1,740
Views
43
CrossRef citations to date
0
Altmetric
Review

Aggregated proteins in schizophrenia and other chronic mental diseases

DISC1opathies

Pages 134-141 | Received 20 Oct 2011, Accepted 08 Dec 2011, Published online: 01 Apr 2012

References

  • American Psychiatric Association APA. Diagnostic and Statistical Manual IV (DSM IV). Washington, D.C., 1994.
  • an der Heiden W, Häfner H. The epidemiology of onset and course of schizophrenia. Eur Arch Psychiatry Clin Neurosci 2000; 250:292 - 303; http://dx.doi.org/10.1007/s004060070004; PMID: 11153964
  • Kirkpatrick B, Fenton WS, Carpenter WT Jr., Marder SR. The NIMH-MATRICS consensus statement on negative symptoms. Schizophr Bull 2006; 32:214 - 9; http://dx.doi.org/10.1093/schbul/sbj053; PMID: 16481659
  • Gur RE, Calkins ME, Gur RC, Horan WP, Nuechterlein KH, Seidman LJ, et al. The Consortium on the Genetics of Schizophrenia: neurocognitive endophenotypes. Schizophr Bull 2007; 33:49 - 68; http://dx.doi.org/10.1093/schbul/sbl055; PMID: 17101692
  • Kraepelin E. Zur Diagnose und Prognose der Dementia praecox. Allg Z Psychiatr 1899; 56:246 - 63
  • Bleuler E. Dementia praecox oder Gruppe der Schizophrenien. Leipzig: F. Deuticke, 1911.
  • Carpenter WT Jr.. Conceptualizing schizophrenia through attenuated symptoms in the population. Am J Psychiatry 2010; 167:1013 - 6; http://dx.doi.org/10.1176/appi.ajp.2010.10060854; PMID: 20826849
  • Kirkpatrick B, Buchanan RW, Ross DE, Carpenter WT Jr.. A separate disease within the syndrome of schizophrenia. Arch Gen Psychiatry 2001; 58:165 - 71; http://dx.doi.org/10.1001/archpsyc.58.2.165; PMID: 11177118
  • Chua SE, McKenna PJ. A Sceptical View of the Neuropathology of Schizophrenia. In: Harrison PJ, Roberts G.W., ed. The Neuropathology of Schizophrenia. Oxford: Oxford University Press, 2000:291-337.
  • Delay J, Deniker P, Harl J-M. Traitement des états d’excitation et d’agitation par une méthode médicamenteuse dérivée de l’hibernothérapie. Ann Med Psychol (Paris) 1952; 110:267 - 73; PMID: 13008201
  • Carlsson A, Lindqvist M. Effect of chlorpromazine or haloperidol on the formation of 3-methoxytyramine and norepinephrine in mouse brain. Acta Pharmacol Toxicol (Copenh) 1963; 20:140 - 4; http://dx.doi.org/10.1111/j.1600-0773.1963.tb01730.x; PMID: 14060771
  • Davis KL, Kahn RS, Ko G, Davidson M. Dopamine in schizophrenia: a review and reconceptualization. Am J Psychiatry 1991; 148:1474 - 86; PMID: 1681750
  • Howes OD, Kapur S. The dopamine hypothesis of schizophrenia: version III--the final common pathway. Schizophr Bull 2009; 35:549 - 62; http://dx.doi.org/10.1093/schbul/sbp006; PMID: 19325164
  • Weinberger DR. Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 1987; 44:660 - 9; http://dx.doi.org/10.1001/archpsyc.1987.01800190080012; PMID: 3606332
  • Jaaro-Peled H, Hayashi-Takagi A, Seshadri S, Kamiya A, Brandon NJ, Sawa A. Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1. Trends Neurosci 2009; 32:485 - 95; http://dx.doi.org/10.1016/j.tins.2009.05.007; PMID: 19712980
  • Kety SS. The significance of genetic factors in the etiology of schizophrenia: results from the national study of adoptees in Denmark. J Psychiatr Res 1987; 21:423 - 9; http://dx.doi.org/10.1016/0022-3956(87)90089-6; PMID: 3440955
