-8674(95)90225-2; PMID: 7553860
   PubMed Web of Science ®Google Scholar
• Abraham RT. PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways. DNA Repair (Amst) 2004; 3:883 - 7; http://dx.doi.org/10.1016/j.dnarep.2004.04.002; PMID: 15279773
   PubMed Web of Science ®Google Scholar
• Lovejoy CA, Cortez D. Common mechanisms of PIKK regulation. DNA Repair (Amst) 2009; http://dx.doi.org/10.1016/j.dnarep.2009.04.006; PMID: 19464237
   PubMed Web of Science ®Google Scholar
• Lavin MF. Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer. Nat Rev Mol Cell Biol 2008; 9:759 - 69; http://dx.doi.org/10.1038/nrm2514; PMID: 18813293
   PubMed Web of Science ®Google Scholar
• Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 2003; 3:155 - 68; http://dx.doi.org/10.1038/nrc1011; PMID: 12612651
   PubMed Web of Science ®Google Scholar
• Lim DS, Kirsch DG, Canman CE, Ahn JH, Ziv Y, Newman LS, et al. ATM binds to beta-adaptin in cytoplasmic vesicles. Proc Natl Acad Sci USA 1998; 95:10146 - 51; http://dx.doi.org/10.1073/pnas.95.17.10146; PMID: 9707615
   PubMed Web of Science ®Google Scholar
• Barlow C, Ribaut-Barassin C, Zwingman TA, Pope AJ, Brown KD, Owens JW, et al. ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation. Proc Natl Acad Sci USA 2000; 97:871 - 6; http://dx.doi.org/10.1073/pnas.97.2.871; PMID: 10639172
   PubMed Web of Science ®Google Scholar
• Watters D, Kedar P, Spring K, Bjorkman J, Chen P, Gatei M, et al. Localization of a portion of extranuclear ATM to peroxisomes. J Biol Chem 1999; 274:34277 - 82; http://dx.doi.org/10.1074/jbc.274.48.34277; PMID: 10567403
   PubMed Web of Science ®Google Scholar
• Li J, Han YR, Plummer MR, Herrup K. Cytoplasmic ATM in Neurons Modulates Synaptic Function. Curr Biol 2009; http://dx.doi.org/10.1016/j.cub.2009.10.039; PMID: 19962314
   PubMed Web of Science ®Google Scholar
• Yang DQ, Kastan MB. Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. Nat Cell Biol 2000; 2:893 - 8; http://dx.doi.org/10.1038/35046542; PMID: 11146653
   PubMed Web of Science ®Google Scholar
• Savitsky K, Bar-Shira A, Gilad S, Rotman G, Ziv Y, Vanagaite L, et al. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 1995; 268:1749 - 53; http://dx.doi.org/10.1126/science.7792600; PMID: 7792600
   PubMed Web of Science ®Google Scholar
• Lavin MF, Shiloh Y. The genetic defect in ataxia-telangiectasia. Annu Rev Immunol 1997; 15:177 - 202; http://dx.doi.org/10.1146/annurev.immunol.15.1.177; PMID: 9143686
   PubMed Web of Science ®Google Scholar
• Xu Y, Ashley T, Brainerd EE, Bronson RT, Meyn MS, Baltimore D. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev 1996; 10:2411 - 22; http://dx.doi.org/10.1101/gad.10.19.2411; PMID: 8843194
   PubMed Web of Science ®Google Scholar
• Hishiya A, Ito M, Aburatani H, Motoyama N, Ikeda K, Watanabe K. Ataxia telangiectasia mutated (Atm) knockout mice as a model of osteopenia due to impaired bone formation. Bone 2005; 37:497 - 503; http://dx.doi.org/10.1016/j.bone.2005.05.012; PMID: 16027059
   PubMed Web of Science ®Google Scholar
• Inomata K, Aoto T, Binh NT, Okamoto N, Tanimura S, Wakayama T, et al. Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation. Cell 2009; 137:1088 - 99; http://dx.doi.org/10.1016/j.cell.2009.03.037; PMID: 19524511
   PubMed Web of Science ®Google Scholar
• Cimprich KA, Cortez D. ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol 2008; 9:616 - 27; http://dx.doi.org/10.1038/nrm2450; PMID: 18594563
   PubMed Web of Science ®Google Scholar
• Kaygun H, Marzluff WF. Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1. Nat Struct Mol Biol 2005; 12:794 - 800; http://dx.doi.org/10.1038/nsmb972; PMID: 16086026
   PubMed Web of Science ®Google Scholar
• de Klein A, Muijtjens M, van Os R, Verhoeven Y, Smit B, Carr AM, et al. Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice. Curr Biol 2000; 10:479 - 82; http://dx.doi.org/10.1016/S0960-9822(00)00447-4; PMID: 10801416
   PubMed Web of Science ®Google Scholar
• Naumovski L, Friedberg EC. A DNA repair gene required for the incision of damaged DNA is essential for viability in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 1983; 80:4818 - 21; http://dx.doi.org/10.1073/pnas.80.15.4818; PMID: 6308653
   PubMed Web of Science ®Google Scholar
• Ruzankina Y, Pinzon-Guzman C, Asare A, Ong T, Pontano L, Cotsarelis G, et al. Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell 2007; 1:113 - 26; http://dx.doi.org/10.1016/j.stem.2007.03.002; PMID: 18371340
   PubMed Web of Science ®Google Scholar
• O'Driscoll M, Ruiz-Perez VL, Woods CG, Jeggo PA, Goodship JA. A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat Genet 2003; 33:497 - 501; http://dx.doi.org/10.1038/ng1129; PMID: 12640452
   PubMed Web of Science ®Google Scholar
• Collis SJ, DeWeese TL, Jeggo PA, Parker AR. The life and death of DNA-PK. Oncogene 2005; 24:949 - 61; http://dx.doi.org/10.1038/sj.onc.1208332; PMID: 15592499
   PubMed Web of Science ®Google Scholar
• Mahaney BL, Meek K, Lees-Miller SP. Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem J 2009; 417:639 - 50; http://dx.doi.org/10.1042/BJ20080413; PMID: 19133841
   PubMed Web of Science ®Google Scholar
• Kirchgessner CU, Patil CK, Evans JW, Cuomo CA, Fried LM, Carter T, et al. DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science 1995; 267:1178 - 83; http://dx.doi.org/10.1126/science.7855601; PMID: 7855601
