Four danger response programs determine glomerular and tubulointerstitial kidney pathology

References

• Puhle M. Die Vitalienbrüder: Klaus Störtebeker und die Seeräuber der Hansezeit. Frankfurt am Main, Campus Verlag. 1992.
   Google Scholar
• Nichols SA, Dirks W, Pearse JS, King N. Early evolution of animal cell signaling and adhesion genes. Proc Natl Acad Sci U S A 2006; 103:12451 - 6; http://dx.doi.org/10.1073/pnas.0604065103; PMID: 16891419
   PubMed Web of Science ®Google Scholar
• Schilmiller AL, Howe GA. Systemic signaling in the wound response. Curr Opin Plant Biol 2005; 8:369 - 77; http://dx.doi.org/10.1016/j.pbi.2005.05.008; PMID: 15939667
   PubMed Web of Science ®Google Scholar
• Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature 2008; 453:314 - 21; http://dx.doi.org/10.1038/nature07039; PMID: 18480812
   PubMed Web of Science ®Google Scholar
• Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med 1999; 341:738 - 46; http://dx.doi.org/10.1056/NEJM199909023411006; PMID: 10471461
   PubMed Web of Science ®Google Scholar
• Clark RA. Cutaneous tissue repair: basic biologic considerations. I. J Am Acad Dermatol 1985; 13:701 - 25; http://dx.doi.org/10.1016/S0190-9622(85)70213-7; PMID: 2416789
   PubMed Web of Science ®Google Scholar
• Martin P. Wound healing--aiming for perfect skin regeneration. Science 1997; 276:75 - 81; http://dx.doi.org/10.1126/science.276.5309.75; PMID: 9082989
   PubMed Web of Science ®Google Scholar
• Nurden AT. Platelets, inflammation and tissue regeneration. Thromb Haemost 2011; 105:Suppl 1 S13 - 33; http://dx.doi.org/10.1160/THS10-11-0720; PMID: 21479340
   PubMed Web of Science ®Google Scholar
• Medzhitov R. Origin and physiological roles of inflammation. Nature 2008; 454:428 - 35; http://dx.doi.org/10.1038/nature07201; PMID: 18650913
   PubMed Web of Science ®Google Scholar
• Messier-Solek C, Buckley KM, Rast JP. Highly diversified innate receptor systems and new forms of animal immunity. Semin Immunol 2010; 22:39 - 47; http://dx.doi.org/10.1016/j.smim.2009.11.007; PMID: 20022762
   PubMed Web of Science ®Google Scholar
• Gauthier ME, Du Pasquier L, Degnan BM. The genome of the sponge Amphimedon queenslandica provides new perspectives into the origin of Toll-like and interleukin 1 receptor pathways. Evol Dev 2010; 12:519 - 33; http://dx.doi.org/10.1111/j.1525-142X.2010.00436.x; PMID: 20883219
   PubMed Web of Science ®Google Scholar
• Wiens M, Korzhev M, Perovic-Ottstadt S, Luthringer B, Brandt D, Klein S, et al. Toll-like receptors are part of the innate immune defense system of sponges (demospongiae: Porifera). Mol Biol Evol 2007; 24:792 - 804; http://dx.doi.org/10.1093/molbev/msl208; PMID: 17190971
   PubMed Web of Science ®Google Scholar
• Rock KL, Latz E, Ontiveros F, Kono H. The sterile inflammatory response. Annu Rev Immunol 2010; 28:321 - 42; http://dx.doi.org/10.1146/annurev-immunol-030409-101311; PMID: 20307211
   PubMed Web of Science ®Google Scholar
• Anders HJ. Toll-like receptors and danger signaling in kidney injury. J Am Soc Nephrol 2010; 21:1270 - 4; http://dx.doi.org/10.1681/ASN.2010030233; PMID: 20651159
   PubMed Web of Science ®Google Scholar
• Semple JW, Italiano JE Jr., Freedman J. Platelets and the immune continuum. Nat Rev Immunol 2011; 11:264 - 74; http://dx.doi.org/10.1038/nri2956; PMID: 21436837
   PubMed Web of Science ®Google Scholar
• Stearns-Kurosawa DJ, Osuchowski MF, Valentine C, Kurosawa S, Remick DG. The pathogenesis of sepsis. Annu Rev Pathol 2011; 6:19 - 48; http://dx.doi.org/10.1146/annurev-pathol-011110-130327; PMID: 20887193
   PubMed Web of Science ®Google Scholar
• Ahronowitz I, Harp J, Shinkai K. Etiology and management of pyoderma gangrenosum: a comprehensive review. Am J Clin Dermatol 2012; 13:191 - 211; http://dx.doi.org/10.2165/11595240-000000000-00000; PMID: 22356259
   PubMed Web of Science ®Google Scholar
• Romagnani P. From Proteus to Prometheus: learning from fish to modulate regeneration. J Am Soc Nephrol 2010; 21:726 - 8; http://dx.doi.org/10.1681/ASN.2010020228; PMID: 20378822
   PubMed Web of Science ®Google Scholar
• Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev 2003; 83:835 - 70; PMID: 12843410
   PubMed Web of Science ®Google Scholar
• Sopova K, Tatsidou P, Stellos K. Platelets and Platelet Interaction with Progenitor Cells in Vascular Homeostasis and Inflammation. Curr Vasc Pharmacol 2012; PMID: 22338570
   PubMed Web of Science ®Google Scholar
• Zenewicz LA, Flavell RA. Recent advances in IL-22 biology. Int Immunol 2011; 23:159 - 63; http://dx.doi.org/10.1093/intimm/dxr001; PMID: 21393631
   PubMed Web of Science ®Google Scholar
• Sugawara T, Gallucci RM, Simeonova PP, Luster MI. Regulation and role of interleukin 6 in wounded human epithelial keratinocytes. Cytokine 2001; 15:328 - 36; http://dx.doi.org/10.1006/cyto.2001.0946; PMID: 11594800
   PubMed Web of Science ®Google Scholar
• Pickert G, Neufert C, Leppkes M, Zheng Y, Wittkopf N, Warntjen M, et al. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J Exp Med 2009; 206:1465 - 72; http://dx.doi.org/10.1084/jem.20082683; PMID: 19564350
   PubMed Web of Science ®Google Scholar
• Nishida T, Nakamura M, Mishima H, Otori T. Interleukin 6 promotes epithelial migration by a fibronectin-dependent mechanism. J Cell Physiol 1992; 153:1 - 5; http://dx.doi.org/10.1002/jcp.1041530102; PMID: 1522123
   PubMed Web of Science ®Google Scholar
