Role of histone methylation and demethylation in adipogenesis and obesity

References

• Wolffe AP. Transcriptional regulation in the context of chromatin structure. Essays Biochem 2001; 37:45 - 57
   PubMed Web of Science ®Google Scholar
• Kornberg RD, Lorch Y. Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. Cell 1999; 98:285 - 294
   PubMed Web of Science ®Google Scholar
• Jenuwein T, Allis CD. Translating the histone code. Science 2001; 293:1074 - 1080
   PubMed Web of Science ®Google Scholar
• Fischle W, Wang Y, Allis CD. Histone and chromatin cross-talk. Curr Opin Cell Biol 2003; 15:172 - 183
   PubMed Web of Science ®Google Scholar
• Margueron R, Trojer P, Reinberg D. The key to development: interpreting the histone code?. Curr Opin Genet Dev 2005; 15:163 - 176
   PubMed Web of Science ®Google Scholar
• Martin C, Zhang Y. The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol 2005; 6:838 - 849
   PubMed Web of Science ®Google Scholar
• Bedford MT, Richard S. Arginine methylation an emerging regulator of protein function. Mol Cell 2005; 18:263 - 272
   PubMed Web of Science ®Google Scholar
• Bannister AJ, Kouzarides T. Reversing histone methylation. Nature 2005; 436:1103 - 1106
   PubMed Web of Science ®Google Scholar
• Lachner M, O’Carroll D, Rea S, Mechtler K, Jenuwein T. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 2001; 410:116 - 120
   PubMed Web of Science ®Google Scholar
• Klose RJ, Kallin EM, Zhang Y. JmjC-domaincontaining proteins and histone demethylation. Nat Rev 2006; 7:715 - 727
   Google Scholar
• Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 2006; 444:847 - 853
   PubMed Web of Science ®Google Scholar
• Farmer SR. Molecular determinants of brown adipocyte formation and function. Genes Dev 2008; 22:1269 - 1275
   PubMed Web of Science ®Google Scholar
• Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 2004; 92:347 - 355
   PubMed Web of Science ®Google Scholar
• Friedman JM. Obesity in the new millennium. Nature 2000; 404:632 - 634
   PubMed Web of Science ®Google Scholar
• Rosen ED, Hsu CH, Wang X, Sakai S, Freeman MW, Gonzalez FJ, et al. C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev 2002; 16:22 - 26
   PubMed Web of Science ®Google Scholar
• Farmer SR. Transcriptional control of adipocyte formation. Cell Metab 2006; 4:263 - 273
   PubMed Web of Science ®Google Scholar
• Zhu Y, Qi C, Korenberg JR, Chen XN, Noya D, Rao MS, Reddy JK. Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR-gamma) gene: alternative promoter use and different splicing yield two mPPARgamma isoforms. Proc Natl Acad Sci USA 1995; 92:7921 - 7925
   PubMed Web of Science ®Google Scholar
• Morrison RF, Farmer SR. Role of PPARgamma in regulating a cascade expression of cyclin-dependent kinase inhibitors, p18(INK4c) and p21(Waf1/Cip1), during adipogenesis. J Biol Chem 1999; 274:17088 - 17097
   PubMed Web of Science ®Google Scholar
• Tong Q, Dalgin G, Xu H, Ting CN, Leiden JM, Hotamisligil GS. Function of GATA transcription factors in preadipocyte-adipocyte transition. Science 2000; 290:134 - 138
   PubMed Web of Science ®Google Scholar
• Birsoy K, Chen Z, Friedman J. Transcriptional regulation of adipogenesis by KLF4. Cell Metab 2008; 7:339 - 347
   PubMed Web of Science ®Google Scholar
• Oishi Y, Manabe I, Tobe K, Tsushima K, Shindo T, Fujiu K, et al. Kruppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab 2005; 1:27 - 39
   PubMed Web of Science ®Google Scholar
• Mori T, Sakaue H, Iguchi H, Gomi H, Okada Y, Takashima Y, et al. Role of Kruppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. J Biol Chem 2005; 280:12867 - 12875
   PubMed Web of Science ®Google Scholar
