671
Views
31
CrossRef citations to date
0
Altmetric
Commentary & View

The role of the prion protein membrane anchor in prion infection

&
Pages 134-138 | Received 24 Mar 2009, Accepted 07 Aug 2009, Published online: 01 Jul 2009

References

  • Stahl N, Borchelt DR, Prusiner SB. Differential release of cellular and scrapie prion proteins from cellular membranes by phosphatidylinositol-specific phospholipase C. Biochemistry 1990; 29:5405 - 5412
  • Caughey B, Raymond GJ. The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive. J Biol Chem 1991; 266:18217 - 18223
  • Borchelt DR, Taraboulos A, Prusiner SB. Evidence for synthesis of scrapie prion protein in the endocytic pathway. J Biol Chem 1992; 267:16188 - 16199
  • Marijanovic Z, Caputo A, Campana V, Zurzolo C. Identification of an intracellular site of prion conversion. PLoS Pathog 2009; 5:1000426
  • Kaneko K, Vey M, Scott M, Pilkuhn S, Cohen FE, Prusiner SB. COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform. Proc Natl Acad Sci USA 1997; 94:2333 - 2338
  • Taraboulos A, Scott M, Semenov A, Avraham D, Laszlo L, Prusiner SB. Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform. J Cell Biol 1995; 129:121 - 132
  • Baron GS, Wehrly K, Dorward DW, Chesebro B, Caughey B. Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes. EMBO J 2002; 21:1031 - 1040
  • Baron GS, Caughey B. Effect of glycosylphosphatidylinositol anchor-dependent and -independent prion protein association with model raft membranes on conversion to the protease-resistant Isoform. J Biol Chem 2003; 278:14883 - 14892
  • Campana V, Sarnataro D, Zurzolo C. The highways and byways of prion protein trafficking. Trends Cell Biol 2005; 15:102 - 111
  • Kocisko DA, Come JH, Priola SA, Chesebro B, Raymond GJ, Lansbury PT, et al. Cell-free formation of protease-resistant prion protein. Nature 1994; 370:471 - 474
  • Deleault NR, Harris BT, Rees JR, Supattapone S. Formation of native prions from minimal components in vitro. Proc Natl Acad Sci USA 2007; 104:9741 - 9746
  • Kirby L, Birkett CR, Rudyk H, Gilbert IH, Hope J. In vitro cell-free conversion of bacterial recombinant PrP to PrPres as a model for conversion. J Gen Virol 2003; 84:1013 - 1020
  • Colby DW, Zhang Q, Wang S, Groth D, Legname G, Riesner D, et al. Prion detection by an amyloid seeding assay. Proc Natl Acad Sci USA 2007; 104:20914 - 20919
  • Atarashi R, Moore RA, Sim VL, Hughson AG, Dorward DW, Onwubiko HA, et al. Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein. Nat Methods 2007; 4:645 - 650
  • Legname G, Baskakov IV, Nguyen HO, Riesner D, Cohen FE, DeArmond SJ, et al. Synthetic mammalian prions. Science 2004; 305:673 - 676
  • Chesebro B, Trifilo M, Race R, Meade-White K, Teng C, LaCasse R, et al. Anchorless prion protein results in infectious amyloid disease without clinical scrapie. Science 2005; 308:1435 - 1439
  • McNally KL, Ward AE, Priola SA. Cells expressing anchorless prion protein are resistant to scrapie infection. J Virol 2009; 83:4469 - 4475
  • Baron GS, Magalhaes AC, Prado MA, Caughey B. Mouse-adapted scrapie infection of SN56 cells: greater efficiency with microsome-associated versus purified PrP-res. J Virol 2006; 80:2106 - 2117
  • Magalhaes AC, Baron GS, Lee KS, Steele-Mortimer O, Dorward D, Prado MA, et al. Uptake and neuritic transport of scrapie prion protein coincident with infection of neuronal cells. J Neurosci 2005; 25:5207 - 5216
  • Gousset K, Schiff E, Langevin C, Marijanovic Z, Caputo A, Browman DT, et al. Prions hijack tunnelling nanotubes for intercellular spread. Nat Cell Biol 2009; 11:328 - 336
  • Greil CS, Vorberg IM, Ward AE, Meade-White KD, Harris DA, Priola SA. Acute cellular uptake of abnormal prion protein is cell type and scrapie-strain independent. Virology 2008; 379:284 - 293