• Mizoguchi A. Healing of intestinal inflammation by IL-22. Inflamm Bowel Dis 2012; In press http://dx.doi.org/10.1002/ibd.22929; PMID: 22359410
   PubMed Web of Science ®Google Scholar
• Jiang GX, Zhong XY, Cui YF, Liu W, Tai S, Wang ZD, et al. IL-6/STAT3/TFF3 signaling regulates human biliary epithelial cell migration and wound healing in vitro. Mol Biol Rep 2010; 37:3813 - 8; http://dx.doi.org/10.1007/s11033-010-0036-z; PMID: 20229017
   PubMed Web of Science ®Google Scholar
• Braun RK, Ferrick C, Neubauer P, Sjoding M, Sterner-Kock A, Kock M, et al. IL-17 producing gammadelta T cells are required for a controlled inflammatory response after bleomycin-induced lung injury. Inflammation 2008; 31:167 - 79; http://dx.doi.org/10.1007/s10753-008-9062-6; PMID: 18338242
   PubMed Web of Science ®Google Scholar
• Brockes JP. Amphibian limb regeneration: rebuilding a complex structure. Science 1997; 276:81 - 7; http://dx.doi.org/10.1126/science.276.5309.81; PMID: 9082990
   PubMed Web of Science ®Google Scholar
• Sipos F, Valcz G, Molńr B. Physiological and pathological role of local and immigrating colonic stem cells. World J Gastroenterol 2012; 18:295 - 301; http://dx.doi.org/10.3748/wjg.v18.i4.295; PMID: 22294835
   PubMed Web of Science ®Google Scholar
• Yang L, Besschetnova TY, Brooks CR, Shah JV, Bonventre JV. Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med 2010; 16:535 - 43, 1p, 143; http://dx.doi.org/10.1038/nm.2144; PMID: 20436483
   PubMed Web of Science ®Google Scholar
• Liu Y. New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol 2010; 21:212 - 22; http://dx.doi.org/10.1681/ASN.2008121226; PMID: 20019167
   PubMed Web of Science ®Google Scholar
• Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003; 112:1776 - 84; PMID: 14679171
   PubMed Web of Science ®Google Scholar
• Niedermeier M, Reich B, Rodriguez Gomez M, Denzel A, Schmidbauer K, Göbel N, et al. CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes. Proc Natl Acad Sci U S A 2009; 106:17892 - 7; http://dx.doi.org/10.1073/pnas.0906070106; PMID: 19815530
   PubMed Web of Science ®Google Scholar
• Humphreys BD, Lin SL, Kobayashi A, Hudson TE, Nowlin BT, Bonventre JV, et al. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 2010; 176:85 - 97; http://dx.doi.org/10.2353/ajpath.2010.090517; PMID: 20008127
   PubMed Web of Science ®Google Scholar
• Zeisberg M, Neilson EG. Mechanisms of tubulointerstitial fibrosis. J Am Soc Nephrol 2010; 21:1819 - 34; http://dx.doi.org/10.1681/ASN.2010080793; PMID: 20864689
   PubMed Web of Science ®Google Scholar
• Chapman K, Seldon M, Richards R. Thrombotic microangiopathies, thrombotic thrombocytopenic purpura, and ADAMTS-13. Semin Thromb Hemost 2012; 38:47 - 54; http://dx.doi.org/10.1055/s-0031-1300951; PMID: 22314603
   PubMed Web of Science ®Google Scholar
• Amengual O, Atsumi T, Koike T. Pathophysiology of thrombosis and potential targeted therapies in antiphospholipid syndrome. Curr Vasc Pharmacol 2011; 9:606 - 18; http://dx.doi.org/10.2174/157016111796642715; PMID: 21692741
   PubMed Web of Science ®Google Scholar
• Bonsib SM. Glomerular basement membrane discontinuities. Scanning electron microscopic study of acellular glomeruli. Am J Pathol 1985; 119:357 - 60; PMID: 4014431
   PubMed Web of Science ®Google Scholar
• Sörensen I, Susnik N, Inhester T, Degen JL, Melk A, Haller H, et al. Fibrinogen, acting as a mitogen for tubulointerstitial fibroblasts, promotes renal fibrosis. Kidney Int 2011; 80:1035 - 44; http://dx.doi.org/10.1038/ki.2011.214; PMID: 21734641
   PubMed Web of Science ®Google Scholar
• Drew AF, Tucker HL, Liu H, Witte DP, Degen JL, Tipping PG. Crescentic glomerulonephritis is diminished in fibrinogen-deficient mice. Am J Physiol Renal Physiol 2001; 281:F1157 - 63; PMID: 11704568
   PubMed Web of Science ®Google Scholar
• Ryu M, Migliorini M, Miosge N, Gross O, Shankland S, Brinkoetter PT, et al. Plasma leakage through glomerular basement membrane ruptures triggers the proliferation of parietal epithelial cells and crescent formation in non-inflammatory glomerular injury. J Pathol 2012; 226:120 - 31; PMID: 21953121
   PubMed Web of Science ®Google Scholar
• Nelson PJ, Rees AJ, Griffin MD, Hughes J, Kurts C, Duffield J. The renal mononuclear phagocytic system. J Am Soc Nephrol 2012; 23:194 - 203; http://dx.doi.org/10.1681/ASN.2011070680; PMID: 22135312
   PubMed Web of Science ®Google Scholar
• Lech M, Avila-Ferrufino A, Skuginna V, Susanti HE, Anders HJ. Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice. Int Immunol 2010; 22:717 - 28; http://dx.doi.org/10.1093/intimm/dxq058; PMID: 20584763
   PubMed Web of Science ®Google Scholar
• Anders HJ, Banas B, Schlöndorff D. Signaling danger: toll-like receptors and their potential roles in kidney disease. J Am Soc Nephrol 2004; 15:854 - 67; http://dx.doi.org/10.1097/01.ASN.0000121781.89599.16; PMID: 15034087
   PubMed Web of Science ®Google Scholar
• Patole PS, Pawar RD, Lech M, Zecher D, Schmidt H, Segerer S, et al. Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice. Nephrol Dial Transplant 2006; 21:3062 - 73; http://dx.doi.org/10.1093/ndt/gfl336; PMID: 16954173
   PubMed Web of Science ®Google Scholar
• Anders HJ. Innate pathogen recognition in the kidney: toll-like receptors, NOD-like receptors, and RIG-like helicases. Kidney Int 2007; 72:1051 - 6; http://dx.doi.org/10.1038/sj.ki.5002436; PMID: 17653134
   PubMed Web of Science ®Google Scholar
• Anders HJ, Muruve DA. The inflammasomes in kidney disease. J Am Soc Nephrol 2011; 22:1007 - 18; http://dx.doi.org/10.1681/ASN.2010080798; PMID: 21566058
