Prion infection promotes extensive accumulation of α-synuclein in aged human α-synuclein transgenic mice

References

• Forman MS, Trojanowski JQ, Lee VM. Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs. Nat Med 2004; 10:1055 - 63; http://dx.doi.org/10.1038/nm1113; PMID: 15459709
   PubMed Web of Science ®Google Scholar
• Lansbury PT, Lashuel HA. A century-old debate on protein aggregation and neurodegeneration enters the clinic. Nature 2006; 443:774 - 9; http://dx.doi.org/10.1038/nature05290; PMID: 17051203
   PubMed Web of Science ®Google Scholar
• Masliah E, Rockenstein E, Veinbergs I, Sagara Y, Mallory M, Hashimoto M, et al. beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer’s disease and Parkinson’s disease. Proc Natl Acad Sci U S A 2001; 98:12245 - 50; http://dx.doi.org/10.1073/pnas.211412398; PMID: 11572944
   PubMed Web of Science ®Google Scholar
• Tsigelny IF, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H, et al. Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer’s and Parkinson’s diseases. PLoS One 2008; 3:e3135; http://dx.doi.org/10.1371/journal.pone.0003135; PMID: 18769546
   PubMed Web of Science ®Google Scholar
• Small SA, Duff K. Linking Abeta and tau in late-onset Alzheimer’s disease: a dual pathway hypothesis. Neuron 2008; 60:534 - 42; http://dx.doi.org/10.1016/j.neuron.2008.11.007; PMID: 19038212
   PubMed Web of Science ®Google Scholar
• Head MW, Lowrie S, Chohan G, Knight R, Scoones DJ, Ironside JW. Variably protease-sensitive prionopathy in a PRNP codon 129 heterozygous UK patient with co-existing tau, α synuclein and Aβ pathology. Acta Neuropathol 2010; 120:821 - 3; http://dx.doi.org/10.1007/s00401-010-0766-y; PMID: 21046409
   PubMed Web of Science ®Google Scholar
• Harper JD, Lansbury PT Jr.. Models of amyloid seeding in Alzheimer’s disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins. Annu Rev Biochem 1997; 66:385 - 407; http://dx.doi.org/10.1146/annurev.biochem.66.1.385; PMID: 9242912
   PubMed Web of Science ®Google Scholar
• Giasson BI, Forman MS, Higuchi M, Golbe LI, Graves CL, Kotzbauer PT, et al. Initiation and synergistic fibrillization of tau and alpha-synuclein. Science 2003; 300:636 - 40; http://dx.doi.org/10.1126/science.1082324; PMID: 12714745
   PubMed Web of Science ®Google Scholar
• Schmidt ML, Martin JA, Lee VM, Trojanowski JQ. Convergence of Lewy bodies and neurofibrillary tangles in amygdala neurons of Alzheimer’s disease and Lewy body disorders. Acta Neuropathol 1996; 91:475 - 81; http://dx.doi.org/10.1007/s004010050454; PMID: 8740227
   PubMed Web of Science ®Google Scholar
• Marui W, Iseki E, Uéda K, Kosaka K. Occurrence of human alpha-synuclein immunoreactive neurons with neurofibrillary tangle formation in the limbic areas of patients with Alzheimer’s disease. J Neurol Sci 2000; 174:81 - 4; http://dx.doi.org/10.1016/S0022-510X(99)00327-5; PMID: 10727692
   PubMed Web of Science ®Google Scholar
• Morales R, Estrada LD, Diaz-Espinoza R, Morales-Scheihing D, Jara MC, Castilla J, et al. Molecular cross talk between misfolded proteins in animal models of Alzheimer’s and prion diseases. J Neurosci 2010; 30:4528 - 35; http://dx.doi.org/10.1523/JNEUROSCI.5924-09.2010; PMID: 20357103
   PubMed Web of Science ®Google Scholar
• Aguzzi A, Calella AM. Prions: protein aggregation and infectious diseases. Physiol Rev 2009; 89:1105 - 52; http://dx.doi.org/10.1152/physrev.00006.2009; PMID: 19789378