   PubMed Web of Science ®Google Scholar
• Blunt T, Finnie NJ, Taccioli GE, Smith GC, Demengeot J, Gottlieb TM, et al. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 1995; 80:813 - 23; http://dx.doi.org/10.1016/0092-8674(95)90360-7; PMID: 7889575
   PubMed Web of Science ®Google Scholar
• Bozulic L, Surucu B, Hynx D, Hemmings BA. PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival. Mol Cell 2008; 30:203 - 13; http://dx.doi.org/10.1016/j.molcel.2008.02.024; PMID: 18439899
   PubMed Web of Science ®Google Scholar
• Shi M, Vivian CJ, Lee KJ, Ge C, Morotomi-Yano K, Manzl C, et al. DNA-PKcs-PIDDosome: a nuclear caspase-2-activating complex with role in G2/M checkpoint maintenance. Cell 2009; 136:508 - 20; http://dx.doi.org/10.1016/j.cell.2008.12.021; PMID: 19203584
   PubMed Web of Science ®Google Scholar
• Lucero H, Gae D, Taccioli GE. Novel localization of the DNA-PK complex in lipid rafts: a putative role in the signal transduction pathway of the ionizing radiation response. J Biol Chem 2003; 278:22136 - 43; http://dx.doi.org/10.1074/jbc.M301579200; PMID: 12672807
   PubMed Web of Science ®Google Scholar
• Powley IR, Kondrashov A, Young LA, Dobbyn HC, Hill K, Cannell IG, et al. Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes. Genes Dev 2009; 23:1207 - 20; http://dx.doi.org/10.1101/gad.516509; PMID: 19451221
   PubMed Web of Science ®Google Scholar
• Müller B, Blackburn J, Feijoo C, Zhao X, Smythe C. DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication. J Cell Biol 2007; 179:1385 - 98; http://dx.doi.org/10.1083/jcb.200708106; PMID: 18158334
   PubMed Web of Science ®Google Scholar
• Gilley D, Tanaka H, Hande MP, Kurimasa A, Li GC, Oshimura M, et al. DNA-PKcs is critical for telomere capping. Proc Natl Acad Sci USA 2001; 98:15084 - 8; http://dx.doi.org/10.1073/pnas.261574698; PMID: 11742099
   PubMed Web of Science ®Google Scholar
• Yamashita A, Kashima I, Ohno S. The role of SMG-1 in nonsense-mediated mRNA decay. Biochim Biophys Acta 2005; 1754:305 - 15; PMID: 16289965
   PubMed Web of Science ®Google Scholar
• Abraham RT. The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways. DNA Repair (Amst) 2004; 3:919 - 25; http://dx.doi.org/10.1016/j.dnarep.2004.04.003; PMID: 15279777
   PubMed Web of Science ®Google Scholar
• Yamashita A, Izumi N, Kashima I, Ohnishi T, Saari B, Katsuhata Y, et al. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev 2009; 23:1091 - 105; http://dx.doi.org/10.1101/gad.1767209; PMID: 19417104
   PubMed Web of Science ®Google Scholar
• Li S, Wilkinson MF. Nonsense surveillance in lymphocytes?. Immunity 1998; 8:135 - 41; http://dx.doi.org/10.1016/S1074-7613(00)80466-5; PMID: 9491995
   PubMed Web of Science ®Google Scholar
• Kashima I, Yamashita A, Izumi N, Kataoka N, Morishita R, Hoshino S, et al. Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. Genes Dev 2006; 20:355 - 67; http://dx.doi.org/10.1101/gad.1389006; PMID: 16452507
   PubMed Web of Science ®Google Scholar
• Ohnishi T, Yamashita A, Kashima I, Schell T, Anders KR, Grimson A, et al. Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol Cell 2003; 12:1187 - 200; http://dx.doi.org/10.1016/S1097-2765(03)00443-X; PMID: 14636577
   PubMed Web of Science ®Google Scholar
• Isken O, Kim YK, Hosoda N, Mayeur GL, Hershey JW, Maquat LE. Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay. Cell 2008; 133:314 - 27; http://dx.doi.org/10.1016/j.cell.2008.02.030; PMID: 18423202
   PubMed Web of Science ®Google Scholar
• Okada-Katsuhata Y, Yamashita A, Kutsuzawa K, Izumi N, Hirahara F, Ohno S. N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD. Nucleic Acids Res 2011; http://dx.doi.org/10.1093/nar/gkr791; PMID: 21965535
   PubMed Web of Science ®Google Scholar
• Brumbaugh KM, Otterness DM, Geisen C, Oliveira V, Brognard J, Li X, et al. The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. Mol Cell 2004; 14:585 - 98; http://dx.doi.org/10.1016/j.molcel.2004.05.005; PMID: 15175154
   PubMed Web of Science ®Google Scholar
• Chen RQ, Yang QK, Chen YL, Oliveira VA, Dalton WS, Fearns C, et al. Kinome siRNA screen identifies SMG-1 as a negative regulator of hypoxia-inducible factor-1alpha in hypoxia. J Biol Chem 2009; 284:16752 - 8; http://dx.doi.org/10.1074/jbc.M109.014316; PMID: 19406746
   PubMed Web of Science ®Google Scholar
• Brown JA, Roberts TL, Richards R, Woods R, Birrell G, Lim YC, et al. A Novel Role for hSMG-1 in Stress Granule Formation. Mol Cell Biol 2011; 31:4417 - 29; http://dx.doi.org/10.1128/MCB.05987-11; PMID: 21911475
   PubMed Web of Science ®Google Scholar
• Oliveira V, Romanow WJ, Geisen C, Otterness DM, Mercurio F, Wang HG, et al. A protective role for the human SMG-1 kinase against tumor necrosis factor-alpha-induced apoptosis. J Biol Chem 2008; 283:13174 - 84; http://dx.doi.org/10.1074/jbc.M708008200; PMID: 18326048
   PubMed Web of Science ®Google Scholar
• Azzalin CM, Reichenbach P, Khoriauli L, Giulotto E, Lingner J. Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science 2007; 318:798 - 801; http://dx.doi.org/10.1126/science.1147182; PMID: 17916692
   PubMed Web of Science ®Google Scholar
• McIlwain DR, Pan Q, Reilly PT, Elia AJ, McCracken S, Wakeham AC, et al. Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay. Proc Natl Acad Sci USA 2010; 107:12186 - 91; http://dx.doi.org/10.1073/pnas.1007336107; PMID: 20566848