   PubMed Web of Science ®Google Scholar
• Pawar RD, Castrezana-Lopez L, Allam R, Kulkarni OP, Segerer S, Radomska E, et al. Bacterial lipopeptide triggers massive albuminuria in murine lupus nephritis by activating Toll-like receptor 2 at the glomerular filtration barrier. Immunology 2009; 128:Suppl e206 - 21; http://dx.doi.org/10.1111/j.1365-2567.2008.02948.x; PMID: 19175801
   PubMed Web of Science ®Google Scholar
• Patole PS, Gröne HJ, Segerer S, Ciubar R, Belemezova E, Henger A, et al. Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells. J Am Soc Nephrol 2005; 16:1326 - 38; http://dx.doi.org/10.1681/ASN.2004100820; PMID: 15772251
   PubMed Web of Science ®Google Scholar
• Pawar RD, Patole PS, Zecher D, Segerer S, Kretzler M, Schlöndorff D, et al. Toll-like receptor-7 modulates immune complex glomerulonephritis. J Am Soc Nephrol 2006; 17:141 - 9; http://dx.doi.org/10.1681/ASN.2005070714; PMID: 16280469
   PubMed Web of Science ®Google Scholar
• Anders HJ, Banas B, Linde Y, Weller L, Cohen CD, Kretzler M, et al. Bacterial CpG-DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors. J Am Soc Nephrol 2003; 14:317 - 26; http://dx.doi.org/10.1097/01.ASN.0000042169.23931.73; PMID: 12538732
   PubMed Web of Science ®Google Scholar
• Anders HJ, Vielhauer V, Eis V, Linde Y, Kretzler M, Perez de Lema G, et al. Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice. FASEB J 2004; 18:534 - 6; PMID: 14734643
   PubMed Web of Science ®Google Scholar
• Allam R, Pawar RD, Kulkarni OP, Hornung V, Hartmann G, Segerer S, et al. Viral 5′-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses. Eur J Immunol 2008; 38:3487 - 98; http://dx.doi.org/10.1002/eji.200838604; PMID: 19009528
   PubMed Web of Science ®Google Scholar
• Brown HJ, Lock HR, Sacks SH, Robson MG. TLR2 stimulation of intrinsic renal cells in the induction of immune-mediated glomerulonephritis. J Immunol 2006; 177:1925 - 31; PMID: 16849506
   PubMed Web of Science ®Google Scholar
• Brown HJ, Lock HR, Wolfs TG, Buurman WA, Sacks SH, Robson MG. Toll-like receptor 4 ligation on intrinsic renal cells contributes to the induction of antibody-mediated glomerulonephritis via CXCL1 and CXCL2. J Am Soc Nephrol 2007; 18:1732 - 9; http://dx.doi.org/10.1681/ASN.2006060634; PMID: 17460147
   PubMed Web of Science ®Google Scholar
• Brown HJ, Sacks SH, Robson MG. Toll-like receptor 2 agonists exacerbate accelerated nephrotoxic nephritis. J Am Soc Nephrol 2006; 17:1931 - 9; http://dx.doi.org/10.1681/ASN.2005111167; PMID: 16738018
   PubMed Web of Science ®Google Scholar
• Wörnle M, Schmid H, Banas B, Merkle M, Henger A, Roeder M, et al. Novel role of toll-like receptor 3 in hepatitis C-associated glomerulonephritis. Am J Pathol 2006; 168:370 - 85; http://dx.doi.org/10.2353/ajpath.2006.050491; PMID: 16436653
   PubMed Web of Science ®Google Scholar
• Lichtnekert J, Vielhauer V, Zecher D, Kulkarni OP, Clauss S, Segerer S, et al. Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif. Am J Physiol Renal Physiol 2009; 296:F867 - 74; http://dx.doi.org/10.1152/ajprenal.90213.2008; PMID: 19158348
   PubMedGoogle Scholar
• Vilaysane A, Chun J, Seamone ME, Wang W, Chin R, Hirota S, et al. The NLRP3 inflammasome promotes renal inflammation and contributes to CKD. J Am Soc Nephrol 2010; 21:1732 - 44; http://dx.doi.org/10.1681/ASN.2010020143; PMID: 20688930
   PubMed Web of Science ®Google Scholar
• Lichtnekert J, Kulkarni OP, Mulay SR, Rupanagudi KV, Ryu M, Allam R, et al. Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1. PLoS One 2011; 6:e26778; http://dx.doi.org/10.1371/journal.pone.0026778; PMID: 22046355
   PubMed Web of Science ®Google Scholar
• Iyer SS, Pulskens WP, Sadler JJ, Butter LM, Teske GJ, Ulland TK, et al. Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci U S A 2009; 106:20388 - 93; http://dx.doi.org/10.1073/pnas.0908698106; PMID: 19918053
   PubMed Web of Science ®Google Scholar
• Ryu M, Kulkarni OP, Radomska E, Miosge N, Gross O, Anders HJ. Bacterial CpG-DNA accelerates Alport glomerulosclerosis by inducing an M1 macrophage phenotype and tumor necrosis factor-α-mediated podocyte loss. Kidney Int 2011; 79:189 - 98; http://dx.doi.org/10.1038/ki.2010.373; PMID: 20962742
   PubMed Web of Science ®Google Scholar
• Pawar RD, Ramanjaneyulu A, Kulkarni OP, Lech M, Segerer S, Anders HJ. Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus. J Am Soc Nephrol 2007; 18:1721 - 31; http://dx.doi.org/10.1681/ASN.2006101162; PMID: 17460144
   PubMed Web of Science ®Google Scholar
• Wu H, Ma J, Wang P, Corpuz TM, Panchapakesan U, Wyburn KR, et al. HMGB1 contributes to kidney ischemia reperfusion injury. J Am Soc Nephrol 2010; 21:1878 - 90; http://dx.doi.org/10.1681/ASN.2009101048; PMID: 20847143
   PubMed Web of Science ®Google Scholar
• Shigeoka AA, Holscher TD, King AJ, Hall FW, Kiosses WB, Tobias PS, et al. TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both MyD88-dependent and -independent pathways. J Immunol 2007; 178:6252 - 8; PMID: 17475853
   PubMed Web of Science ®Google Scholar
• Leemans JC, Stokman G, Claessen N, Rouschop KM, Teske GJ, Kirschning CJ, et al. Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney. J Clin Invest 2005; 115:2894 - 903; http://dx.doi.org/10.1172/JCI22832; PMID: 16167081
   PubMed Web of Science ®Google Scholar
