Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromising immune homeostasis

Heidi HarjunpääCancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia;School of Medicine, The University of Queensland, Herston, Queensland, Australia

Stephen J. BlakeCancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia

Elizabeth AhernCancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia;Immunology of Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia;School of Medicine, The University of Queensland, Herston, Queensland, Australia;Medical Oncology, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia

Stacey AllenCancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia

Jing LiuCancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia

Juming YanCancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia;School of Medicine, The University of Queensland, Herston, Queensland, Australia

Viviana LutzkyImmunology of Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia

Kazuyoshi TakedaDivision of Cell Biology, Biomedical Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan

http://orcid.org/0000-0002-5539-310X

Amy Roman AguileraImmunology of Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia

Camille GuillereyImmunology of Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia;School of Medicine, The University of Queensland, Herston, Queensland, Australia

Deepak MittalImmunology of Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia;School of Medicine, The University of Queensland, Herston, Queensland, Australia

Xian Yang LiImmunology of Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia

http://orcid.org/0000-0003-4163-5283

William C. DougallImmunology of Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia

Mark J. SmythImmunology of Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia;School of Medicine, The University of Queensland, Herston, Queensland, Australia

Michele W. L. TengCancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia;School of Medicine, The University of Queensland, Herston, Queensland, AustraliaCorrespondence[email protected]

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Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromising immune homeostasis

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Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromising immune homeostasis

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