Sortilin, a novel APOE receptor implicated in Alzheimer disease

References

• Pitas RE, Boyles JK, Lee SH, Foss D, Mahley RW. Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins. Biochim Biophys Acta 1987; 917:148 - 61; http://dx.doi.org/10.1016/0005-2760(87)90295-5; PMID: 3539206
   PubMed Web of Science ®Google Scholar
• Grehan S, Tse E, Taylor JM. Two distal downstream enhancers direct expression of the human apolipoprotein E gene to astrocytes in the brain. J Neurosci 2001; 21:812 - 22; PMID: 11157067
   PubMed Web of Science ®Google Scholar
• Xu Q, Bernardo A, Walker D, Kanegawa T, Mahley RW, Huang Y. Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus. J Neurosci 2006; 26:4985 - 94; http://dx.doi.org/10.1523/JNEUROSCI.5476-05.2006; PMID: 16687490
   PubMed Web of Science ®Google Scholar
• Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science 1993; 261:921 - 3; http://dx.doi.org/10.1126/science.8346443; PMID: 8346443
   PubMed Web of Science ®Google Scholar
• Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen GS, Pericak-Vance M, Schmechel D, Saunders AM, Goldgaber D, Roses AD. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc Natl Acad Sci U S A 1993; 90:8098 - 102; http://dx.doi.org/10.1073/pnas.90.17.8098; PMID: 8367470
   PubMed Web of Science ®Google Scholar
• Holtzman DM, Herz J, Bu G. Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. Cold Spring Harb Perspect Med 2012; 2:a006312; http://dx.doi.org/10.1101/cshperspect.a006312; PMID: 22393530
   PubMed Web of Science ®Google Scholar
• Brown MS, Goldstein JL. A receptor-mediated pathway for cholesterol homeostasis. Science 1986; 232:34 - 47; http://dx.doi.org/10.1126/science.3513311; PMID: 3513311
   PubMed Web of Science ®Google Scholar
• Herz J. Apolipoprotein E receptors in the nervous system. Curr Opin Lipidol 2009; 20:190 - 6; http://dx.doi.org/10.1097/MOL.0b013e32832d3a10; PMID: 19433918
   PubMed Web of Science ®Google Scholar
• Kim J, Castellano JM, Jiang H, Basak JM, Parsadanian M, Pham V, Mason SM, Paul SM, Holtzman DM. Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron 2009; 64:632 - 44; http://dx.doi.org/10.1016/j.neuron.2009.11.013; PMID: 20005821
   PubMed Web of Science ®Google Scholar
• Zerbinatti CV, Wahrle SE, Kim H, Cam JA, Bales K, Paul SM, Holtzman DM, Bu G. Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice. J Biol Chem 2006; 281:36180 - 6; http://dx.doi.org/10.1074/jbc.M604436200; PMID: 17012232
   PubMed Web of Science ®Google Scholar
• Castellano JM, Deane R, Gottesdiener AJ, Verghese PB, Stewart FR, West T, Paoletti AC, Kasper TR, DeMattos RB, Zlokovic BV, et al. Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis. Proc Natl Acad Sci U S A 2012; 109:15502 - 7; http://dx.doi.org/10.1073/pnas.1206446109; PMID: 22927427
   PubMed Web of Science ®Google Scholar
• Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest 2008; 118:4002 - 13; http://dx.doi.org/10.1172/JCI36663; PMID: 19033669
   PubMed Web of Science ®Google Scholar
• Ruiz J, Kouiavskaia D, Migliorini M, Robinson S, Saenko EL, Gorlatova N, Li D, Lawrence D, Hyman BT, Weisgraber KH, et al. The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor. J Lipid Res 2005; 46:1721 - 31; http://dx.doi.org/10.1194/jlr.M500114-JLR200; PMID: 15863833
   PubMed Web of Science ®Google Scholar
• Petersen CM, Nielsen MS, Nykjaer A, Jacobsen L, Tommerup N, Rasmussen HH, Roigaard H, Gliemann J, Madsen P, Moestrup SK. Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography. J Biol Chem 1997; 272:3599 - 605; http://dx.doi.org/10.1074/jbc.272.6.3599; PMID: 9013611
   PubMed Web of Science ®Google Scholar
• Nykjaer A, Willnow TE. Sortilin: a receptor to regulate neuronal viability and function. Trends Neurosci 2012; 35:261 - 70; http://dx.doi.org/10.1016/j.tins.2012.01.003; PMID: 22341525
   PubMed Web of Science ®Google Scholar