• Wu H, Chen G, Wyburn KR, Yin J, Bertolino P, Eris JM, et al. TLR4 activation mediates kidney ischemia/reperfusion injury. J Clin Invest 2007; 117:2847 - 59; http://dx.doi.org/10.1172/JCI31008; PMID: 17853945
   PubMed Web of Science ®Google Scholar
• Anders HJ, Schlöndorff D. Toll-like receptors: emerging concepts in kidney disease. Curr Opin Nephrol Hypertens 2007; 16:177 - 83; http://dx.doi.org/10.1097/MNH.0b013e32803fb767; PMID: 17420659
   PubMed Web of Science ®Google Scholar
• Lech M, Garlanda C, Mantovani A, Kirschning CJ, Schlöndorff D, Anders HJ. Different roles of TiR8/Sigirr on toll-like receptor signaling in intrarenal antigen-presenting cells and tubular epithelial cells. Kidney Int 2007; 72:182 - 92; http://dx.doi.org/10.1038/sj.ki.5002293; PMID: 17495864
   PubMed Web of Science ®Google Scholar
• Lassen S, Lech M, Römmele C, Mittruecker HW, Mak TW, Anders HJ. Ischemia reperfusion induces IFN regulatory factor 4 in renal dendritic cells, which suppresses postischemic inflammation and prevents acute renal failure. J Immunol 2010; 185:1976 - 83; http://dx.doi.org/10.4049/jimmunol.0904207; PMID: 20601597
   PubMed Web of Science ®Google Scholar
• Lech M, Avila-Ferrufino A, Allam R, Segerer S, Khandoga A, Krombach F, et al. Resident dendritic cells prevent postischemic acute renal failure by help of single Ig IL-1 receptor-related protein. J Immunol 2009; 183:4109 - 18; http://dx.doi.org/10.4049/jimmunol.0900118; PMID: 19692646
   PubMed Web of Science ®Google Scholar
• Gong J, Wei T, Stark RW, Jamitzky F, Heckl WM, Anders HJ, et al. Inhibition of Toll-like receptors TLR4 and 7 signaling pathways by SIGIRR: a computational approach. J Struct Biol 2010; 169:323 - 30; http://dx.doi.org/10.1016/j.jsb.2009.12.007; PMID: 20025973
   PubMed Web of Science ®Google Scholar
• Pawar RD, Patole PS, Wörnle M, Anders HJ. Microbial nucleic acids pay a Toll in kidney disease. Am J Physiol Renal Physiol 2006; 291:F509 - 16; http://dx.doi.org/10.1152/ajprenal.00453.2005; PMID: 16597607
   PubMedGoogle Scholar
• Marshak-Rothstein A, Rifkin IR. Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease. Annu Rev Immunol 2007; 25:419 - 41; http://dx.doi.org/10.1146/annurev.immunol.22.012703.104514; PMID: 17378763
   PubMed Web of Science ®Google Scholar
• Leadbetter EA, Rifkin IR, Hohlbaum AM, Beaudette BC, Shlomchik MJ, Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 2002; 416:603 - 7; http://dx.doi.org/10.1038/416603a; PMID: 11948342
   PubMed Web of Science ®Google Scholar
• Migliorini A, Anders HJ. A novel pathogenetic concept-antiviral immunity in lupus nephritis. Nat Rev Nephrol 2012; 8:183 - 9; http://dx.doi.org/10.1038/nrneph.2011.197; PMID: 22249778
   PubMed Web of Science ®Google Scholar
• Anders HJ. Pseudoviral immunity—a novel concept for lupus. Trends Mol Med 2009; 15:553 - 61; http://dx.doi.org/10.1016/j.molmed.2009.10.004; PMID: 19896418
   PubMed Web of Science ®Google Scholar
• Anders HJ, Lichtnekert J, Allam R. Interferon-alpha and -beta in kidney inflammation. Kidney Int 2010; 77:848 - 54; http://dx.doi.org/10.1038/ki.2010.71; PMID: 20237459
   PubMed Web of Science ®Google Scholar
• Flür K, Allam R, Zecher D, Kulkarni OP, Lichtnekert J, Schwarz M, et al. Viral RNA induces type I interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5: Implications for viral infection-associated glomerulonephritis. Am J Pathol 2009; 175:2014 - 22; http://dx.doi.org/10.2353/ajpath.2009.080585; PMID: 19850889
   PubMed Web of Science ®Google Scholar
• Hägele H, Allam R, Pawar RD, Anders HJ. Double-stranded RNA activates type I interferon secretion in glomerular endothelial cells via retinoic acid-inducible gene (RIG)-1. Nephrol Dial Transplant 2009; 24:3312 - 8; http://dx.doi.org/10.1093/ndt/gfp339; PMID: 19608629
   PubMed Web of Science ®Google Scholar
• Hägele H, Allam R, Pawar RD, Reichel CA, Krombach F, Anders HJ. Double-stranded DNA activates glomerular endothelial cells and enhances albumin permeability via a toll-like receptor-independent cytosolic DNA recognition pathway. Am J Pathol 2009; 175:1896 - 904; http://dx.doi.org/10.2353/ajpath.2009.090182; PMID: 19834059
   PubMed Web of Science ®Google Scholar
• Allam R, Lichtnekert J, Moll A, Taubitz A, Vielhauer V, Anders HJ. Viral RNA and DNA sense common antiviral responses including type I interferons in mesangial cells. J Am Soc Nephrol 2009; 20:1986 - 96; http://dx.doi.org/10.1681/ASN.2008101067; PMID: 19713315
   PubMed Web of Science ®Google Scholar
• Fairhurst AM, Mathian A, Connolly JE, Wang A, Gray HF, George TA, et al. Systemic IFN-alpha drives kidney nephritis in B6.Sle123 mice. Eur J Immunol 2008; 38:1948 - 60; http://dx.doi.org/10.1002/eji.200837925; PMID: 18506882
   PubMed Web of Science ®Google Scholar
• Fairhurst AM, Xie C, Fu Y, Wang A, Boudreaux C, Zhou XJ, et al. Type I interferons produced by resident renal cells may promote end-organ disease in autoantibody-mediated glomerulonephritis. J Immunol 2009; 183:6831 - 8; http://dx.doi.org/10.4049/jimmunol.0900742; PMID: 19864599
   PubMed Web of Science ®Google Scholar
• Anders HJ, Vielhauer V, Schlöndorff D. Chemokines and chemokine receptors are involved in the resolution or progression of renal disease. Kidney Int 2003; 63:401 - 15; http://dx.doi.org/10.1046/j.1523-1755.2003.00750.x; PMID: 12631106
   PubMed Web of Science ®Google Scholar
• Vielhauer V, Kulkarni O, Reichel CA, Anders HJ. Targeting the recruitment of monocytes and macrophages in renal disease. Semin Nephrol 2010; 30:318 - 33; http://dx.doi.org/10.1016/j.semnephrol.2010.03.006; PMID: 20620675
