Discovery of novel polysubstituted N-alkyl acridone analogues as histone deacetylase isoform-selective inhibitors for cancer therapy

Ze Wanga Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People’s Republic of ChinaView further author information

Li Zhaob Institute of Drug Discovery Technology, Ningbo University, Ningbo, People’s Republic of ChinaView further author information

Bo Zhanga Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People’s Republic of ChinaView further author information

Jiahe Fenga Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People’s Republic of ChinaView further author information

Yule Wanga Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People’s Republic of ChinaView further author information

Bin Zhanga Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People’s Republic of ChinaCorrespondence[email protected]

https://orcid.org/0000-0002-4371-4746 View further author information

Haixiao Jina Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People’s Republic of ChinaView further author information

Lijian Dinga Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People’s Republic of ChinaView further author information

Ning Wangb Institute of Drug Discovery Technology, Ningbo University, Ningbo, People’s Republic of ChinaCorrespondence[email protected]

https://orcid.org/0000-0002-5625-5358 View further author information

Shan Hea Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People’s Republic of China;c Ningbo Institute of Marine Medicine, Peking University, Ningbo, People’s Republic of ChinaCorrespondence[email protected]
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Discovery of novel polysubstituted N-alkyl acridone analogues as histone deacetylase isoform-selective inhibitors for cancer therapy

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Discovery of novel polysubstituted N-alkyl acridone analogues as histone deacetylase isoform-selective inhibitors for cancer therapy

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