  • Gottesman II, Shields J. A critical review of recent adoption, twin, and family studies of schizophrenia: behavioral genetics perspectives. Schizophr Bull 1976; 2:360 - 401; PMID: 1034336
  • Millar JK, Wilson-Annan JC, Anderson S, Christie S, Taylor MS, Semple CA, et al. Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet 2000; 9:1415 - 23; http://dx.doi.org/10.1093/hmg/9.9.1415; PMID: 10814723
  • Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, et al. Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 2002; 71:877 - 92; http://dx.doi.org/10.1086/342734; PMID: 12145742
  • Schwab SG, Knapp M, Mondabon S, Hallmayer J, Borrmann-Hassenbach M, Albus M, et al. Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families. Am J Hum Genet 2003; 72:185 - 90; http://dx.doi.org/10.1086/345463; PMID: 12474144
  • Harrison PJ, Weinberger DR. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 2005; 10:40 - 68; http://dx.doi.org/10.1038/sj.mp.4001558; PMID: 15263907
  • Owen MJ, Craddock N, Jablensky A. The genetic deconstruction of psychosis. Schizophr Bull 2007; 33:905 - 11; http://dx.doi.org/10.1093/schbul/sbm053; PMID: 17551090
  • Craddock N, Owen MJ. Rethinking psychosis: the disadvantages of a dichotomous classification now outweigh the advantages. World Psychiatry 2007; 6:84 - 91; PMID: 18235858
  • Kellendonk C, Simpson EH, Kandel ER. Modeling cognitive endophenotypes of schizophrenia in mice. Trends Neurosci 2009; 32:347 - 58; http://dx.doi.org/10.1016/j.tins.2009.02.003; PMID: 19409625
  • Arguello PA, Gogos JA. Modeling madness in mice: one piece at a time. Neuron 2006; 52:179 - 96; http://dx.doi.org/10.1016/j.neuron.2006.09.023; PMID: 17015235
  • Powers ET, Morimoto RI, Dillin A, Kelly JW, Balch WE. Biological and chemical approaches to diseases of proteostasis deficiency. Annu Rev Biochem 2009; 78:959 - 91; http://dx.doi.org/10.1146/annurev.biochem.052308.114844; PMID: 19298183
  • Prusiner SB. Shattuck lecture--neurodegenerative diseases and prions. N Engl J Med 2001; 344:1516 - 26; http://dx.doi.org/10.1056/NEJM200105173442006; PMID: 11357156
  • Taylor JP, Hardy J, Fischbeck KH. Toxic proteins in neurodegenerative disease. Science 2002; 296:1991 - 5; http://dx.doi.org/10.1126/science.1067122; PMID: 12065827
  • Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA 1985; 82:4245 - 9; http://dx.doi.org/10.1073/pnas.82.12.4245; PMID: 3159021
  • Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease. Nature 1991; 349:704 - 6; http://dx.doi.org/10.1038/349704a0; PMID: 1671712
  • Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M. alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with lewy bodies. Proc Natl Acad Sci USA 1998; 95:6469 - 73; http://dx.doi.org/10.1073/pnas.95.11.6469; PMID: 9600990
  • Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson’s disease. Science 1997; 276:2045 - 7; http://dx.doi.org/10.1126/science.276.5321.2045; PMID: 9197268
  • Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, et al. Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol 2009; 11:909 - 13; http://dx.doi.org/10.1038/ncb1901; PMID: 19503072
  • Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, et al. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci USA 2009; 106:13010 - 5; http://dx.doi.org/10.1073/pnas.0903691106; PMID: 19651612