   PubMed Web of Science ®Google Scholar
• Heller F, Lindenmeyer MT, Cohen CD, Brandt U, Draganovici D, Fischereder M, et al. The contribution of B cells to renal interstitial inflammation. Am J Pathol 2007; 170:457 - 68; http://dx.doi.org/10.2353/ajpath.2007.060554; PMID: 17255314
   PubMed Web of Science ®Google Scholar
• Steinmetz OM, Stahl RA, Panzer U. Chemokines and B cells in renal inflammation and allograft rejection. Front Biosci (Schol Ed) 2009; 1:13 - 22; PMID: 19482678
   PubMedGoogle Scholar
• Panzer U, Kurts C. T cell cross-talk with kidney dendritic cells in glomerulonephritis. J Mol Med (Berl) 2010; 88:19 - 26; http://dx.doi.org/10.1007/s00109-009-0541-5; PMID: 19798477
   PubMed Web of Science ®Google Scholar
• Anders HJ, Ryu M. Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis. Kidney Int 2011; 80:915 - 25; http://dx.doi.org/10.1038/ki.2011.217; PMID: 21814171
   PubMed Web of Science ®Google Scholar
• Anders HJ, Frink M, Linde Y, Banas B, Wörnle M, Cohen CD, et al. CC chemokine ligand 5/RANTES chemokine antagonists aggravate glomerulonephritis despite reduction of glomerular leukocyte infiltration. J Immunol 2003; 170:5658 - 66; PMID: 12759447
   PubMed Web of Science ®Google Scholar
• Pawar RD, Patole PS, Ellwart A, Lech M, Segerer S, Schlondorff D, et al. Ligands to nucleic acid-specific toll-like receptors and the onset of lupus nephritis. J Am Soc Nephrol 2006; 17:3365 - 73; http://dx.doi.org/10.1681/ASN.2006030263; PMID: 17082246
   PubMed Web of Science ®Google Scholar
• Anders HJ, Zecher D, Pawar RD, Patole PS. Molecular mechanisms of autoimmunity triggered by microbial infection. Arthritis Res Ther 2005; 7:215 - 24; http://dx.doi.org/10.1186/ar1818; PMID: 16207351
   PubMed Web of Science ®Google Scholar
• Ble A, Mosca M, Di Loreto G, Guglielmotti A, Biondi G, Bombardieri S, et al. Antiproteinuric effect of chemokine C-C motif ligand 2 inhibition in subjects with acute proliferative lupus nephritis. Am J Nephrol 2011; 34:367 - 72; http://dx.doi.org/10.1159/000330685; PMID: 21876349
   PubMed Web of Science ®Google Scholar
• Kulkarni O, Pawar RD, Purschke W, Eulberg D, Selve N, Buchner K, et al. Spiegelmer inhibition of CCL2/MCP-1 ameliorates lupus nephritis in MRL-(Fas)lpr mice. J Am Soc Nephrol 2007; 18:2350 - 8; http://dx.doi.org/10.1681/ASN.2006121348; PMID: 17625118
   PubMed Web of Science ®Google Scholar
• Ninichuk V, Clauss S, Kulkarni O, Schmid H, Segerer S, Radomska E, et al. Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3’PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice. Am J Pathol 2008; 172:628 - 37; http://dx.doi.org/10.2353/ajpath.2008.070601; PMID: 18258851
   PubMed Web of Science ®Google Scholar
• Kulkarni O, Eulberg D, Selve N, Zöllner S, Allam R, Pawar RD, et al. Anti-Ccl2 Spiegelmer permits 75% dose reduction of cyclophosphamide to control diffuse proliferative lupus nephritis and pneumonitis in MRL-Fas(lpr) mice. J Pharmacol Exp Ther 2009; 328:371 - 7; http://dx.doi.org/10.1124/jpet.108.142711; PMID: 18997060
   PubMed Web of Science ®Google Scholar
• Sayyed SG, Ryu M, Kulkarni OP, Schmid H, Lichtnekert J, Grüner S, et al. An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes. Kidney Int 2011; 80:68 - 78; http://dx.doi.org/10.1038/ki.2011.102; PMID: 21508925
   PubMed Web of Science ®Google Scholar
• Clauss S, Gross O, Kulkarni O, Avila-Ferrufino A, Radomska E, Segerer S, et al. Ccl2/Mcp-1 blockade reduces glomerular and interstitial macrophages but does not ameliorate renal pathology in collagen4A3-deficient mice with autosomal recessive Alport nephropathy. J Pathol 2009; 218:40 - 7; http://dx.doi.org/10.1002/path.2505; PMID: 19156777
   PubMed Web of Science ®Google Scholar
• Ribeiro A, Wörnle M, Motamedi N, Anders HJ, Gröne EF, Nitschko H, et al. Activation of innate immune defense mechanisms contributes to polyomavirus BK-associated nephropathy. Kidney Int 2012; 81:100 - 11; http://dx.doi.org/10.1038/ki.2011.311; PMID: 21918500
   PubMed Web of Science ®Google Scholar
• Anders HJ, Patole PS. Toll-like receptors recognize uropathogenic Escherichia coli and trigger inflammation in the urinary tract. Nephrol Dial Transplant 2005; 20:1529 - 32; http://dx.doi.org/10.1093/ndt/gfh922; PMID: 15941847
   PubMed Web of Science ®Google Scholar
• Patole PS, Schubert S, Hildinger K, Khandoga S, Khandoga A, Segerer S, et al. Toll-like receptor-4: renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis. Kidney Int 2005; 68:2582 - 7; http://dx.doi.org/10.1111/j.1523-1755.2005.00729.x; PMID: 16316333
   PubMed Web of Science ®Google Scholar
• Kulkarni OP, Ryu M, Kantner C, Sárdy M, Naylor D, Lambert D, et al. Recombinant chaperonin 10 suppresses cutaneous lupus and lupus nephritis in MRL-(Fas)lpr mice. Nephrol Dial Transplant 2012; 27:1358 - 67; http://dx.doi.org/10.1093/ndt/gfr544; PMID: 21987536
   PubMed Web of Science ®Google Scholar
• Bonventre JV. Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. J Am Soc Nephrol 2003; 14:Suppl 1 S55 - 61; http://dx.doi.org/10.1097/01.ASN.0000067652.51441.21; PMID: 12761240
   PubMed Web of Science ®Google Scholar
• Abuelo JG. Normotensive ischemic acute renal failure. N Engl J Med 2007; 357:797 - 805; http://dx.doi.org/10.1056/NEJMra064398; PMID: 17715412
   PubMed Web of Science ®Google Scholar
• Sugimoto H, Lebleu VS, Bosukonda D, Keck P, Taduri G, Bechtel W, et al. Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis. Nat Med 2012; 18:396 - 404; http://dx.doi.org/10.1038/nm.2629; PMID: 22306733
