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Research Paper
Triple targeting of mutant EGFRL858R/T790M, COX-2, and 15-LOX: design and synthesis of novel quinazolinone tethered phenyl urea derivatives for anti-inflammatory and anticancer evaluation
Hend Kothayera Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, EgyptCorrespondence[email protected] [email protected]
https://orcid.org/0000-0002-2954-0751View further author information
, https://orcid.org/0000-0002-2954-0751View further author information
Samar Rezqb Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt;c Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, USA;d Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center, Jackson, MS, USA;e Women’s Health Research Center, University of Mississippi Medical Center, Jackson, MS, USA;f Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson, MS, USAhttps://orcid.org/0000-0003-4421-0686View further author information
, Ahmed S. Abdelkhaleka Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypthttps://orcid.org/0000-0003-2198-0549View further author information
, Damian G. Romeroc Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, USA;d Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center, Jackson, MS, USA;e Women’s Health Research Center, University of Mississippi Medical Center, Jackson, MS, USA;f Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson, MS, USAhttps://orcid.org/0000-0002-7268-9690View further author information
& Samar S. Elbaramawia Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypthttps://orcid.org/0000-0001-8658-1296View further author information
Article: 2199166
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Received 29 Dec 2022, Accepted 30 Mar 2023, Published online: 11 Apr 2023
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