• Quistgaard EM, Madsen P, Grøftehauge MK, Nissen P, Petersen CM, Thirup SS. Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain. Nat Struct Mol Biol 2009; 16:96 - 8; http://dx.doi.org/10.1038/nsmb.1543; PMID: 19122660
   PubMed Web of Science ®Google Scholar
• Nielsen MS, Jacobsen C, Olivecrona G, Gliemann J, Petersen CM. Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. J Biol Chem 1999; 274:8832 - 6; http://dx.doi.org/10.1074/jbc.274.13.8832; PMID: 10085125
   PubMed Web of Science ®Google Scholar
• Kjolby M, Andersen OM, Breiderhoff T, Fjorback AW, Pedersen KM, Madsen P, Jansen P, Heeren J, Willnow TE, Nykjaer A. Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export. Cell Metab 2010; 12:213 - 23; http://dx.doi.org/10.1016/j.cmet.2010.08.006; PMID: 20816088
   PubMed Web of Science ®Google Scholar
• Herz J, Strickland DK. LRP: a multifunctional scavenger and signaling receptor. J Clin Invest 2001; 108:779 - 84; PMID: 11560943
   PubMed Web of Science ®Google Scholar
• Willnow TE, Kjølby M, Nykjaer A. Sortilins: new players in lipoprotein metabolism. Curr Opin Lipidol 2011; 22:79 - 85; http://dx.doi.org/10.1097/MOL.0b013e3283416f2b; PMID: 21124217
   PubMed Web of Science ®Google Scholar
• Jansen P, Giehl K, Nyengaard JR, Teng K, Lioubinski O, Sjoegaard SS, Breiderhoff T, Gotthardt M, Lin F, Eilers A, et al. Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nat Neurosci 2007; 10:1449 - 57; http://dx.doi.org/10.1038/nn2000; PMID: 17934455
   PubMed Web of Science ®Google Scholar
• Nykjaer A, Lee R, Teng KK, Jansen P, Madsen P, Nielsen MS, Jacobsen C, Kliemannel M, Schwarz E, Willnow TE, et al. Sortilin is essential for proNGF-induced neuronal cell death. Nature 2004; 427:843 - 8; http://dx.doi.org/10.1038/nature02319; PMID: 14985763
   PubMed Web of Science ®Google Scholar
• Vaegter CB, Jansen P, Fjorback AW, Glerup S, Skeldal S, Kjolby M, Richner M, Erdmann B, Nyengaard JR, Tessarollo L, et al. Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nat Neurosci 2011; 14:54 - 61; http://dx.doi.org/10.1038/nn.2689; PMID: 21102451
   PubMed Web of Science ®Google Scholar
• Hu F, Padukkavidana T, Vægter CB, Brady OA, Zheng Y, Mackenzie IR, Feldman HH, Nykjaer A, Strittmatter SM. Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. Neuron 2010; 68:654 - 67; http://dx.doi.org/10.1016/j.neuron.2010.09.034; PMID: 21092856
   PubMed Web of Science ®Google Scholar
• Carlo AS, Gustafsen C, Mastrobuoni G, Nielsen MS, Burgert T, Hartl D, Rohe M, Nykjaer A, Herz J, Heeren J, et al. The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain. J Neurosci 2013; 33:358 - 70; http://dx.doi.org/10.1523/JNEUROSCI.2425-12.2013; PMID: 23283348
   PubMed Web of Science ®Google Scholar
• Di Paolo G, Kim TW. Linking lipids to Alzheimer’s disease: cholesterol and beyond. Nat Rev Neurosci 2011; 12:284 - 96; http://dx.doi.org/10.1038/nrn3012; PMID: 21448224
   PubMed Web of Science ®Google Scholar
• Han X, Cheng H, Fryer JD, Fagan AM, Holtzman DM. Novel role for apolipoprotein E in the central nervous system. Modulation of sulfatide content. J Biol Chem 2003; 278:8043 - 51; http://dx.doi.org/10.1074/jbc.M212340200; PMID: 12501252
   PubMed Web of Science ®Google Scholar
• Chen Y, Durakoglugil MS, Xian X, Herz J. ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling. Proc Natl Acad Sci U S A 2010; 107:12011 - 6; http://dx.doi.org/10.1073/pnas.0914984107; PMID: 20547867
   PubMed Web of Science ®Google Scholar
• Laatsch A, Panteli M, Sornsakrin M, Hoffzimmer B, Grewal T, Heeren J. Low density lipoprotein receptor-related protein 1 dependent endosomal trapping and recycling of apolipoprotein E. PLoS One 2012; 7:e29385; http://dx.doi.org/10.1371/journal.pone.0029385; PMID: 22238606
   PubMedGoogle Scholar
• Nielsen MS, Madsen P, Christensen EI, Nykjaer A, Gliemann J, Kasper D, Pohlmann R, Petersen CM. The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein. EMBO J 2001; 20:2180 - 90; http://dx.doi.org/10.1093/emboj/20.9.2180; PMID: 11331584
   PubMed Web of Science ®Google Scholar