   PubMed Web of Science ®Google Scholar
• Mulay SR, Thomasova D, Ryu M, Anders HJ. MDM2 (murine double minute-2) links inflammation and tubular cell healing during acute kidney injury in mice. Kidney Int 2012; 81:1199 - 211; http://dx.doi.org/10.1038/ki.2011.482; PMID: 22297670
   PubMed Web of Science ®Google Scholar
• Weidenbusch M, Anders HJ. Tissue microenvironments define and get reinforced by macrophage phenotypes in homeostasis or during inflammation, repair, and fibrosis. J Innate Immun 2012; In press
   PubMed Web of Science ®Google Scholar
• Duffield JS, Forbes SJ, Constandinou CM, Clay S, Partolina M, Vuthoori S, et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest 2005; 115:56 - 65; PMID: 15630444
   PubMed Web of Science ®Google Scholar
• Lee S, Huen S, Nishio H, Nishio S, Lee HK, Choi BS, et al. Distinct macrophage phenotypes contribute to kidney injury and repair. J Am Soc Nephrol 2011; 22:317 - 26; http://dx.doi.org/10.1681/ASN.2009060615; PMID: 21289217
   PubMed Web of Science ®Google Scholar
• Lee SB, Kalluri R. Mechanistic connection between inflammation and fibrosis. Kidney Int Suppl 2010; 78:S22 - 6; http://dx.doi.org/10.1038/ki.2010.418; PMID: 21116313
   PubMed Web of Science ®Google Scholar
• Lasagni L, Romagnani P. Glomerular epithelial stem cells: the good, the bad, and the ugly. J Am Soc Nephrol 2010; 21:1612 - 9; http://dx.doi.org/10.1681/ASN.2010010048; PMID: 20829409
   PubMed Web of Science ®Google Scholar
• Humphreys BD, Czerniak S, DiRocco DP, Hasnain W, Cheema R, Bonventre JV. Repair of injured proximal tubule does not involve specialized progenitors. Proc Natl Acad Sci U S A 2011; 108:9226 - 31; http://dx.doi.org/10.1073/pnas.1100629108; PMID: 21576461
   PubMed Web of Science ®Google Scholar
• Humphreys BD, Valerius MT, Kobayashi A, Mugford JW, Soeung S, Duffield JS, et al. Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2008; 2:284 - 91; http://dx.doi.org/10.1016/j.stem.2008.01.014; PMID: 18371453
   PubMed Web of Science ®Google Scholar
• Duffield JS, Park KM, Hsiao LL, Kelley VR, Scadden DT, Ichimura T, et al. Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells. J Clin Invest 2005; 115:1743 - 55; http://dx.doi.org/10.1172/JCI22593; PMID: 16007251
   PubMed Web of Science ®Google Scholar
• Romagnani P. Family portrait: renal progenitor of Bowman’s capsule and its tubular brothers. Am J Pathol 2011; 178:490 - 3; http://dx.doi.org/10.1016/j.ajpath.2010.11.044; PMID: 21281781
   PubMed Web of Science ®Google Scholar
• Tögel FE, Westenfelder C. Mesenchymal stem cells: a new therapeutic tool for AKI. Nat Rev Nephrol 2010; 6:179 - 83; http://dx.doi.org/10.1038/nrneph.2009.229; PMID: 20186233
   PubMed Web of Science ®Google Scholar
• Kriz W, Lemley KV. The role of the podocyte in glomerulosclerosis. Curr Opin Nephrol Hypertens 1999; 8:489 - 97; http://dx.doi.org/10.1097/00041552-199907000-00014; PMID: 10491745
   PubMed Web of Science ®Google Scholar
• Teixeira VdeP, Blattner SM, Li M, Anders HJ, Cohen CD, Edenhofer I, et al. Functional consequences of integrin-linked kinase activation in podocyte damage. Kidney Int 2005; 67:514 - 23; http://dx.doi.org/10.1111/j.1523-1755.2005.67108.x; PMID: 15673299
   PubMed Web of Science ®Google Scholar
• Wharram BL, Goyal M, Wiggins JE, Sanden SK, Hussain S, Filipiak WE, et al. Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J Am Soc Nephrol 2005; 16:2941 - 52; http://dx.doi.org/10.1681/ASN.2005010055; PMID: 16107576
   PubMed Web of Science ®Google Scholar
• Sugimoto H, Mundel TM, Sund M, Xie L, Cosgrove D, Kalluri R. Bone-marrow-derived stem cells repair basement membrane collagen defects and reverse genetic kidney disease. Proc Natl Acad Sci U S A 2006; 103:7321 - 6; http://dx.doi.org/10.1073/pnas.0601436103; PMID: 16648256
   PubMed Web of Science ®Google Scholar
• LeBleu V, Sugimoto H, Mundel TM, Gerami-Naini B, Finan E, Miller CA, et al. Stem cell therapies benefit Alport syndrome. J Am Soc Nephrol 2009; 20:2359 - 70; http://dx.doi.org/10.1681/ASN.2009010123; PMID: 19833902
   PubMed Web of Science ®Google Scholar
• Gross O, Borza DB, Anders HJ, Licht C, Weber M, Segerer S, et al. Stem cell therapy for Alport syndrome: the hope beyond the hype. Nephrol Dial Transplant 2009; 24:731 - 4; http://dx.doi.org/10.1093/ndt/gfn722; PMID: 19110486
   PubMed Web of Science ®Google Scholar
• Ronconi E, Sagrinati C, Angelotti ML, Lazzeri E, Mazzinghi B, Ballerini L, et al. Regeneration of glomerular podocytes by human renal progenitors. J Am Soc Nephrol 2009; 20:322 - 32; http://dx.doi.org/10.1681/ASN.2008070709; PMID: 19092120
   PubMed Web of Science ®Google Scholar
• Appel D, Kershaw DB, Smeets B, Yuan G, Fuss A, Frye B, et al. Recruitment of podocytes from glomerular parietal epithelial cells. J Am Soc Nephrol 2009; 20:333 - 43; http://dx.doi.org/10.1681/ASN.2008070795; PMID: 19092119
   PubMed Web of Science ®Google Scholar
• Lazzeri E, Crescioli C, Ronconi E, Mazzinghi B, Sagrinati C, Netti GS, et al. Regenerative potential of embryonic renal multipotent progenitors in acute renal failure. J Am Soc Nephrol 2007; 18:3128 - 38; http://dx.doi.org/10.1681/ASN.2007020210; PMID: 17978305
   PubMed Web of Science ®Google Scholar
• Lasagni L, Ballerini L, Angelotti ML, Parente E, Sagrinati C, Mazzinghi B, et al. Notch activation differentially regulates renal progenitors proliferation and differentiation toward the podocyte lineage in glomerular disorders. Stem Cells 2010; 28:1674 - 85; http://dx.doi.org/10.1002/stem.492; PMID: 20680961