  • Ren PH, Lauckner JE, Kachirskaia I, Heuser JE, Melki R, Kopito RR. Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates. Nat Cell Biol 2009; 11:219 - 25; http://dx.doi.org/10.1038/ncb1830; PMID: 19151706
  • Münch C, O’Brien J, Bertolotti A. Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells. Proc Natl Acad Sci USA 2011; 108:3548 - 53; http://dx.doi.org/10.1073/pnas.1017275108; PMID: 21321227
  • Grad LI, Guest WC, Yanai A, Pokrishevsky E, O’Neill MA, Gibbs E, et al. Intermolecular transmission of superoxide dismutase 1 misfolding in living cells. Proc Natl Acad Sci USA 2011; 108:16398 - 403; http://dx.doi.org/10.1073/pnas.1102645108; PMID: 21930926
  • Li JY, Englund E, Holton JL, Soulet D, Hagell P, Lees AJ, et al. Lewy bodies in grafted neurons in subjects with Parkinson’s disease suggest host-to-graft disease propagation. Nat Med 2008; 14:501 - 3; http://dx.doi.org/10.1038/nm1746; PMID: 18391963
  • Lee SJ, Desplats P, Sigurdson C, Tsigelny I, Masliah E. Cell-to-cell transmission of non-prion protein aggregates. Nat Rev Neurol 2010; 6:702 - 6; http://dx.doi.org/10.1038/nrneurol.2010.145; PMID: 21045796
  • St Clair D, Blackwood D, Muir W, Carothers A, Walker M, Spowart G, et al. Association within a family of a balanced autosomal translocation with major mental illness. Lancet 1990; 336:13 - 6; http://dx.doi.org/10.1016/0140-6736(90)91520-K; PMID: 1973210
  • Blackwood DH, Fordyce A, Walker MT, St Clair DM, Porteous DJ, Muir WJ. Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Am J Hum Genet 2001; 69:428 - 33; http://dx.doi.org/10.1086/321969; PMID: 11443544
  • Chubb JE, Bradshaw NJ, Soares DC, Porteous DJ, Millar JK. The DISC locus in psychiatric illness. Mol Psychiatry 2008; 13:36 - 64; http://dx.doi.org/10.1038/sj.mp.4002106; PMID: 17912248
  • Kamiya A, Kubo K, Tomoda T, Takaki M, Youn R, Ozeki Y, et al. A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Nat Cell Biol 2005; 7:1167 - 78; http://dx.doi.org/10.1038/ncb1328; PMID: 16299498
  • Pletnikov MV, Ayhan Y, Xu Y, Nikolskaia O, Ovanesov M, Huang H, et al. Enlargement of the lateral ventricles in mutant DISC1 transgenic mice. Mol Psychiatry 2008; 13:115; http://dx.doi.org/10.1038/sj.mp.4002144; PMID: 18202691
  • Hikida T, Jaaro-Peled H, Seshadri S, Oishi K, Hookway C, Kong S, et al. Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proc Natl Acad Sci USA 2007; 104:14501 - 6; http://dx.doi.org/10.1073/pnas.0704774104; PMID: 17675407
  • Shen S, Lang B, Nakamoto C, Zhang F, Pu J, Kuan SL, et al. Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1. J Neurosci 2008; 28:10893 - 904; http://dx.doi.org/10.1523/JNEUROSCI.3299-08.2008; PMID: 18945897
  • Ekelund J, Hovatta I, Parker A, Paunio T, Varilo T, Martin R, et al. Chromosome 1 loci in Finnish schizophrenia families. Hum Mol Genet 2001; 10:1611 - 7; http://dx.doi.org/10.1093/hmg/10.15.1611; PMID: 11468279
  • Hamshere ML, Bennett P, Williams N, Segurado R, Cardno A, Norton N, et al. Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13. Arch Gen Psychiatry 2005; 62:1081 - 8; http://dx.doi.org/10.1001/archpsyc.62.10.1081; PMID: 16203953
  • Hwu HG, Liu CM, Fann CS, Ou-Yang WC, Lee SF. Linkage of schizophrenia with chromosome 1q loci in Taiwanese families. Mol Psychiatry 2003; 8:445 - 52; http://dx.doi.org/10.1038/sj.mp.4001235; PMID: 12740602