• Xu Z, Yu S, Hsu C-H, Eguchi J, Rosen ED. The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis. Proc Natl Acad Sci USA 2008; 0707082105
   Web of Science ®Google Scholar
• Okamura M, Kudo H, Wakabayashi K, Tanaka T, Nonaka A, Uchida A, et al. COUP-TFII acts downstream of Wnt/β-catenin signal to silence PPARγ gene expression and repress adipogenesis. Proc Natl Acad Sci USA 2009; 106:5819 - 5824
   PubMed Web of Science ®Google Scholar
• Rosen ED, MacDougald OA. Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 2006; 7:885 - 896
   PubMed Web of Science ®Google Scholar
• Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 2003; 33:245 - 254
   PubMed Web of Science ®Google Scholar
• Wakabayashi K, Okamura M, Tsutsumi S, Nishikawa NS, Tanaka T, Sakakibara I, et al. The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop. Mol Cell Biol 2009; 29:3544 - 3555
   PubMed Web of Science ®Google Scholar
• Talasz H, Lindner HH, Sarg B, Helliger W. Histone H4-lysine 20 monomethylation is increased in promoter and coding regions of active genes and correlates with hyperacetylation. J Biol Chem 2005; 280:38814 - 38822
   PubMed Web of Science ®Google Scholar
• Vakoc CR, Sachdeva MM, Wang H, Blobel GA. Profile of histone lysine methylation across transcribed mammalian chromatin. Mol Cell Biol 2006; 26:9185 - 9195
   PubMed Web of Science ®Google Scholar
• Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, et al. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev 2004; 18:1251 - 1262
   PubMed Web of Science ®Google Scholar
• Barski A, Cuddapah S, Cui K, Roh TY, Schones DE, Wang Z, et al. High-resolution profiling of histone methylations in the human genome. Cell 2007; 129:823 - 837
   PubMed Web of Science ®Google Scholar
• Gong Y, et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 2001; 107:513 - 523
   PubMed Web of Science ®Google Scholar
• Boyden LM, Mao J, Belsky J, Mitzner L, Farhi A, Mitnick MA, et al. High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med 2002; 346:1513 - 1521
   PubMed Web of Science ®Google Scholar
• Fujino T, et al. Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc Natl Acad Sci USA 2003; 100:229 - 234
   PubMed Web of Science ®Google Scholar
• Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006; 127:469 - 480
   PubMed Web of Science ®Google Scholar
• Takada I, Mihara M, Suzawa M, Ohtake F, Kobayashi S, Igarashi M, et al. A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPARgamma transactivation. Nat Cell Biol 2007; 9:1273 - 1285
   PubMed Web of Science ®Google Scholar
• Vissers LE, van Ravenswaaij CM, Admiraal R, Hurst JA, de Vries BB, Janssen IM, et al. Mutations in a new member of the chromodomain gene family cause CHARGE syndrome. Nat Genet 2004; 36:955 - 957
   PubMed Web of Science ®Google Scholar
• Schultz DC, Ayyanathan K, Negorev D, Maul GG, Rauscher FJ 3rd. SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev 2002; 16:919 - 932
   PubMed Web of Science ®Google Scholar
• Wang H, An W, Cao R, Xia L, Erdjument-Bromage H, Chatton B, et al. mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol Cell 2003; 12:475 - 487
   PubMed Web of Science ®Google Scholar
• Ruthenburg AJ, Allis CD, Wysocka J. Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol Cell 2007; 25:15 - 30
   PubMed Web of Science ®Google Scholar
• Shilatifard A. Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression. Annu Rev Biochem 2006; 75:243 - 269
   PubMed Web of Science ®Google Scholar
• Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, et al. Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. Mol Cell Biol 2003; 23:140 - 149
   PubMed Web of Science ®Google Scholar
