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Research Paper
Synthesis and pharmacological evaluation of novel isoquinoline N-sulphonylhydrazones designed as ROCK inhibitors
Ramon Guerra de OliveiraLaboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; ;Programa de Pós-Graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; http://orcid.org/0000-0002-2407-5766View further author information
, Fabiana Sélos GuerraPrograma de Pós-Graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; ;Laboratório de Farmacologia da Dor e da Inflamação, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; View further author information
, Cláudia dos Santos MermelsteinLaboratório de Diferenciação Muscular, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; http://orcid.org/0000-0002-8897-8526View further author information
, Patrícia Dias FernandesPrograma de Pós-Graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; ;Laboratório de Farmacologia da Dor e da Inflamação, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; http://orcid.org/0000-0001-6870-6745View further author information
, Isadora Tairinne de Sena BastosInstituto de Física, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; View further author information
, Fanny Nascimento CostaCentro de Ciências Naturais e Humanas (CCNH), Universidade Federal do ABC (UFABC), São Paulo, Brazilhttp://orcid.org/0000-0001-9368-5640View further author information
, Regina Cely Rodrigues BarrosoInstituto de Física, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; View further author information
, Fabio Furlan FerreiraCentro de Ciências Naturais e Humanas (CCNH), Universidade Federal do ABC (UFABC), São Paulo, Brazilhttp://orcid.org/0000-0003-1516-1221View further author information
& Carlos Alberto Manssour FragaLaboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; ;Programa de Pós-Graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Correspondence[email protected]
http://orcid.org/0000-0001-6733-7079View further author information
show allhttp://orcid.org/0000-0001-6733-7079View further author information
Pages 1181-1193
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Received 07 May 2018, Accepted 15 Jun 2018, Published online: 25 Jul 2018
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