Interplays Between Covalent Modifications in the Endoplasmic Reticulum Increase Conformational Diversity in Nascent Prion Protein

References

• Sitia R, Braakman I. Quality control in the endoplasmic reticulum protein factory. Nature 2003; 426:891 - 894
   PubMed Web of Science ®Google Scholar
• Johnson AE, van Waes MA. The translocon: a dynamic gateway at the ER membrane. Annu Rev Cell Dev Biol 1999; 15:799 - 842
   PubMed Web of Science ®Google Scholar
• Frand AR, Cuozzo JW, Kaiser CA. Pathways for protein disulphide bond formation. Trends Cell Biol 2000; 10:203 - 210
   PubMed Web of Science ®Google Scholar
• Helenius A, Aebi M. Intracellular functions of N-linked glycans. Science 2001; 291:2364 - 2369
   PubMed Web of Science ®Google Scholar
• Udenfriend S, Kodukula K. How glycosylphosphatidylinositol-anchored membrane proteins are made. Annu Rev Biochem 1995; 64:563 - 591
   PubMed Web of Science ®Google Scholar
• Prusiner SB. Prions. Proc Natl Acad Sci USA 1998; 95:13363 - 13383
   PubMed Web of Science ®Google Scholar
• Orsi A, Fioriti L, Chiesa R, Sitia R. Conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion protein. J Biol Chem 2006; 281:30431 - 30438
   PubMed Web of Science ®Google Scholar
• Walmsley AR, Zeng F, Hooper NM. Membrane topology influences N-glycosylation of the prion protein. Embo J 2001; 20:703 - 712
   PubMed Web of Science ®Google Scholar
• Parchi P, Castellani R, Capellari S, Ghetti B, Young K, Chen SG, Farlow M, Dickson DW, Sima AA, Trojanowski JQ, Petersen RB, Gambetti P. Molecular basis of phenotypic variability in sporadic Creutzfeldt-Jakob disease. Ann Neurol 1996; 39:767 - 778
   PubMed Web of Science ®Google Scholar
• Kang SW, Rane NS, Kim SJ, Garrison JL, Taunton J, Hegde RS. Substrate-Specific Translocational Attenuation during ER Stress Defines a Pre-Emptive Quality Control Pathway. Cell 2006; 127:999 - 1013
   PubMed Web of Science ®Google Scholar
• Fioriti L, Dossena S, Stewart LR, Stewart RS, Harris DA, Forloni G, Chiesa R. Cytosolic prion protein (PrP) is not toxic in N2a cells and primary neurons expressing pathogenic PrP mutations. J Biol Chem 2005; 280:11320 - 11328
   PubMed Web of Science ®Google Scholar
• Lehmann S, Harris DA. A mutant prion protein displays an aberrant membrane association when expressed in cultured cells. J Biol Chem 1995; 270:24589 - 24597
   PubMed Web of Science ®Google Scholar
• Bertoli G, Simmen T, Anelli T, Molteni SN, Fesce R, Sitia R. Two conserved cysteine triads in human Ero1alpha cooperate for efficient disulfide bond formation in the endoplasmic reticulum. J Biol Chem 2004; 279:30047 - 30052
   PubMed Web of Science ®Google Scholar
• Kascsak RJ, Rubenstein R, Merz PA, Tonna DeMasi M, Fersko R, Carp RI, Wisniewski HM, Diringer H. Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins. J Virol 1987; 61:3688 - 3693
   PubMed Web of Science ®Google Scholar
• Angelini G, Gardella S, Ardy M, Ciriolo MR, Filomeni G, Di Trapani G, Clarke F, Sitia R, Rubartelli A. Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation. Proc Natl Acad Sci USA 2002; 99:1491 - 1496
   PubMed Web of Science ®Google Scholar
• Jessop CE, Bulleid NJ. Glutathione directly reduces an oxidoreductase in the endoplasmic reticulum of mammalian cells. J Biol Chem 2004; 279:55341 - 55347
   PubMed Web of Science ®Google Scholar
• Turk E, Teplow DB, Hood LE, Prusiner SB. Purification and properties of the cellular and scrapie hamster prion proteins. Eur J Biochem 1988; 176:21 - 30
   PubMedGoogle Scholar
• Capellari S, Zaidi SI, Urig CB, Perry G, Smith MA, Petersen RB. Prion protein glycosylation is sensitive to redox change. J Biol Chem 1999; 274:34846 - 34850
   PubMed Web of Science ®Google Scholar
• Valetti C, Sitia R. The differential effects of dithiothreitol and 2-mercaptoethanol on the secretion of partially and completely assembled immunoglobulins suggest that thiol-mediated retention does not take place in or beyond the Golgi. Mol Biol Cell 1994; 5:1311 - 1324
   PubMed Web of Science ®Google Scholar
• Mezghrani A, Fassio A, Benham A, Simmen T, Braakman I, Sitia R. Manipulation of oxidative protein folding and PDI redox state in mammalian cells. EMBO J 2001; 20:6288 - 6296
   PubMed Web of Science ®Google Scholar
• Stahl N, Borchelt DR, Hsiao K, Prusiner SB. Scrapie prion protein contains a phosphatidylinositol glycolipid. Cell 1987; 51:229 - 240
   PubMed Web of Science ®Google Scholar
• Whitley P, Nilsson IM, von Heijne G. A nascent secretory protein may traverse the ribosome/endoplasmic reticulum translocase complex as an extended chain. J Biol Chem 1996; 271:6241 - 6244
   PubMed Web of Science ®Google Scholar
• Walmsley AR, Hooper NM. Distance of sequons to the C-terminus influences the cellular N-glycosylation of the prion protein. Biochem J 2003; 370:351 - 355
   PubMed Web of Science ®Google Scholar
• Mattioli L, Anelli T, Fagioli C, Tacchetti C, Sitia R, Valetti C. ER storage diseases: a role for ERGIC-53 in controlling the formation and shape of Russell bodies. J Cell Sci 2006; 119:2532 - 2541
   PubMed Web of Science ®Google Scholar
• Collinge J, Sidle KC, Meads J, Ironside J, Hill AF. Molecular analysis of prion strain variation and the aetiology of ‘new variant’ CJD. Nature 1996; 383:685 - 690
   PubMed Web of Science ®Google Scholar
• Lehmann S, Harris DA. Blockade of glycosylation promotes acquisition of scrapie-like properties by the prion protein in cultured cells. J Biol Chem 1997; 272:21479 - 21487
   PubMed Web of Science ®Google Scholar
• Taraboulos A, Rogers M, Borchelt DR, McKinley MP, Scott M, Serban D, Prusiner SB. Acquisition of protease resistance by prion proteins in scrapie-infected cells does not require asparagine-linked glycosylation. Proc Natl Acad Sci USA 1990; 87:8262 - 8266
   PubMed Web of Science ®Google Scholar