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The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection—suramin inhibits EV71 infection in vitro and in vivo

Peijun RenUnit of Anti-infective Research, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China;Université Paris Diderot, Sorbonne Paris Cité, Cellule Pasteur, 75013, Paris, France;Institut National de la Santé et de la Recherche Médicale, U1108 & Viral Pathogenesis Unit, Department of Virology, Institut Pasteur, 75724 Paris, France

Gang ZouUnit of Anti-infective Research, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China

Benjamin BaillyUnit of Anti-infective Research, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China;Institute for Glycomics, Gold Coast Campus, Griffith University, 4222 Queensland, Australia

Shanshan XuUnit of Anti-infective Research, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China

Mei ZengDepartment of Infectious Diseases, Children's Hospital of Fudan University, Shanghai 201102, China

Xinsheng Chen State Key Laboratory of Lead Compound Research, WuXi AppTec, Co., Ltd, Shanghai 200131, China

Liang Shen State Key Laboratory of Lead Compound Research, WuXi AppTec, Co., Ltd, Shanghai 200131, China

Ying ZhangInstitute of Medical Biology, Chinese Academy of Medicine Science, Kunming 650118, Yunnan Province, China

Patrice GuillonInstitute for Glycomics, Gold Coast Campus, Griffith University, 4222 Queensland, Australia

Fernando Arenzana-SeisdedosInstitut National de la Santé et de la Recherche Médicale, U1108 & Viral Pathogenesis Unit, Department of Virology, Institut Pasteur, 75724 Paris, France

Philippe BuchyVirology Unit, Institut Pasteur in Cambodia, 12201 Phnom Penh, Cambodia

Jian Li State Key Laboratory of Lead Compound Research, WuXi AppTec, Co., Ltd, Shanghai 200131, China

Mark von ItzsteinInstitute for Glycomics, Gold Coast Campus, Griffith University, 4222 Queensland, Australia

Qihan LiInstitute of Medical Biology, Chinese Academy of Medicine Science, Kunming 650118, Yunnan Province, China

Ralf AltmeyerUnit of Anti-infective Research, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, ChinaCorrespondence[email protected]

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The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection—suramin inhibits EV71 infection in vitro and in vivo

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The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection—suramin inhibits EV71 infection in vitro and in vivo

Supplementary Table S1

Supplementary Table S2

Supplementary Table S3

Supplementary Table S4

Supplementary Figure S1

Supplementary Figure S2

Supplementary Figure S3

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