Supplemental material
Journal of Enzyme Inhibition and Medicinal Chemistry
Volume 33, 2018 - Issue 1
Research Paper
Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy
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Mikhail S. DrenichevEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federationhttp://orcid.org/0000-0001-7624-8801View further author information
http://orcid.org/0000-0001-7624-8801View further author information, Nadezhda S. DyrkheevaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation; http://orcid.org/0000-0002-8360-1041View further author information
http://orcid.org/0000-0002-8360-1041View further author information, , , Olga D. ZakharovaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation; http://orcid.org/0000-0001-5980-8889View further author information
http://orcid.org/0000-0001-5980-8889View further author information, , Sergey N. MikhailovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federationhttp://orcid.org/0000-0002-1363-9706View further author information
http://orcid.org/0000-0002-1363-9706View further author information & show allRelated Research Data
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Quantitative characterization of protein-protein complexes involved in base excision DNA repair.
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A versatile strategy for the design and synthesis of novel ADP conjugates and their evaluation as potential poly(ADP-ribose) polymerase 1 inhibitors
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Design and synthesis of fluorescent substrates for human tyrosyl-DNA phosphodiesterase I
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Disaccharide Nucleosides and their Incorporation into Oligonucleotides
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Oligonucleotides Containing Disaccharide Nucleosides
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The Crystal Structure of Human Tyrosyl-DNA Phosphodiesterase, Tdp1
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Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential ☆
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A New Protocol for SelectiveCleavage of Acyl Protecting Groups in 2′-O-Modified 3′,5′-O-(Tetraisopropyldisiloxane-1,3-diyl)ribonucleosides
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Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK.
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Disaccharide nucleosides as an important group of natural compounds
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Poly(ADP-ribose)polymerase 1 stimulates the AP-site cleavage activity of tyrosyl-DNA phosphodiesterase 1
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Portland Press Ltd.
Ribosylation of pyrimidine 2'-deoxynucleosides
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TDP1 Overexpression in Human Cells Counteracts DNA Damage Mediated by Topoisomerases I and II
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Elsevier BV
Synthesis and Properties of O-β-D-ribofuranosyl-(1″2′)-guanosine-5″- O-phosphate and Its Derivatives
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Evolving landscape of tumor molecular profiling for personalized cancer therapy: a comprehensive review
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Disaccharide nucleosides
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Insights into substrate binding and catalytic mechanism of human tyrosyl-DNA phosphodiesterase (Tdp1) from vanadate and tungstate-inhibited structures.
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[Tyrosyl-DNA Phosphodiesterase 1 Is a New Player in Repair of Apurinic/Apyrimidinic Sites].
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The Development of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors. Combination of Monoterpene and Adamantine Moieties via Amide or Thioamide Bridges
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Distinct Requirements for the Rad32Mre11 Nuclease and Ctp1CtIP in the Removal of Covalently Bound Topoisomerase I and II from DNA
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American Association for Cancer Research (AACR)
Effective anomerisation of 2'-deoxyadenosine derivatives during disaccharide nucleoside synthesis.
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Informa UK Limited
Disaccharide nucleosides and oligonucleotides on their basis. New tools for the study of enzymes of nucleic acid metabolism.
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The Determination of Enzyme Dissociation Constants
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Targeted cancer therapy
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Oxford University Press (OUP)
Targeted cancer therapy
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Springer Science and Business Media LLC
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Synthesis of a series of NAD+ analogues, potential inhibitors of PARP 1, using ADP conjugates functionalized at the terminal phosphate group
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Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage
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