588
Views
9
CrossRef citations to date
0
Altmetric
Extra View

Conserved amyloid core structure of stop mutants of the human prion protein

Pages 193-197 | Received 16 Jan 2013, Accepted 11 Feb 2013, Published online: 13 Feb 2013

References

  • Aguzzi A, Sigurdson C, Heikenwaelder M. Molecular mechanisms of prion pathogenesis. Annu Rev Pathol 2008; 3:11 - 40; http://dx.doi.org/10.1146/annurev.pathmechdis.3.121806.154326; PMID: 18233951
  • Parchi P, Gambetti P. Human prion diseases. Curr Opin Neurol 1995; 8:286 - 93; http://dx.doi.org/10.1097/00019052-199508000-00007; PMID: 7582044
  • Finckh U, Müller-Thomsen T, Mann U, Eggers C, Marksteiner J, Meins W, et al. High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes. Am J Hum Genet 2000; 66:110 - 7; http://dx.doi.org/10.1086/302702; PMID: 10631141
  • Jayadev S, Nochlin D, Poorkaj P, Steinbart EJ, Mastrianni JA, Montine TJ, et al. Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype. Ann Neurol 2011; 69:712 - 20; http://dx.doi.org/10.1002/ana.22264; PMID: 21416485
  • Kundu B, Maiti NR, Jones EM, Surewicz KA, Vanik DL, Surewicz WK. Nucleation-dependent conformational conversion of the Y145Stop variant of human prion protein: structural clues for prion propagation. Proc Natl Acad Sci U S A 2003; 100:12069 - 74; http://dx.doi.org/10.1073/pnas.2033281100; PMID: 14519851
  • Watzlawik J, Skora L, Frense D, Griesinger C, Zweckstetter M, Schulz-Schaeffer WJ, et al. Prion protein helix1 promotes aggregation but is not converted into beta-sheet. J Biol Chem 2006; 281:30242 - 50; http://dx.doi.org/10.1074/jbc.M605141200; PMID: 17012240
  • Skora L, Fonseca-Ornelas L, Hofele RV, Riedel D, Giller K, Watzlawik J, et al. Burial of the polymorphic residue 129 in amyloid fibrils of prion stop mutants. J Biol Chem 2013; 288:2994 - 3002; http://dx.doi.org/10.1074/jbc.M112.423715; PMID: 23209282
  • Skora L, Zweckstetter M. Determination of amyloid core structure using chemical shifts. Protein Sci 2012; 21:1948 - 53; http://dx.doi.org/10.1002/pro.2170; PMID: 23033250
  • Helmus JJ, Surewicz K, Nadaud PS, Surewicz WK, Jaroniec CP. Molecular conformation and dynamics of the Y145Stop variant of human prion protein in amyloid fibrils. Proc Natl Acad Sci U S A 2008; 105:6284 - 9; http://dx.doi.org/10.1073/pnas.0711716105; PMID: 18436646
  • Wüthrich K, Riek R. Three-dimensional structures of prion proteins. Adv Protein Chem 2001; 57:55 - 82; http://dx.doi.org/10.1016/S0065-3233(01)57018-7; PMID: 11447697
  • Ghetti B, Piccardo P, Spillantini MG, Ichimiya Y, Porro M, Perini F, et al. Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP. Proc Natl Acad Sci U S A 1996; 93:744 - 8; http://dx.doi.org/10.1073/pnas.93.2.744; PMID: 8570627
  • Jansen C, Parchi P, Capellari S, Vermeij AJ, Corrado P, Baas F, et al. Prion protein amyloidosis with divergent phenotype associated with two novel nonsense mutations in PRNP. Acta Neuropathol 2010; 119:189 - 97; http://dx.doi.org/10.1007/s00401-009-0609-x; PMID: 19911184
  • Tagliavini F, Prelli F, Ghiso J, Bugiani O, Serban D, Prusiner SB, et al. Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58. EMBO J 1991; 10:513 - 9; PMID: 1672107
  • Govaerts C, Wille H, Prusiner SB, Cohen FE. Evidence for assembly of prions with left-handed beta-helices into trimers. Proc Natl Acad Sci U S A 2004; 101:8342 - 7; http://dx.doi.org/10.1073/pnas.0402254101; PMID: 15155909