  • Thomson PA, Wray NR, Millar JK, Evans KL, Hellard SL, Condie A, et al. Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population. Mol Psychiatry 2005; 10:6 57 - 68; http://dx.doi.org/10.1038/sj.mp.4001669; PMID: 15838535
  • Hennah W, Tuulio-Henriksson A, Paunio T, Ekelund J, Varilo T, Partonen T, et al. A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia. Mol Psychiatry 2005; 10:1097 - 103; http://dx.doi.org/10.1038/sj.mp.4001731; PMID: 16103888
  • Cannon TD, Hennah W, van Erp TG, Thompson PM, Lonnqvist J, Huttunen M, et al. Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. Arch Gen Psychiatry 2005; 62:1205 - 13; http://dx.doi.org/10.1001/archpsyc.62.11.1205; PMID: 16275808
  • Qu M, Tang F, Yue W, Ruan Y, Lu T, Liu Z, et al. Positive association of the Disrupted-in-Schizophrenia-1 gene (DISC1) with schizophrenia in the Chinese Han population. Am J Med Genet B Neuropsychiatr Genet 2007; 144B:266 - 70; http://dx.doi.org/10.1002/ajmg.b.30322; PMID: 17286247
  • Palo OM, Antila M, Silander K, Hennah W, Kilpinen H, Soronen P, et al. Association of distinct allelic haplotypes of DISC1 with psychotic and bipolar spectrum disorders and with underlying cognitive impairments. Hum Mol Genet 2007; 16:2517 - 28; http://dx.doi.org/10.1093/hmg/ddm207; PMID: 17673452
  • Thomson PA, Harris SE, Starr JM, Whalley LJ, Porteous DJ, Deary IJ. Association between genotype at an exonic SNP in DISC1 and normal cognitive aging. Neurosci Lett 2005; 389:41 - 5; http://dx.doi.org/10.1016/j.neulet.2005.07.004; PMID: 16054297
  • Hashimoto R, Numakawa T, Ohnishi T, Kumamaru E, Yagasaki Y, Ishimoto T, et al. Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling. Hum Mol Genet 2006; 15:3024 - 33; http://dx.doi.org/10.1093/hmg/ddl244; PMID: 16959794
  • Kilpinen H, Ylisaukko-Oja T, Hennah W, Palo OM, Varilo T, Vanhala R, et al. Association of DISC1 with autism and Asperger syndrome. Mol Psychiatry 2008; 13:187 - 96; http://dx.doi.org/10.1038/sj.mp.4002031; PMID: 17579608
  • Bradshaw NJ, Porteous DJ. DISC1-binding proteins in neural development, signalling and schizophrenia. Neuropharmacology 2010; PMID: 21195721
  • Korth C. DISCopathies: brain disorders related to DISC1 dysfunction. Rev Neurosci 2009; 20:321 - 30; http://dx.doi.org/10.1515/REVNEURO.2009.20.5-6.321; PMID: 20397618
  • Pletnikov MV, Ayhan Y, Nikolskaia O, Xu Y, Ovanesov MV, Huang H, et al. Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia. Mol Psychiatry 2008; 13:173 - 86; http://dx.doi.org/10.1038/sj.mp.4002079; PMID: 17848917
  • Clapcote SJ, Lipina TV, Millar JK, Mackie S, Christie S, Ogawa F, et al. Behavioral phenotypes of Disc1 missense mutations in mice. Neuron 2007; 54:387 - 402; http://dx.doi.org/10.1016/j.neuron.2007.04.015; PMID: 17481393
  • Kuroda K, Yamada S, Tanaka M, Iizuka M, Yano H, Mori D, et al. Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. Hum Mol Genet 2011; 20:4666 - 83; http://dx.doi.org/10.1093/hmg/ddr400; PMID: 21903668
  • Camargo LM, Collura V, Rain JC, Mizuguchi K, Hermjakob H, Kerrien S, et al. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Mol Psychiatry 2007; 12:74 - 86; http://dx.doi.org/10.1038/sj.mp.4001880; PMID: 17043677
  • Soares CC, Carlyle BC, Bradshaw NJ, Porteous D. DISC1: Structure, Function, and Therapeutic Postential for Major Mental Illness. ACS Chem Neurosci 2011:dx.doi.org/10.1021/cn200062k.
