High-throughput sequencing of two populations of extracellular vesicles provides an mRNA signature that can be detected in the circulation of breast cancer patients

Andrew ConleyDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA

Valentina R. MinciacchiDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA;Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA;Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA;Department of Surgery, Division of Cancer Biology and Therapeutics, Cedars-Sinai Medical Center, Los Angeles, CA, USA

Dhong Hyun LeeDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA;Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA;Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA;Department of Surgery, Division of Cancer Biology and Therapeutics, Cedars-Sinai Medical Center, Los Angeles, CA, USA

Beatrice S. KnudsenDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA;Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA

Beth Y. KarlanSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA;Women's Cancer Program and Division of Gynecologic Oncology Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA

Luigi CitrignoDepartment of Surgery, Division of Cancer Biology and Therapeutics, Cedars-Sinai Medical Center, Los Angeles, CA, USA;Department of Experimental and Clinical Medicine, University Magna Graecia, Catanzaro, Italy

Giuseppe VigliettoDepartment of Experimental and Clinical Medicine, University Magna Graecia, Catanzaro, Italy

Muneesh TewariDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA;Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA;Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA;Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA;Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA

Michael R. FreemanDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA;Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA;Department of Surgery, Division of Cancer Biology and Therapeutics, Cedars-Sinai Medical Center, Los Angeles, CA, USA;The Urological Diseases Research Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA;Department of Medicine, University of California, Los Angeles, USA

Francesca DemichelisCentre for Integrative Biology, University of Trento, Trento, Italy;Institute for Precision Medicine, Weill Cornell Medicine, New YorkNY, USA

Dolores Di VizioDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA;Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA;Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA;Department of Surgery, Division of Cancer Biology and Therapeutics, Cedars-Sinai Medical Center, Los Angeles, CA, USA;The Urological Diseases Research Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA;Department of Medicine, University of California, Los Angeles, USACorrespondence[email protected]

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High-throughput sequencing of two populations of extracellular vesicles provides an mRNA signature that can be detected in the circulation of breast cancer patients

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High-throughput sequencing of two populations of extracellular vesicles provides an mRNA signature that can be detected in the circulation of breast cancer patients

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