Supplemental material
Open access
2,771
Views
27
CrossRef citations to date
0
Altmetric
Research Paper
Synthesis, antitumour and antioxidant activities of novel α,β-unsaturated ketones and related heterocyclic analogues: EGFR inhibition and molecular modelling study
Walaa M. El-HusseinyDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt; View further author information
, Magda A.-A. El-SayedDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt; ;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University, New Damietta, Egypt; http://orcid.org/0000-0001-9599-9248View further author information
, Naglaa I. Abdel-AzizDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt; Correspondence[email protected]
View further author information
, View further author information
Adel S. El-AzabDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; ;Department of Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt; Correspondence[email protected]
http://orcid.org/0000-0001-7197-1515View further author information
, http://orcid.org/0000-0001-7197-1515View further author information
Esam R. AhmedConfirmatory Diagnostic Unit, Vacsera, Giza, EgyptView further author information
& Alaa A.-M. Abdel-AzizDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt; ;Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; http://orcid.org/0000-0002-3362-9337View further author information
Pages 507-518
|
Received 15 Jul 2017, Accepted 23 Jan 2018, Published online: 19 Feb 2018
Related Research Data
The antioxidant activity of some curcuminoids and chalcones.
Source:
Springer
Telomerase activity in HeLa cervical carcinoma cell line proliferation
Source:
Springer Science and Business Media LLC
Synthesis of coumarin heterocyclic derivatives with antioxidant activity and in vitro cytotoxic activity against tumour cells
Source:
Croatian Pharmaceutical Society
Antitumor Activity of Sorafenib in Human Cancer Cell Lines with Acquired Resistance to EGFR and VEGFR Tyrosine Kinase Inhibitors
Source:
Public Library of Science (PLoS)
Synthesis of Chalcones with Anticancer Activities
Source:
MDPI AG
Synthesis of Curcumin Analogues as Potential Antioxidant, Cancer Chemopreventive Agents.
Source:
Wiley
Design, synthesis and biological evaluation of 2-mercapto-3-phenethylquinazoline bearing anilide fragments as potential antitumor agents: molecular docking study.
Source:
Elsevier BV
Design, synthesis and molecular modeling of pyrazole–quinoline–pyridine hybrids as a new class of antimicrobial and anticancer agents
Source:
Elsevier BV
Synthesis, in vitro antitumour activity, and molecular docking study of novel 2-substituted mercapto-3-(3,4,5-trimethoxybenzyl)-4(3H)-quinazolinone analogues.
Source:
Taylor & Francis
Dual ALK and EGFR inhibition targets a mechanism of acquired resistance to the tyrosine kinase inhibitor crizotinib in ALK rearranged lung cancer.
Source:
Elsevier BV
Synthesis and biological evaluation of 2-styrylquinolines as antitumour agents and EGFR kinase inhibitors: molecular docking study.
Source:
Informa UK Limited
The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ERBB2 inhibitor HKI-272
Source:
Springer Science and Business Media LLC
Design, synthesis and biological evaluation of some novel substituted quinazolines as antitumor agents.
Source:
Elsevier BV
Free radicals in cell biology.
Source:
Elsevier
Design, Synthesis and Docking Studies of Novel Macrocyclic Pentapeptides as Anticancer Multi-Targeted Kinase Inhibitors
Source:
MDPI AG
Total antioxidant potential of resinous exudates from Heliotropium species, and a comparison of the ABTS and DPPH methods.
Source:
Informa UK Limited
Recent progress in the development of anticancer agents.
Source:
Bentham Science Publishers Ltd.
Enantiodivergent Synthesis of (R)- and (S)-Rolipram
Source:
MDPI AG
Design, synthesis and molecular docking of α,β-unsaturated cyclohexanone analogous of curcumin as potent EGFR inhibitors with antiproliferative activity.
Source:
Elsevier BV
Synthesis, Characterization and Anti-Cancer Activity of Hydrazide Derivatives Incorporating a Quinoline Moiety
Source:
Multidisciplinary Digital Publishing Institute
Synthesis and biological evaluation of new curcumin derivatives as antioxidant and antitumor agents
Source:
Springer Science and Business Media LLC
Design, synthesis, single-crystal and preliminary antitumor activity of novel arenesulfonylimidazolidin-2-ones
Source:
Elsevier BV
Design, synthesis and biological evaluation of some novel substituted 2-mercapto-3-phenethylquinazolines as antitumor agents
Source:
Springer Science and Business Media LLC
The New Era in Cancer Research
Source:
American Association for the Advancement of Science (AAAS)
Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: Molecular docking study
Source:
Elsevier BV
Natural product-based design, synthesis and biological evaluation of Albiziabioside A derivatives that selectively induce HCT116 cell death.
Source:
Elsevier BV
Synthesis and potential antitumor activity of 7-(4-substituted piperazin-1-yl)-4-oxoquinolines based on ciprofloxacin and norfloxacin scaffolds: in silico studies.
Source:
Informa UK Limited
ABTS•+ scavenging activity of polypyrrole, polyaniline and poly(3,4-ethylenedioxythiophene)
Source:
Wiley
Application of chalcones in heterocycles synthesis: Synthesis of 2-(isoxazolo, pyrazolo and pyrimido) substituted analogues of 1,4-benzodiazepin-5-carboxamides linked through an oxyphenyl bridge
Source:
Springer Science and Business Media LLC
A simple one-pot synthesis of quinoline-4-carboxylic acid derivatives by pfitzinger reaction of isatin with ketones in water
Source:
Springer Science and Business Media LLC
Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects
Source:
Elsevier BV
Chalcones in cancer: understanding their role in terms of QSAR
Source:
Bentham Science Publishers Ltd.
Oxidants, antioxidants, and the degenerative diseases of aging
Source:
Proceedings of the National Academy of Sciences
Synthesis, antitumor activity and molecular docking study of some novel 3-benzyl-4(3H)quinazolinone analogues.
Source:
Taylor & Francis
Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability.
Source:
Elsevier BV
Oxidative Stress and Antioxidant Defense
Source:
Elsevier BV
Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal Results.
Source:
Hindawi
Identification of novel 3,5-diarylpyrazoline derivatives containing salicylamide moiety as potential anti-melanoma agents.
Source:
Elsevier BV
Isoliquiritigenin Induces Apoptosis and Inhibits Xenograft Tumor Growth of Human Lung Cancer Cells by Targeting Both Wild Type and L858R/T790M Mutant EGFR
Source:
American Society for Biochemistry & Molecular Biology (ASBMB)
Synthesis, anticancer and apoptosis-inducing activities of quinazoline–isatin conjugates: epidermal growth factor receptor-tyrosine kinase assay and molecular docking studies
Source:
Informa UK Limited
Related research
People also read lists articles that other readers of this article have read.
Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.
Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.