The missing LINC

References

• Wilkins AS, Holliday R. The evolution of meiosis from mitosis. Genetics 2009; 181:3 - 12; http://dx.doi.org/10.1534/genetics.108.099762; PMID: 19139151
   PubMed Web of Science ®Google Scholar
• Fraune J, Schramm S, Alsheimer M, Benavente R. The mammalian synaptonemal complex: protein components, assembly and role in meiotic recombination. Exp Cell Res 2012; 318:1340 - 6; http://dx.doi.org/10.1016/j.yexcr.2012.02.018; PMID: 22394509
   PubMed Web of Science ®Google Scholar
• Revenkova E, Jessberger R. Shaping meiotic prophase chromosomes: cohesins and synaptonemal complex proteins. Chromosoma 2006; 115:235 - 40; http://dx.doi.org/10.1007/s00412-006-0060-x; PMID: 16518630
   PubMed Web of Science ®Google Scholar
• Vallente RU, Cheng EY, Hassold TJ. The synaptonemal complex and meiotic recombination in humans: new approaches to old questions. Chromosoma 2006; 115:241 - 9; http://dx.doi.org/10.1007/s00412-006-0058-4; PMID: 16547726
   PubMed Web of Science ®Google Scholar
• Zickler D. From early homologue recognition to synaptonemal complex formation. Chromosoma 2006; 115:158 - 74; http://dx.doi.org/10.1007/s00412-006-0048-6; PMID: 16570189
   PubMed Web of Science ®Google Scholar
• Scherthan H. A bouquet makes ends meet. Nat Rev Mol Cell Biol 2001; 2:621 - 7; http://dx.doi.org/10.1038/35085086; PMID: 11483995
   PubMed Web of Science ®Google Scholar
• Lee CY, Conrad MN, Dresser ME. Meiotic chromosome pairing is promoted by telomere-led chromosome movements independent of bouquet formation. PLoS Genet 2012; 8:e1002730; http://dx.doi.org/10.1371/journal.pgen.1002730; PMID: 22654677
   PubMed Web of Science ®Google Scholar
• Trelles-Sticken E, Adelfalk C, Loidl J, Scherthan H. Meiotic telomere clustering requires actin for its formation and cohesin for its resolution. J Cell Biol 2005; 170:213 - 23; http://dx.doi.org/10.1083/jcb.200501042; PMID: 16027219
   PubMed Web of Science ®Google Scholar
• Conrad MN, Lee CY, Chao G, Shinohara M, Kosaka H, Shinohara A, Conchello JA, Dresser ME. Rapid telomere movement in meiotic prophase is promoted by NDJ1, MPS3, and CSM4 and is modulated by recombination. Cell 2008; 133:1175 - 87; http://dx.doi.org/10.1016/j.cell.2008.04.047; PMID: 18585352
   PubMed Web of Science ®Google Scholar
• Koszul R, Kim KP, Prentiss M, Kleckner N, Kameoka S. Meiotic chromosomes move by linkage to dynamic actin cables with transduction of force through the nuclear envelope. Cell 2008; 133:1188 - 201; http://dx.doi.org/10.1016/j.cell.2008.04.050; PMID: 18585353
   PubMed Web of Science ®Google Scholar
• Wilson KL, Dawson SC. Evolution: functional evolution of nuclear structure. J Cell Biol 2011; 195:171 - 81; http://dx.doi.org/10.1083/jcb.201103171; PMID: 22006947
   PubMed Web of Science ®Google Scholar
• Stewart CL, Roux KJ, Burke B. Blurring the boundary: the nuclear envelope extends its reach. Science 2007; 318:1408 - 12; http://dx.doi.org/10.1126/science.1142034; PMID: 18048680
   PubMed Web of Science ®Google Scholar
• Schirmer EC, Florens L, Guan T, Yates JR 3rd, Gerace L. Nuclear membrane proteins with potential disease links found by subtractive proteomics. Science 2003; 301:1380 - 2; http://dx.doi.org/10.1126/science.1088176; PMID: 12958361
   PubMed Web of Science ®Google Scholar
• Burke B, Stewart CL. The nuclear lamins: flexibility in function. Nat Rev Mol Cell Biol 2013; 14:13 - 24; http://dx.doi.org/10.1038/nrm3488; PMID: 23212477
   PubMed Web of Science ®Google Scholar
• Burke B, Roux KJ. Nuclei take a position: managing nuclear location. Dev Cell 2009; 17:587 - 97; http://dx.doi.org/10.1016/j.devcel.2009.10.018; PMID: 19922864
