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Xenobiotica
the fate of foreign compounds in biological systems
Volume 51, 2021 - Issue 8
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Animal Pharmacokinetics and Metabolism

Pharmacokinetics, metabolism and off-target effects in the rat of 8-[(1H- benzotriazol-1-yl)amino]octanoic acid, a selective inhibitor of human cytochrome P450 4Z1: β-oxidation as a potential augmenting pathway for inhibition

John P. Kowalskia Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, USA;b Department of Drug Metabolism and Pharmacokinetics, Pfizer Boulder R&D, Boulder, CO, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-0343-8425
ORCID Icon,
Robert D. Pelletiera Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, USA
,
Matthew G. McDonalda Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, USA;b Department of Drug Metabolism and Pharmacokinetics, Pfizer Boulder R&D, Boulder, CO, USA
,
Edward J. Kellyc Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA, USA
&
Allan E. Rettiea Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, USA
Pages 901-915 | Received 26 Feb 2021, Accepted 10 May 2021, Published online: 11 Jun 2021

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