  • Wille H, Govaerts C, Borovinskiy A, Latawiec D, Downing KH, Cohen FE, et al. Electron crystallography of the scrapie prion protein complexed with heavy metals. Arch Biochem Biophys 2007; 467:239 - 48; http://dx.doi.org/10.1016/j.abb.2007.08.010; PMID: 17935686
  • Salmona M, Morbin M, Massignan T, Colombo L, Mazzoleni G, Capobianco R, et al. Structural properties of Gerstmann-Straussler-Scheinker disease amyloid protein. J Biol Chem 2003; 278:48146 - 53; http://dx.doi.org/10.1074/jbc.M307295200; PMID: 12970341
  • Goldsbury C, Baxa U, Simon MN, Steven AC, Engel A, Wall JS, et al. Amyloid structure and assembly: insights from scanning transmission electron microscopy. J Struct Biol 2011; 173:1 - 13; http://dx.doi.org/10.1016/j.jsb.2010.09.018; PMID: 20868754
  • Comeau SR, Gatchell DW, Vajda S, Camacho CJ. ClusPro: a fully automated algorithm for protein-protein docking. Nucleic Acids Res 2004; 32:Web Server issue W96-9; http://dx.doi.org/10.1093/nar/gkh354; PMID: 15215358
  • Sajnani G, Pastrana MA, Dynin I, Onisko B, Requena JR. Scrapie prion protein structural constraints obtained by limited proteolysis and mass spectrometry. J Mol Biol 2008; 382:88 - 98; http://dx.doi.org/10.1016/j.jmb.2008.06.070; PMID: 18621059
  • Paravastu AK, Leapman RD, Yau WM, Tycko R. Molecular structural basis for polymorphism in Alzheimer’s beta-amyloid fibrils. Proc Natl Acad Sci U S A 2008; 105:18349 - 54; http://dx.doi.org/10.1073/pnas.0806270105; PMID: 19015532
  • Lu X, Wintrode PL, Surewicz WK. Beta-sheet core of human prion protein amyloid fibrils as determined by hydrogen/deuterium exchange. Proc Natl Acad Sci U S A 2007; 104:1510 - 5; http://dx.doi.org/10.1073/pnas.0608447104; PMID: 17242357
  • Bocharova OV, Breydo L, Salnikov VV, Gill AC, Baskakov IV. Synthetic prions generated in vitro are similar to a newly identified subpopulation of PrPSc from sporadic Creutzfeldt-Jakob Disease. Protein Sci 2005; 14:1222 - 32; http://dx.doi.org/10.1110/ps.041186605; PMID: 15802644
  • Smirnovas V, Kim JI, Lu X, Atarashi R, Caughey B, Surewicz WK. Distinct structures of scrapie prion protein (PrPSc)-seeded versus spontaneous recombinant prion protein fibrils revealed by hydrogen/deuterium exchange. J Biol Chem 2009; 284:24233 - 41; http://dx.doi.org/10.1074/jbc.M109.036558; PMID: 19596861
  • Wopfner F, Weidenhöfer G, Schneider R, von Brunn A, Gilch S, Schwarz TF, et al. Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein. J Mol Biol 1999; 289:1163 - 78; http://dx.doi.org/10.1006/jmbi.1999.2831; PMID: 10373359
  • Hölscher C, Delius H, Bürkle A. Overexpression of nonconvertible PrPc delta114-121 in scrapie-infected mouse neuroblastoma cells leads to trans-dominant inhibition of wild-type PrP(Sc) accumulation. J Virol 1998; 72:1153 - 9; PMID: 9445012
  • Smirnovas V, Baron GS, Offerdahl DK, Raymond GJ, Caughey B, Surewicz WK. Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange. Nat Struct Mol Biol 2011; 18:504 - 6; http://dx.doi.org/10.1038/nsmb.2035; PMID: 21441913
  • Simons KT, Bonneau R, Ruczinski I, Baker D. Ab initio protein structure prediction of CASP III targets using ROSETTA. Proteins 1999; Suppl 3 171 - 6; http://dx.doi.org/10.1002/(SICI)1097-0134(1999)37:3+<171::AID-PROT21>3.0.CO;2-Z; PMID: 10526365

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.