Supplemental material
Open access
12,076
Views
58
CrossRef citations to date
0
Altmetric
Research Paper
RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells
Xianming Dinga Department of Biochemistry, and Department of Cardiology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaView further author information
, Xiao Jianga Department of Biochemistry, and Department of Cardiology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaView further author information
, Rui Tiana Department of Biochemistry, and Department of Cardiology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaView further author information
, Pengwei Zhaoa Department of Biochemistry, and Department of Cardiology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaView further author information
, Lin Lib Proteomics Center, National Institute of Biological Sciences, Beijing, ChinaView further author information
, Xinyi Wanga Department of Biochemistry, and Department of Cardiology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaView further author information
, She Chenb Proteomics Center, National Institute of Biological Sciences, Beijing, ChinaView further author information
, Yushan Zhuc State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Sciences, College of Life Sciences, Nankai University, Tianjin, ChinaView further author information
, Mei Meid State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, ChinaView further author information
, Shilai Baod State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, ChinaView further author information
, Wei Liua Department of Biochemistry, and Department of Cardiology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaView further author information
, Zaiming Tange Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaView further author information
& Qiming Suna Department of Biochemistry, and Department of Cardiology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaCorrespondence[email protected] [email protected]
https://orcid.org/0000-0003-4988-9886View further author information
Pages 1774-1786
|
Received 06 Feb 2018, Accepted 01 Mar 2019, Published online: 06 Apr 2019
Related Research Data
Rab Conversion as a Mechanism of Progression from Early to Late Endosomes
Source:
Elsevier BV
Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy.
Source:
Springer Science and Business Media LLC
Atg9 trafficking in the yeast Saccharomyces cerevisiae.
Source:
Informa UK Limited
Atg9 is required for intraluminal vesicles in amphisomes and autolysosomes
Source:
The Company of Biologists
Small GTPase Rab1B is associated with ATG9A vesicles and regulates autophagosome formation
Source:
Wiley
Identification of the switch in early-to-late endosome transition.
Source:
Elsevier BV
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
Source:
Springer Science and Business Media LLC
The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14
Source:
Informa UK Limited
GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex.
Source:
Rockefeller University Press
Exit from the Golgi is required for the expansion of the autophagosomal phagophore in yeast Saccharomyces cerevisiae.
Source:
American Society for Cell Biology (ASCB)
The small GTPase Rab2 functions in the removal of apoptotic cells in Caenorhabditis elegans
Source:
Rockefeller University Press
Regulation Mechanisms and Signaling Pathways of Autophagy
Source:
Annual Reviews
Assembly and dynamics of the autophagy-initiating Atg1 complex
Source:
Proceedings of the National Academy of Sciences
Spatial and Functional Aspects of ER-Golgi Rabs and Tethers.
Source:
Frontiers Media S.A.
Regulation of autophagy by the Rab GTPase network
Source:
Springer Science and Business Media LLC
Self-interaction is critical for Atg9 transport and function at the phagophore assembly site during autophagy
Source:
American Society for Cell Biology (ASCB)
Targeting Rab GTPases to distinct membrane compartments.
Source:
Springer Science and Business Media LLC
Purification and functional interactions of GRASP55 with Rab2.
Source:
Elsevier
Autophagosome Formation: Tracing the Source
Source:
Elsevier BV
Atg1 kinase organizes autophagosome formation by phosphorylating Atg9.
Source:
Informa UK Limited
Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment
Source:
eLife Sciences Publications, Ltd
The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy
Source:
Rockefeller University Press
Receptor-Bound Targets of Selective Autophagy Use a Scaffold Protein to Activate the Atg1 Kinase
Source:
Elsevier BV
Mechanisms of Autophagy Initiation.
Source:
Annual Reviews
Post-Golgi Sec Proteins Are Required for Autophagy in Saccharomyces cerevisiae
Source:
American Society for Cell Biology (ASCB)
Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130.
Source:
Elsevier BV
C. elegans Rab GTPase 2 is required for the degradation of apoptotic cells.
Source:
The Company of Biologists
AP1 is essential for generation of autophagosomes from the trans-Golgi network.
Source:
The Company of Biologists
Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy
Source:
eScholarship, University of California
GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans.
Source:
Rockefeller University Press
Ypt1 recruits the Atg1 kinase to the preautophagosomal structure
Source:
Proceedings of the National Academy of Sciences
Rabs and GAPs in starvation-induced autophagy
Source:
Informa UK Limited
Syntaxin 16’s Newly Deciphered Roles in Autophagy
Source:
MDPI AG
C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking
Source:
Oxford University Press (OUP)
Dissection of the Autophagosome Maturation Process by a Novel Reporter Protein, Tandem Fluorescent-Tagged LC3
Source:
Informa UK Limited
A Rab2 Mutant with Impaired GTPase Activity Stimulates Vesicle Formation from Pre-Golgi Intermediates
Source:
American Society for Cell Biology (ASCB)
Related research
People also read lists articles that other readers of this article have read.
Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.
Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.