   PubMed Web of Science ®Google Scholar
• Starr DA, Han M. ANChors away: an actin based mechanism of nuclear positioning. J Cell Sci 2003; 116:211 - 6; http://dx.doi.org/10.1242/jcs.00248; PMID: 12482907
   PubMed Web of Science ®Google Scholar
• Starr DA. A nuclear-envelope bridge positions nuclei and moves chromosomes. J Cell Sci 2009; 122:577 - 86; http://dx.doi.org/10.1242/jcs.037622; PMID: 19225124
   PubMed Web of Science ®Google Scholar
• Zhang Q, Ragnauth C, Greener MJ, Shanahan CM, Roberts RG. The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300. Genomics 2002; 80:473 - 81; http://dx.doi.org/10.1006/geno.2002.6859; PMID: 12408964
   PubMed Web of Science ®Google Scholar
• Zhang X, Xu R, Zhu B, Yang X, Ding X, Duan S, Xu T, Zhuang Y, Han M. Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation. Development 2007; 134:901 - 8; http://dx.doi.org/10.1242/dev.02783; PMID: 17267447
   PubMed Web of Science ®Google Scholar
• Zhen YY, Libotte T, Munck M, Noegel AA, Korenbaum E. NUANCE, a giant protein connecting the nucleus and actin cytoskeleton. J Cell Sci 2002; 115:3207 - 22; PMID: 12118075
   PubMed Web of Science ®Google Scholar
• Padmakumar VC, Abraham S, Braune S, Noegel AA, Tunggal B, Karakesisoglou I, Korenbaum E. Enaptin, a giant actin-binding protein, is an element of the nuclear membrane and the actin cytoskeleton. Exp Cell Res 2004; 295:330 - 9; http://dx.doi.org/10.1016/j.yexcr.2004.01.014; PMID: 15093733
   PubMed Web of Science ®Google Scholar
• Starr DA, Han M. Role of ANC-1 in tethering nuclei to the actin cytoskeleton. Science 2002; 298:406 - 9; http://dx.doi.org/10.1126/science.1075119; PMID: 12169658
   PubMed Web of Science ®Google Scholar
• Mosley-Bishop KL, Li Q, Patterson L, Fischer JA. Molecular analysis of the klarsicht gene and its role in nuclear migration within differentiating cells of the Drosophila eye. Curr Biol 1999; 9:1211 - 20; http://dx.doi.org/10.1016/S0960-9822(99)80501-6; PMID: 10556085
   PubMed Web of Science ®Google Scholar
• Malone CJ, Misner L, Le Bot N, Tsai MC, Campbell JM, Ahringer J, White JG. The C. elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus. Cell 2003; 115:825 - 36; http://dx.doi.org/10.1016/S0092-8674(03)00985-1; PMID: 14697201
   PubMed Web of Science ®Google Scholar
• Roux KJ, Crisp ML, Liu Q, Kim D, Kozlov S, Stewart CL, Burke B. Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization. Proc Natl Acad Sci U S A 2009; 106:2194 - 9; http://dx.doi.org/10.1073/pnas.0808602106; PMID: 19164528
   PubMed Web of Science ®Google Scholar
• Horn HF, Brownstein Z, Lenz DR, Shivatzki S, Dror AA, Dagan-Rosenfeld O, Friedman LM, Roux KJ, Kozlov S, Jeang KT, et al. The LINC complex is essential for hearing. J Clin Invest 2013; 123:740 - 50; PMID: 23348741
   PubMed Web of Science ®Google Scholar
• Ketema M, Kreft M, Secades P, Janssen H, Sonnenberg A. Nesprin-3 connects plectin and vimentin to the nuclear envelope of Sertoli cells but is not required for Sertoli cell function in spermatogenesis. Mol Biol Cell 2013; 24:2454 - 66; http://dx.doi.org/10.1091/mbc.E13-02-0100; PMID: 23761073
   PubMed Web of Science ®Google Scholar
• Ketema M, Wilhelmsen K, Kuikman I, Janssen H, Hodzic D, Sonnenberg A. Requirements for the localization of nesprin-3 at the nuclear envelope and its interaction with plectin. J Cell Sci 2007; 120:3384 - 94; http://dx.doi.org/10.1242/jcs.014191; PMID: 17881500
   PubMed Web of Science ®Google Scholar
