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Emerging Microbes & Infections Volume 7, 2018 - Issue 1
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Original Articles

Overexpression of OqxAB and MacAB efflux pumps contributes to eravacycline resistance and heteroresistance in clinical isolates of Klebsiella pneumoniae

Jin-xin ZhengDepartment of Infectious Diseases and the Key Lab of Endogenous Infection, Shenzhen Nanshan People’s HospitalShenzhen University School of Medicine No 89, Taoyuan Road, Nanshan District 518052ShenzhenChina;Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Science and Institutes of Biomedical SciencesShanghai Medical College of Fudan University200032ShanghaiChina
,
Zhi-wei LinDepartment of Infectious Diseases and the Key Lab of Endogenous Infection, Shenzhen Nanshan People’s HospitalShenzhen University School of Medicine No 89, Taoyuan Road, Nanshan District 518052ShenzhenChina
,
Xiang SunDepartment of Infectious Diseases and the Key Lab of Endogenous Infection, Shenzhen Nanshan People’s HospitalShenzhen University School of Medicine No 89, Taoyuan Road, Nanshan District 518052ShenzhenChina
,
Wei-hong LinKey Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Science and Institutes of Biomedical SciencesShanghai Medical College of Fudan University200032ShanghaiChina
,
Zhong ChenDepartment of Infectious Diseases and the Key Lab of Endogenous Infection, Shenzhen Nanshan People’s HospitalShenzhen University School of Medicine No 89, Taoyuan Road, Nanshan District 518052ShenzhenChina;Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Science and Institutes of Biomedical SciencesShanghai Medical College of Fudan University200032ShanghaiChina
,
Yang WuKey Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Science and Institutes of Biomedical SciencesShanghai Medical College of Fudan University200032ShanghaiChina
,
Guo-bin QiKey Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Science and Institutes of Biomedical SciencesShanghai Medical College of Fudan University200032ShanghaiChina
,
Qi-wen DengDepartment of Infectious Diseases and the Key Lab of Endogenous Infection, Shenzhen Nanshan People’s HospitalShenzhen University School of Medicine No 89, Taoyuan Road, Nanshan District 518052ShenzhenChina
,
Di QuKey Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medical Science and Institutes of Biomedical SciencesShanghai Medical College of Fudan University200032ShanghaiChinaCorrespondence[email protected]
&
Zhi-jian YuDepartment of Infectious Diseases and the Key Lab of Endogenous Infection, Shenzhen Nanshan People’s HospitalShenzhen University School of Medicine No 89, Taoyuan Road, Nanshan District 518052ShenzhenChinaCorrespondence[email protected]
 show all
Pages 1-11 | Received 24 Mar 2018, Accepted 03 Jul 2018, Published online: 01 Aug 2018

Related Research Data

Major Variation in MICs of Tigecycline in Gram-Negative Bacilli as a Function of Testing Method
Source: American Society for Microbiology
Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.
Source: American Society for Microbiology
Treatment Options for Colistin Resistant Klebsiella pneumoniae: Present and Future.
Source: MDPI AG
Antibacterial Activity of Eravacycline (TP-434), a Novel Fluorocycline, against Hospital and Community Pathogens
Source: American Society for Microbiology
Effect of transcriptional activators SoxS, RobA, and RamA on expression of multidrug efflux pump AcrAB-TolC in Enterobacter cloacae.
Source: American Society for Microbiology
Klebsiella pneumoniae: Going on the Offense with a Strong Defense
Source: American Society for Microbiology
Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump.
Source: Springer Science and Business Media LLC
Tigecycline susceptibility in Klebsiella pneumoniae and Escherichia coli causing neonatal septicaemia (2007–10) and role of an efflux pump in tigecycline non-susceptibility
Source: Oxford University Press (OUP)
Step-Wise Increase in Tigecycline Resistance in Klebsiella pneumoniae Associated with Mutations in ramR, lon and rpsJ
Source: Public Library of Science (PLoS)
Overexpression of the Multidrug Efflux Operon acrEF by Insertional Activation with IS1 or IS10 Elements in Salmonella enterica Serovar Typhimurium DT204 acrB Mutants Selected with Fluoroquinolones
Source: HAL CCSD
Review of Eravacycline, a Novel Fluorocycline Antibacterial Agent
Source: Springer Science and Business Media LLC
Overexpression of OqxAB and MacAB efflux pumps contributes to eravacycline resistance and heteroresistance in clinical isolates of Klebsiella pneumoniae
Source: Taylor & Francis
Molecular Epidemiology and Risk Factors of Carbapenem-Resistant Klebsiella pneumoniae Infections in Eastern China.
Source: Frontiers Media S.A.
Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic
Source: American Society for Microbiology
Role of newer and re-emerging older agents in the treatment of infections caused by carbapenem-resistant Enterobacteriaceae
Source: Informa UK Limited
Klebsiella pneumoniae: development of a mixed population of carbapenem and tigecycline resistance during antimicrobial therapy in a kidney transplant patient
Source: Elsevier BV

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