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Research Paper
Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania
Andrea Medeirosa Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay;b Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
https://orcid.org/0000-0001-9677-8834View further author information
Diego Beníteza Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay
https://orcid.org/0000-0003-4639-8539View further author information
Ricarda S. Kornc Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Braunschweig, GermanyView further author information
, Vinicius C. Ferreirad Instituto Gonçalo Moniz (IGM), FIOCRUZ, Salvador, BrazilView further author information
, Exequiel Barrerae Biomolecular Simulations Group, Institut Pasteur de Montevideo, Montevideo, Uruguay
https://orcid.org/0000-0002-0388-3078View further author information
Federico Carriónf Protein Biophysics Unit, Institut Pasteur de Montevideo, Montevideo, UruguayView further author information
, Otto Pritschf Protein Biophysics Unit, Institut Pasteur de Montevideo, Montevideo, Uruguay;g Departamento de Inmunobiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.View further author information
, Sergio Pantanoe Biomolecular Simulations Group, Institut Pasteur de Montevideo, Montevideo, Uruguay
https://orcid.org/0000-0001-6435-4543View further author information
Conrad Kunickc Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Braunschweig, Germany
https://orcid.org/0000-0001-7041-5322View further author information
Camila I. de Oliveirad Instituto Gonçalo Moniz (IGM), FIOCRUZ, Salvador, BrazilView further author information
, Oliver C. F. Orbanc Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Braunschweig, GermanyCorrespondence[email protected]
https://orcid.org/0000-0002-5506-789XView further author information
Marcelo A. Cominia Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, UruguayCorrespondence[email protected]
https://orcid.org/0000-0001-5000-1333View further author information
Pages 1345-1358
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Received 10 Apr 2020, Accepted 02 Jun 2020, Published online: 26 Jun 2020
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