• Dou Y, Milne TA, Ruthenburg AJ, Lee S, Lee JW, Verdine GL, et al. Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat Struct Mol Biol 2006; 13:713 - 719
   PubMed Web of Science ®Google Scholar
• Steward MM, Lee JS, O’Donovan A, Wyatt M, Bernstein BE, Shilatifard A. Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes. Nat Struct Mol Biol 2006; 13:852 - 854
   PubMed Web of Science ®Google Scholar
• Wysocka J, Swigut T, Milne TA, Dou Y, Zhang X, Burlingame AL, et al. WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell 2005; 121:859 - 872
   PubMed Web of Science ®Google Scholar
• Mahajan MA, Samuels HH. Nuclear hormone receptor coregulator: role in hormone action, metabolism, growth and development. Endocr Rev 2005; 26:583 - 597
   PubMed Web of Science ®Google Scholar
• Lee S, Lee DK, Dou Y, Lee J, Lee B, Kwak E, et al. Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc Natl Acad Sci USA 2006; 103:15392 - 15397
   PubMed Web of Science ®Google Scholar
• Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, et al. PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem 2007; 282:20395 - 20406
   PubMed Web of Science ®Google Scholar
• Issaeva I, Zonis Y, Rozovskaia T, Orlovsky K, Croce CM, Nakamura T, et al. Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth. Mol Cell Biol 2007; 27:1889 - 1903
   PubMed Web of Science ®Google Scholar
• Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, et al. A histone H3 lysine 27 demethylase regulates animal posterior development. Nature 2007; 449:689 - 694
   PubMed Web of Science ®Google Scholar
• Lee MG, Villa R, Trojer P, Norman J, Yan KP, Reinberg D, et al. Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science 2007; 318:447 - 450
   PubMed Web of Science ®Google Scholar
• Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 2007; 449:731 - 734
   PubMed Web of Science ®Google Scholar
• Hong S, Cho YW, Yu LR, Yu H, Veenstra TD, Ge K. Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. Proc Natl Acad Sci USA 2007; 104:18439 - 18444
   PubMed Web of Science ®Google Scholar
• Kuang SQ, Liao L, Zhang H, Pereira FA, Yuan Y, DeMayo FJ, et al. Deletion of the cancer-amplified coactivator AIB3 results in defective placentation and embryonic lethality. J Biol Chem 2002; 277:45356 - 45360
   PubMed Web of Science ®Google Scholar
• Antonson P, Schuster GU, Wang L, Rozell B, Holter E, Flodby P, et al. Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction. Mol Cell Biol 2003; 23:1260 - 1268
   PubMed Web of Science ®Google Scholar
• Qi C, Surapureddi S, Zhu YJ, Yu S, Kashireddy P, Rao MS, et al. Transcriptional coactivator PRIP, the peroxisome proliferator-activated receptor gamma (PPARgamma)-interacting protein, is required for PPARgamma-mediated adipogenesis. J Biol Chem 2003; 278:25281 - 25284
   PubMed Web of Science ®Google Scholar
• Hong S, Lee MY, Cheong J. Functional interaction of transcriptional coactivator ASC-2 and C/EBPalpha in granulocyte differentiation of HL-60 promyelocytic cell. Biochem Biophys Res Commun 2001; 282:1257 - 1262
   PubMed Web of Science ®Google Scholar
• Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM. Transcriptional regulation of adipogenesis. Genes Dev 2000; 14:1293 - 1307
   PubMed Web of Science ®Google Scholar
• Lee J, Saha PK, Yang QH, Lee S, Park JY, Suh Y, et al. Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Proc Natl Acad Sci USA 2008; 105:19229 - 19234
   PubMed Web of Science ®Google Scholar
• Cho YW, Hong S, Jin Q, Wang L, Lee JE, Gavrilova O, et al. Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis. Cell Metab 2009; 10:27 - 39
   PubMed Web of Science ®Google Scholar