   PubMed Web of Science ®Google Scholar
• Hodgkin J, Papp A, Pulak R, Ambros V, Anderson P. A new kind of informational suppression in the nematode Caenorhabditis elegans. Genetics 1989; 123:301 - 13; PMID: 2583479
   PubMed Web of Science ®Google Scholar
• Chen Z, Smith KR, Batterham P, Robin C. Smg1 nonsense mutations do not abolish nonsense-mediated mRNA decay in Drosophila melanogaster. Genetics 2005; 171:403 - 6; http://dx.doi.org/10.1534/genetics.105.045674; PMID: 15965240
   PubMed Web of Science ®Google Scholar
• Masse I, Molin L, Mouchiroud L, Vanhems P, Palladino F, Billaud M, et al. A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans. PLoS ONE 2008; 3:e3354; http://dx.doi.org/10.1371/journal.pone.0003354; PMID: 18836529
   PubMedGoogle Scholar
• Jorgensen EM, Mango SE. The art and design of genetic screens: caenorhabditis elegans. Nat Rev Genet 2002; 3:356 - 69; http://dx.doi.org/10.1038/nrg794; PMID: 11988761
   PubMed Web of Science ®Google Scholar
• Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006; 124:471 - 84; http://dx.doi.org/10.1016/j.cell.2006.01.016; PMID: 16469695
   PubMed Web of Science ®Google Scholar
• Heitman J, Movva NR, Hall MN. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 1991; 253:905 - 9; http://dx.doi.org/10.1126/science.1715094; PMID: 1715094
   PubMed Web of Science ®Google Scholar
• Sabatini DM, Erdjument-Bromage H, Lui M, Tempst P, Snyder SH. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 1994; 78:35 - 43; http://dx.doi.org/10.1016/0092-8674(94)90570-3; PMID: 7518356
   PubMed Web of Science ®Google Scholar
• Ma XM, Blenis J. Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol 2009; 10:307 - 18; http://dx.doi.org/10.1038/nrm2672; PMID: 19339977
   PubMed Web of Science ®Google Scholar
• Mayer C, Grummt I. Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases. Oncogene 2006; 25:6384 - 91; http://dx.doi.org/10.1038/sj.onc.1209883; PMID: 17041624
   PubMed Web of Science ®Google Scholar
• Ma XM, Yoon SO, Richardson CJ, Julich K, Blenis J. SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. Cell 2008; 133:303 - 13; http://dx.doi.org/10.1016/j.cell.2008.02.031; PMID: 18423201
   PubMed Web of Science ®Google Scholar
• Ruvinsky I, Sharon N, Lerer T, Cohen H, Stolovich-Rain M, Nir T, et al. Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev 2005; 19:2199 - 211; http://dx.doi.org/10.1101/gad.351605; PMID: 16166381
   PubMed Web of Science ®Google Scholar
• Chang YY, Juhasz G, Goraksha-Hicks P, Arsham AM, Mallin DR, Muller LK, et al. Nutrient-dependent regulation of autophagy through the target of rapamycin pathway. Biochem Soc Trans 2009; 37:232 - 6; http://dx.doi.org/10.1042/BST0370232; PMID: 19143638
   PubMed Web of Science ®Google Scholar
• Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004; 14:1296 - 302; http://dx.doi.org/10.1016/j.cub.2004.06.054; PMID: 15268862
   PubMed Web of Science ®Google Scholar
• Jacinto E, Loewith R, Schmidt A, Lin S, Ruegg MA, Hall A, et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 2004; 6:1122 - 8; http://dx.doi.org/10.1038/ncb1183; PMID: 15467718
   PubMed Web of Science ®Google Scholar
• Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307:1098 - 101; http://dx.doi.org/10.1126/science.1106148; PMID: 15718470
   PubMed Web of Science ®Google Scholar
• García-Martínez JM, Alessi DR. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem J 2008; 416:375 - 85; http://dx.doi.org/10.1042/BJ20081668; PMID: 18925875
   PubMed Web of Science ®Google Scholar
• Jones KT, Greer ER, Pearce D, Ashrafi K. Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1. PLoS Biol 2009; 7:e60; http://dx.doi.org/10.1371/journal.pbio.1000060; PMID: 19260765
   PubMed Web of Science ®Google Scholar
• Soukas AA, Kane EA, Carr CE, Melo JA, Ruvkun G. Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev 2009; 23:496 - 511; http://dx.doi.org/10.1101/gad.1775409; PMID: 19240135
   PubMed Web of Science ®Google Scholar
• Gangloff YG, Mueller M, Dann SG, Svoboda P, Sticker M, Spetz JF, et al. Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol 2004; 24:9508 - 16; http://dx.doi.org/10.1128/MCB.24.21.9508-9516.2004; PMID: 15485918
   PubMed Web of Science ®Google Scholar
• Murakami M, Ichisaka T, Maeda M, Oshiro N, Hara K, Edenhofer F, et al. mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol Cell Biol 2004; 24:6710 - 8; http://dx.doi.org/10.1128/MCB.24.15.6710-6718.2004; PMID: 15254238
   PubMed Web of Science ®Google Scholar
• Stanfel MN, Shamieh LS, Kaeberlein M, Kennedy BK. The TOR pathway comes of age. Biochim Biophys Acta 2009; 1790:1067 - 74; http://dx.doi.org/10.1016/j.bbagen.2009.06.007; PMID: 19539012
   PubMed Web of Science ®Google Scholar
• Murr R, Vaissiere T, Sawan C, Shukla V, Herceg Z. Orchestration of chromatin-based processes: mind the TRRAP. Oncogene 2007; 26:5358 - 72; http://dx.doi.org/10.1038/sj.onc.1210605; PMID: 17694078
   PubMed Web of Science ®Google Scholar
• McMahon SB, Van Buskirk HA, Dugan KA, Copeland TD, Cole MD. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell 1998; 94:363 - 74; http://dx.doi.org/10.1016/S0092-8674(00)81479-8; PMID: 9708738
   PubMed Web of Science ®Google Scholar
• Herceg Z, Li H, Cuenin C, Shukla V, Radolf M, Steinlein P, et al. Genome-wide analysis of gene expression regulated by the HAT cofactor Trrap in conditional knockout cells. Nucleic Acids Res 2003; 31:7011 - 23; http://dx.doi.org/10.1093/nar/gkg902; PMID: 14627834
