563
Views
4
CrossRef citations to date
0
Altmetric
Research Paper

Inhibition of PrPSc formation in scrapie infected N2a cells by 5,7,8-trimethyl-3,4-dihydro-2H-1,4-benzoxazine derivatives

, , , , , & show all
Pages 470-476 | Published online: 23 Aug 2012

References

  • Prusiner SB. Shattuck lecture--neurodegenerative diseases and prions. N Engl J Med 2001; 344:1516 - 26; http://dx.doi.org/10.1056/NEJM200105173442006; PMID: 11357156
  • Prusiner SB. Prions. Proc Natl Acad Sci U S A 1998; 95:13363 - 83; http://dx.doi.org/10.1073/pnas.95.23.13363; PMID: 9811807
  • Aguzzi A, Glatzel M, Montrasio F, Prinz M, Heppner FL. Interventional strategies against prion diseases. Nat Rev Neurosci 2001; 2:745 - 9; http://dx.doi.org/10.1038/35094590; PMID: 11584312
  • Cashman NR, Caughey B. Prion diseases--close to effective therapy?. Nat Rev Drug Discov 2004; 3:874 - 84; http://dx.doi.org/10.1038/nrd1525; PMID: 15459678
  • Solassol J, Crozet C, Lehmann S. Prion propagation in cultured cells. Br Med Bull 2003; 66:87 - 97; http://dx.doi.org/10.1093/bmb/66.1.87; PMID: 14522851
  • Béranger F, Mangé A, Solassol J, Lehmann S. Cell culture models of transmissible spongiform encephalopathies. Biochem Biophys Res Commun 2001; 289:311 - 6; http://dx.doi.org/10.1006/bbrc.2001.5941; PMID: 11716473
  • Trevitt CR, Collinge J. A systematic review of prion therapeutics in experimental models. Brain 2006; 129:2241 - 65; http://dx.doi.org/10.1093/brain/awl150; PMID: 16816391
  • Gilch S, Nunziante M, Ertmer A, Schätzl HM. Strategies for eliminating PrP(c) as substrate for prion conversion and for enhancing PrP(Sc) degradation. Vet Microbiol 2007; 123:377 - 86; http://dx.doi.org/10.1016/j.vetmic.2007.04.006; PMID: 17493775
  • Caughey B, Raymond GJ. Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells. J Virol 1993; 67:643 - 50; PMID: 7678300
  • Yudovin-Farber I, Azzam T, Metzer E, Taraboulos A, Domb AJ. Cationic polysaccharides as antiprion agents. J Med Chem 2005; 48:1414 - 20; http://dx.doi.org/10.1021/jm049378o; PMID: 15743185
  • Mangé A, Nishida N, Milhavet O, McMahon HE, Casanova D, Lehmann S. Amphotericin B inhibits the generation of the scrapie isoform of the prion protein in infected cultures. J Virol 2000; 74:3135 - 40; http://dx.doi.org/10.1128/JVI.74.7.3135-3140.2000; PMID: 10708429
  • Pocchiari M, Schmittinger S, Masullo C. Amphotericin B delays the incubation period of scrapie in intracerebrally inoculated hamsters. J Gen Virol 1987; 68:219 - 23; http://dx.doi.org/10.1099/0022-1317-68-1-219; PMID: 2433387
  • Rudyk H, Vasiljevic S, Hennion RM, Birkett CR, Hope J, Gilbert IH. Screening Congo Red and its analogues for their ability to prevent the formation of PrP-res in scrapie-infected cells. J Gen Virol 2000; 81:1155 - 64; PMID: 10725446
  • Supattapone S, Nishina K, Rees JR. Pharmacological approaches to prion research. Biochem Pharmacol 2002; 63:1383 - 8; http://dx.doi.org/10.1016/S0006-2952(02)00874-2; PMID: 11996878
  • Korth C, May BC, Cohen FE, Prusiner SB. Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease. Proc Natl Acad Sci U S A 2001; 98:9836 - 41; http://dx.doi.org/10.1073/pnas.161274798; PMID: 11504948
  • Kocisko DA, Baron GS, Rubenstein R, Chen J, Kuizon S, Caughey B. New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products. J Virol 2003; 77:10288 - 94; http://dx.doi.org/10.1128/JVI.77.19.10288-10294.2003; PMID: 12970413