   PubMed Web of Science ®Google Scholar
• Prusiner SB. Novel proteinaceous infectious particles cause scrapie. Science 1982; 216:136 - 44; http://dx.doi.org/10.1126/science.6801762; PMID: 6801762
   PubMed Web of Science ®Google Scholar
• Hadlow WJ. Neuropathology and the scrapie-kuru connection. Brain Pathol 1995; 5:27 - 31; http://dx.doi.org/10.1111/j.1750-3639.1995.tb00574.x; PMID: 7767488
   PubMed Web of Science ®Google Scholar
• Lashuel HA, Petre BM, Wall J, Simon M, Nowak RJ, Walz T, et al. Alpha-synuclein, especially the Parkinson’s disease-associated mutants, forms pore-like annular and tubular protofibrils. J Mol Biol 2002; 322:1089 - 102; http://dx.doi.org/10.1016/S0022-2836(02)00735-0; PMID: 12367530
   PubMed Web of Science ®Google Scholar
• Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, et al. In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A 2011; 108:4194 - 9; http://dx.doi.org/10.1073/pnas.1100976108; PMID: 21325059
   PubMed Web of Science ®Google Scholar
• Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, et al. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A 2009; 106:13010 - 5; http://dx.doi.org/10.1073/pnas.0903691106; PMID: 19651612
   PubMed Web of Science ®Google Scholar
• Lee HJ, Suk JE, Patrick C, Bae EJ, Cho JH, Rho S, et al. Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. J Biol Chem 2010; 285:9262 - 72; http://dx.doi.org/10.1074/jbc.M109.081125; PMID: 20071342
   PubMed Web of Science ®Google Scholar
• Lee SJ, Desplats P, Sigurdson C, Tsigelny I, Masliah E. Cell-to-cell transmission of non-prion protein aggregates. Nat Rev Neurol 2010; 6:702 - 6; http://dx.doi.org/10.1038/nrneurol.2010.145; PMID: 21045796
   PubMed Web of Science ®Google Scholar
• Haïk S, Privat N, Adjou KT, Sazdovitch V, Dormont D, Duyckaerts C, et al. Alpha-synuclein-immunoreactive deposits in human and animal prion diseases. Acta Neuropathol 2002; 103:516 - 20; http://dx.doi.org/10.1007/s00401-001-0499-z; PMID: 11935269
   PubMed Web of Science ®Google Scholar
• Adjou KT, Allix S, Ouidja MO, Backer S, Couquet C, Cornuejols MJ, et al. Alpha-synuclein accumulates in the brain of scrapie-affected sheep and goats. J Comp Pathol 2007; 137:78 - 81; http://dx.doi.org/10.1016/j.jcpa.2007.03.007; PMID: 17544436
   PubMed Web of Science ®Google Scholar
• Herms J, Tings T, Gall S, Madlung A, Giese A, Siebert H, et al. Evidence of presynaptic location and function of the prion protein. J Neurosci 1999; 19:8866 - 75; PMID: 10516306
   PubMed Web of Science ®Google Scholar
• Iwai A, Masliah E, Yoshimoto M, Ge N, Flanagan L, de Silva HA, et al. The precursor protein of non-A beta component of Alzheimer’s disease amyloid is a presynaptic protein of the central nervous system. Neuron 1995; 14:467 - 75; http://dx.doi.org/10.1016/0896-6273(95)90302-X; PMID: 7857654
   PubMed Web of Science ®Google Scholar
• Mougenot AL, Bencsik A, Nicot S, Vulin J, Morignat E, Verchère J, et al. Transmission of prion strains in a transgenic mouse model overexpressing human A53T mutated α-synuclein. J Neuropathol Exp Neurol 2011; 70:377 - 85; http://dx.doi.org/10.1097/NEN.0b013e318217d95f; PMID: 21487306
   PubMed Web of Science ®Google Scholar
• Rodriguez-Diehl R, Rey MJ, Gironell A, Martinez-Saez E, Ferrer I, Sanchez-Valle R, et al. “Preclinical” MSA in definite Creutzfeldt-Jakob disease. Neuropathology.
