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Commentary & View

The p75NTR extracellular domain

A potential molecule regulating the solubility and removal of amyloid-β

&
Pages 161-163 | Received 08 Jun 2011, Accepted 29 Jun 2011, Published online: 01 Jul 2011

References

  • Mawuenyega KG, Sigurdson W, Ovod V, Munsell L, Kasten T, Morris JC, et al. Decreased clearance of CNS beta-amyloid in Alzheimer's disease. Science 2010; 330:1774
  • Selkoe DJ. Alzheimer's disease: genes, proteins and therapy. Physiol Rev 2001; 81:741 - 766
  • Hardy JA, Higgins GA. Alzheimer's disease: the amyloid cascade hypothesis. Science 1992; 256:184 - 185
  • Wang YJ, Zhou HD, Zhou XF. Clearance of amyloid-beta in Alzheimer's disease: progress, problems and perspectives. Drug Discov Today 2006; 11:931 - 938
  • Blennow K, Zetterberg H. Cerebrospinal fluid biomarkers for Alzheimer's disease. J Alzheimers Dis 2009; 18:413 - 417
  • Kim J, Basak JM, Holtzman DM. The role of apolipoprotein E in Alzheimer's disease. Neuron 2009; 63:287 - 303
  • Wang YJ, Wang X, Lu JJ, Li QX, Gao CY, Liu XH, et al. p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain. J Neurosci 2011; 31:2292 - 2304
  • Yaar M, Zhai S, Pilch PF, Doyle SM, Eisenhauer PB, Fine RE, et al. Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease. J Clin Invest 1997; 100:2333 - 2340
  • Weskamp G, Schlondorff J, Lum L, Becherer JD, Kim TW, Saftig P, et al. Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR). J Biol Chem 2004; 279:4241 - 4249
  • Chakravarthy B, Gaudet C, Menard M, Atkinson T, Brown L, Laferla FM, et al. Amyloid-beta peptides stimulate the expression of the p75NTR neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice. J Alzheimers Dis 2010; 19:915 - 925
  • Costantini C, Weindruch R, Della Valle G, Puglielli L. A TrkA to p75NTR molecular switch activates amyloid beta-peptide generation during aging. Biochem J 2005; 391:59 - 67
  • Shibata M, Yamada S, Kumar SR, Calero M, Bading J, Frangione B, et al. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest 2000; 106:1489 - 1499
  • Bronfman FC, Tcherpakov M, Jovin TM, Fainzilber M. Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome. J Neurosci 2003; 23:3209 - 3220
  • Spuch C, Carro E. The p75 neurotrophin receptor localization in blood-CSF barrier: expression in choroid plexus epithelium. BMC Neurosci 2011; 12:39
  • Copray S, Kust B, Emmer B, Lin MY, Liem R, Amor S, et al. Deficient p75 low-affinity neurotrophin receptor expression exacerbates experimental allergic encephalomyelitis in C57/BL6 mice. J Neuroimmunol 2004; 148:41 - 53