• Wilhelmsen K, Litjens SH, Kuikman I, Tshimbalanga N, Janssen H, van den Bout I, Raymond K, Sonnenberg A. Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin. J Cell Biol 2005; 171:799 - 810; http://dx.doi.org/10.1083/jcb.200506083; PMID: 16330710
   PubMed Web of Science ®Google Scholar
• Liu Q, Pante N, Misteli T, Elsagga M, Crisp M, Hodzic D, Burke B, Roux KJ. Functional association of Sun1 with nuclear pore complexes. J Cell Biol 2007; 178:785 - 98; http://dx.doi.org/10.1083/jcb.200704108; PMID: 17724119
   PubMed Web of Science ®Google Scholar
• Sohaskey ML, Jiang Y, Zhao JJ, Mohr A, Roemer F, Harland RM. Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice. J Cell Biol 2010; 189:511 - 25; http://dx.doi.org/10.1083/jcb.201003006; PMID: 20440000
   PubMed Web of Science ®Google Scholar
• Hodzic DM, Yeater DB, Bengtsson L, Otto H, Stahl PD. Sun2 is a novel mammalian inner nuclear membrane protein. J Biol Chem 2004; 279:25805 - 12; http://dx.doi.org/10.1074/jbc.M313157200; PMID: 15082709
   PubMed Web of Science ®Google Scholar
• Hasan S, Güttinger S, Mühlhäusser P, Anderegg F, Bürgler S, Kutay U. Nuclear envelope localization of human UNC84A does not require nuclear lamins. FEBS Lett 2006; 580:1263 - 8; http://dx.doi.org/10.1016/j.febslet.2006.01.039; PMID: 16445915
   PubMed Web of Science ®Google Scholar
• Haque F, Lloyd DJ, Smallwood DT, Dent CL, Shanahan CM, Fry AM, Trembath RC, Shackleton S. SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton. Mol Cell Biol 2006; 26:3738 - 51; http://dx.doi.org/10.1128/MCB.26.10.3738-3751.2006; PMID: 16648470
   PubMed Web of Science ®Google Scholar
• Crisp M, Liu Q, Roux K, Rattner JB, Shanahan C, Burke B, Stahl PD, Hodzic D. Coupling of the nucleus and cytoplasm: role of the LINC complex. J Cell Biol 2006; 172:41 - 53; http://dx.doi.org/10.1083/jcb.200509124; PMID: 16380439
   PubMed Web of Science ®Google Scholar
• Padmakumar VC, Libotte T, Lu W, Zaim H, Abraham S, Noegel AA, Gotzmann J, Foisner R, Karakesisoglou I. The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope. J Cell Sci 2005; 118:3419 - 30; http://dx.doi.org/10.1242/jcs.02471; PMID: 16079285
   PubMed Web of Science ®Google Scholar
• McGee MD, Rillo R, Anderson AS, Starr DA. UNC-83 IS a KASH protein required for nuclear migration and is recruited to the outer nuclear membrane by a physical interaction with the SUN protein UNC-84. Mol Biol Cell 2006; 17:1790 - 801; http://dx.doi.org/10.1091/mbc.E05-09-0894; PMID: 16481402
   PubMed Web of Science ®Google Scholar
• Sosa BA, Rothballer A, Kutay U, Schwartz TU. LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins. Cell 2012; 149:1035 - 47; http://dx.doi.org/10.1016/j.cell.2012.03.046; PMID: 22632968
   PubMed Web of Science ®Google Scholar
• Zhou Z, Du X, Cai Z, Song X, Zhang H, Mizuno T, Suzuki E, Yee MR, Berezov A, Murali R, et al. Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope. J Biol Chem 2012; 287:5317 - 26; http://dx.doi.org/10.1074/jbc.M111.304543; PMID: 22170055
   PubMed Web of Science ®Google Scholar
• Luxton GW, Gomes ER, Folker ES, Vintinner E, Gundersen GG. Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement. Science 2010; 329:956 - 9; http://dx.doi.org/10.1126/science.1189072; PMID: 20724637
   PubMed Web of Science ®Google Scholar
• Zhang X, Lei K, Yuan X, Wu X, Zhuang Y, Xu T, Xu R, Han M. SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron 2009; 64:173 - 87; http://dx.doi.org/10.1016/j.neuron.2009.08.018; PMID: 19874786
   PubMed Web of Science ®Google Scholar
• Lindeman RE, Pelegri F. Localized products of futile cycle/lrmp promote centrosome-nucleus attachment in the zebrafish zygote. Curr Biol 2012; 22:843 - 51; http://dx.doi.org/10.1016/j.cub.2012.03.058; PMID: 22542100
