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OncoImmunology
Volume 7, 2018 - Issue 7
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Original Research
D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization
Martin BöttcherDepartment of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, GermanyCorrespondence[email protected]
http://orcid.org/0000-0003-2911-8830View further author information
, http://orcid.org/0000-0003-2911-8830View further author information
Kathrin RennerInternal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, GermanyView further author information
, Raffaela BergerInstitute of Functional Genomics, University of Regensburg, Regensburg, GermanyView further author information
, Kristin MentzDepartment of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, GermanyView further author information
, Simone ThomasInternal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, Germanyhttp://orcid.org/0000-0001-6308-3649View further author information
, Zugey Elizabeth Cardenas-ConejoInternal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, GermanyView further author information
, Katja DettmerInstitute of Functional Genomics, University of Regensburg, Regensburg, GermanyView further author information
, Peter J. OefnerInstitute of Functional Genomics, University of Regensburg, Regensburg, GermanyView further author information
, Andreas MackensenDepartment of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, GermanyView further author information
, Marina KreutzInternal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, GermanyView further author information
& Dimitrios MougiakakosDepartment of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, GermanyView further author information
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Article: e1445454
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Received 15 Dec 2017, Accepted 21 Feb 2018, Published online: 26 Mar 2018
Related Research Data
Immunometabolic Regulation of Anti-Tumor T-Cell Responses by the Oncometabolite D-2-Hydroxyglutarate
Source:
Hapres
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