897
Views
18
CrossRef citations to date
0
Altmetric
Author's View

Systemic cancer immunotherapy with Toll-like receptor 7 agonists

Timing is everything

&
Pages 227-228 | Published online: 01 Mar 2012

References

  • Peris K, Campione E, Micantonio T, Marulli GC, Fargnoli MC, Chimenti S. Imiquimod treatment of superficial and nodular basal cell carcinoma: 12-week open-label trial. Dermatol Surg 2005; 31:318 - 23; http://dx.doi.org/10.1111/j.1524-4725.2005.31081; PMID: 15841634
  • Bourquin C, Schmidt L, Lanz AL, Storch B, Wurzenberger C, Anz D, et al. Immunostimulatory RNA oligonucleotides induce an effective antitumoral NK cell response through the TLR7. J Immunol 2009; 183:6078 - 86; http://dx.doi.org/10.4049/jimmunol.0901594; PMID: 19890064
  • Anz D, Koelzer VH, Moder S, Thaler R, Schwerd T, Lahl K, et al. Immunostimulatory RNA blocks suppression by regulatory T cells. J Immunol 2010; 184:939 - 46; http://dx.doi.org/10.4049/jimmunol.0901245; PMID: 19966212
  • Zoglmeier C, Bauer H, Norenberg D, Wedekind G, Bittner P, Sandholzer N, et al. CpG blocks immunosuppression by myeloid-derived suppressor cells in tumor-bearing mice. Clin Cancer Res 2011; 17:1765 - 75; http://dx.doi.org/10.1158/1078-0432.CCR-10-2672; PMID: 21233400
  • Dummer R, Hauschild A, Becker JC, Grob JJ, Schadendorf D, Tebbs V, et al. An exploratory study of systemic administration of the toll-like receptor-7 agonist 852A in patients with refractory metastatic melanoma. Clin Cancer Res 2008; 14:856 - 64; http://dx.doi.org/10.1158/1078-0432.CCR-07-1938; PMID: 18245549
  • Geller MA, Cooley S, Argenta PA, Downs LS, Carson LF, Judson PL, et al. Toll-like receptor-7 agonist administered subcutaneously in a prolonged dosing schedule in heavily pretreated recurrent breast, ovarian, and cervix cancers. Cancer Immunol Immunother 2010; 59:1877 - 84; http://dx.doi.org/10.1007/s00262-010-0914-1; PMID: 20820775
  • Rajagopal D, Paturel C, Morel Y, Uematsu S, Akira S, Diebold SS. Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists. Blood 2010; 115:1949 - 57; http://dx.doi.org/10.1182/blood-2009-08-238543; PMID: 20065291
  • Broad A, Kirby JA, Jones DE. Toll-like receptor interactions: tolerance of MyD88-dependent cytokines but enhancement of MyD88-independent interferon-beta production. Immunology 2007; 120:103 - 11; http://dx.doi.org/10.1111/j.1365-2567.2006.02485.x; PMID: 17034424
  • Bourquin C, Hotz C, Noerenberg D, Voelkl A, Heidegger S, Roetzer LC, et al. Systemic Cancer Therapy with a Small Molecule Agonist of Toll-like Receptor 7 Can Be Improved by Circumventing TLR Tolerance. Cancer Res 2011; 71:5123 - 33; http://dx.doi.org/10.1158/0008-5472.CAN-10-3903; PMID: 21697281
  • Bogunovic D, Manches O, Godefroy E, Yewdall A, Gallois A, Salazar AM, et al. TLR4 Engagement during TLR3-Induced Proinflammatory Signaling in Dendritic Cells Promotes IL-10-Mediated Suppression of Antitumor Immunity. Cancer Res 2011; 71:5467 - 76; http://dx.doi.org/10.1158/0008-5472.CAN-10-3988; PMID: 21730023