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Review

Wnt signaling in kidney development and disease

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Pages 55-59 | Published online: 11 Jun 2008

References

  • Saxén L. Organogenesis of the kidney 1987; Cambridge Cambridge University Press
  • Logan CY, Nusse R. The wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004; 20:781 - 810
  • Sharpe C, Lawrence N, Martinez Arias A. Wnt signaling: A theme with nuclear variations. Bioessays 2001; 23:311 - 318
  • Merkel CE, Karner CM, Carrol TJ. Molecular regulation of kidney development: is the answer blowing in the Wnt?. Pediatr Nephrol 2007; 22:1825 - 1838
  • Lin Y, Liu A, Zhang S, Ruusunen T, Kreidberg JA, Peltoketo H, Drummond I, Vainio S. Induction of ureter branching as a response to wnt-2b signaling during early kidney organogenesis. Dev Dyn 2001; 222:26 - 39
  • Kispert A, Vainio S, McMahon AP. Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney. Development 1998; 125:4225 - 4234
  • Itaranta P, Lin Y, Perasaari J, Roel G, Destree O, Vainio S. Wnt-6 is expressed in the ureter bud and induces kidney tubule development in vitro. Genesis 2002; 32:259 - 268
  • Kispert A, Vainio S, Shen L, Rowitch DH, McMahon AP. Proteoglycans are required for maintenance of wnt-11 expression in the ureter tips. Development 1996; 122:3627 - 3637
  • Carroll TJ, Park JS, Hayashi S, Majumdar A, McMahon AP. Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell 2005; 9:283 - 292
  • Sadler GJ, Anderson MR, Moss MS, Wilson PG. Metastases from renal cell carcinoma presenting as gastrointestinal bleeding: Two case reports and a review of the literature. BMC Gastroenterol 2007; 7:4
  • Togashi A, Katagiri T, Ashida S, Fujioka T, Maruyama O, Wakumoto Y, Sakamoto Y, Fujime M, Kawachi Y, Shuin T, Nakamura Y. Hypoxia-inducible protein 2 (HIG2), a novel diagnostic marker for renal cell carcinoma and potential target for molecular therapy. Cancer Res 2005; 65:4817 - 4826
  • Janssens N, Andries L, Janicot M, Perera T, Bakker A. Alteration of frizzled expression in renal cell carcinoma. Tumor Biol 2004; 25:161 - 171
  • Dahl E, Wiesmann F, Woenckhaus M, Stoehr R, Wild PJ, Veeck J, Knuchel R, Klopocki E, Sauter G, Simon R, Wieland WF, Walter B, Denzinger S, Hartmann A, Hammerschmied CG. Frequent loss of SFRP1 expression in multiple human solid tumors: Association with aberrant promoter methylation in renal cell carcinoma. Oncogene 2007; 26:5680 - 5691
  • Guo A, Salomoni P, Luo J, Shih A, Zhong S, Gu W, Pandolfi PP. The function of PML in p53-dependent apoptosis. Nat Cell Biol 2000; 2:730 - 736
  • Gumz ML, Zou H, Kreinest PA, Childs AC, Belmonte LS, LeGrand SN, Wu KJ, Luxon BA, Sinha M, Parker AS, Sun LZ, Ahlquist DA, Wood CG, Copland JA. Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma. Clin Cancer Res 2007; 13:4740 - 4749
  • Sansom OJ, Griffiths DF, Reed KR, Winton DJ, Clarke AR. Apc deficiency predisposes to renal carcinoma in the mouse. Oncogene 2005; 24:8205 - 8210
  • Shiina H, Igawa M, Breault J, Ribeiro-Filho L, Pookot D, Urakami S, Terashima M, Deguchi M, Yamanaka M, Shirai M, Kaneuchi M, Kane CJ, Dahiya R. The human T-cell factor-4 gene splicing isoforms, Wnt signal pathway, and apoptosis in renal cell carcinoma. Clin Cancer Res 2003; 9:2121 - 2132
  • Lowe LH, Isuani BH, Heller RM, Stein SM, Johnson JE, Navarro OM, Hernanz-Schulman M. Pediatric renal masses: Wilms tumor and beyond. Radiographics 2000; 20:1585 - 1603
  • Koesters R, Ridder R, Kopp-Schneider A, Betts D, Adams V, Niggli F, Briner J, von Knebel Doeberitz M. Mutational activation of the beta-catenin proto-oncogene is a common event in the development of wilms' tumors. Cancer Res 1999; 59:3880 - 3882
  • Li CM, Kim CE, Margolin AA, Guo M, Zhu J, Mason JM, Hensle TW, Murty VV, Grundy PE, Fearon ER, D'Agati V, Licht JD, Tycko B. CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant wilms' tumors. Am J Pathol 2004; 165:1943 - 1953
  • Fukuzawa R, Heathcott RW, Sano M, Morison IM, Yun K, Reeve AE. Myogenesis in Wilms' tumors is associated with mutations of the WT1 gene and activation of bcl-2 and the Wnt signaling pathway. Pediatr Dev Pathol 2004; 7:125 - 137
  • Maiti S, Alam R, Amos CI, Huff V. Frequent association of beta-catenin and WT1 mutations in wilms tumors. Cancer Res 2000; 60:6288 - 6292
