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Research Paper
Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors
Ibrahim M. Salema Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, EgyptCorrespondence[email protected]
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Samia M. Mostafaa Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, EgyptView further author information
, Ismail Salamaa Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypthttps://orcid.org/0000-0002-1360-0430View further author information
, Osama I. El-Sabbaghb Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, EgyptView further author information
, Wael A. H. Hegazyc Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt;d Pharmacy Program, Department of Pharmaceutical Sciences, Oman College of Health Sciences, Muscat, Omanhttps://orcid.org/0000-0001-5683-4803View further author information
& Tarek S. Ibrahime Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia;f Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, EgyptCorrespondence[email protected]
https://orcid.org/0000-0002-3049-4617View further author information
https://orcid.org/0000-0002-3049-4617View further author information
Pages 203-215
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Received 26 Jul 2022, Accepted 28 Oct 2022, Published online: 16 Nov 2022
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