  • Kirkpatrick B, Xu L, Cascella N, Ozeki Y, Sawa A, Roberts RC. DISC1 immunoreactivity at the light and ultrastructural level in the human neocortex. J Comp Neurol 2006; 497:436 - 50; http://dx.doi.org/10.1002/cne.21007; PMID: 16736468
  • Brandon NJ, Sawa A. Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nat Rev Neurosci 2011; 12:707 - 22; http://dx.doi.org/10.1038/nrn3120; PMID: 22095064
  • Torrey EF, Webster M, Knable M, Johnston N, Yolken RH. The stanley foundation brain collection and neuropathology consortium. Schizophr Res 2000; 44:151 - 5; http://dx.doi.org/10.1016/S0920-9964(99)00192-9; PMID: 10913747
  • Leliveld SR, Bader V, Hendriks P, Prikulis I, Sajnani G, Requena JR, et al. Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease. J Neurosci 2008; 28:3839 - 45; http://dx.doi.org/10.1523/JNEUROSCI.5389-07.2008; PMID: 18400883
  • Ottis P, Bader V, Trossbach S, Kretzschmar H, Michel M, Leliveld SR, et al. Convergence of two independent mental disease genes on the protein level: recruitment of dysbindin to cell-invasive disrupted-in-schizophrenia 1 aggresomes. Biol Psychiatry 2011; 70:604 - 10; http://dx.doi.org/10.1016/j.biopsych.2011.03.027; PMID: 21531389
  • Mangiarini L, Sathasivam K, Seller M, Cozens B, Harper A, Hetherington C, et al. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 1996; 87:493 - 506; http://dx.doi.org/10.1016/S0092-8674(00)81369-0; PMID: 8898202
  • Blackwood DH, Muir WJ. Clinical phenotypes associated with DISC1, a candidate gene for schizophrenia. Neurotox Res 2004; 6:35 - 41; http://dx.doi.org/10.1007/BF03033294; PMID: 15184103
  • Masison DC, Wickner RB. Prion-inducing domain of yeast Ure2p and protease resistance of Ure2p in prion-containing cells. Science 1995; 270:93 - 5; http://dx.doi.org/10.1126/science.270.5233.93; PMID: 7569955
  • Greenwald J, Riek R. Biology of amyloid: structure, function, and regulation. Structure 2010; 18:1244 - 60; http://dx.doi.org/10.1016/j.str.2010.08.009; PMID: 20947013
  • Braak H, Del Tredici K. Alzheimer’s pathogenesis: is there neuron-to-neuron propagation?. Acta Neuropathol 2011; 121:589 - 95; http://dx.doi.org/10.1007/s00401-011-0825-z; PMID: 21516512
  • Soto C. Prion hypothesis: the end of the controversy?. Trends Biochem Sci 2011; 36:151 - 8; http://dx.doi.org/10.1016/j.tibs.2010.11.001; PMID: 21130657
  • Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, et al. Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science 2006; 313:1781 - 4; http://dx.doi.org/10.1126/science.1131864; PMID: 16990547
  • Morales R, Duran-Aniotz C, Castilla J, Estrada LD, Soto C. De novo induction of amyloid-β deposition in vivo. Mol Psychiatry 2011; http://dx.doi.org/10.1038/mp.2011.120; PMID: 21968933
  • Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991; 82:239 - 59; http://dx.doi.org/10.1007/BF00308809; PMID: 1759558
  • Braak H, Del Tredici K, Rüb U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol Aging 2003; 24:197 - 211; http://dx.doi.org/10.1016/S0197-4580(02)00065-9; PMID: 12498954
  • Brandon NJ, Millar JK, Korth C, Sive H, Singh KK, Sawa A. Understanding the role of DISC1 in psychiatric disease and during normal development. J Neurosci 2009; 29:12768 - 75; http://dx.doi.org/10.1523/JNEUROSCI.3355-09.2009; PMID: 19828788