   PubMed Web of Science ®Google Scholar
• Herceg Z, Hulla W, Gell D, Cuenin C, Lleonart M, Jackson S, et al. Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression. Nat Genet 2001; 29:206 - 11; http://dx.doi.org/10.1038/ng725; PMID: 11544477
   PubMed Web of Science ®Google Scholar
• Saleh A, Schieltz D, Ting N, McMahon SB, Litchfield DW, Yates JR 3rd, et al. Tra1p is a component of the yeast Ada.Spt transcriptional regulatory complexes. J Biol Chem 1998; 273:26559 - 65; http://dx.doi.org/10.1074/jbc.273.41.26559; PMID: 9756893
   PubMed Web of Science ®Google Scholar
• Murr R, Loizou JI, Yang YG, Cuenin C, Li H, Wang ZQ, et al. Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks. Nat Cell Biol 2006; 8:91 - 9; http://dx.doi.org/10.1038/ncb1343; PMID: 16341205
   PubMed Web of Science ®Google Scholar
• Robert F, Hardy S, Nagy Z, Baldeyron C, Murr R, Dery U, et al. The transcriptional histone acetyltransferase cofactor TRRAP associates with the MRN repair complex and plays a role in DNA double-strand break repair. Mol Cell Biol 2006; 26:402 - 12; http://dx.doi.org/10.1128/MCB.26.2.402-412.2006; PMID: 16382133
   PubMed Web of Science ®Google Scholar
• Jha S, Dutta A. RVB1/RVB2: running rings around molecular biology. Mol Cell 2009; 34:521 - 33; http://dx.doi.org/10.1016/j.molcel.2009.05.016; PMID: 19524533
   PubMed Web of Science ®Google Scholar
• West SC. Processing of recombination intermediates by the RuvABC proteins. Annu Rev Genet 1997; 31:213 - 44; http://dx.doi.org/10.1146/annurev.genet.31.1.213; PMID: 9442895
   PubMed Web of Science ®Google Scholar
• Yamada K, Ariyoshi M, Morikawa K. Three-dimensional structural views of branch migration and resolution in DNA homologous recombination. Curr Opin Struct Biol 2004; 14:130 - 7; http://dx.doi.org/10.1016/j.sbi.2004.03.005; PMID: 15093826
   PubMed Web of Science ®Google Scholar
• Kanemaki M, Kurokawa Y, Matsu-ura T, Makino Y, Masani A, Okazaki K, et al. TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a. J Biol Chem 1999; 274:22437 - 44; http://dx.doi.org/10.1074/jbc.274.32.22437; PMID: 10428817
   PubMed Web of Science ®Google Scholar
• Torreira E, Jha S, Lopez-Blanco JR, Arias-Palomo E, Chacon P, Canas C, et al. Architecture of the pontin/reptin complex, essential in the assembly of several macromolecular complexes. Structure 2008; 16:1511 - 20; http://dx.doi.org/10.1016/j.str.2008.08.009; PMID: 18940606
   PubMed Web of Science ®Google Scholar
• Puri T, Wendler P, Sigala B, Saibil H, Tsaneva IR. Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex. J Mol Biol 2007; 366:179 - 92; http://dx.doi.org/10.1016/j.jmb.2006.11.030; PMID: 17157868
   PubMed Web of Science ®Google Scholar
• Kim JH, Kim B, Cai L, Choi HJ, Ohgi KA, Tran C, et al. Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes. Nature 2005; 434:921 - 6; http://dx.doi.org/10.1038/nature03452; PMID: 15829968
   PubMed Web of Science ®Google Scholar
• Diop SB, Bertaux K, Vasanthi D, Sarkeshik A, Goirand B, Aragnol D, et al. Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control. EMBO Rep 2008; 9:260 - 6; http://dx.doi.org/10.1038/embor.2008.8; PMID: 18259215
   PubMed Web of Science ®Google Scholar
• Izumi N, Yamashita A, Iwamatsu A, Kurata R, Nakamura H, Saari B, et al. AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay. Sci Signal 2010; 3:ra27; http://dx.doi.org/10.1126/scisignal.2000468; PMID: 20371770
   PubMed Web of Science ®Google Scholar
• Venteicher AS, Meng Z, Mason PJ, Veenstra TD, Artandi SE. Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly. Cell 2008; 132:945 - 57; http://dx.doi.org/10.1016/j.cell.2008.01.019; PMID: 18358808
   PubMed Web of Science ®Google Scholar
• Matias PM, Gorynia S, Donner P, Carrondo MA. Crystal structure of the human AAA+ protein RuvBL1. J Biol Chem 2006; 281:38918 - 29; http://dx.doi.org/10.1074/jbc.M605625200; PMID: 17060327
   PubMed Web of Science ®Google Scholar
• Qiu XB, Lin YL, Thome KC, Pian P, Schlegel BP, Weremowicz S, et al. An eukaryotic RuvB-like protein (RUVBL1) essential for growth. J Biol Chem 1998; 273:27786 - 93; http://dx.doi.org/10.1074/jbc.273.43.27786; PMID: 9774387
   PubMed Web of Science ®Google Scholar
• Bauer A, Chauvet S, Huber O, Usseglio F, Rothbacher U, Aragnol D, et al. Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity. EMBO J 2000; 19:6121 - 30; http://dx.doi.org/10.1093/emboj/19.22.6121; PMID: 11080158
   PubMed Web of Science ®Google Scholar
• Gallant P. Control of transcription by Pontin and Reptin. Trends Cell Biol 2007; 17:187 - 92; http://dx.doi.org/10.1016/j.tcb.2007.02.005; PMID: 17320397
   PubMed Web of Science ®Google Scholar
• Shen X, Mizuguchi G, Hamiche A, Wu C. A chromatin remodelling complex involved in transcription and DNA processing. Nature 2000; 406:541 - 4; http://dx.doi.org/10.1038/35020123; PMID: 10952318
   PubMed Web of Science ®Google Scholar
• Mizuguchi G, Shen X, Landry J, Wu WH, Sen S, Wu C. ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 2004; 303:343 - 8; http://dx.doi.org/10.1126/science.1090701; PMID: 14645854
   PubMed Web of Science ®Google Scholar
• Ikura T, Ogryzko VV, Grigoriev M, Groisman R, Wang J, Horikoshi M, et al. Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell 2000; 102:463 - 73; http://dx.doi.org/10.1016/S0092-8674(00)00051-9; PMID: 10966108