  • Kocisko DA, Morrey JD, Race RE, Chen J, Caughey B. Evaluation of new cell culture inhibitors of protease-resistant prion protein against scrapie infection in mice. J Gen Virol 2004; 85:2479 - 83; http://dx.doi.org/10.1099/vir.0.80082-0; PMID: 15269390
  • Thompson MJ, Borsenberger V, Louth JC, Judd KE, Chen B. Design, synthesis, and structure-activity relationship of indole-3-glyoxylamide libraries possessing highly potent activity in a cell line model of prion disease. J Med Chem 2009; 52:7503 - 11; http://dx.doi.org/10.1021/jm900920x; PMID: 19842664
  • Kawasaki Y, Kawagoe K, Chen CJ, Teruya K, Sakasegawa Y, Doh-ura K. Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner. J Virol 2007; 81:12889 - 98; http://dx.doi.org/10.1128/JVI.01563-07; PMID: 17881452
  • Ghaemmaghami S, May BC, Renslo AR, Prusiner SB. Discovery of 2-aminothiazoles as potent antiprion compounds. J Virol 2010; 84:3408 - 12; http://dx.doi.org/10.1128/JVI.02145-09; PMID: 20032192
  • Wang L, Ankati H, Akubathini SK, Balderamos M, Storey CA, Patel AV, et al. Identification of novel 1,4-benzoxazine compounds that are protective in tissue culture and in vivo models of neurodegeneration. J Neurosci Res 2010; 88:1970 - 84; PMID: 20143421
  • Koini EN, Papazafiri P, Vassilopoulos A, Koufaki M, Horváth Z, Koncz I, et al. 5,7,8-Trimethyl-benzopyran and 5,7,8-trimethyl-1,4-benzoxazine aminoamide derivatives as novel antiarrhythmics against ischemia-reperfusion injury. J Med Chem 2009; 52:2328 - 40; http://dx.doi.org/10.1021/jm801228h; PMID: 19309156
  • Race RE, Fadness LH, Chesebro B. Characterization of scrapie infection in mouse neuroblastoma cells. J Gen Virol 1987; 68:1391 - 9; http://dx.doi.org/10.1099/0022-1317-68-5-1391; PMID: 3106566
  • Nishida N, Harris DA, Vilette D, Laude H, Frobert Y, Grassi J, et al. Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein. J Virol 2000; 74:320 - 5; http://dx.doi.org/10.1128/JVI.74.1.320-325.2000; PMID: 10590120
  • Vilette D. Cell models of prion infection. Vet Res 2008; 39:10; http://dx.doi.org/10.1051/vetres:2007049; PMID: 18073097
  • Gao H, Frost MR, Siegwart JT Jr., Norton TT. Patterns of mRNA and protein expression during minus-lens compensation and recovery in tree shrew sclera. Mol Vis 2011; 17:903 - 19; PMID: 21541268
  • Maier T, Güell M, Serrano L. Correlation of mRNA and protein in complex biological samples. FEBS Lett 2009; 583:3966 - 73; http://dx.doi.org/10.1016/j.febslet.2009.10.036; PMID: 19850042
  • Schedel J, Distler O, Woenckhaus M, Gay RE, Simmen B, Michel BA, et al. Discrepancy between mRNA and protein expression of tumour suppressor maspin in synovial tissue may contribute to synovial hyperplasia in rheumatoid arthritis. Ann Rheum Dis 2004; 63:1205 - 11; http://dx.doi.org/10.1136/ard.2003.006312; PMID: 15361372
  • MacKay VL, Li X, Flory MR, Turcott E, Law GL, Serikawa KA, et al. Gene expression analyzed by high-resolution state array analysis and quantitative proteomics: response of yeast to mating pheromone. Mol Cell Proteomics 2004; 3:478 - 89; http://dx.doi.org/10.1074/mcp.M300129-MCP200; PMID: 14766929
  • Koini EN, Avlonitis N, Calogeropoulou T. Simple and Efficient Method for the Halogenation of Oxygenated Aromatic Compounds. Synlett 2011; 1537 - 42
  • Filippou PS, Koini EN, Calogeropoulou T, Kalliakmani P, Panagiotidis CA, Kyriakidis DA. Regulation of the Escherichia coli AtoSC two component system by synthetic biologically active 5;7;8-trimethyl-1;4-benzoxazine analogues. Bioorg Med Chem 2011; 19:5061 - 70; http://dx.doi.org/10.1016/j.bmc.2011.06.029; PMID: 21757361

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.