  • Rivera MN, Kim WJ, Wells J, Driscoll DR, Brannigan BW, Han M, Kim JC, Feinberg AP, Gerald WL, Vargas SO, Chin L, Iafrate AJ, Bell DW, Haber DA. An X chromosome gene, WTX, is commonly inactivated in wilms tumor. Science 2007; 315:642 - 645
  • Major MB, Camp ND, Berndt JD, Yi X, Goldenberg SJ, Hubbert C, Biechele TL, Gingras AC, Zheng N, Maccoss MJ, Angers S, Moon RT. Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. Science 2007; 316:1043 - 1046
  • Sim EU, Smith A, Szilagi E, Rae F, Ioannou P, Lindsay MH, Little MH. Wnt-4 regulation by the wilms' tumor suppressor gene, WT1. Oncogene 2002; 21:2948 - 2960
  • Haber DA, Sohn RL, Buckler AJ, Pelletier J, Call KM, Housman DE. Alternative splicing and genomic structure of the wilms tumor gene WT1. Proc Natl Acad Sci USA 1991; 88:9618 - 9622
  • Holmes G, Boterashvili S, English M, Wainwright B, Licht J, Little M. Two N-terminal self-association domains are required for the dominant negative transcriptional activity of WT1 Denys-Drash mutant proteins. Biochem Biophys Res Commun 1997; 233:723 - 728
  • Stark K, Vainio S, Vassileva G, McMahon AP. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by wnt-4. Nature 1994; 372:679 - 683
  • Costantini F. Renal branching morphogenesis: Concepts, questions, and recent advances. Differentiation 2006; 74:402 - 421
  • Le Floch N, Rivat C, De Wever O, Bruyneel E, Mareel M, Dale T, Gespach C. The pro-invasive activity of wnt-2 is mediated through a noncanonical wnt pathway coupled to GSK-3beta and c-Jun/AP-1 signaling. FASEB J 2005; 19:144 - 146
  • Haumaitre C, Fabre M, Cormier S, Baumann C, Delezoide AL, Cereghini S. Severe pancreas hypoplasia and multicystic renal dysplasia in two human fetuses carrying novel HNF1beta/MODY5 mutations. Hum Mol Genet 2006; 15:2363 - 2375
  • Qian CN, Knol J, Igarashi P, Lin F, Zylstra U, Teh BT, Williams BO. Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium. J Biol Chem 2005; 280:3938 - 3945
  • Saadi-Kheddouci S, Berrebi D, Romagnolo B, Cluzeaud F, Peuchmaur M, Kahn A, Vandewalle A, Perret C. Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the beta-catenin gene. Oncogene 2001; 20:5972 - 5981
  • Hu MC, Piscione TD, Rosenblum ND. Elevated SMAD1/beta-catenin molecular complexes and renal medullary cystic dysplasia in ALK3 transgenic mice. Development 2003; 130:2753 - 2766
  • Liu Y. Epithelial to mesenchymal transition in renal fibrogenesis: Pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 2004; 15:1 - 12
  • Taki M, Kamata N, Yokoyama K, Fujimoto R, Tsutsumi S, Nagayama M. Downregulation of wnt-4 and upregulation of wnt-5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells. Cancer Sci 2003; 94:593 - 597
  • Kim K, Lu Z, Hay ED. Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT. Cell Biol Int 2002; 26:463 - 476
  • Surendran K, Schiavi S, Hruska KA. Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol 2005; 16:2373 - 2384
  • Surendran K, McCaul SP, Simon TC. A role for wnt-4 in renal fibrosis. Am J Physiol Renal Physiol 2002; 282:431 - 441
  • Atala A, Freeman MR, Mandell J, Beier DR. Juvenile cystic kidneys (jck): A new mouse mutation which causes polycystic kidneys. Kidney Int 1993; 43:1081 - 1085
  • Surendran K, Simon TC, Liapis H, McGuire JK. Matrilysin (MMP-7) expression in renal tubular damage: Association with Wnt4. Kidney Int 2004; 65:2212 - 2222
  • Terada Y, Tanaka H, Okado T, Shimamura H, Inoshita S, Kuwahara M, Sasaki S. Expression and function of the developmental gene wnt-4 during experimental acute renal failure in rats. J Am Soc Nephrol 2003; 14:1223 - 1233
  • Price VR, Reed CA, Lieberthal W, Schwartz JH. ATP depletion of tubular cells causes dissociation of the zonula adherens and nuclear translocation of beta-catenin and LEF-1. J Am Soc Nephrol 2002; 13:1152 - 1161
  • Lin CL, Wang JY, Huang YT, Kuo YH, Surendran K, Wang FS. Wnt/beta-catenin signaling modulates survival of high glucose-stressed mesangial cells. J Am Soc Nephrol 2006; 17:2812 - 2820
  • Gumz ML, Zou H, Kreinest PA, Childs AC, Belmonte LS, LeGrand SN, Wu KJ, Luxon BA, Sinha M, Parker AS, Sun LZ, Ahlquist DA, Wood CG, Copland JA. Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma. Clin Cancer Res 2007; 13:4740 - 4749