   PubMed Web of Science ®Google Scholar
• Jónsson ZO, Jha S, Wohlschlegel JA, Dutta A. Rvb1p/Rvb2p recruit Arp5p and assemble a functional Ino80 chromatin remodeling complex. Mol Cell 2004; 16:465 - 77; http://dx.doi.org/10.1016/j.molcel.2004.09.033; PMID: 15525518
   PubMed Web of Science ®Google Scholar
• Jha S, Shibata E, Dutta A. Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage. Mol Cell Biol 2008; 28:2690 - 700; http://dx.doi.org/10.1128/MCB.01983-07; PMID: 18285460
   PubMed Web of Science ®Google Scholar
• Morrison AJ, Shen X. DNA repair in the context of chromatin. Cell Cycle 2005; 4:568 - 71; http://dx.doi.org/10.4161/cc.4.4.1612; PMID: 15753656
   PubMed Web of Science ®Google Scholar
• van Attikum H, Gasser SM. The histone code at DNA breaks: a guide to repair?. Nat Rev Mol Cell Biol 2005; 6:757 - 65; http://dx.doi.org/10.1038/nrm1737; PMID: 16167054
   PubMed Web of Science ®Google Scholar
• Jónsson ZO, Dhar SK, Narlikar GJ, Auty R, Wagle N, Pellman D, et al. Rvb1p and Rvb2p are essential components of a chromatin remodeling complex that regulates transcription of over 5% of yeast genes. J Biol Chem 2001; 276:16279 - 88; http://dx.doi.org/10.1074/jbc.M011523200; PMID: 11278922
   PubMed Web of Science ®Google Scholar
• Matera AG, Terns RM, Terns MP. Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs. Nat Rev Mol Cell Biol 2007; 8:209 - 20; http://dx.doi.org/10.1038/nrm2124; PMID: 17318225
   PubMed Web of Science ®Google Scholar
• King TH, Decatur WA, Bertrand E, Maxwell ES, Fournier MJ. A well-connected and conserved nucleoplasmic helicase is required for production of box C/D and H/ACA snoRNAs and localization of snoRNP proteins. Mol Cell Biol 2001; 21:7731 - 46; http://dx.doi.org/10.1128/MCB.21.22.7731-7746.2001; PMID: 11604509
   PubMed Web of Science ®Google Scholar
• Watkins NJ, Lemm I, Ingelfinger D, Schneider C, Hossbach M, Urlaub H, et al. Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex. Mol Cell 2004; 16:789 - 98; http://dx.doi.org/10.1016/j.molcel.2004.11.012; PMID: 15574333
   PubMed Web of Science ®Google Scholar
• Zhao R, Davey M, Hsu YC, Kaplanek P, Tong A, Parsons AB, et al. Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell 2005; 120:715 - 27; http://dx.doi.org/10.1016/j.cell.2004.12.024; PMID: 15766533
   PubMed Web of Science ®Google Scholar
• Te J, Jia L, Rogers J, Miller A, Hartson SD. Novel subunits of the mammalian Hsp90 signal transduction chaperone. J Proteome Res 2007; 6:1963 - 73; http://dx.doi.org/10.1021/pr060595i; PMID: 17348703
   PubMed Web of Science ®Google Scholar
• Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, et al. Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI. Science 2003; 302:1208 - 12; http://dx.doi.org/10.1126/science.1088401; PMID: 14615539
   PubMed Web of Science ®Google Scholar
• Ducat D, Kawaguchi S, Liu H, Yates JR 3rd, Zheng Y. Regulation of microtubule assembly and organization in mitosis by the AAA+ ATPase Pontin. Mol Biol Cell 2008; 19:3097 - 110; http://dx.doi.org/10.1091/mbc.E07-11-1202; PMID: 18463163
   PubMed Web of Science ®Google Scholar
• Sigala B, Edwards M, Puri T, Tsaneva IR. Relocalization of human chromatin remodeling cofactor TIP48 in mitosis. Exp Cell Res 2005; 310:357 - 69; http://dx.doi.org/10.1016/j.yexcr.2005.07.030; PMID: 16157330
   PubMed Web of Science ®Google Scholar
• Skop AR, Liu H, Yates J 3rd, Meyer BJ, Heald R. Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science 2004; 305:61 - 6; http://dx.doi.org/10.1126/science.1097931; PMID: 15166316
   PubMed Web of Science ®Google Scholar
• Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007; 316:1160 - 6; http://dx.doi.org/10.1126/science.1140321; PMID: 17525332
   PubMed Web of Science ®Google Scholar
• Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA, et al. E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev 2002; 16:245 - 56; http://dx.doi.org/10.1101/gad.949802; PMID: 11799067
   PubMed Web of Science ®Google Scholar
• Berkovich E, Ginsberg D. ATM is a target for positive regulation by E2F-1. Oncogene 2003; 22:161 - 7; http://dx.doi.org/10.1038/sj.onc.1206144; PMID: 12527885
   PubMed Web of Science ®Google Scholar
• Cole MD, Cowling VH. Specific regulation of mRNA cap methylation by the c-Myc and E2F1 transcription factors. Oncogene 2009; 28:1169 - 75; http://dx.doi.org/10.1038/onc.2008.463; PMID: 19137018
   PubMed Web of Science ®Google Scholar
• Arias-Palomo E, Yamashita A, Fernandez IS, Nunez-Ramirez R, Bamba Y, Izumi N, et al. The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8. Genes Dev 2011; 25:153 - 64; http://dx.doi.org/10.1101/gad.606911; PMID: 21245168
   PubMed Web of Science ®Google Scholar
• Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002; 110:163 - 75; http://dx.doi.org/10.1016/S0092-8674(02)00808-5; PMID: 12150925
   PubMed Web of Science ®Google Scholar
• Ball HL, Myers JS, Cortez D. ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. Mol Biol Cell 2005; 16:2372 - 81; http://dx.doi.org/10.1091/mbc.E04-11-1006; PMID: 15743907
   PubMed Web of Science ®Google Scholar
• You Z, Chahwan C, Bailis J, Hunter T, Russell P. ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol Cell Biol 2005; 25:5363 - 79; http://dx.doi.org/10.1128/MCB.25.13.5363-5379.2005; PMID: 15964794
   PubMed Web of Science ®Google Scholar