   PubMed Web of Science ®Google Scholar
• Bollée G, Flamant M, Schordan S, Fligny C, Rumpel E, Milon M, et al. Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nat Med 2011; 17:1242 - 50; http://dx.doi.org/10.1038/nm.2491; PMID: 21946538
   PubMed Web of Science ®Google Scholar
• Sayyed SG, Hägele H, Kulkarni OP, Endlich K, Segerer S, Eulberg D, et al. Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes. Diabetologia 2009; 52:2445 - 54; http://dx.doi.org/10.1007/s00125-009-1493-6; PMID: 19707743
   PubMed Web of Science ®Google Scholar
• Darisipudi MN, Kulkarni OP, Sayyed SG, Ryu M, Migliorini A, Sagrinati C, et al. Dual blockade of the homeostatic chemokine CXCL12 and the proinflammatory chemokine CCL2 has additive protective effects on diabetic kidney disease. Am J Pathol 2011; 179:116 - 24; http://dx.doi.org/10.1016/j.ajpath.2011.03.004; PMID: 21703397
   PubMed Web of Science ®Google Scholar
• Macconi D, Sangalli F, Bonomelli M, Conti S, Condorelli L, Gagliardini E, et al. Podocyte repopulation contributes to regression of glomerular injury induced by ACE inhibition. Am J Pathol 2009; 174:797 - 807; http://dx.doi.org/10.2353/ajpath.2009.080227; PMID: 19164508
   PubMed Web of Science ®Google Scholar
• Remuzzi G, Benigni A, Remuzzi A. Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes. J Clin Invest 2006; 116:288 - 96; http://dx.doi.org/10.1172/JCI27699; PMID: 16453013
   PubMed Web of Science ®Google Scholar
• Gaikwad AB, Sayyed SG, Lichtnekert J, Tikoo K, Anders HJ. Renal failure increases cardiac histone h3 acetylation, dimethylation, and phosphorylation and the induction of cardiomyopathy-related genes in type 2 diabetes. Am J Pathol 2010; 176:1079 - 83; http://dx.doi.org/10.2353/ajpath.2010.090528; PMID: 20075197
   PubMed Web of Science ®Google Scholar
• Sayyed SG, Gaikwad AB, Lichtnekert J, Kulkarni O, Eulberg D, Klussmann S, et al. Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10. Nephrol Dial Transplant 2010; 25:1811 - 7; http://dx.doi.org/10.1093/ndt/gfp730; PMID: 20067909
   PubMed Web of Science ®Google Scholar
• Smeets B, Angelotti ML, Rizzo P, Dijkman H, Lazzeri E, Mooren F, et al. Renal progenitor cells contribute to hyperplastic lesions of podocytopathies and crescentic glomerulonephritis. J Am Soc Nephrol 2009; 20:2593 - 603; http://dx.doi.org/10.1681/ASN.2009020132; PMID: 19875807
   PubMed Web of Science ®Google Scholar
• Smeets B, Uhlig S, Fuss A, Mooren F, Wetzels JF, Floege J, et al. Tracing the origin of glomerular extracapillary lesions from parietal epithelial cells. J Am Soc Nephrol 2009; 20:2604 - 15; http://dx.doi.org/10.1681/ASN.2009010122; PMID: 19917779
   PubMed Web of Science ®Google Scholar
• Atkins RC, Nikolic-Paterson DJ, Song Q, Lan HY. Modulators of crescentic glomerulonephritis. J Am Soc Nephrol 1996; 7:2271 - 8; PMID: 8959617
   PubMed Web of Science ®Google Scholar
• Tipping PG, Kitching PR, Holdsworth SR. The formation of the glomerular crescent. In: Immunologic Renal Diseases. 2. Neilson EG, Couser WG, eds. Philadelphia: Lippincott Williams & Wilkins Publishers, 2001.
   Google Scholar
• Lindgren D, Boström AK, Nilsson K, Hansson J, Sjölund J, Möller C, et al. Isolation and characterization of progenitor-like cells from human renal proximal tubules. Am J Pathol 2011; 178:828 - 37; http://dx.doi.org/10.1016/j.ajpath.2010.10.026; PMID: 21281815
   PubMed Web of Science ®Google Scholar
• Forbes MS, Thornhill BA, Chevalier RL. Proximal tubular injury and rapid formation of atubular glomeruli in mice with unilateral ureteral obstruction: a new look at an old model. Am J Physiol Renal Physiol 2011; 301:F110 - 7; http://dx.doi.org/10.1152/ajprenal.00022.2011; PMID: 21429968
   PubMed Web of Science ®Google Scholar
• Chevalier RL, Forbes MS. Generation and evolution of atubular glomeruli in the progression of renal disorders. J Am Soc Nephrol 2008; 19:197 - 206; http://dx.doi.org/10.1681/ASN.2007080862; PMID: 18199796
   PubMed Web of Science ®Google Scholar
• Ninichuk V, Gross O, Segerer S, Hoffmann R, Radomska E, Buchstaller A, et al. Multipotent mesenchymal stem cells reduce interstitial fibrosis but do not delay progression of chronic kidney disease in collagen4A3-deficient mice. Kidney Int 2006; 70:121 - 9; http://dx.doi.org/10.1038/sj.ki.5001521; PMID: 16723981
   PubMed Web of Science ®Google Scholar
• Higgins DF, Lappin DW, Kieran NE, Anders HJ, Watson RW, Strutz F, et al. DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition. Kidney Int 2003; 64:2079 - 91; http://dx.doi.org/10.1046/j.1523-1755.2003.00306.x; PMID: 14633130
   PubMed Web of Science ®Google Scholar
• Li Y, Liu Z, Guo X, Shu J, Chen Z, Li L. Aristolochic acid I-induced DNA damage and cell cycle arrest in renal tubular epithelial cells in vitro. Arch Toxicol 2006; 80:524 - 32; http://dx.doi.org/10.1007/s00204-006-0090-4; PMID: 16609888
   PubMed Web of Science ®Google Scholar
• Debelle FD, Vanherweghem JL, Nortier JL. Aristolochic acid nephropathy: a worldwide problem. Kidney Int 2008; 74:158 - 69; http://dx.doi.org/10.1038/ki.2008.129; PMID: 18418355
   PubMed Web of Science ®Google Scholar
• Smeets B, Kuppe C, Sicking EM, Fuss A, Jirak P, van Kuppevelt TH, et al. Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis. J Am Soc Nephrol 2011; 22:1262 - 74; http://dx.doi.org/10.1681/ASN.2010090970; PMID: 21719782