   PubMed Web of Science ®Google Scholar
• Chikashige Y, Tsutsumi C, Yamane M, Okamasa K, Haraguchi T, Hiraoka Y. Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes. Cell 2006; 125:59 - 69; http://dx.doi.org/10.1016/j.cell.2006.01.048; PMID: 16615890
   PubMed Web of Science ®Google Scholar
• Ding X, Xu R, Yu J, Xu T, Zhuang Y, Han M. SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. Dev Cell 2007; 12:863 - 72; http://dx.doi.org/10.1016/j.devcel.2007.03.018; PMID: 17543860
   PubMed Web of Science ®Google Scholar
• Chi YH, Cheng LI, Myers T, Ward JM, Williams E, Su Q, Faucette L, Wang JY, Jeang KT. Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA. Development 2009; 136:965 - 73; http://dx.doi.org/10.1242/dev.029868; PMID: 19211677
   PubMed Web of Science ®Google Scholar
• Sato A, Isaac B, Phillips CM, Rillo R, Carlton PM, Wynne DJ, Kasad RA, Dernburg AF. Cytoskeletal forces span the nuclear envelope to coordinate meiotic chromosome pairing and synapsis. Cell 2009; 139:907 - 19; http://dx.doi.org/10.1016/j.cell.2009.10.039; PMID: 19913287
   PubMed Web of Science ®Google Scholar
• Hiraoka Y, Dernburg AF. The SUN rises on meiotic chromosome dynamics. Dev Cell 2009; 17:598 - 605; http://dx.doi.org/10.1016/j.devcel.2009.10.014; PMID: 19922865
   PubMed Web of Science ®Google Scholar
• Miki F, Kurabayashi A, Tange Y, Okazaki K, Shimanuki M, Niwa O. Two-hybrid search for proteins that interact with Sad1 and Kms1, two membrane-bound components of the spindle pole body in fission yeast. Mol Genet Genomics 2004; 270:449 - 61; http://dx.doi.org/10.1007/s00438-003-0938-8; PMID: 14655046
   PubMed Web of Science ®Google Scholar
• Miki F, Okazaki K, Shimanuki M, Yamamoto A, Hiraoka Y, Niwa O. The 14-kDa dynein light chain-family protein Dlc1 is required for regular oscillatory nuclear movement and efficient recombination during meiotic prophase in fission yeast. Mol Biol Cell 2002; 13:930 - 46; http://dx.doi.org/10.1091/mbc.01-11-0543; PMID: 11907273
   PubMed Web of Science ®Google Scholar
• Chikashige Y, Yamane M, Okamasa K, Tsutsumi C, Kojidani T, Sato M, Haraguchi T, Hiraoka Y. Membrane proteins Bqt3 and -4 anchor telomeres to the nuclear envelope to ensure chromosomal bouquet formation. J Cell Biol 2009; 187:413 - 27; http://dx.doi.org/10.1083/jcb.200902122; PMID: 19948484
   PubMed Web of Science ®Google Scholar
• Jaspersen SL, Giddings TH Jr., Winey M. Mps3p is a novel component of the yeast spindle pole body that interacts with the yeast centrin homologue Cdc31p. J Cell Biol 2002; 159:945 - 56; http://dx.doi.org/10.1083/jcb.200208169; PMID: 12486115
   PubMed Web of Science ®Google Scholar
• Conrad MN, Lee CY, Wilkerson JL, Dresser ME. MPS3 mediates meiotic bouquet formation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 2007; 104:8863 - 8; http://dx.doi.org/10.1073/pnas.0606165104; PMID: 17495028
   PubMed Web of Science ®Google Scholar
• Penkner A, Tang L, Novatchkova M, Ladurner M, Fridkin A, Gruenbaum Y, Schweizer D, Loidl J, Jantsch V. The nuclear envelope protein Matefin/SUN-1 is required for homologous pairing in C. elegans meiosis. Dev Cell 2007; 12:873 - 85; http://dx.doi.org/10.1016/j.devcel.2007.05.004; PMID: 17543861
   PubMed Web of Science ®Google Scholar
• Penkner AM, Fridkin A, Gloggnitzer J, Baudrimont A, Machacek T, Woglar A, Csaszar E, Pasierbek P, Ammerer G, Gruenbaum Y, et al. Meiotic chromosome homology search involves modifications of the nuclear envelope protein Matefin/SUN-1. Cell 2009; 139:920 - 33; http://dx.doi.org/10.1016/j.cell.2009.10.045; PMID: 19913286