• Sun Y, Jiang X, Chen S, Fernandes N, Price BD. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc Natl Acad Sci USA 2005; 102:13182 - 7; http://dx.doi.org/10.1073/pnas.0504211102; PMID: 16141325
   PubMed Web of Science ®Google Scholar
• Morita T, Yamashita A, Kashima I, Ogata K, Ishiura S, Ohno S. Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay. J Biol Chem 2007; 282:7799 - 808; http://dx.doi.org/10.1074/jbc.M610159200; PMID: 17229728
   PubMed Web of Science ®Google Scholar
• Priestley A, Beamish HJ, Gell D, Amatucci AG, Muhlmann-Diaz MC, Singleton BK, et al. Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20. Nucleic Acids Res 1998; 26:1965 - 73; http://dx.doi.org/10.1093/nar/26.8.1965; PMID: 9518490
   PubMed Web of Science ®Google Scholar
• Beamish HJ, Jessberger R, Riballo E, Priestley A, Blunt T, Kysela B, et al. The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity. Nucleic Acids Res 2000; 28:1506 - 13; http://dx.doi.org/10.1093/nar/28.7.1506; PMID: 10710416
   PubMed Web of Science ®Google Scholar
• Takahashi T, Hara K, Inoue H, Kawa Y, Tokunaga C, Hidayat S, et al. Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro. Genes Cells 2000; 5:765 - 75; http://dx.doi.org/10.1046/j.1365-2443.2000.00365.x; PMID: 10971657
   PubMed Web of Science ®Google Scholar
• Jiang X, Sun Y, Chen S, Roy K, Price BD. The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM. J Biol Chem 2006; 281:15741 - 6; http://dx.doi.org/10.1074/jbc.M513172200; PMID: 16603769
   PubMed Web of Science ®Google Scholar
• Zhang S, Hemmerich P, Grosse F. Centrosomal localization of DNA damage checkpoint proteins. J Cell Biochem 2007; 101:451 - 65; http://dx.doi.org/10.1002/jcb.21195; PMID: 17171639
   PubMed Web of Science ®Google Scholar
• Smith E, Dejsuphong D, Balestrini A, Hampel M, Lenz C, Takeda S, et al. An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63. Nat Cell Biol 2009; 11:278 - 85; http://dx.doi.org/10.1038/ncb1835; PMID: 19182792
   PubMed Web of Science ®Google Scholar
• Gartner W, Rossbacher J, Zierhut B, Daneva T, Base W, Weissel M, et al. The ATP-dependent helicase RUVBL1/TIP49a associates with tubulin during mitosis. Cell Motil Cytoskeleton 2003; 56:79 - 93; http://dx.doi.org/10.1002/cm.10136; PMID: 14506706
   PubMed Web of Science ®Google Scholar
• Sheaffer KL, Updike DL, Mango SE. The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging. Curr Biol 2008; 18:1355 - 64; http://dx.doi.org/10.1016/j.cub.2008.07.097; PMID: 18804378
   PubMed Web of Science ®Google Scholar
• Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, Lukas J, et al. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol 2006; 8:37 - 45; http://dx.doi.org/10.1038/ncb1337; PMID: 16327781
   PubMed Web of Science ®Google Scholar
• Myers JS, Cortez D. Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J Biol Chem 2006; 281:9346 - 50; http://dx.doi.org/10.1074/jbc.M513265200; PMID: 16431910
   PubMed Web of Science ®Google Scholar
• Stiff T, Walker SA, Cerosaletti K, Goodarzi AA, Petermann E, Concannon P, et al. ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J 2006; 25:5775 - 82; http://dx.doi.org/10.1038/sj.emboj.7601446; PMID: 17124492
   PubMed Web of Science ®Google Scholar
• Chen BP, Uematsu N, Kobayashi J, Lerenthal Y, Krempler A, Yajima H, et al. Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break. J Biol Chem 2007; 282:6582 - 7; http://dx.doi.org/10.1074/jbc.M611605200; PMID: 17189255
   PubMed Web of Science ®Google Scholar
• Yajima H, Lee KJ, Chen BP. ATR-dependent phosphorylation of DNA-dependent protein kinase catalytic subunit in response to UV-induced replication stress. Mol Cell Biol 2006; 26:7520 - 8; http://dx.doi.org/10.1128/MCB.00048-06; PMID: 16908529
   PubMed Web of Science ®Google Scholar
• Izumi N, Yamashita A, Hirano H, Ohno S. Hsp90 regulates PIKK family proteins together with the RUVBL1/2 and Tel2-containing co-factor complex. Cancer Sci 2012; 103:50 - 7; http://dx.doi.org/10.1111/j.1349-7006.2011.02112.x; PMID: 21951644
   PubMed Web of Science ®Google Scholar
• Peng Y, Woods RG, Beamish H, Ye R, Lees-Miller SP, Lavin MF, et al. Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. Cancer Res 2005; 65:1670 - 7; http://dx.doi.org/10.1158/0008-5472.CAN-04-3451; PMID: 15753361
   PubMed Web of Science ®Google Scholar
• Feng Z, Zhang H, Levine AJ, Jin S. The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci USA 2005; 102:8204 - 9; http://dx.doi.org/10.1073/pnas.0502857102; PMID: 15928081
   PubMed Web of Science ®Google Scholar
• Schonbrun M, Laor D, Lopez-Maury L, Bahler J, Kupiec M, Weisman R. TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions. Mol Cell Biol 2009; 29:4584 - 94; http://dx.doi.org/10.1128/MCB.01879-08; PMID: 19546237
   PubMed Web of Science ®Google Scholar
• Beuvink I, Boulay A, Fumagalli S, Zilbermann F, Ruetz S, O'Reilly T, et al. The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Cell 2005; 120:747 - 59; http://dx.doi.org/10.1016/j.cell.2004.12.040; PMID: 15797377
   PubMed Web of Science ®Google Scholar
• Shen C, Lancaster CS, Shi B, Guo H, Thimmaiah P, Bjornsti MA. TOR signaling is a determinant of cell survival in response to DNA damage. Mol Cell Biol 2007; 27:7007 - 17; http://dx.doi.org/10.1128/MCB.00290-07; PMID: 17698581
   PubMed Web of Science ®Google Scholar
