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Research Article
The role of 5-arylalkylamino- and 5-piperazino- moieties on the 7-aminopyrazolo[4,3-d]pyrimidine core in affecting adenosine A1 and A2A receptor affinity and selectivity profiles
Lucia SquarcialupiDipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino, Sezione di Farmaceutica e Nutraceutica, Università di Firenze, Sesto Fiorentino, Italy;
, Marco BettiDipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino, Sezione di Farmaceutica e Nutraceutica, Università di Firenze, Sesto Fiorentino, Italy;
, Daniela CatarziDipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino, Sezione di Farmaceutica e Nutraceutica, Università di Firenze, Sesto Fiorentino, Italy;
, Flavia VaranoDipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino, Sezione di Farmaceutica e Nutraceutica, Università di Firenze, Sesto Fiorentino, Italy;
, Matteo FalsiniDipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino, Sezione di Farmaceutica e Nutraceutica, Università di Firenze, Sesto Fiorentino, Italy;
, Annalisa RavaniDipartimento di Scienze Mediche, Sezione di Farmacologia, Università di Ferrara, Ferrara, Italy;
, Silvia PasquiniDipartimento di Scienze Mediche, Sezione di Farmacologia, Università di Ferrara, Ferrara, Italy;
, Fabrizio VincenziDipartimento di Scienze Mediche, Sezione di Farmacologia, Università di Ferrara, Ferrara, Italy;
, Veronica SalmasoMolecular Modeling Section (MMS), Dipartimento di Scienze del Farmaco, Università di Padova, Padova, Italy
, Mattia SturleseMolecular Modeling Section (MMS), Dipartimento di Scienze del Farmaco, Università di Padova, Padova, Italy
, Katia VaraniDipartimento di Scienze Mediche, Sezione di Farmacologia, Università di Ferrara, Ferrara, Italy;
, Stefano MoroMolecular Modeling Section (MMS), Dipartimento di Scienze del Farmaco, Università di Padova, Padova, ItalyCorrespondence[email protected]
& Vittoria ColottaDipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino, Sezione di Farmaceutica e Nutraceutica, Università di Firenze, Sesto Fiorentino, Italy; Correspondence[email protected]
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Pages 248-263
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Received 03 Aug 2016, Accepted 04 Oct 2016, Published online: 23 Jan 2017
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