   Google Scholar
• Yoshida H, Terada S, Ishizu H, Ikeda K, Hayabara T, Ikeda K, et al. An autopsy case of Creutzfeldt-Jakob disease with a V180I mutation of the PrP gene and Alzheimer-type pathology. Neuropathology 2010; 30:159 - 64; http://dx.doi.org/10.1111/j.1440-1789.2009.01048.x; PMID: 19703264
   PubMed Web of Science ®Google Scholar
• Debatin L, Streffer J, Geissen M, Matschke J, Aguzzi A, Glatzel M. Association between deposition of beta-amyloid and pathological prion protein in sporadic Creutzfeldt-Jakob disease. Neurodegener Dis 2008; 5:347 - 54; http://dx.doi.org/10.1159/000121389; PMID: 18349519
   PubMed Web of Science ®Google Scholar
• Rockenstein E, Mallory M, Hashimoto M, Song D, Shults CW, Lang I, et al. Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters. J Neurosci Res 2002; 68:568 - 78; http://dx.doi.org/10.1002/jnr.10231; PMID: 12111846
   PubMed Web of Science ®Google Scholar
• Conway KA, Harper JD, Lansbury PT. Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nat Med 1998; 4:1318 - 20; http://dx.doi.org/10.1038/3311; PMID: 9809558
   PubMed Web of Science ®Google Scholar
• Lim Y, Kehm VM, Li C, Trojanowski JQ, Lee VM. Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption. Exp Neurol 2010; 221:86 - 97; http://dx.doi.org/10.1016/j.expneurol.2009.10.005; PMID: 19833127
   PubMed Web of Science ®Google Scholar
• Asuni AA, Hilton K, Siskova Z, Lunnon K, Reynolds R, Perry VH, et al. Alpha-synuclein deficiency in the C57BL/6JOlaHsd strain does not modify disease progression in the ME7-model of prion disease. Neuroscience 2010; 165:662 - 74; http://dx.doi.org/10.1016/j.neuroscience.2009.10.047; PMID: 19879926
   PubMed Web of Science ®Google Scholar
• Lopez CD, Yost CS, Prusiner SB, Myers RM, Lingappa VR. Unusual topogenic sequence directs prion protein biogenesis. Science 1990; 248:226 - 9; http://dx.doi.org/10.1126/science.1970195; PMID: 1970195
   PubMed Web of Science ®Google Scholar
• Hegde RS, Mastrianni JA, Scott MR, DeFea KA, Tremblay P, Torchia M, et al. A transmembrane form of the prion protein in neurodegenerative disease. Science 1998; 279:827 - 34; http://dx.doi.org/10.1126/science.279.5352.827; PMID: 9452375
   PubMed Web of Science ®Google Scholar
• Jiang P, Gan M, Ebrahim AS, Lin WL, Melrose HL, Yen SH. ER stress response plays an important role in aggregation of α-synuclein. Mol Neurodegener 2010; 5:56; http://dx.doi.org/10.1186/1750-1326-5-56; PMID: 21144044
   PubMed Web of Science ®Google Scholar
• Baron GS, Wehrly K, Dorward DW, Chesebro B, Caughey B. Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes. EMBO J 2002; 21:1031 - 40; http://dx.doi.org/10.1093/emboj/21.5.1031; PMID: 11867531
   PubMed Web of Science ®Google Scholar
• Fortin DL, Troyer MD, Nakamura K, Kubo S, Anthony MD, Edwards RH. Lipid rafts mediate the synaptic localization of alpha-synuclein. J Neurosci 2004; 24:6715 - 23; http://dx.doi.org/10.1523/JNEUROSCI.1594-04.2004; PMID: 15282274
   PubMed Web of Science ®Google Scholar
• Masliah E, Rockenstein E. Genetically altered transgenic models of Alzheimer’s disease. J Neural Transm Suppl 2000; 59:175 - 83; PMID: 10961430
   PubMedGoogle Scholar
• Magen I, Chesselet MF. Genetic mouse models of Parkinson’s disease The state of the art. Prog Brain Res 2010; 184:53 - 87; http://dx.doi.org/10.1016/S0079-6123(10)84004-X; PMID: 20887870
   PubMed Web of Science ®Google Scholar
• Polymenidou M, Moos R, Scott M, Sigurdson C, Shi YZ, Yajima B, et al. The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes. PLoS One 2008; 3:e3872; http://dx.doi.org/10.1371/journal.pone.0003872; PMID: 19060956
   PubMed Web of Science ®Google Scholar