• O'Sullivan RJ, Karlseder J. Telomeres: protecting chromosomes against genome instability. Nat Rev Mol Cell Biol 2010; 11:171 - 81; PMID: 20125188
   PubMed Web of Science ®Google Scholar
• d'Adda di Fagagna F, Teo SH, Jackson SP. Functional links between telomeres and proteins of the DNA-damage response. Genes Dev 2004; 18:1781 - 99; http://dx.doi.org/10.1101/gad.1214504; PMID: 15289453
   PubMed Web of Science ®Google Scholar
• Moser BA, Subramanian L, Khair L, Chang YT, Nakamura TM. Fission yeast Tel1(ATM) and Rad3(ATR) promote telomere protection and telomerase recruitment. PLoS Genet 2009; 5:e1000622; http://dx.doi.org/10.1371/journal.pgen.1000622; PMID: 19714219
   PubMedGoogle Scholar
• Verdun RE, Karlseder J. The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. Cell 2006; 127:709 - 20; http://dx.doi.org/10.1016/j.cell.2006.09.034; PMID: 17110331
   PubMed Web of Science ®Google Scholar
• Nikiforov MA, Chandriani S, Park J, Kotenko I, Matheos D, Johnsson A, et al. TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins. Mol Cell Biol 2002; 22:5054 - 63; http://dx.doi.org/10.1128/MCB.22.14.5054-5063.2002; PMID: 12077335
   PubMed Web of Science ®Google Scholar
• Atanassov BS, Evrard YA, Multani AS, Zhang Z, Tora L, Devys D, et al. Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance. Mol Cell 2009; 35:352 - 64; http://dx.doi.org/10.1016/j.molcel.2009.06.015; PMID: 19683498
   PubMed Web of Science ®Google Scholar
• Zhou C, Gehrig PA, Whang YE, Boggess JF. Rapamycin inhibits telomerase activity by decreasing the hTERT mRNA level in endometrial cancer cells. Mol Cancer Ther 2003; 2:789 - 95; PMID: 12939469
   PubMed Web of Science ®Google Scholar
• Chen YC, Teng SC, Wu KJ. Phosphorylation of telomeric repeat binding factor 1 (TRF1) by Akt causes telomere shortening. Cancer Invest 2009; 27:24 - 8; http://dx.doi.org/10.1080/07357900802027081; PMID: 19160102
   PubMed Web of Science ®Google Scholar
• Takai H, Wang RC, Takai KK, Yang H, de Lange T. Tel2 regulates the stability of PI3K-related protein kinases. Cell 2007; 131:1248 - 59; http://dx.doi.org/10.1016/j.cell.2007.10.052; PMID: 18160036
   PubMed Web of Science ®Google Scholar
• Hurov KE, Cotta-Ramusino C, Elledge SJ. A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. Genes Dev 2010; 24:1939 - 50; http://dx.doi.org/10.1101/gad.1934210; PMID: 20810650
   PubMed Web of Science ®Google Scholar
• Takai H, Xie Y, de Lange T, Pavletich NP. Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev 2010; http://dx.doi.org/10.1101/gad.1956410; PMID: 20801936
   PubMed Web of Science ®Google Scholar
• Hayashi T, Hatanaka M, Nagao K, Nakaseko Y, Kanoh J, Kokubu A, et al. Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits. Genes Cells 2007; 12:1357 - 70; http://dx.doi.org/10.1111/j.1365-2443.2007.01141.x; PMID: 18076573
   PubMed Web of Science ®Google Scholar
• Kaizuka T, Hara T, Oshiro N, Kikkawa U, Yonezawa K, Takehana K, et al. Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. J Biol Chem 2010; 285:20109 - 16; http://dx.doi.org/10.1074/jbc.M110.121699; PMID: 20427287
   PubMed Web of Science ®Google Scholar
• Collis SJ, Barber LJ, Clark AJ, Martin JS, Ward JD, Boulton SJ. HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability. Nat Cell Biol 2007; 9:391 - 401; http://dx.doi.org/10.1038/ncb1555; PMID: 17384638
   PubMed Web of Science ®Google Scholar
• Anderson CM, Korkin D, Smith DL, Makovets S, Seidel JJ, Sali A, et al. Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break. Genes Dev 2008; 22:854 - 9; http://dx.doi.org/10.1101/gad.1646208; PMID: 18334620
   PubMed Web of Science ®Google Scholar
• Shikata M, Ishikawa F, Kanoh J. Tel2 is required for activation of the Mrc1-mediated replication checkpoint. J Biol Chem 2007; 282:5346 - 55; http://dx.doi.org/10.1074/jbc.M607432200; PMID: 17189249
   PubMed Web of Science ®Google Scholar
• Rendtlew Danielsen JM, Larsen DH, Schou KB, Freire R, Falck J, Bartek J, et al. HCLK2 is required for activity of the DNA damage response kinase ATR. J Biol Chem 2009; 284:4140 - 7; http://dx.doi.org/10.1074/jbc.M808174200; PMID: 19097996
   PubMed Web of Science ®Google Scholar
• Taipale M, Jarosz DF, Lindquist S. HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol 2010; 11:515 - 28; http://dx.doi.org/10.1038/nrm2918; PMID: 20531426
   PubMed Web of Science ®Google Scholar
• Falsone SF, Gesslbauer B, Tirk F, Piccinini AM, Kungl AJ. A proteomic snapshot of the human heat shock protein 90 interactome. FEBS Lett 2005; 579:6350 - 4; http://dx.doi.org/10.1016/j.febslet.2005.10.020; PMID: 16263121
   PubMed Web of Science ®Google Scholar
• Dote H, Burgan WE, Camphausen K, Tofilon PJ. Inhibition of hsp90 compromises the DNA damage response to radiation. Cancer Res 2006; 66:9211 - 20; http://dx.doi.org/10.1158/0008-5472.CAN-06-2181; PMID: 16982765
   PubMed Web of Science ®Google Scholar
• Ohji G, Hidayat S, Nakashima A, Tokunaga C, Oshiro N, Yoshino K, et al. Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin. J Biochem 2006; 139:129 - 35; http://dx.doi.org/10.1093/jb/mvj008; PMID: 16428328
   PubMed Web of Science ®Google Scholar
• Eckert K, Saliou JM, Monlezun L, Vigouroux A, Atmane N, Caillat C, et al. The Pih1-Tah1 cochaperone complex inhibits Hsp90 molecular chaperone ATPase activity. J Biol Chem 2010; http://dx.doi.org/10.1074/jbc.M110.138263; PMID: 20663878
