NOTCH signaling in immune-mediated bone marrow failure of aplastic anemia

References

• Young NS, Scheinberg P, Calado RT. Aplastic anemia. Curr Opin Hematol 2008; 15:162 - 8; http://dx.doi.org/10.1097/MOH.0b013e3282fa7470; PMID: 18391779
   PubMed Web of Science ®Google Scholar
• Chen J, Brandt JS, Ellison FM, Calado RT, Young NS. Defective stromal cell function in a mouse model of infusion-induced bone marrow failure. Exp Hematol 2005; 33:901 - 8; http://dx.doi.org/10.1016/j.exphem.2005.04.008; PMID: 16038782
   PubMed Web of Science ®Google Scholar
• Dezern AE, Brodsky RA. Clinical management of aplastic anemia. Expert Rev Hematol 2011; 4:221 - 30; http://dx.doi.org/10.1586/ehm.11.11; PMID: 21495931
   PubMed Web of Science ®Google Scholar
• Osborne BA, Minter LM. Notch signalling during peripheral T-cell activation and differentiation. Nat Rev Immunol 2007; 7:64 - 75; http://dx.doi.org/10.1038/nri1998; PMID: 17170755
   PubMed Web of Science ®Google Scholar
• Minter LM, Osborne BA. Canonical and non-canonical Notch signaling in CD4⁺ T cells. Curr Top Microbiol Immunol 2012; 360:99 - 114; http://dx.doi.org/10.1007/82_2012_233; PMID: 22695917
   PubMed Web of Science ®Google Scholar
• De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, et al. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 1999; 398:518 - 22; http://dx.doi.org/10.1038/19083; PMID: 10206645
   PubMed Web of Science ®Google Scholar
• Shih IeM, Wang TL. Notch signaling, gamma-secretase inhibitors, and cancer therapy. Cancer Res 2007; 67:1879 - 82; http://dx.doi.org/10.1158/0008-5472.CAN-06-3958; PMID: 17332312
   PubMed Web of Science ®Google Scholar
• Minter LM, Turley DM, Das P, Shin HM, Joshi I, Lawlor RG, Cho OH, Palaga TP, Gottipati S, Telfer JC, et al. Inhibitors of gamma-secretase block invivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21.. Nat Immunol 2005; 7:680 - 8; http://dx.doi.org/10.1038/ni1209
   Google Scholar
• Wei P, Walls M, Qiu M, Ding R, Denlinger RH, Wong A, Tsaparikos K, Jani JP, Hosea N, Sands M, et al. Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design. Mol Cancer Ther 2010; 9:1618 - 28; http://dx.doi.org/10.1158/1535-7163.MCT-10-0034; PMID: 20530712
   PubMed Web of Science ®Google Scholar
• Adler SH, Chiffoleau E, Xu L, Dalton NM, Burg JM, Wells AD, Wolfe MS, Turka LA, Pear WS. Notch signaling augments T cell responsiveness by enhancing CD25 expression. J Immunol 2003; 171:2896 - 903; PMID: 12960312
   PubMed Web of Science ®Google Scholar
• Palaga T, Miele L, Golde TE, Osborne BA. TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells. J Immunol 2003; 171:3019 - 24; PMID: 12960327
   PubMed Web of Science ®Google Scholar
• Joshi I, Minter LM, Telfer J, Demarest RM, Capobianco AJ, Aster JC, Sicinski P, Fauq A, Golde TE, Osborne BA. Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases. Blood 2009; 113:1689 - 98; http://dx.doi.org/10.1182/blood-2008-03-147967; PMID: 19001083
   PubMed Web of Science ®Google Scholar
• Maekawa Y, Tsukumo S-I, Chiba S, Hirai H, Hayashi Y, Okada H, Kishihara K, Yasutomo K. Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells. Immunity 2003; 19:549 - 59; http://dx.doi.org/10.1016/S1074-7613(03)00270-X; PMID: 14563319
   PubMed Web of Science ®Google Scholar
• Skokos D, Nussenzweig MC. CD8- DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS. J Exp Med 2007; 204:1525 - 31; PMID: 17576775
   PubMed Web of Science ®Google Scholar
• Zhang Y, Sandy AR, Wang J, Radojcic V, Shan GT, Tran IT, Friedman A, Kato K, He S, Cui S, et al. Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease. Blood 2011; 117:299 - 308; http://dx.doi.org/10.1182/blood-2010-03-271940; PMID: 20870902
   PubMed Web of Science ®Google Scholar
• Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000; 100:655 - 69; http://dx.doi.org/10.1016/S0092-8674(00)80702-3; PMID: 10761931
   PubMed Web of Science ®Google Scholar