   PubMed Web of Science ®Google Scholar
• Helal I, Fick-Brosnahan GM, Reed-Gitomer B, Schrier RW. Glomerular hyperfiltration: definitions, mechanisms and clinical implications. Nat Rev Nephrol 2012; 8:293 - 300; http://dx.doi.org/10.1038/nrneph.2012.19; PMID: 22349487
   PubMed Web of Science ®Google Scholar
• Bariety J, Hill GS, Mandet C, Irinopoulou T, Jacquot C, Meyrier A, et al. Glomerular epithelial-mesenchymal transdifferentiation in pauci-immune crescentic glomerulonephritis. Nephrol Dial Transplant 2003; 18:1777 - 84; http://dx.doi.org/10.1093/ndt/gfg231; PMID: 12937224
   PubMed Web of Science ®Google Scholar
• Duffield JS. Epithelial to mesenchymal transition in injury of solid organs: fact or artifact?. Gastroenterology 2010; 139:1081 - 3, 1083, e1-5; http://dx.doi.org/10.1053/j.gastro.2010.08.017; PMID: 20800655
   PubMed Web of Science ®Google Scholar
• Zeisberg M, Duffield JS. Resolved: EMT produces fibroblasts in the kidney. J Am Soc Nephrol 2010; 21:1247 - 53; http://dx.doi.org/10.1681/ASN.2010060616; PMID: 20651165
   PubMed Web of Science ®Google Scholar
• Kriz W, Kaissling B, Le Hir M. Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?. J Clin Invest 2011; 121:468 - 74; http://dx.doi.org/10.1172/JCI44595; PMID: 21370523
   PubMed Web of Science ®Google Scholar
• Ninichuk V, Anders HJ. Bone marrow-derived progenitor cells and renal fibrosis. Front Biosci 2008; 13:5163 - 73; http://dx.doi.org/10.2741/3072; PMID: 18508578
   PubMed Web of Science ®Google Scholar
• Vielhauer V, Anders HJ, Mack M, Cihak J, Strutz F, Stangassinger M, et al. Obstructive nephropathy in the mouse: progressive fibrosis correlates with tubulointerstitial chemokine expression and accumulation of CC chemokine receptor 2- and 5-positive leukocytes. J Am Soc Nephrol 2001; 12:1173 - 87; PMID: 11373340
   PubMed Web of Science ®Google Scholar
• Anders HJ, Vielhauer V, Kretzler M, Cohen CD, Segerer S, Luckow B, et al. Chemokine and chemokine receptor expression during initiation and resolution of immune complex glomerulonephritis. J Am Soc Nephrol 2001; 12:919 - 31; PMID: 11316850
   PubMed Web of Science ®Google Scholar
• Mayer V, Hudkins KL, Heller F, Schmid H, Kretzler M, Brandt U, et al. Expression of the chemokine receptor CCR1 in human renal allografts. Nephrol Dial Transplant 2007; 22:1720 - 9; http://dx.doi.org/10.1093/ndt/gfm007; PMID: 17298994
   PubMed Web of Science ®Google Scholar
• Vielhauer V, Anders HJ. Chemokines and chemokine receptors as therapeutic targets in chronic kidney disease. Front Biosci (Schol Ed) 2009; 1:1 - 12; PMID: 19482677
   PubMedGoogle Scholar
• Jedlicka J, Soleiman A, Draganovici D, Mandelbaum J, Ziegler U, Regele H, et al. Interstitial inflammation in Alport syndrome. Hum Pathol 2010; 41:582 - 93; http://dx.doi.org/10.1016/j.humpath.2009.08.024; PMID: 20004949
   PubMed Web of Science ®Google Scholar
• Anders HJ, Ninichuk V, Schlöndorff D. Progression of kidney disease: blocking leukocyte recruitment with chemokine receptor CCR1 antagonists. Kidney Int 2006; 69:29 - 32; http://dx.doi.org/10.1038/sj.ki.5000053; PMID: 16374420
   PubMed Web of Science ®Google Scholar
• Eis V, Vielhauer V, Anders HJ. Targeting the chemokine network in renal inflammation. Arch Immunol Ther Exp (Warsz) 2004; 52:164 - 72; PMID: 15247883
   PubMed Web of Science ®Google Scholar
• Eis V, Luckow B, Vielhauer V, Siveke JT, Linde Y, Segerer S, et al. Chemokine receptor CCR1 but not CCR5 mediates leukocyte recruitment and subsequent renal fibrosis after unilateral ureteral obstruction. J Am Soc Nephrol 2004; 15:337 - 47; http://dx.doi.org/10.1097/01.ASN.0000111246.87175.32; PMID: 14747380
   PubMed Web of Science ®Google Scholar
• Anders HJ, Vielhauer V, Frink M, Linde Y, Cohen CD, Blattner SM, et al. A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J Clin Invest 2002; 109:251 - 9; PMID: 11805137
   PubMed Web of Science ®Google Scholar
• Anders HJ, Belemezova E, Eis V, Segerer S, Vielhauer V, Perez de Lema G, et al. Late onset of treatment with a chemokine receptor CCR1 antagonist prevents progression of lupus nephritis in MRL-Fas(lpr) mice. J Am Soc Nephrol 2004; 15:1504 - 13; http://dx.doi.org/10.1097/01.ASN.0000130082.67775.60; PMID: 15153561
   PubMed Web of Science ®Google Scholar
• Vielhauer V, Berning E, Eis V, Kretzler M, Segerer S, Strutz F, et al. CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndrome. Kidney Int 2004; 66:2264 - 78; http://dx.doi.org/10.1111/j.1523-1755.2004.66038.x; PMID: 15569315
   PubMed Web of Science ®Google Scholar
• Ninichuk V, Gross O, Reichel C, Khandoga A, Pawar RD, Ciubar R, et al. Delayed chemokine receptor 1 blockade prolongs survival in collagen 4A3-deficient mice with Alport disease. J Am Soc Nephrol 2005; 16:977 - 85; http://dx.doi.org/10.1681/ASN.2004100871; PMID: 15716328
   PubMed Web of Science ®Google Scholar
• Ninichuk V, Khandoga AG, Segerer S, Loetscher P, Schlapbach A, Revesz L, et al. The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice. Am J Pathol 2007; 170:1267 - 76; http://dx.doi.org/10.2353/ajpath.2007.060937; PMID: 17392166
   PubMed Web of Science ®Google Scholar
• Rao VH, Meehan DT, Delimont D, Nakajima M, Wada T, Gratton MA, et al. Role for macrophage metalloelastase in glomerular basement membrane damage associated with alport syndrome. Am J Pathol 2006; 169:32 - 46; http://dx.doi.org/10.2353/ajpath.2006.050896; PMID: 16816359
   PubMed Web of Science ®Google Scholar