   PubMed Web of Science ®Google Scholar
• Millson SH, Vaughan CK, Zhai C, Ali MM, Panaretou B, Piper PW, et al. Chaperone ligand-discrimination by the TPR-domain protein Tah1. Biochem J 2008; 413:261 - 8; http://dx.doi.org/10.1042/BJ20080105; PMID: 18412542
   PubMed Web of Science ®Google Scholar
• Hahn JS. The Hsp90 chaperone machinery: from structure to drug development. BMB Rep 2009; 42:623 - 30; http://dx.doi.org/10.5483/BMBRep.2009.42.10.623; PMID: 19874705
   PubMed Web of Science ®Google Scholar
• Hanson PI, Whiteheart SW. AAA+ proteins: have engine, will work. Nat Rev Mol Cell Biol 2005; 6:519 - 29; http://dx.doi.org/10.1038/nrm1684; PMID: 16072036
   PubMed Web of Science ®Google Scholar
• Young JC, Agashe VR, Siegers K, Hartl FU. Pathways of chaperone-mediated protein folding in the cytosol. Nat Rev Mol Cell Biol 2004; 5:781 - 91; http://dx.doi.org/10.1038/nrm1492; PMID: 15459659
   PubMed Web of Science ®Google Scholar
• Cloutier P, Al-Khoury R, Lavallee-Adam M, Faubert D, Jiang H, Poitras C, et al. High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes. Methods 2009; 48:381 - 6; http://dx.doi.org/10.1016/j.ymeth.2009.05.005; PMID: 19450687
   PubMed Web of Science ®Google Scholar
• Djouder N, Metzler SC, Schmidt A, Wirbelauer C, Gstaiger M, Aebersold R, et al. S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. Mol Cell 2007; 28:28 - 40; http://dx.doi.org/10.1016/j.molcel.2007.08.010; PMID: 17936702
   PubMed Web of Science ®Google Scholar
• Parusel CT, Kritikou EA, Hengartner MO, Krek W, Gotta M. URI-1 is required for DNA stability in C. elegans. Development 2006; 133:621 - 9; http://dx.doi.org/10.1242/dev.02235; PMID: 16436622
   PubMed Web of Science ®Google Scholar
• Woychik NA, Liao SM, Kolodziej PA, Young RA. Subunits shared by eukaryotic nuclear RNA polymerases. Genes Dev 1990; 4:313 - 23; http://dx.doi.org/10.1101/gad.4.3.313; PMID: 2186966
   PubMed Web of Science ®Google Scholar
• Dorjsuren D, Lin Y, Wei W, Yamashita T, Nomura T, Hayashi N, et al. RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein. Mol Cell Biol 1998; 18:7546 - 55; PMID: 9819440
   PubMed Web of Science ®Google Scholar
• Itsuki Y, Saeki M, Nakahara H, Egusa H, Irie Y, Terao Y, et al. Molecular cloning of novel Monad binding protein containing tetratricopeptide repeat domains. FEBS Lett 2008; 582:2365 - 70; http://dx.doi.org/10.1016/j.febslet.2008.05.041; PMID: 18538670
   PubMed Web of Science ®Google Scholar
• Horejsí Z, Takai H, Adelman CA, Collis SJ, Flynn H, Maslen S, et al. CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. Mol Cell 2010; 39:839 - 50; http://dx.doi.org/10.1016/j.molcel.2010.08.037; PMID: 20864032
   PubMed Web of Science ®Google Scholar
• Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, et al. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Mol Cell 2007; 27:262 - 74; http://dx.doi.org/10.1016/j.molcel.2007.06.027; PMID: 17643375
   PubMed Web of Science ®Google Scholar
• Boulon S, Pradet-Balade B, Verheggen C, Molle D, Boireau S, Georgieva M, et al. HSP90 and its R2TP/Prefoldin-like cochaperone are involved in the cytoplasmic assembly of RNA polymerase II. Mol Cell 2010; 39:912 - 24; http://dx.doi.org/10.1016/j.molcel.2010.08.023; PMID: 20864038
   PubMed Web of Science ®Google Scholar
• Boulon S, Marmier-Gourrier N, Pradet-Balade B, Wurth L, Verheggen C, Jady BE, et al. The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery. J Cell Biol 2008; 180:579 - 95; http://dx.doi.org/10.1083/jcb.200708110; PMID: 18268104
   PubMed Web of Science ®Google Scholar
• Zhao R, Kakihara Y, Gribun A, Huen J, Yang G, Khanna M, et al. Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation. J Cell Biol 2008; 180:563 - 78; http://dx.doi.org/10.1083/jcb.200709061; PMID: 18268103
   PubMed Web of Science ®Google Scholar
• Easton JB, Houghton PJ. mTOR and cancer therapy. Oncogene 2006; 25:6436 - 46; http://dx.doi.org/10.1038/sj.onc.1209886; PMID: 17041628
   PubMed Web of Science ®Google Scholar
• Helleday T, Petermann E, Lundin C, Hodgson B, Sharma RA. DNA repair pathways as targets for cancer therapy. Nat Rev Cancer 2008; 8:193 - 204; http://dx.doi.org/10.1038/nrc2342; PMID: 18256616
   PubMed Web of Science ®Google Scholar
• Pastor F, Kolonias D, Giangrande PH, Gilboa E. Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay. Nature 2010; 465:227 - 30; http://dx.doi.org/10.1038/nature08999; PMID: 20463739
   PubMed Web of Science ®Google Scholar
• Harley CB. Telomerase and cancer therapeutics. Nat Rev Cancer 2008; 8:167 - 79; http://dx.doi.org/10.1038/nrc2275; PMID: 18256617
   PubMed Web of Science ®Google Scholar
• Taldone T, Gozman A, Maharaj R, Chiosis G. Targeting Hsp90: small-molecule inhibitors and their clinical development. Curr Opin Pharmacol 2008; 8:370 - 4; http://dx.doi.org/10.1016/j.coph.2008.06.015; PMID: 18644253
   PubMed Web of Science ®Google Scholar
• Wood MA, McMahon SB, Cole MD. An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc. Mol Cell 2000; 5:321 - 30; http://dx.doi.org/10.1016/S1097-2765(00)80427-X; PMID: 10882073
   PubMed Web of Science ®Google Scholar
• Huber O, Menard L, Haurie V, Nicou A, Taras D, Rosenbaum J. Pontin and reptin, two related ATPases with multiple roles in cancer. Cancer Res 2008; 68:6873 - 6; http://dx.doi.org/10.1158/0008-5472.CAN-08-0547; PMID: 18757398
   PubMed Web of Science ®Google Scholar