  • Young-Pearse TL, Suth S, Luth ES, Sawa A, Selkoe DJ. Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development. J Neurosci 2010; 30:10431 - 40; http://dx.doi.org/10.1523/JNEUROSCI.1445-10.2010; PMID: 20685985
  • Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, et al. Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell 2009; 136:1017 - 31; http://dx.doi.org/10.1016/j.cell.2008.12.044; PMID: 19303846
  • Millar JK, Pickard BS, Mackie S, James R, Christie S, Buchanan SR, et al. DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science 2005; 310:1187 - 91; http://dx.doi.org/10.1126/science.1112915; PMID: 16293762
  • Kamiya A, Tan PL, Kubo K, Engelhard C, Ishizuka K, Kubo A, et al. Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses. Arch Gen Psychiatry 2008; 65:996 - 1006; http://dx.doi.org/10.1001/archpsyc.65.9.996; PMID: 18762586
  • Ishizuka K, Kamiya A, Oh EC, Kanki H, Seshadri S, Robinson JF, et al. DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. Nature 2011; 473:92 - 6; http://dx.doi.org/10.1038/nature09859; PMID: 21471969
  • Olzscha H, Schermann SM, Woerner AC, Pinkert S, Hecht MH, Tartaglia GG, et al. Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions. Cell 2011; 144:67 - 78; http://dx.doi.org/10.1016/j.cell.2010.11.050; PMID: 21215370
  • Di Giorgio A, Blasi G, Sambataro F, Rampino A, Papazacharias A, Gambi F, et al. Association of the SerCys DISC1 polymorphism with human hippocampal formation gray matter and function during memory encoding. Eur J Neurosci 2008; 28:2129 - 36; http://dx.doi.org/10.1111/j.1460-9568.2008.06482.x; PMID: 19046394
  • Kamiya A, Tomoda T, Chang J, Takaki M, Zhan C, Morita M, et al. DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1. Hum Mol Genet 2006; 15:3313 - 23; http://dx.doi.org/10.1093/hmg/ddl407; PMID: 17035248
  • Leliveld SR, Hendriks P, Michel M, Sajnani G, Bader V, Trossbach S, et al. Oligomer assembly of the C-terminal DISC1 domain (640-854) is controlled by self-association motifs and disease-associated polymorphism S704C. Biochemistry 2009; 48:7746 - 55; http://dx.doi.org/10.1021/bi900901e; PMID: 19583211
  • Narayanan S, Arthanari H, Wolfe MS, Wagner G. Molecular characterization of disrupted in schizophrenia-1 risk variant S704C reveals the formation of altered oligomeric assembly. J Biol Chem 2011; 286:44266 - 76; http://dx.doi.org/10.1074/jbc.M111.271593; PMID: 21998303
  • Brandon NJ, Handford EJ, Schurov I, Rain JC, Pelling M, Duran-Jimeniz B, et al. Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders. Mol Cell Neurosci 2004; 25:42 - 55; http://dx.doi.org/10.1016/j.mcn.2003.09.009; PMID: 14962739
  • Shen Y, Li N, Wu S, Zhou Y, Shan Y, Zhang Q, et al. Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells. Dev Cell 2008; 14:342 - 53; http://dx.doi.org/10.1016/j.devcel.2008.01.001; PMID: 18331715
  • Seshadri S, Kamiya A, Yokota Y, Prikulis I, Kano SI, Hayashi-Takagi A, et al. Disrupted-in-Schizphrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade. Proc Natl Acad Sci USA 2010; 107:5622 - 7; http://dx.doi.org/10.1073/pnas.0909284107; PMID: 20212127