   PubMed Web of Science ®Google Scholar
• Phillips CM, Dernburg AF. A family of zinc-finger proteins is required for chromosome-specific pairing and synapsis during meiosis in C. elegans. Dev Cell 2006; 11:817 - 29; http://dx.doi.org/10.1016/j.devcel.2006.09.020; PMID: 17141157
   PubMed Web of Science ®Google Scholar
• Phillips CM, Wong C, Bhalla N, Carlton PM, Weiser P, Meneely PM, Dernburg AF. HIM-8 binds to the X chromosome pairing center and mediates chromosome-specific meiotic synapsis. Cell 2005; 123:1051 - 63; http://dx.doi.org/10.1016/j.cell.2005.09.035; PMID: 16360035
   PubMed Web of Science ®Google Scholar
• Baudrimont A, Penkner A, Woglar A, Machacek T, Wegrostek C, Gloggnitzer J, Fridkin A, Klein F, Gruenbaum Y, Pasierbek P, et al. Leptotene/zygotene chromosome movement via the SUN/KASH protein bridge in Caenorhabditis elegans. PLoS Genet 2010; 6:e1001219; http://dx.doi.org/10.1371/journal.pgen.1001219; PMID: 21124819
   PubMed Web of Science ®Google Scholar
• Harper L, Golubovskaya I, Cande WZ. A bouquet of chromosomes. J Cell Sci 2004; 117:4025 - 32; http://dx.doi.org/10.1242/jcs.01363; PMID: 15316078
   PubMed Web of Science ®Google Scholar
• Morimoto A, Shibuya H, Zhu X, Kim J, Ishiguro K, Han M, Watanabe Y. A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis. J Cell Biol 2012; 198:165 - 72; http://dx.doi.org/10.1083/jcb.201204085; PMID: 22826121
   PubMed Web of Science ®Google Scholar
• Horn HF, Kim DI, Wright GD, Wong ES, Stewart CL, Burke B, Roux KJ. A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton. J Cell Biol 2013; 202:1023 - 39; http://dx.doi.org/10.1083/jcb.201304004; PMID: 24062341
   PubMed Web of Science ®Google Scholar
• Dekens MP, Pelegri FJ, Maischein HM, Nüsslein-Volhard C. The maternal-effect gene futile cycle is essential for pronuclear congression and mitotic spindle assembly in the zebrafish zygote. Development 2003; 130:3907 - 16; http://dx.doi.org/10.1242/dev.00606; PMID: 12874114
   PubMed Web of Science ®Google Scholar
• Kretsinger RH, Barry CD. The predicted structure of the calcium-binding component of troponin. Biochim Biophys Acta 1975; 405:40 - 52; http://dx.doi.org/10.1016/0005-2795(75)90312-8; PMID: 1174567
   PubMed Web of Science ®Google Scholar
• Schermelleh L, Carlton PM, Haase S, Shao L, Winoto L, Kner P, Burke B, Cardoso MC, Agard DA, Gustafsson MG, et al. Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy. Science 2008; 320:1332 - 6; http://dx.doi.org/10.1126/science.1156947; PMID: 18535242
   PubMed Web of Science ®Google Scholar
• Zhang Q, Skepper JN, Yang F, Davies JD, Hegyi L, Roberts RG, Weissberg PL, Ellis JA, Shanahan CM. Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues. J Cell Sci 2001; 114:4485 - 98; PMID: 11792814
   PubMed Web of Science ®Google Scholar
• Behrens TW, Jagadeesh J, Scherle P, Kearns G, Yewdell J, Staudt LM. Jaw1, A lymphoid-restricted membrane protein localized to the endoplasmic reticulum. J Immunol 1994; 153:682 - 90; PMID: 8021504
   PubMed Web of Science ®Google Scholar
• Schneider M, Lu W, Neumann S, Brachner A, Gotzmann J, Noegel AA, Karakesisoglou I. Molecular mechanisms of centrosome and cytoskeleton anchorage at the nuclear envelope. Cell Mol Life Sci 2011; 68:1593 - 610; http://dx.doi.org/10.1007/s00018-010-0535-z; PMID: 20922455
   PubMed Web of Science ®Google Scholar
• Shindo Y, Kim MR, Miura H, Yuuki T, Kanda T, Hino A, Kusakabe Y. Lrmp/Jaw1 is expressed in sweet, bitter, and umami receptor-expressing cells. Chem Senses 2010; 35:171 - 7; http://dx.doi.org/10.1093/chemse/bjp097; PMID: 20071408
   PubMed Web of Science ®Google Scholar