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Short Communication

The RXLR motif of oomycete effectors is not a sufficient element for binding to phosphatidylinositol monophosphates

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Article: e23865 | Published online: 20 Feb 2013

References

  • Kamoun S. A catalogue of the effector secretome of plant pathogenic oomycetes. Annu Rev Phytopathol 2006; 44:41 - 60; http://dx.doi.org/10.1146/annurev.phyto.44.070505.143436; PMID: 16448329
  • Oliva R, Win J, Raffaele S, Boutemy L, Bozkurt TO, Chaparro-Garcia A, et al. Recent developments in effector biology of filamentous plant pathogens. Cell Microbiol 2010; 12:705 - 15; http://dx.doi.org/10.1111/j.1462-5822.2010.01471.x; PMID: 20374248
  • Birch PRJ, Boevink PC, Gilroy EM, Hein I, Pritchard L, Whisson SC. Oomycete RXLR effectors: delivery, functional redundancy and durable disease resistance. Curr Opin Plant Biol 2008; 11:373 - 9; http://dx.doi.org/10.1016/j.pbi.2008.04.005; PMID: 18511334
  • Whisson SC, Boevink PC, Moleleki L, Avrova AO, Morales JG, Gilroy EM, et al. A translocation signal for delivery of oomycete effector proteins into host plant cells. Nature 2007; 450:115 - 8; http://dx.doi.org/10.1038/nature06203; PMID: 17914356
  • Yaeno T, Li H, Chaparro-Garcia A, Schornack S, Koshiba S, Watanabe S, et al. Phosphatidylinositol monophosphate-binding interface in the oomycete RXLR effector AVR3a is required for its stability in host cells to modulate plant immunity. Proc Natl Acad Sci USA 2011; 108:14682 - 7; http://dx.doi.org/10.1073/pnas.1106002108; PMID: 21821794
  • Kale SD, Gu B, Capelluto DGS, Dou D, Feldman E, Rumore A, et al. External lipid PI3P mediates entry of eukaryotic pathogen effectors into plant and animal host cells. Cell 2010; 142:284 - 95; http://dx.doi.org/10.1016/j.cell.2010.06.008; PMID: 20655469
  • Wawra S, Agacan M, Boddey JA, Davidson I, Gachon CMM, Zanda M, et al. Avirulence protein 3a (AVR3a) from the potato pathogen Phytophthora infestans forms homodimers through its predicted translocation region and does not specifically bind phospholipids. J Biol Chem 2012; 287:38101 - 9; http://dx.doi.org/10.1074/jbc.M112.395129; PMID: 22977236
  • Plett JM, Kemppainen M, Kale SD, Kohler A, Legué V, Brun A, et al. A secreted effector protein of Laccaria bicolor is required for symbiosis development. Curr Biol 2011; 21:1197 - 203; http://dx.doi.org/10.1016/j.cub.2011.05.033; PMID: 21757352
  • Boutemy LS, King SRF, Win J, Hughes RK, Clarke TA, Blumenschein TMA, et al. Structures of Phytophthora RXLR effector proteins: a conserved but adaptable fold underpins functional diversity. J Biol Chem 2011; 286:35834 - 42; http://dx.doi.org/10.1074/jbc.M111.262303; PMID: 21813644
  • Chou S, Krasileva KV, Holton JM, Steinbrenner AD, Alber T, Staskawicz BJ. Hyaloperonospora arabidopsidis ATR1 effector is a repeat protein with distributed recognition surfaces. Proc Natl Acad Sci USA 2011; 108:13323 - 8; http://dx.doi.org/10.1073/pnas.1109791108; PMID: 21788488
  • Win J, Krasileva KV, Kamoun S, Shirasu K, Staskawicz BJ, Banfield MJ. Sequence divergent RXLR effectors share a structural fold conserved across plant pathogenic oomycete species. PLoS Pathog 2012; 8:e1002400; http://dx.doi.org/10.1371/journal.ppat.1002400; PMID: 22253591
  • Sun F, Kale SD, Azurmendi HF, Li D, Tyler BM, Capelluto DGS. Structural basis for interactions of the Phytophthora sojae RxLR effector Avh5 with phosphatidylinositol 3-phosphate and for host cell entry. Mol Plant Microbe Interact 2012; In press http://dx.doi.org/10.1094/MPMI-07-12-0184-R; PMID: 23075041
  • Rafiqi M, Gan PHP, Ravensdale M, Lawrence GJ, Ellis JG, Jones DA, et al. Internalization of flax rust avirulence proteins into flax and tobacco cells can occur in the absence of the pathogen. Plant Cell 2010; 22:2017 - 32; http://dx.doi.org/10.1105/tpc.109.072983; PMID: 20525849
  • Gan PHP, Rafiqi M, Ellis JG, Jones DA, Hardham AR, Dodds PN. Lipid binding activities of flax rust AvrM and AvrL567 effectors. Plant Signal Behav 2010; 5:1272 - 5; http://dx.doi.org/10.4161/psb.5.10.13013; PMID: 20855950
  • Wawra S, Bain J, Durward E, de Bruijn I, Minor KL, Matena A, et al. Host-targeting protein 1 (SpHtp1) from the oomycete Saprolegnia parasitica translocates specifically into fish cells in a tyrosine-O-sulphate-dependent manner. Proc Natl Acad Sci USA 2012; 109:2096 - 101; http://dx.doi.org/10.1073/pnas.1113775109; PMID: 22308362
  • Hiller NL, Bhattacharjee S, van Ooij C, Liolios K, Harrison T, Lopez-Estraño C, et al. A host-targeting signal in virulence proteins reveals a secretome in malarial infection. Science 2004; 306:1934 - 7; http://dx.doi.org/10.1126/science.1102737; PMID: 15591203
  • Marti M, Good RT, Rug M, Knuepfer E, Cowman AF. Targeting malaria virulence and remodeling proteins to the host erythrocyte. Science 2004; 306:1930 - 3; http://dx.doi.org/10.1126/science.1102452; PMID: 15591202
  • Bhattacharjee S, Stahelin RV, Speicher KD, Speicher DW, Haldar K. Endoplasmic reticulum PI(3)P lipid binding targets malaria proteins to the host cell. Cell 2012; 148:201 - 12; http://dx.doi.org/10.1016/j.cell.2011.10.051; PMID: 22265412
  • Boddey JA, Hodder AN, Günther S, Gilson PR, Patsiouras H, Kapp EA, et al. An aspartyl protease directs malaria effector proteins to the host cell. Nature 2010; 463:627 - 31; http://dx.doi.org/10.1038/nature08728; PMID: 20130643
  • Russo I, Babbitt S, Muralidharan V, Butler T, Oksman A, Goldberg DE. Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte. Nature 2010; 463:632 - 6; http://dx.doi.org/10.1038/nature08726; PMID: 20130644
  • de Koning-Ward TF, Gilson PR, Boddey JA, Rug M, Smith BJ, Papenfuss AT, et al. A newly discovered protein export machine in malaria parasites. Nature 2009; 459:945 - 9; http://dx.doi.org/10.1038/nature08104; PMID: 19536257
  • Dou D, Kale SD, Wang X, Jiang RHY, Bruce NA, Arredondo FD, et al. RXLR-mediated entry of Phytophthora sojae effector Avr1b into soybean cells does not require pathogen-encoded machinery. Plant Cell 2008; 20:1930 - 47; http://dx.doi.org/10.1105/tpc.107.056093; PMID: 18621946