  • Hijazi N, Kariv-Inbal Z, Gasset M, Gabizon R. PrPSc incorporation to cells requires endogenous glycosaminoglycan expression. J Biol Chem 2005; 280:17057 - 17061
  • Paquet S, Daude N, Courageot MP, Chapuis J, Laude H, Vilette D. PrPc does not mediate internalization of PrPSc but is required at an early stage for de novo prion infection of Rov cells. J Virol 2007; 81:10786 - 10791
  • Vorberg I, Raines A, Priola SA. Acute formation of protease-resistant prion protein does not always lead to persistent scrapie infection in vitro. J Biol Chem 2004; 279:29218 - 29225
  • Ghaemmaghami S, Phuan PW, Perkins B, Ullman J, May BC, Cohen FE, et al. Cell division modulates prion accumulation in cultured cells. Proc Natl Acad Sci USA 2007; 104:17971 - 17976
  • Kanu N, Imokawa Y, Drechsel DN, Williamson RA, Birkett CR, Bostock CJ, et al. Transfer of scrapie prion infectivity by cell contact in culture. Curr Biol 2002; 12:523 - 530
  • Paquet S, Langevin C, Chapuis J, Jackson GS, Laude H, Vilette D. Efficient dissemination of prions through preferential transmission to nearby cells. J Gen Virol 2007; 88:706 - 713
  • Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, et al. Cells release prions in association with exosomes. Proc Natl Acad Sci USA 2004; 101:9683 - 9688
  • Mishra RS, Basu S, Gu Y, Luo X, Zou WQ, Mishra R, et al. Protease-resistant human prion protein and ferritin are cotransported across Caco-2 epithelial cells: implications for species barrier in prion uptake from the intestine. J Neurosci 2004; 24:11280 - 11290
  • Brandner S, Isenmann S, Raeber A, Fischer M, Sailer A, Kobayashi Y, et al. Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature 1996; 379:339 - 343
  • Blattler T, Brandner S, Raeber AJ, Klein MA, Voigtlander T, Weissmann C, et al. PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain. Nature 1997; 389:69 - 73
  • Glatzel M, Aguzzi A. PrP(C) expression in the peripheral nervous system is a determinant of prion neuroinvasion. J Gen Virol 2000; 81:2813 - 2821
  • Race R, Oldstone M, Chesebro B. Entry versus blockade of brain infection following oral or intraperitoneal scrapie administration: Role of prion protein expression in peripheral nerves and spleen. J Virol 2000; 74:828 - 833
  • Vorberg I, Raines A, Story B, Priola SA. Susceptibility of common fibroblast cell lines to transmissible spongiform encephalopathy agents. J Infect Dis 2004; 189:431 - 439
  • Glatzel M, Aguzzi A. Peripheral pathogenesis of prion diseases. Microbes Infect 2000; 2:613 - 619
  • Follet J, Lemaire-Vieille C, Blanquet-Grossard F, Podevin-Dimster V, Lehmann S, Chauvin JP, et al. PrP expression and replication by Schwann cells: implications in prion spreading. J Virol 2002; 76:2434 - 2439
  • Groschup MH, Beekes M, McBride PA, Hardt M, Hainfellner JA, Budka H. Deposition of disease-associated prion protein involves the peripheral nervous system in experimental scrapie. Acta Neuropathol 1999; 98:453 - 457
  • Hainfellner JA, Budka H. Disease associated prion protein may deposit in the peripheral nervous system in human transmissible spongiform encephalopathies. Acta Neuropathol 1999; 98:458 - 460
  • Kratzel C, Kruger D, Beekes M. Prion propagation in a nerve conduit model containing segments devoid of axons. J Gen Virol 2007; 88:3479 - 3485
  • Vorberg I, Priola SA. Molecular basis of scrapie strain glycoform variation. J Biol Chem 2002; 277:36775 - 36781
  • Beekes M, McBride PA. The spread of prions through the body in naturally acquired transmissible spongiform encephalopathies. FEBS J 2007; 274:588 - 605
  • Weller RO. Pathology of cerebrospinal fluid and interstitial fluid of the CNS: significance for Alzheimer disease, prion disorders and multiple sclerosis. J Neuropathol Exp Neurol 1998; 57:885 - 894