• Tang Y, Desierto MJ, Chen J, Young NS. The role of the Th1 transcription factor T-bet in a mouse model of immune-mediated bone-marrow failure. Blood 2010; 115:541 - 8; http://dx.doi.org/10.1182/blood-2009-03-211383; PMID: 19903901
   PubMed Web of Science ®Google Scholar
• Solomou EE, Keyvanfar K, Young NS. T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemia. Blood 2006; 107:3983 - 91; http://dx.doi.org/10.1182/blood-2005-10-4201; PMID: 16434488
   PubMed Web of Science ®Google Scholar
• Roderick JE, Gonzalez-Perez G, Kuksin CA, Dongre A, Roberts ER, Srinivasan J, Andrzejewski CA Jr., Fauq AH, Golde TE, Miele L, et al. Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia. J Exp Med 2013; 210:1311 - 29; http://dx.doi.org/10.1084/jem.20112615; PMID: 23733784
   PubMed Web of Science ®Google Scholar
• de Latour RP, Visconte V, Takaku T, Wu C, Erie AJ, Sarcon AK, Desierto MJ, Scheinberg P, Keyvanfar K, Nunez O, et al. Th17 immune responses contribute to the pathophysiology of aplastic anemia. Blood 2010; 116:4175 - 84; http://dx.doi.org/10.1182/blood-2010-01-266098; PMID: 20733158
   PubMed Web of Science ®Google Scholar
• Jiao Z, Wang W, Xu H, Wang S, Guo M, Chen Y, Gao J. Engagement of activated Notch signalling in collagen II-specific T helper type 1 (Th1)- and Th17-type expansion involving Notch3 and Delta-like1. Clin Exp Immunol 2011; 164:66 - 71; http://dx.doi.org/10.1111/j.1365-2249.2010.04310.x; PMID: 21235539
   PubMed Web of Science ®Google Scholar
• Jurynczyk M, Jurewicz A, Raine CS, Selmaj K. Notch3 inhibition in myelin-reactive T cells down-regulates protein kinase C theta and attenuates experimental autoimmune encephalomyelitis. J Immunol 2008; 180:2634 - 40; PMID: 18250475
   PubMed Web of Science ®Google Scholar
• Basu R, Hatton RD, Weaver CT. The Th17 family: flexibility follows function. Immunol Rev 2013; 252:89 - 103; http://dx.doi.org/10.1111/imr.12035; PMID: 23405897
   PubMed Web of Science ®Google Scholar
• Henriques A, Gomes V, Duarte C, Pedreiro S, Carvalheiro T, Areias M, Caseiro A, Gabriel AJ, Laranjeira P, Pais ML, et al. Distribution and functional plasticity of peripheral blood Th(c)17 and Th(c)1 in rheumatoid arthritis. Rheumatol Int 2013; 33:2093 - 9; http://dx.doi.org/10.1007/s00296-013-2703-6; PMID: 23412693
   PubMed Web of Science ®Google Scholar
• Zhang HL, Azimullah S, Zheng XY, Wang XK, Amir N, Mensah-Brown EP, Al Shamsi M, Shahin A, Press R, Zhu J, et al. IFN-γ deficiency exacerbates experimental autoimmune neuritis in mice despite a mitigated systemic Th1 immune response. J Neuroimmunol 2012; 246:18 - 26; http://dx.doi.org/10.1016/j.jneuroim.2012.02.011; PMID: 22445739
   PubMed Web of Science ®Google Scholar
• Young NS. Acquired aplastic anemia. JAMA 1999; 282:271 - 8; http://dx.doi.org/10.1001/jama.282.3.271; PMID: 10422997
   PubMed Web of Science ®Google Scholar
• Amsen D, Blander JM, Lee GR, Tanigaki K, Honjo T, Flavell RA. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 2004; 117:515 - 26; http://dx.doi.org/10.1016/S0092-8674(04)00451-9; PMID: 15137944
   PubMed Web of Science ®Google Scholar
• Sun J, Krawczyk CJ, Pearce EJ. Suppression of Th2 cell development by Notch ligands Delta1 and Delta4. J Immunol 2008; 180:1655 - 61; PMID: 18209061
   PubMed Web of Science ®Google Scholar
• Ikeuchi T, Sisodia SS. The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent “gamma-secretase” cleavage. J Biol Chem 2003; 278:7751 - 4; http://dx.doi.org/10.1074/jbc.C200711200; PMID: 12551931
   PubMed Web of Science ®Google Scholar
• LaVoie MJ, Selkoe DJ. The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments. J Biol Chem 2003; 278:34427 - 37; http://dx.doi.org/10.1074/jbc.M302659200; PMID: 12826675
   PubMed Web of Science ®Google Scholar
• Albain et al. Thirty-Fourth Annual CTRC-AACR San Antonio Breast Cancer Symposium. Abstr. S1–5; Means-Powell et al. 2012. Thirty-Fifth Annual CTRC-AACR San Antonio Breast Cancer Symposium. Abstr. P2–14–04.
   Google Scholar