• Kim D, Wang M, Cai Q, Brooks H, Dressler GR. Pax transactivation-domain interacting protein is required for urine concentration and osmotolerance in collecting duct epithelia. J Am Soc Nephrol 2007; 18:1458 - 1465
   PubMed Web of Science ®Google Scholar
• Seale P, Kajimura S, Yang W, Chin S, Rohas LM, Uldry M, et al. Transcriptional control of brown fat determination by PRDM16. Cell Metab 2007; 6:38 - 54
   PubMed Web of Science ®Google Scholar
• He W, Barak Y, Hevener A, Olson P, Liao D, Le J, et al. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci USA 2003; 100:15712 - 15717
   PubMed Web of Science ®Google Scholar
• Lowell BB, V SS, Hamann A, Lawitts JA, Himms-Hagen J, Boyer BB, et al. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 1993; 366:740 - 742
   PubMed Web of Science ®Google Scholar
• Kajimura S, Seale P, Tomaru T, Erdjument-Bromage H, Cooper MP, Ruas JL, et al. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev 2008; 22:1397 - 1409
   PubMed Web of Science ®Google Scholar
• Ross SE, Hemati N, Longo KA, Bennett CN, Lucas PC, Erickson RL, et al. Inhibition of adipogenesis by Wnt signaling. Science 2000; 289:950 - 953
   PubMed Web of Science ®Google Scholar
• Bennett CN, Ross SE, Longo KA, Bajnok L, Hemati N, Johnson KW, et al. Regulation of Wnt signaling during adipogenesis. J Biol Chem 2002; 277:30998 - 31004
   PubMed Web of Science ®Google Scholar
• Musri MM, Corominola H, Casamitjana R, Gomis R, Parrizas M. Histone H3 lysine 4 dimethylation signals the transcriptional competence of the adiponectin promoter in preadipocytes. J Biol Chem 2006; 281:17180 - 17188
   PubMed Web of Science ®Google Scholar
• Mikkelsen TS, et al. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 2007; 448:553 - 560
   PubMed Web of Science ®Google Scholar
• Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006; 125:315 - 326
   PubMed Web of Science ®Google Scholar
• Cao R, Zhang Y. The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. Curr Opin Genet Dev 2004; 14:155 - 164
   PubMed Web of Science ®Google Scholar
• Shi Y, Whetstine JR. Dynamic regulation of histone lysine methylation by demethylases. Mol Cell 2007; 25:1 - 14
   PubMed Web of Science ®Google Scholar
• Yamane K, Toumazou C, Tsukada Y, Erdjument-Bromage H, Tempst P, Wong J, et al. JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell 2006; 125:483 - 495
   PubMed Web of Science ®Google Scholar
• Okada Y, Scott G, Ray MK, Mishina Y, Zhang Y. Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis. Nature 2007; 450:119 - 123
   PubMed Web of Science ®Google Scholar
• Tateishi K, Okada Y, Kallin EM, Zhang Y. Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature 2009; 458:757 - 761
   PubMed Web of Science ®Google Scholar
• Inagaki T, Tachibana M, Magoori K, Kudo H, Tanaka T, Okamura M, et al. Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice. Genes Cells 2009; 14:991 - 1001
   PubMed Web of Science ®Google Scholar
• Koza RA, Nikonova L, Hogan J, Rim J-S, Mendoza T, Faulk C, et al. Changes in gene expression foreshadow diet-induced obesity in genetically identical mice. PLoS Genet 2006; 2:81
   Web of Science ®Google Scholar
• Jong MC, Voshol PJ, Muurling M, Dahlmans VE, Romijn JA, Pijl H, et al. Protection from obesity and insulin resistance in mice overexpressing human apolipoprotein C1. Diabetes 2001; 50:2779 - 2785
   PubMed Web of Science ®Google Scholar
• Rossetti L, Stenbit AE, Chen W, Hu M, Barzilai N, Katz EB, et al. Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene. J Clin Invest 1997; 100:1831 - 1839
   PubMed Web of Science ®Google Scholar
• Zeggini E, et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 2008; 40:638 - 645
   PubMed Web of Science ®Google Scholar